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公开(公告)号：US08080255B2
公开(公告)日：2011-12-20
申请号：US11582540
申请日：2006-10-18
申请人： Gale Smith , Rick Bright , Peter Pushko , Jinyou Zhang , Kutub Mahmood
发明人： Gale Smith , Rick Bright , Peter Pushko , Jinyou Zhang , Kutub Mahmood
IPC分类号： A61K39/145
CPC分类号： A61K39/145 , A61K39/12 , A61K39/39 , A61K2039/5258 , A61K2039/543 , A61K2039/55505 , A61K2039/55555 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2710/14143 , C12N2760/16023 , C12N2760/16034 , C12N2760/16071 , C12N2760/16122 , C12N2760/16123 , C12N2760/16134
摘要： The present invention discloses and claims virus like particles (VLPs) that express and/or contains seasonal influenza virus proteins, avian influenza virus proteins and/or influenza virus proteins from viruses with pandemic potential. The invention includes vector constructs comprising said proteins, cells comprising said constructs, formulations and vaccines comprising VLPs of the inventions. The invention also includes methods of making and administrating VLPs to vertebrates, including methods of inducing substantial immunity to either seasonal and avian influenza, or at least one symptom thereof.
摘要翻译： 本发明公开并要求从具有大流行潜力的病毒中表达和/或含有季节性流感病毒蛋白，禽流感病毒蛋白和/或流感病毒蛋白质的病毒样颗粒（VLPs）。 本发明包括包含所述蛋白质的载体构建体，包含所述构建体的细胞，制剂和包含本发明的VLP的疫苗。 本发明还包括制备和施用VLP到脊椎动物的方法，包括诱导季节性和禽流感的实质性免疫或其至少一种症状的方法。
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公开(公告)号：US08951537B2
公开(公告)日：2015-02-10
申请号：US13297125
申请日：2011-11-15
申请人： Gale Smith , Rick Bright , Peter Pushko , Jinyou Zhang , Kutub Mahmood
发明人： Gale Smith , Rick Bright , Peter Pushko , Jinyou Zhang , Kutub Mahmood
IPC分类号： A61K39/145 , C12N7/00 , C12N7/04 , C07K14/005 , C12N15/86 , A61K39/00
CPC分类号： A61K39/145 , A61K39/12 , A61K39/39 , A61K2039/5258 , A61K2039/543 , A61K2039/55505 , A61K2039/55555 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2710/14143 , C12N2760/16023 , C12N2760/16034 , C12N2760/16071 , C12N2760/16122 , C12N2760/16123 , C12N2760/16134
摘要： The present invention discloses and claims virus like particles (VLPs) that express and/or contains seasonal influenza virus proteins, avian influenza virus proteins and/or influenza virus proteins from viruses with pandemic potential. The invention includes vector constructs comprising said proteins, cells comprising said constructs, formulations and vaccines comprising VLPs of the inventions. The invention also includes methods of making and administrating VLPs to vertebrates, including methods of inducing substantial immunity to either seasonal and avian influenza, or at least one symptom thereof.
摘要翻译： 本发明公开并要求从具有大流行潜力的病毒中表达和/或含有季节性流感病毒蛋白，禽流感病毒蛋白和/或流感病毒蛋白质的病毒样颗粒（VLPs）。 本发明包括包含所述蛋白质的载体构建体，包含所述构建体的细胞，制剂和包含本发明的VLP的疫苗。 本发明还包括制备和施用VLP到脊椎动物的方法，包括诱导季节性和禽流感的实质性免疫或其至少一种症状的方法。
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公开(公告)号：US20120207786A1
公开(公告)日：2012-08-16
申请号：US13297125
申请日：2011-11-15
申请人： Gale SMITH , Rick Bright , Peter Pushko , Jinyou Zhang , Kutub Mahmood
发明人： Gale SMITH , Rick Bright , Peter Pushko , Jinyou Zhang , Kutub Mahmood
IPC分类号： A61K39/145 , A61P31/16
CPC分类号： A61K39/145 , A61K39/12 , A61K39/39 , A61K2039/5258 , A61K2039/543 , A61K2039/55505 , A61K2039/55555 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2710/14143 , C12N2760/16023 , C12N2760/16034 , C12N2760/16071 , C12N2760/16122 , C12N2760/16123 , C12N2760/16134
摘要： The present invention discloses and claims virus like particles (VLPs) that express and/or contains seasonal influenza virus proteins, avian influenza virus proteins and/or influenza virus proteins from viruses with pandemic potential. The invention includes vector constructs comprising said proteins, cells comprising said constructs, formulations and vaccines comprising VLPs of the inventions. The invention also includes methods of making and administrating VLPs to vertebrates, including methods of inducing substantial immunity to either seasonal and avian influenza, or at least one symptom thereof.
