公开(公告)号：US20190353273A1

公开(公告)日：2019-11-21

申请号：US16530003

申请日：2019-08-02

Applicant: John Leslie Johnson ,  James G. Johnson

Inventor： John Leslie Johnson ,  James G. Johnson

IPC: F16K31/122 ,  F16K21/04 ,  F16K27/02 ,  F16K31/383 ,  F16K39/02 ,  F15B13/04 ,  F16K1/12 ,  F16K11/065 ,  F16K31/06 ,  F16K31/12 ,  F16K31/124 ,  F16K31/363 ,  F16K31/22

Abstract: A double action directional fluid flow valve includes a stepped piston connected with a poppet valve and moveable by a controller between open and closed positions by applying a continuous pressure to a small diameter piston face and selectively applying and removing pressure from a large diameter piston face to move the poppet valve between an open position and a closed position.

公开(公告)号：US10378671B2

公开(公告)日：2019-08-13

申请号：US15835671

申请日：2017-12-08

Applicant: John Leslie Johnson ,  James G. Johnson

Inventor： John Leslie Johnson ,  James G. Johnson

IPC: F16K31/122 ,  F16K21/04 ,  F16K31/22 ,  F15B13/04 ,  F16K1/12 ,  F16K11/065 ,  F16K27/02 ,  F16K31/06 ,  F16K31/12 ,  F16K31/124 ,  F16K31/363 ,  F16K31/383 ,  F16K39/02

Abstract: A double action directional fluid flow valve includes a stepped piston connected with a poppet valve and moveable by a controller between open and closed positions by applying a continuous pressure to a small diameter piston face and selectively applying and removing pressure from a large diameter piston face to move the poppet valve between an open position and a closed position.

公开(公告)号：US20180355996A1

公开(公告)日：2018-12-13

申请号：US15835671

申请日：2017-12-08

Applicant: John Leslie Johnson ,  James G. Johnson

Inventor： John Leslie Johnson ,  James G. Johnson

IPC: F16K31/122 ,  F16K39/02 ,  F16K31/383 ,  F16K31/363 ,  F16K31/22 ,  F16K31/124 ,  F16K31/12 ,  F16K31/06 ,  F16K27/02 ,  F16K21/04 ,  F16K11/065 ,  F16K1/12 ,  F15B13/04

CPC classification number: F16K31/122 ,  F15B13/04 ,  F16K1/126 ,  F16K11/0655 ,  F16K21/04 ,  F16K27/02 ,  F16K31/0603 ,  F16K31/12 ,  F16K31/1221 ,  F16K31/124 ,  F16K31/22 ,  F16K31/363 ,  F16K31/383 ,  F16K39/02 ,  F16K39/022 ,  Y10T137/8667

Abstract: A double action directional fluid flow valve includes a stepped piston connected with a poppet valve and moveable by a controller between open and closed positions by applying a continuous pressure to a small diameter piston face and selectively applying and removing pressure from a large diameter piston face to move the poppet valve between an open position and a closed position.

公开(公告)号：US09841116B2

公开(公告)日：2017-12-12

申请号：US15450134

申请日：2017-03-06

Applicant: John Leslie Johnson ,  James G. Johnson

Inventor： John Leslie Johnson ,  James G. Johnson

IPC: F16K31/12 ,  F16K31/122 ,  F16K1/12 ,  F16K21/04 ,  F16K27/02 ,  F16K31/124 ,  F16K31/363

CPC classification number: F16K31/122 ,  F15B13/04 ,  F16K1/126 ,  F16K11/0655 ,  F16K21/04 ,  F16K27/02 ,  F16K31/0603 ,  F16K31/12 ,  F16K31/1221 ,  F16K31/124 ,  F16K31/22 ,  F16K31/363 ,  F16K31/383 ,  F16K39/02 ,  F16K39/022 ,  Y10T137/8667

Abstract: A double action directional fluid flow valve includes a stepped piston connected with a poppet valve and moveable by a controller between open and closed positions by applying a continuous pressure to a small diameter piston face and selectively applying and removing pressure from a large diameter piston face to move the poppet valve between an open position and a closed position.

