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    Use of sigma receptor antagonists for treatment of cocaine abuse
    3.
    发明授权
    Use of sigma receptor antagonists for treatment of cocaine abuse 失效
    使用SIGMA受体拮抗剂治疗酷酷症

    公开(公告)号：US5180729A

    公开(公告)日：1993-01-19

    申请号：US659444

    申请日：1991-02-22

    Applicant: Leonard Cook

    Inventor： Leonard Cook

    IPC: A61K31/445

    CPC classification number: A61K31/445

    Abstract: The invention relates to a method of treating cocaine abuse or addiction in a mammal which comprises administering to the mammal an effective amount of a sigma receptor antagonist lacking or having relatively weak dopamine receptor-blocking activity, to reduce the pharmacological effects of the cocaine.

    Abstract translation: 本发明涉及治疗哺乳动物中可卡因滥用或成瘾的方法，其包括向哺乳动物施用有效量的缺乏或具有相对较弱的多巴胺受体阻断活性的σ受体拮抗剂，以降低可卡因的药理作用。

    Use of sigma receptor antagonists for treatment of amphetamine abuse
    4.
    发明授权
    Use of sigma receptor antagonists for treatment of amphetamine abuse 失效
    使用SIGMA受体拮抗剂治疗AMPHETAMINE的治疗

    公开(公告)号：US5162341A

    公开(公告)日：1992-11-10

    申请号：US659443

    申请日：1991-02-22

    Applicant: Leonard Cook

    Inventor： Leonard Cook

    IPC: A61K31/44 ,  A61K31/445

    CPC classification number: A61K31/44 ,  A61K31/445

    Abstract: The invention relates to a method of treating drug abuse or addiction involving amphetamine or amphetamine-related drugs with pharmacological effects similar to amphetamine in a mammal which comprises administering to the mammal an effective amount, to reduce the pharmacological effects of the amphetamine or amphetamine-related drug, of certain piperidine sigma receptor antagonists.

    Abstract translation: 本发明涉及一种治疗药物滥用或成瘾的方法，其涉及在哺乳动物中具有类似于苯丙胺的药理作用的安非他明或苯丙胺相关药物，其包括向哺乳动物施用有效量，以降低苯丙胺或苯丙胺相关的药理作用 药物，某些哌啶西格玛受体拮抗剂。

    DIESEL FUEL COMPOSITIONS
    7.
    发明申请
    DIESEL FUEL COMPOSITIONS 有权
    柴油燃料组合物

    公开(公告)号：US20140174390A1

    公开(公告)日：2014-06-26

    申请号：US14236754

    申请日：2012-08-02

    Applicant: Jacqueline Reid ,  Stephen Leonard Cook

    Inventor： Jacqueline Reid ,  Stephen Leonard Cook

    IPC: C10L10/04

    CPC classification number: C10L10/04 ,  C10L1/146 ,  C10L1/1616 ,  C10L1/198 ,  C10L1/238 ,  C10L1/2383 ,  C10L1/2387 ,  C10L1/285 ,  C10L10/18 ,  C10L2270/026 ,  C10L2300/20

    Abstract: A diesel fuel composition comprising a quaternary ammonium salt additive which additive is formed by the reaction of (1) a quaternising agent and (2) a compound formed by the reaction of a hydrocarbyl-substituted acylating agent and at least 1.4 molar equivalents of an amine of formula (B1) or (B2), wherein R2 and R3 are the same or different alkyl, alkenyl or aryl groups having from 1 to 22 carbon atoms; X is a bond or alkylene group having from 1 to 20 carbon atoms; n is from 0 to 20; m is from 1 to 5; and R4 is hydrogen or a C1 to C22 alkyl group.

    Abstract translation: 一种柴油燃料组合物，其包含季铵盐添加剂，该添加剂通过（1）季铵化剂和（2）通过烃基取代的酰化剂与至少1.4摩尔当量胺的反应形成的化合物 式（B1）或（B2）表示，其中R2和R3是相同或不同的具有1至22个碳原子的烷基，烯基或芳基; X是具有1至20个碳原子的键或亚烷基; n为0〜20; m为1至5; R4为氢或C1〜C22烷基。

    Composition
    8.
    发明授权
    Composition 失效
    组成

    公开(公告)号：US07959691B2

    公开(公告)日：2011-06-14

    申请号：US12482789

    申请日：2009-06-11

    Applicant: Stephen Leonard Cook ,  Werner Kalischewski ,  Gabriele Lohmann

    Inventor： Stephen Leonard Cook ,  Werner Kalischewski ,  Gabriele Lohmann

    IPC: C10L1/30

    CPC classification number: C10L10/06 ,  C07F17/02 ,  C10L1/305 ,  C10L10/02 ,  F01N3/023 ,  F01N2430/04

    Abstract: The present invention provides a composition comprising: i) at least one compound of formula (I): wherein R1 and R2 are independently selected from a group consisting of hydrogen, unsubstituted or substituted C1-19 hydrocarbyl or a group of formula (II): wherein Q is a bond or an unsubstituted or substituted hydrocarbyl group; wherein R3 is selected from a group consisting of hydrogen and unsubstituted or substituted C1-18 hydrocarbyl; wherein the R1—C—R2 backbone is from 5 to 20 atoms in length; wherein each A and B is independently an unsubstituted or substituted unsaturated cyclic hydrocarbyl group; and wherein n is an integer from 0 to 10; and ii) a diluent or carrier; wherein the compound(s) of formula (I) is present in an amount sufficient to provide, at −30° C., at least 1 wt % of iron, based on the weight of the composition.

