Biologically pure culture of Actinoplanes missouriensis
    1.
    发明授权
    Biologically pure culture of Actinoplanes missouriensis 失效
    生物学纯文化的流行性感冒

    公开(公告)号:US4375513A

    公开(公告)日:1983-03-01

    申请号:US309965

    申请日:1981-10-09

    摘要: Antibiotic A-4696 factors B.sub.1, B.sub.2, B.sub.3, C.sub.1a, C.sub.3, and E.sub.1 are isolated from antibiotic A-4696, the latter being produced by Actinoplanes missouriensis strains ATCC 31680, ATCC 31682, and ATCC 31683 under submerged aerobic conditions in a culture medium and isolated from the fermentation broth by absorption on an ion exchange resin and eluted therefrom at p.sup.H 10.5 with sodium hydroxide. The novel factors are separated by thin layer chromatography and high pressure liquid chromatography and have antimicrobial and growth promotant activity.

    摘要翻译: 抗生素A-4696因子B1,B2,B3,C1a,C3和E1从抗生素A-4696中分离,抗生素A-4696是由浸润好氧条件下的培养基中的流行性感冒菌ATCC 31680,ATCC 31682和ATCC 31683产生的 并通过在离子交换树脂上吸收并从pH7.10用氢氧化钠洗脱而从发酵液中分离。 新型因子通过薄层色谱和高压液相色谱分离,并具有抗微生物和生长促进作用。

    Actaplanin antibiotics
    4.
    发明授权
    Actaplanin antibiotics 失效
    抗抑素药物

    公开(公告)号:US4558036A

    公开(公告)日:1985-12-10

    申请号:US581016

    申请日:1984-02-17

    申请人: Kurt E. Merkel

    发明人: Kurt E. Merkel

    IPC分类号: C07K9/00 A61K37/00 C07H17/08

    摘要: Antibiotic A4696 factor H is isolated from the purified antibiotic complex produced by Actinoplanes missouriensis ATCC 31683 and exhibits excellent activity vs. gram-positive bacteria.

    摘要翻译: 抗生素A4696因子H从由Actinoplanes Missouriensis ATCC 31683产生的纯化抗生素复合物中分离,并且表现出优异的活性与革兰氏阳性细菌。

    Actaplanin antibiotics
    8.
    发明授权
    Actaplanin antibiotics 失效
    抗抑素药物

    公开(公告)号:US4479897A

    公开(公告)日:1984-10-30

    申请号:US488967

    申请日:1983-04-27

    摘要: Actaplanin antibiotics (A4696) designated as C.sub.2a, D.sub.1, D.sub.2, K, L, M, N, and O are obtained by the partial acidic hydrolysis of known actaplanins at about pH 1.85 for 2.5 hours at about 90.degree. C. The new actaplanins, like the known actaplanins, are glycopeptides which possess antibacterial activity and, either alone or as a mixture with other actaplanins, improve the feed efficiency in ruminants, swine and poultry.

    摘要翻译: 通过已知的actaplanins在大约pH 1.85下在约90℃下进行2.5小时的部分酸性水解获得指定为C2a,D1,D2,K,L,M,N和O的灭帕普兰抗生素(A4696)。新的actaplanins, 像已知的actaplanins一样,是具有抗菌活性的糖肽,单独或作为与其他actaplanins的混合物,提高反刍动物,猪和家禽的饲料效率。