公开(公告)号：US09587757B2

公开(公告)日：2017-03-07

申请号：US15213732

申请日：2016-07-19

Applicant: John Leslie Johnson ,  James G. Johnson

Inventor： John Leslie Johnson ,  James G. Johnson

IPC: F16K31/12 ,  F16K31/122 ,  F16K1/12 ,  F16K31/06 ,  F16K21/04 ,  F16K31/124 ,  F16K31/363 ,  F16K31/383 ,  F16K39/02 ,  F16K11/065 ,  F16K27/02 ,  F16K31/22 ,  F15B13/04

CPC classification number: F16K31/122 ,  F15B13/04 ,  F16K1/126 ,  F16K11/0655 ,  F16K21/04 ,  F16K27/02 ,  F16K31/0603 ,  F16K31/12 ,  F16K31/1221 ,  F16K31/124 ,  F16K31/22 ,  F16K31/363 ,  F16K31/383 ,  F16K39/02 ,  F16K39/022 ,  Y10T137/8667

Abstract: A double action directional fluid flow valve includes a stepped piston connected with a poppet valve and moveable by a controller between open and closed positions by applying a continuous pressure to a small diameter piston face and selectively applying and removing pressure from a large diameter piston face to move the poppet valve between an open position and a closed position.

Abstract translation: 双作用方向流体流量阀包括与提升阀连接的阶梯式活塞，并通过向开口和关闭位置之间的控制器移动，通过对小直径活塞面施加连续的压力并选择性地将压力从大直径的活塞面施加到和移除 在提升阀在打开位置和关闭位置之间移动。

公开(公告)号：US08714196B2

公开(公告)日：2014-05-06

申请号：US13425820

申请日：2012-03-21

Applicant: John Leslie Johnson ,  James G. Johnson

Inventor： John Leslie Johnson ,  James G. Johnson

IPC: F16K31/00

CPC classification number: G01M3/2853 ,  F16K1/126 ,  F16K27/003 ,  F16K31/122 ,  F16K31/1225 ,  F16K37/0066 ,  F16K37/0091 ,  G01M3/2876 ,  G01M3/3236 ,  Y10T137/87201 ,  Y10T137/87209 ,  Y10T137/87225

Abstract: A valve manifold includes a valve body carrying pairs of laterally spaced piston actuated valves controlled by control modules operative to selectively pressurize and exhaust an outlet port connected to a fluid device and configured in groupings permitting varying valve functionalities.

Abstract translation: 阀歧管包括承载成对的侧向间隔开的活塞致动阀的阀体，控制模块可操作以选择性地加压和排出连接到流体装置的出口，并且被配置为允许变化的阀功能的组。

公开(公告)号：US08371450B2

公开(公告)日：2013-02-12

申请号：US12940757

申请日：2010-11-05

Applicant: Ronald Keith McGregor ,  Ronald Leslie Johnson

Inventor： Ronald Keith McGregor ,  Ronald Leslie Johnson

IPC: B07B1/49

CPC classification number: B07B1/4645

Abstract: A screening module for a screening assembly includes a panel member defining a plurality of screening apertures; and a support arrangement with which the panel member is fast. The support arrangement includes a plurality of strengthening arrays arranged, in use, beneath the panel member, each strengthening array comprising a skirt portion bounding an area on a bottom surface of the panel member.

Abstract translation: 用于筛选组件的筛选模块包括限定多个筛孔的面板构件; 以及面板构件快速的支撑装置。 支撑装置包括在使用中在面板构件下面布置的多个强化阵列，每个强化阵列包括限定面板构件的底表面上的区域的裙部。

公开(公告)号：US08177188B1

公开(公告)日：2012-05-15

申请号：US12131092

申请日：2008-06-01

Applicant: John Leslie Johnson ,  James G. Johnson

Inventor： John Leslie Johnson ,  James G. Johnson

IPC: F16K31/00

CPC classification number: G01M3/2853 ,  F16K1/126 ,  F16K27/003 ,  F16K31/122 ,  F16K31/1225 ,  F16K37/0066 ,  F16K37/0091 ,  G01M3/2876 ,  G01M3/3236 ,  Y10T137/87201 ,  Y10T137/87209 ,  Y10T137/87225

Abstract: A valve manifold includes a valve body carrying pairs of laterally spaced piston actuated valves controlled by control modules operative to selectively pressurize and exhaust an outlet port connected to a fluid device and configured in groupings permitting varying valve functionalities.

