公开(公告)号：US08344140B2

公开(公告)日：2013-01-01

申请号：US12595297

申请日：2008-04-11

Applicant: Simon Mensah Ametamey ,  Rudolf Moser ,  Tobias Ludwig Ross ,  Thomas Leighton Mindt ,  Viola Groehn

Inventor： Simon Mensah Ametamey ,  Rudolf Moser ,  Tobias Ludwig Ross ,  Thomas Leighton Mindt ,  Viola Groehn

IPC: A61K31/41 ,  C07D249/00 ,  C07D257/04

CPC classification number: C07D475/04 ,  A61K51/0402 ,  A61K51/0459 ,  C07B59/002 ,  C07D487/04

Abstract: The present invention is directed towards new 18F-folate radiopharmaceuticals, wherein fluorine-18 is covalently linked through a triazole- or tetrazole linker to a folate or derivative thereof, a method of their preparation, as well as their use in diagnosis and monitoring of therapy of cancer and inflammatory and autoimmune diseases.

Abstract translation: 本发明涉及新的18F-叶酸放射性药物，其中氟-18通过三唑或四唑接头共价连接到叶酸或其衍生物上，其制备方法以及它们在诊断和监测治疗中的用途 的癌症和炎症和自身免疫性疾病。

公开(公告)号：US20120237161A1

公开(公告)日：2012-09-20

申请号：US13472910

申请日：2012-05-16

Applicant: LUDWIG ROSS ,  STEFAN KUFNER ,  MARIA KUFNER ,  WOLFGANG FOSS ,  MARCO BOCK ,  FRANK BAETZ

Inventor： LUDWIG ROSS ,  STEFAN KUFNER ,  MARIA KUFNER ,  WOLFGANG FOSS ,  MARCO BOCK ,  FRANK BAETZ

IPC: G02B6/28 ,  B23P17/04

CPC classification number: G02B6/30 ,  G02B6/125 ,  G02B2006/1215 ,  Y10T29/49826

Abstract: An optical assembly, which is in particular in the form of a splitter component with a so-called splitter forming a passive optical component, is produced particularly inexpensively. In a first step a plurality of splitters are produced on a common wafer by forming a corresponding conductor track pattern. In a second step optical fibers are coupled simultaneously to the connection sides of the individual splitters with the aid of a connection carrier. Then, in a third step the individual splitters with the connection carriers connected thereto are separated form one another. Only one common coupling operation for a large number of splitters is required. The splitters may then be connected to form a splitter cascade.

Abstract translation: 以特别廉价的方式制造光学组件，其特别是具有形成无源光学部件的所谓分束器的分离器部件形式。 在第一步骤中，通过形成对应的导体轨道图案，在公共晶片上产生多个分离器。 在第二步中，借助于连接载体，光纤同时耦合到各个分离器的连接侧。 然后，在第三步骤中，连接有连接载体的各个分离器彼此分离。 只需要大量分流器的一个常见耦合操作。 然后可以将分离器连接以形成分离器级联。

公开(公告)号：US20100056533A1

公开(公告)日：2010-03-04

申请号：US12595301

申请日：2008-04-11

Applicant: Simon Mensah Ametamey ,  Rudolf Moser ,  Tobias Ludwig Ross ,  Viola Groehn

Inventor： Simon Mensah Ametamey ,  Rudolf Moser ,  Tobias Ludwig Ross ,  Viola Groehn

IPC: A61K31/5025 ,  C07D475/04 ,  A61P35/00

CPC classification number: C07D475/08 ,  A61K51/0459 ,  A61K51/0497 ,  C07B2200/05 ,  C07D475/04 ,  G01N33/57492 ,  G01N33/60 ,  G01N33/82 ,  G01N2333/705

Abstract: The present invention is directed towards new 18F-folate radio-pharmaceuticals, wherein the fluorine-18 is covalently linked to the aminobenzoyl moiety, which connects the condensed pyrimidine heterocycle to the amino acid portion within folate structures, as well as their precursors and their non-radioactive references, a method of their preparation, as well as their use in diagnosis of a cell or population of cells expressing a folate-receptor and monitoring of cancer and inflammatory and autoimmune diseases and therapy thereof.

Abstract translation: 本发明涉及新的18F-叶酸放射性药物，其中氟-18共价连接到氨基苯甲酰基部分，其将稠合的嘧啶杂环连接到叶酸结构内的氨基酸部分，以及它们的前体及其非 - - 放射性参考文献，其制备方法，以及它们在诊断表达叶酸受体的细胞或细胞群以及监测癌症和炎性和自身免疫疾病及其治疗方面的用途。

公开(公告)号：US4734389A

公开(公告)日：1988-03-29

申请号：US827066

申请日：1986-02-07

Applicant: Danuta Grabowski ,  Ludwig Ross ,  Volkmar Geiler

Inventor： Danuta Grabowski ,  Ludwig Ross ,  Volkmar Geiler

IPC: C03C3/062 ,  C03C3/064 ,  C03C3/068 ,  C03C3/07 ,  C03C3/072

CPC classification number: C03C3/072 ,  C03C3/062 ,  C03C3/064 ,  C03C3/068 ,  C03C3/07 ,  Y10S501/901