摘要翻译： 本发明公开并要求从具有大流行潜力的病毒中表达和/或含有季节性流感病毒蛋白，禽流感病毒蛋白和/或流感病毒蛋白质的病毒样颗粒（VLPs）。 本发明包括包含所述蛋白质的载体构建体，包含所述构建体的细胞，制剂和包含本发明的VLP的疫苗。 本发明还包括制备和施用VLP到脊椎动物的方法，包括诱导季节性和禽流感的实质性免疫或其至少一种症状的方法。
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公开(公告)号：US20070184526A1
公开(公告)日：2007-08-09
申请号：US11582540
申请日：2006-10-18
申请人： Gale Smith , Rick Bright , Peter Pushko , Jinyou Zhang , Kutub Mahmood
发明人： Gale Smith , Rick Bright , Peter Pushko , Jinyou Zhang , Kutub Mahmood
CPC分类号： A61K39/145 , A61K39/12 , A61K39/39 , A61K2039/5258 , A61K2039/543 , A61K2039/55505 , A61K2039/55555 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2710/14143 , C12N2760/16023 , C12N2760/16034 , C12N2760/16071 , C12N2760/16122 , C12N2760/16123 , C12N2760/16134
摘要： The present invention discloses and claims virus like particles (VLPs) that express and/or contains seasonal influenza virus proteins, avian influenza virus proteins and/or influenza virus proteins from viruses with pandemic potential. The invention includes vector constructs comprising said proteins, cells comprising said constructs, formulations and vaccines comprising VLPs of the inventions. The invention also includes methods of making and administrating VLPs to vertebrates, including methods of inducing substantial immunity to either seasonal and avian influenza, or at least one symptom thereof.
摘要翻译： 本发明公开并要求从具有大流行潜力的病毒中表达和/或含有季节性流感病毒蛋白，禽流感病毒蛋白和/或流感病毒蛋白质的病毒样颗粒（VLPs）。 本发明包括包含所述蛋白质的载体构建体，包含所述构建体的细胞，制剂和包含本发明的VLP的疫苗。 本发明还包括制备和施用VLP到脊椎动物的方法，包括诱导季节性和禽流感的实质性免疫或其至少一种症状的方法。
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公开(公告)号：US08506967B2
公开(公告)日：2013-08-13
申请号：US12340186
申请日：2008-12-19
申请人： Gale Smith , Rick Bright , Peter M. Pushko , Jinyou Zhang , Kutub Mahmood
发明人： Gale Smith , Rick Bright , Peter M. Pushko , Jinyou Zhang , Kutub Mahmood
IPC分类号： A61K39/145
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5258 , A61K2039/543 , A61K2039/55505 , A61K2039/55555 , A61K2039/55561 , A61K2039/58 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2710/14143 , C12N2760/16022 , C12N2760/16023 , C12N2760/16034 , C12N2760/16122 , C12N2760/16123 , C12N2760/16134
摘要： The present invention discloses and claims virus like particles (VLPs) that express and/or contains seasonal influenza virus proteins, avian influenza virus proteins and/or influenza virus proteins from viruses with pandemic potential. The invention includes vector constructs comprising said proteins, cells comprising said constructs, formulations and vaccines comprising VLPs of the inventions. The invention also includes methods of making and administrating VLPs to vertebrates, including methods of inducing substantial immunity to either seasonal and avian influenza, or at least one symptom thereof.