    Abstract translation: 本发明提供一种组合物，其包含：i）至少一种式（I）化合物：其中R 1和R 2独立地选自氢，未取代或取代的C 1-19烃基或式（II）的基团： 其中Q是键或未取代或取代的烃基; 其中R 3选自氢和未取代的或取代的C 1-18烃基; 其中R1-C-R2主链的长度为5至20个原子; 其中每个A和B独立地是未取代或取代的不饱和环烃基; 并且其中n为0至10的整数; 和ii）稀释剂或载体; 其中式（I）化合物的存在量足以在-30℃下提供至少1重量％的铁，基于组合物的重量。

    Composition
    9.
    发明授权
    Composition 有权
    组成

    公开(公告)号：US07556657B2

    公开(公告)日：2009-07-07

    申请号：US10488134

    申请日：2002-08-29

    Applicant: Stephen Leonard Cook ,  Werner Kalischewski ,  Gabriele Lohmann ,  Armin Marschewski

    Inventor： Stephen Leonard Cook ,  Werner Kalischewski ,  Gabriele Lohmann ,  Armin Marschewski

    IPC: C10L1/30

    CPC classification number: C10L10/06 ,  C07F17/02 ,  C10L1/305 ,  C10L10/02 ,  F01N3/023 ,  F01N2430/04

    Abstract: The present invention provides a composition comprising: i) at least one compound of formula (I): wherein R1 and R2 are independently selected from a group consisting of hydrogen, unsubstituted or substituted C1-19 hydrocarbyl or a group of formula (II): wherein Q is a bond or an unsubstituted or substituted hydrocarbyl group; wherein R3 is selected from a group consisting of hydrogen and unsubstituted or substituted C1-18 hydrocarbyl; wherein the R1—C—R2 backbone is from 5 to 20 atoms in length; wherein each A and B is independently an unsubstituted or substituted unsaturated cyclic hydrocarbyl group; and wherein n is an integer from 0 to 10; and ii) a diluent or carrier; wherein the compound(s) of formula (I) is present in an amount sufficient to provide, at −30° C., at least 1 wt % of iron, based on the weight of the composition.

    Abstract translation: 本发明提供一种组合物，其包含：i）至少一种式（I）化合物：其中R 1和R 2独立地选自氢，未取代或取代的C 1-19烃基或式（II）的基团： 其中Q是键或未取代或取代的烃基; 其中R 3选自氢和未取代的或取代的C 1-18烃基; 其中R1-C-R2主链的长度为5至20个原子; 其中每个A和B独立地是未取代或取代的不饱和环烃基; 并且其中n为0至10的整数; 和ii）稀释剂或载体; 其中式（I）化合物的存在量足以在-30℃下提供至少1重量％的铁，基于组合物的重量。

    Combination of an opioid antagonist and a selective serotonin reuptake inhibitor for treatment of alcoholism and alcohol dependence
    10.
    发明授权
    Combination of an opioid antagonist and a selective serotonin reuptake inhibitor for treatment of alcoholism and alcohol dependence 失效
    阿片样物质拮抗剂与选择性5-羟色胺再摄取抑制剂联合用于治疗酒精中毒和酒精依赖

    公开(公告)号：US6071918A

    公开(公告)日：2000-06-06

    申请号：US357748

    申请日：1999-07-21

    Applicant: Leonard Cook

    Inventor： Leonard Cook

    IPC: A61K31/445 ,  A61K45/06 ,  A61K31/495 ,  A61K31/44 ,  A61K31/40 ,  A61K31/135

    CPC classification number: A61K31/445 ,  A61K45/06

    Abstract: The invention relates to a method of treating alcoholism and alcohol dependence in a mammal comprising administering to the mammal a therapeutically effective amount of a synergistic combination of: (i) at least one opioid antagonist, and (ii) at least one selective serotonin reuptake inhibitor. The invention also relates to compositions and kits containing the same.

    Abstract translation: 本发明涉及一种在哺乳动物中治疗酒精中毒和酒精依赖的方法，包括向哺乳动物施用治疗有效量的协同组合：（i）至少一种阿片样物质拮抗剂和（ii）至少一种选择性5-羟色胺再摄取抑制剂 。 本发明还涉及含有其的组合物和试剂盒。

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