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公开(公告)号：US08513164B2
公开(公告)日：2013-08-20
申请号：US11642593
申请日：2006-12-21
申请人： Achim Knappik , Peter Pack , Liming Ge , Simon Moroney , Andreas Plückthun
发明人： Achim Knappik , Peter Pack , Liming Ge , Simon Moroney , Andreas Plückthun
CPC分类号： C07K1/047 , C07K16/00 , C07K16/005 , C07K16/18 , C07K16/242 , C07K16/26 , C07K16/2854 , C07K16/2896 , C07K16/44 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C07K2319/00 , C12N15/10 , C12N15/1037 , C40B40/02
摘要： The present invention relates to a method of identifying one or more genes encoding one or more proteins having an optimized property. In particular, the method comprises expressing a collection of genes and screening for a desired property, identifying a plurality of genes having the desired property, and replacing one or more one or more sub-sequences of each of said genes with a different, compatible genetic sub-sequence, and screening again in order to identify genes encoding proteins having an optimized property.
摘要翻译： 本发明涉及鉴定编码一种或多种具有优化特性的蛋白质的一种或多种基因的方法。 特别地，所述方法包括表达基因的集合并筛选所需的性质，鉴定具有所需性质的多个基因，并用不同的相容遗传基因替换每个所述基因的一个或多个子序列 亚序列和再次筛选，以便鉴定编码具有优化特性的蛋白质的基因。
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公开(公告)号：US07264963B1
公开(公告)日：2007-09-04
申请号：US09490064
申请日：2000-01-24
申请人： Achim Knappik , Peter Pack , Liming Ge , Simon Moroney , Andreas Plückthun
发明人： Achim Knappik , Peter Pack , Liming Ge , Simon Moroney , Andreas Plückthun
CPC分类号： C40B40/02 , C07K1/047 , C07K16/00 , C07K2319/00 , C12N15/10 , C12N15/1037
摘要： The present invention relates to synthetic DNA sequences which encode one or more collections of homologous proteins/(poly)peptides, and methods for generating and applying libraries of these DNA sequences. In particular, the invention relates to the preparation of a library of human-derived antibody genes by the use of synthetic consensus sequences which cover the structural repertoire of antibodies encoded in the human genome. Furthermore, the invention relates to the use of a single consensus antibody gene as a universal framework for highly diverse antibody libraries.
摘要翻译： 本发明涉及编码一个或多个同源蛋白/（多）肽集合的合成DNA序列，以及用于产生和应用这些DNA序列的文库的方法。 特别地，本发明涉及通过使用覆盖人类基因组中编码的抗体结构谱的合成共有序列来制备人源抗体基因文库。 此外，本发明涉及单一共有抗体基因作为高度多样化抗体文库的通用框架的用途。
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3.发明授权Method and phage for the identification of nucleic acid sequences encoding members of a multimeric (poly)peptide complex 失效用于鉴定编码多聚（多）肽复合物成员的核酸序列的方法和噬菌体公开(公告)号：US07049135B2
公开(公告)日：2006-05-23
申请号：US10634862
申请日：2003-08-06
申请人： Fritz Rudert , Liming Ge , Vic Ilag
发明人： Fritz Rudert , Liming Ge , Vic Ilag
CPC分类号： C40B30/04 , C12N15/1037 , C12N15/1055 , C12Q1/6811 , C40B40/02 , G01N33/68 , G01N33/6845
摘要： The present invention relates to methods for the identification of nucleic acid sequences encoding members of a multimeric (poly)peptide complex by screening for polyphage particles. Furthermore, the invention relates to products and uses thereof for the identification of nucleic acid sequences in accordance with the present invention.
摘要翻译： 本发明涉及通过筛选多肽颗粒来鉴定编码多聚（多）肽复合物成员的核酸序列的方法。 此外，本发明涉及根据本发明的用于鉴定核酸序列的产物及其用途。
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公开(公告)号：US06706484B1
公开(公告)日：2004-03-16
申请号：US09490153
申请日：2000-01-24
申请人： Achim Knappik , Peter Pack , Liming Ge , Simon Moroney , Andreas Plückthun
发明人： Achim Knappik , Peter Pack , Liming Ge , Simon Moroney , Andreas Plückthun
IPC分类号： C12P2106
CPC分类号： C40B40/02 , C07K1/047 , C07K16/00 , C07K2319/00 , C12N15/10 , C12N15/1037
摘要： The present invention relates to synthetic DNA sequences which encode one or more collections of homologous proteins/(poly)peptides, and methods for generating and applying libraries of these DNA sequences. In particular, the invention relates to the preparation of a library of human-derived antibody genes by the use of synthetic consensus sequences which cover the structural repertoire of antibodies encoded in the human genome. Furthermore, the invention relates to the use of a single consensus antibody gene as a universal framework for highly diverse antibody libraries.
