Bioactive amino acid sequence and use therefrom
    2.
    发明申请
    Bioactive amino acid sequence and use therefrom 审中-公开
    生物活性氨基酸序列及其用途

    公开(公告)号:US20130210147A1

    公开(公告)日:2013-08-15

    申请号:US13877915

    申请日:2011-10-06

    IPC分类号: C12N5/071

    摘要: Use of the amino acid sequence Har-Gly-Asp (hRGD) as a bioactive sequence in functional peptides to promote cell adhesion, cell growth, and/or cell differentiation, and in the preparation of hydrogels, preferably hydrogels for cell culture. A hydrogel comprising the hRGD sequence, especially a hydrogel wherein the hRGD sequence is part of the hydrogel scaffold.

    摘要翻译: 在功能性肽中使用氨基酸序列Har-Gly-Asp(hRGD)作为生物活性序列来促进细胞粘附,细胞生长和/或细胞分化,以及制备水凝胶,优选用于细胞培养的水凝胶。 包含hRGD序列,特别是水凝胶的水凝胶,其中hRGD序列是水凝胶支架的一部分。

    Method for modelling fluid flows in a multilayer porous medium crossed by an unevenly distributed fracture network
    4.
    发明授权
    Method for modelling fluid flows in a multilayer porous medium crossed by an unevenly distributed fracture network 失效
    在由不均匀分布的骨折网络穿过的多层多孔介质中对流体流动进行建模的方法

    公开(公告)号:US07565277B2

    公开(公告)日:2009-07-21

    申请号:US10390654

    申请日:2003-03-19

    CPC分类号: E21B49/00

    摘要: A method is disclosed for modelling low or high compressibility fluid flows in a multilayer porous medium crossed by a network of fractures of given geometry, unevenly distributed in the medium, some of the fractures communicating with one another. Each fractured layer is defined by means of a grid pattern comprising fracture grid cells centered on nodes either at the fracture intersections or at the fracture ends. Each node is associated with a matrix block including all the points closer thereto than to neighboring nodes, and the local flows between each fracture grid cell and the associated matrix volume are calculated in a pseudosteady state. A modelling equation whose form is similar to the diffusion equation solved in conventional cases (low compressibility fluids) allows accounting for the compressibility of the fluids. The direct flows between the fracture grid cells and the direct flows between the matrix volumes through the common edges of the grid cells are determined, and the interactions between the pressure and flow rate variations that can be observed in at least one well through the medium are simulated.

    摘要翻译: 公开了一种用于模拟由不均匀分布在介质中的一些由几何形状的骨折网络穿过的多层多孔介质中的低或高可压缩流体流的方法,其中一些裂缝彼此连通。 每个断裂层通过网格图案来定义,该网格图案包括以裂缝交叉点或断裂端处的节点为中心的裂缝网格单元。 每个节点与包括比相邻节点更接近的所有点的矩阵块相关联,并且在伪稳态下计算每个裂缝网格单元和相关联的矩阵体之间的局部流。 其形式与常规情况下解决的扩散方程(低压缩性流体)相似的建模方程可以说明流体的压缩性。 确定裂缝网格单元之间的直接流动和通过网格单元的公共边缘的矩阵体积之间的直接流动,并且可以在至少一个井中通过介质观察到的压力和流速变化之间的相互作用是 模拟。

    Peptide synthesis method using n-carboxyanhydride (UNCA)
    5.
    发明申请
    Peptide synthesis method using n-carboxyanhydride (UNCA) 审中-公开
    使用n-羧酸酐(UNCA)的肽合成方法

    公开(公告)号:US20110105722A1

    公开(公告)日:2011-05-05

    申请号:US12921413

    申请日:2009-03-06

    IPC分类号: C07K1/107 C07K1/14

    CPC分类号: C07K1/02 C07K1/06

    摘要: Method for preparing a peptide or a peptide derivative which comprises it least one step in which a free amino acid or a free peptide is reacted with a urethane-protected amino acid N-carboxyanhydride (UNCA) solution.

    摘要翻译: 制备肽或肽衍生物的方法,其包含其中游离氨基酸或游离肽与氨基甲酸酯保护的氨基酸N-羧酸酐(UNCA)溶液反应的至少一个步骤。