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公开(公告)号：US20100129401A1
公开(公告)日：2010-05-27
申请号：US12340186
申请日：2008-12-19
申请人： Gale Smith , Rick Bright , Peter M. Pushko , Jinyou Zhang , Kutub Mahmood
发明人： Gale Smith , Rick Bright , Peter M. Pushko , Jinyou Zhang , Kutub Mahmood
IPC分类号： A61K39/145 , A61P31/16 , C12N7/00
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5258 , A61K2039/543 , A61K2039/55505 , A61K2039/55555 , A61K2039/55561 , A61K2039/58 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2710/14143 , C12N2760/16022 , C12N2760/16023 , C12N2760/16034 , C12N2760/16122 , C12N2760/16123 , C12N2760/16134
摘要： The present invention discloses and claims virus like particles (VLPs) that express and/or contains seasonal influenza virus proteins, avian influenza virus proteins and/or influenza virus proteins from viruses with pandemic potential. The invention includes vector constructs comprising said proteins, cells comprising said constructs, formulations and vaccines comprising VLPs of the inventions. The invention also includes methods of making and administrating VLPs to vertebrates, including methods of inducing substantial immunity to either seasonal and avian influenza, or at least one symptom thereof.
摘要翻译： 本发明公开并要求从具有大流行潜力的病毒中表达和/或含有季节性流感病毒蛋白，禽流感病毒蛋白和/或流感病毒蛋白质的病毒样颗粒（VLPs）。 本发明包括包含所述蛋白质的载体构建体，包含所述构建体的细胞，制剂和包含本发明的VLP的疫苗。 本发明还包括制备和施用VLP到脊椎动物的方法，包括诱导季节性和禽流感的实质性免疫或其至少一种症状的方法。
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公开(公告)号：US20100143393A1
公开(公告)日：2010-06-10
申请号：US12300427
申请日：2007-05-11
申请人： Gale Smith , Rick Bright , D. Craig Wright
发明人： Gale Smith , Rick Bright , D. Craig Wright
IPC分类号： A61K39/145 , C07K14/00 , A61P31/16
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5258 , A61K2039/55555 , C07K14/005 , C07K2319/00 , C12N2760/16122 , C12N2760/16134
摘要： The present invention includes novel influenza antigenic formulations and vaccines that comprise influenza M2 peptide and VLPs comprising influenza M2 protein. The invention also includes methods of making and administering the novel antigenic formulation and vaccine. The invention also include methods of inducing immunity to ameliorate and/or prevent influenza infections in a subject.
摘要翻译： 本发明包括新型流感抗原制剂和包含流感M2肽和包含流感M2蛋白的VLP的疫苗。 本发明还包括制备和施用新型抗原制剂和疫苗的方法。 本发明还包括诱导免疫力改善和/或预防受试者流感感染的方法。
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公开(公告)号：US20070048861A1
公开(公告)日：2007-03-01
申请号：US11333770
申请日：2006-01-17
申请人： Harriet Robinson , James Smith , Jian Hua , Bernard Moss , Rama Amara , Linda Wyatt , Patricia Earl , Ted Ross , Rick Bright , Salvatore Butera , Dennis Ellenberger , Thomas Folks
发明人： Harriet Robinson , James Smith , Jian Hua , Bernard Moss , Rama Amara , Linda Wyatt , Patricia Earl , Ted Ross , Rick Bright , Salvatore Butera , Dennis Ellenberger , Thomas Folks
CPC分类号： A61K39/145 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/5258 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/55522 , A61K2039/70 , C07K14/005 , C07K14/472 , C07K16/10 , C07K2319/00 , C12N15/63 , C12N15/67 , C12N15/70 , C12N15/85 , C12N15/86 , C12N2710/24134 , C12N2710/24143 , C12N2740/16043 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234 , C12N2740/16334 , C12N2760/16134 , C12N2830/42 , C12N2840/107 , C12N2840/20