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公开(公告)号：US20080026948A1
公开(公告)日：2008-01-31
申请号：US11642593
申请日：2006-12-21
申请人： Achim Knappik , Peter Pack , Liming Ge , Simon Moroney , Andreas Pluckthun
发明人： Achim Knappik , Peter Pack , Liming Ge , Simon Moroney , Andreas Pluckthun
CPC分类号： C07K1/047 , C07K16/00 , C07K16/005 , C07K16/18 , C07K16/242 , C07K16/26 , C07K16/2854 , C07K16/2896 , C07K16/44 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C07K2319/00 , C12N15/10 , C12N15/1037 , C40B40/02
摘要： The present invention relates to synthetic DNA sequence which encode one or more collections of homologous proteins(poly)peptides, and methods for generating and applying libraries of these DNA sequences. In particular, the invention relates to the preparation of a library of human-derived antibody genes by the use of synthetic consensus sequences which cover the structural repertoire of antibodies encoded in the human genome. Furthermore, the invention relates to the use of a single consensus antibody gene as a universal framework for highly diverse antibody libraries.
摘要翻译： 本发明涉及编码一个或多个同源蛋白（多）肽集合的合成DNA序列，以及用于产生和应用这些DNA序列的文库的方法。 特别地，本发明涉及通过使用覆盖人类基因组中编码的抗体结构谱的合成共有序列来制备人源抗体基因文库。 此外，本发明涉及单一共有抗体基因作为高度多样化抗体文库的通用框架的用途。
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6.发明授权Method and phage for the identification of nucleic acid sequences encoding members of a multimeric (poly) peptide complex 失效用于鉴定编码多聚（多）肽复合物成员的核酸序列的方法和噬菌体公开(公告)号：US06667150B1
公开(公告)日：2003-12-23
申请号：US09495880
申请日：2000-02-01
申请人： Fritz Rudert , Liming Ge , Vic Ilag
发明人： Fritz Rudert , Liming Ge , Vic Ilag
IPC分类号： C12Q170
CPC分类号： C40B30/04 , C12N15/1037 , C12N15/1055 , C12Q1/6811 , C40B40/02 , G01N33/68 , G01N33/6845
摘要： The present invention relates to methods for the identification of nucleic acid sequences encoding members of a multimeric (poly)peptide complex by screening for polyphage particles. Furthermore, the invention relates to products and uses thereof for the identification of nucleic acid sequences in accordance with the present invention.
摘要翻译： 本发明涉及通过筛选多肽颗粒来鉴定编码多聚（多）肽复合物成员的核酸序列的方法。 此外，本发明涉及根据本发明的用于鉴定核酸序列的产物及其用途。
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公开(公告)号：US06696248B1
公开(公告)日：2004-02-24
申请号：US09490070
申请日：2000-01-24
申请人： Achim Knappik , Peter Pack , Liming Ge , Simon Moroney , Andreas Plückthun
发明人： Achim Knappik , Peter Pack , Liming Ge , Simon Moroney , Andreas Plückthun
IPC分类号： C12Q168
CPC分类号： C40B40/02 , C07K1/047 , C07K16/00 , C07K2319/00 , C12N15/10 , C12N15/1037
摘要： The present invention relates to synthetic DNA sequences which encode one or more collections of homologous proteins/(poly)peptides, and methods for generating and applying libraries of these DNA sequences. In particular, the invention relates to the preparation of a library of human-derived antibody genes by the use of synthetic consensus sequences which cover the structural repertoire of antibodies encoded in the human genome. Furthermore, the invention relates to the use of a single consensus antibody gene as a universal framework for highly diverse antibody libraries.
摘要翻译： 本发明涉及编码一个或多个同源蛋白/（多）肽集合的合成DNA序列，以及用于产生和应用这些DNA序列的文库的方法。 特别地，本发明涉及通过使用覆盖人类基因组中编码的抗体结构谱的合成共有序列来制备人源抗体基因文库。 此外，本发明涉及单一共有抗体基因作为高度多样化抗体文库的通用框架的用途。
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公开(公告)号：US06300064B1
公开(公告)日：2001-10-09
申请号：US09025769
申请日：1998-02-18
申请人： Achim Knappik , Peter Pack , Liming Ge , Simon Moroney , Andreas Plückthun
发明人： Achim Knappik , Peter Pack , Liming Ge , Simon Moroney , Andreas Plückthun
IPC分类号： G01N3353
CPC分类号： C07K1/047 , C07K16/00 , C07K16/005 , C07K16/18 , C07K16/242 , C07K16/26 , C07K16/2854 , C07K16/2896 , C07K16/44 , C07K2317/21 , C07K2317/565 , C07K2317/622 , C07K2319/00 , C12N15/10 , C12N15/1037 , C40B40/02
摘要： The present invention relates to synthetic DNA sequences which encode one or more collections of homologous proteins/(poly)peptides, and methods for generating and applying libraries of these DNA sequences. In particular, the invention relates to the preparation of a library of human-derived antibody genes by the use of synthetic consensus sequences which cover the structural repertoire of antibodies encoded in the human genome. Furthermore, the invention relates to the use of a single consensus antibody gene as a universal framework for highly diverse antibody libraries.
摘要翻译： 本发明涉及编码一个或多个同源蛋白/（多）肽集合的合成DNA序列，以及用于产生和应用这些DNA序列的文库的方法。 特别地，本发明涉及通过使用覆盖人类基因组中编码的抗体结构谱的合成共有序列来制备人源抗体基因文库。 此外，本发明涉及单一共有抗体基因作为高度多样化抗体文库的通用框架的用途。
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