Abstract translation: 阀歧管包括承载成对的横向间隔开的活塞致动阀的阀体，控制模块可操作以选择性地加压和排出连接到流体装置的出口端口并且被配置为允许变化的阀功能的组。

公开(公告)号：US08113357B2

公开(公告)日：2012-02-14

申请号：US11622897

申请日：2007-01-12

Applicant: Ronald Leslie Johnson ,  Peter Martin Olsen ,  Warren Anthony Spinks

Inventor： Ronald Leslie Johnson ,  Peter Martin Olsen ,  Warren Anthony Spinks

IPC: B07B1/49

CPC classification number: B07B1/4645

Abstract: A screening module 10 comprises a frame component 12 to be secured to an underlying screen deck, in use. A screening panel 14 is carried by the frame component 12. The screening panel 14 comprises an operatively upper screening surface 16 and a support structure 18 underlying the screening surface 16 with a plurality of spaced protrusions 20 being supported by and standing proud of the support structure 18. Operatively upper ends of the protrusions 20 lie substantially in a plane of the screening surface 16 and the protrusions 20 define a plurality of screening apertures 22 in the screening surface 16.

Abstract translation: 遮蔽模块10包括在使用中要固定到下面的屏幕甲板的框架部件12。 筛板14由框架部件12承载。筛板14包括可操作的上筛选表面16和位于筛面16下方的支撑结构18，多个间隔开的突起20由支撑结构 突起20的可操作的上端基本上位于屏蔽表面16的平面中，并且突起20在屏蔽表面16中限定多个筛孔22。

公开(公告)号：US20080044429A1

公开(公告)日：2008-02-21

申请号：US11768852

申请日：2007-06-26

Applicant: Leslie Johnson ,  Ling Huang ,  Robyn Gerena

Inventor： Leslie Johnson ,  Ling Huang ,  Robyn Gerena

IPC: A61K39/395 ,  A61P35/00 ,  C07H21/00 ,  C07K16/00 ,  C07K16/30 ,  C07K7/06 ,  C07K7/08 ,  C12N1/00 ,  C12N15/63 ,  C12P21/02

CPC classification number: C07K16/283 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/732 ,  C07K2317/92

Abstract: The present invention relates to antibodies or fragments thereof that specifically bind FcγRIIB, particularly human FcγRIIB, with greater affinity than said antibodies or fragments thereof bind FcγRIIA, particularly human FcγRIIA. The present invention also provides the use of an anti-FcγRIIB antibody or an antigen-binding fragment thereof, as a single agent therapy for the treatment, prevention, management, or amelioration of a cancer, preferably a B-cell malignancy, particularly, B-cell chronic lymphocytic leukemia or non-Hodgkin's lymphoma, an autoimmune disorder, an inflammatory disorder, an IgE-mediated allergic disorder, or one or more symptoms thereof. The invention provides methods of enhancing the therapeutic effect of therapeutic antibodies by administering the antibodies of the invention to enhance the effector function of the therapeutic antibodies. The invention also provides methods of enhancing efficacy of a vaccine composition by administering the antibodies of the invention.

Abstract translation: 本发明涉及以比所述抗体或其片段更大的亲和力结合FcγRIIA，特别是人FcγRIIA的FcγRIIB特别是人FcγRIIB特异性结合的抗体或其片段。 本发明还提供抗FcγRIIB抗体或其抗原结合片段作为单一药物治疗用于治疗，预防，治疗或改善癌症，优选B细胞恶性肿瘤，特别是B细胞 细胞性慢性淋巴细胞白血病或非霍奇金淋巴瘤，自身免疫性疾病，炎症性疾病，IgE介导的过敏性疾病或其一种或多种症状。 本发明提供了通过施用本发明的抗体来增强治疗性抗体的效应功能来增强治疗性抗体的治疗效果的方法。 本发明还提供了通过施用本发明的抗体来增强疫苗组合物的功效的方法。