摘要： The present invention relates to novel plasmid constructs useful for the delivery of DNA vaccines. The present invention provides novel plasmids having a transcription cassette capable of directing the expression of a vaccine nucleic acid insert encoding immunogens derived from any pathogen, including fungi, bacteria and viruses. The present invention, however, is particularly useful for inducing in a patient an immune response against pathogenic viruses such as HIV, measles or influenza. Immunodeficiency virus vaccine inserts of the present invention express non-infectious HIV virus-like particles (VLP) bearing multiple viral epitopes. VLPs allow presentation of the epitopes to multiple histocompatability types, thereby reducing the possibility of the targeted virus escaping the immune response. Also described are methods for immunizing a patient by delivery of a novel plasmid of the present invention to the patient for expression of the vaccine insert therein. Optionally, the immunization protocol may include a booster vaccination that may be a live vector vaccine such as a recombinant pox virus or modified vaccinia Arbora vector. The booster live vaccine vector includes a transcription cassette expressing the same vaccine insert as the primary immunizing vector.
摘要翻译： 本发明涉及用于递送DNA疫苗的新型质粒构建体。 本发明提供具有转录盒的新颖质粒，其能够引导编码来自任何病原体（包括真菌，细菌和病毒）的免疫原的疫苗核酸插入物的表达。 然而，本发明特别可用于在患者中诱导针对病毒性病毒如HIV，麻疹或流行性感冒的免疫应答。 本发明的免疫缺陷病毒疫苗插入物表达具有多个病毒表位的非传染性HIV病毒样颗粒（VLP）。 VLP允许将表位呈现给多种组织相容性类型，从而降低靶向病毒逃避免疫应答的可能性。 还描述了通过将本发明的新型质粒递送给患者以在其中表达疫苗插入物来免疫患者的方法。 任选地，免疫方案可以包括加强免疫接种，其可以是活载体疫苗，例如重组痘病毒或修饰的牛痘Arbora载体。 增效活疫苗载体包括表达与初次免疫载体相同疫苗插入片段的转录盒。
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公开(公告)号：US20060051839A1
公开(公告)日：2006-03-09
申请号：US11009063
申请日：2004-12-09
申请人： Harriet Robinson , Rama Amara , Ted Ross , Rick Bright
发明人： Harriet Robinson , Rama Amara , Ted Ross , Rick Bright
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/55522 , A61K2039/57 , C07K14/472 , C07K16/10 , C07K2319/00 , C12N15/63 , C12N15/67 , C12N15/70 , C12N15/85 , C12N2710/24143 , C12N2740/15034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234 , C12N2740/16334 , C12N2760/16134 , C12N2760/18434 , C12N2830/42 , C12N2840/107 , C12N2840/20 , Y02A50/466
摘要： The present invention relates to novel plasmid constructs useful for the delivery of DNA vaccines. The present invention provides novel plasmids having a transcription cassette capable of directing the expression of a vaccine nucleic acid insert encoding immunogens derived from any pathogen, including fungi, bacteria and viruses. The present invention, however, is particularly useful for inducing in a patient an immune response against pathogenic viruses such as HIV, measles or influenza. Immunodeficiency virus vaccine inserts of the present invention express non-infectious HIV virus-like particles (VLP) bearing multiple viral epitopes. VLPs allow presentation of the epitopes to multiple histocompatability types, thereby reducing the possibility of the targeted virus escaping the immune response. Also described are methods for immunizing a patient by delivery of a novel plasmid of the present invention to the patient for expression of the vaccine insert therein. Optionally, the immunization protocol may include a booster vaccination that may be a live vector vaccine such as a recombinant pox virus or modified vaccinia Arbora vector. The booster live vaccine vector includes a transcription cassette expressing the same vaccine insert as the primary immunizing vector.
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