Abstract: A highly refractive optical glass (n.sub.d .gtoreq.1.83) with high dispersion (v.sub.d .ltoreq.25) and very good chemical stability at relatively low density (.delta..ltoreq.3.5 g/cm.sup.3) consists of (in weight percent) SiO.sub.2 19-25, Na.sub.2 O 7-10, K.sub.2 O 4-7, Cs.sub.2 O 0-12, Cao 0.5-2.0, BaO 9-15, TiO.sub.2 25-30, ZrO.sub.2 0-6, Nb.sub.2 O.sub.5 16-20, WO.sub.3 0-3, with Nb.sub.2 O.sub.5 :TiO.sub.2 =0.6-0.71.

Abstract translation: 具有高分散度（vd / = 1.83）和在相对低的密度（Δt= 3.5g / cm 3）下的非常好的化学稳定性由以重量百分比计）SiO 2 -25，Na2O 7-10，K2O 4-7，Cs2O 0-12，Cao 0.5-2.0，BaO 9-15，TiO 2 25-30，ZrO 2 0-6，Nb 2 O 5 16-20，WO 3 0-3，Nb 2 O 5 ：TiO2 = 0.6-0.71。

公开(公告)号：US4584279A

公开(公告)日：1986-04-22

申请号：US673317

申请日：1984-11-20

Applicant: Danuta Grabowski ,  Ludwig Ross ,  Volkmar Geiler ,  Karl Mennemann ,  Georg Gliemeroth

Inventor： Danuta Grabowski ,  Ludwig Ross ,  Volkmar Geiler ,  Karl Mennemann ,  Georg Gliemeroth

IPC: C03C3/064 ,  C03C3/068 ,  C03C3/072 ,  C03C3/155 ,  C03C3/19 ,  C03C4/00

CPC classification number: C03C3/155 ,  C03C3/068 ,  Y10S501/901

Abstract: Optical glass with refractive indicies.gtoreq.1.90, Abbe numbers.gtoreq.25 consisting essentially of, in weight percent; 0-10 SiO.sub.2, 2-20 B.sub.2 O.sub.3, 0-2 Al.sub.2 O.sub.3, the sum of SiO.sub.2, B.sub.2 O.sub.3, and Al.sub.2 O.sub.3 being 7.5-25, 1-16 TiO.sub.2, 0-10 ZrO.sub.2, 35-55 La.sub.2 O.sub.3, 0.5-10 Y.sub.2 O.sub.5, 0.5-15 Nb.sub.2 O.sub.5, 0-10 Gd.sub.2 O.sub.3, 0-15 Ta.sub.2 O.sub.5, 0-3 P.sub.2 O.sub.5 wherein the ratio of SiO.sub.2 to B.sub.2 O.sub.3 is between 0.1 and 1.6, and the sum of Nb.sub.2 O.sub.5 and Ta.sub.2 O.sub.5 is from 9 to 20%.

Abstract translation: 折射指数> / = 1.90，阿贝数> / = 25的光学玻璃基本上以重量百分比计; 0-10SiO 2，2-20B 2 O 3，O 2 Al 2 O 3，SiO 2，B 2 O 3和Al 2 O 3的总和为7.5〜25，1-16 TiO 2，0〜10 ZrO 2，35〜55 La 2 O 3，0.5〜10重量％ -15 Nb2O5,0-10 Gd2O3,0-15 Ta2O5,0-3P2O5，其中SiO2与B2O3的比例在0.1和1.6之间，Nb2O5和Ta2O5之和为9％至20％。

公开(公告)号：US20100111863A1

公开(公告)日：2010-05-06

申请号：US12595297

申请日：2008-04-11

Applicant: Simon Mensah Ametamey ,  Rudolf Moser ,  Tobias Ludwig Ross ,  Thomas Leighton Mindt ,  Viola Groehn

Inventor： Simon Mensah Ametamey ,  Rudolf Moser ,  Tobias Ludwig Ross ,  Thomas Leighton Mindt ,  Viola Groehn

IPC: A61K51/04 ,  C07D475/04 ,  A61P35/00 ,  C12Q1/02

CPC classification number: C07D475/04 ,  A61K51/0402 ,  A61K51/0459 ,  C07B59/002 ,  C07D487/04

Abstract: The present invention is directed towards new 18F-folate radiopharmaceuticals, wherein fluorine-18 is covalently linked through a triazole- or tetrazole linker to a folate or derivative thereof, a method of their preparation, as well as their use in diagnosis and monitoring of therapy of cancer and inflammatory and autoimmune diseases.

Abstract translation: 本发明涉及新的18F-叶酸放射性药物，其中氟-18通过三唑或四唑接头共价连接到叶酸或其衍生物上，其制备方法以及它们在诊断和监测治疗中的用途 的癌症和炎症和自身免疫性疾病。

公开(公告)号：US4721690A

公开(公告)日：1988-01-26

申请号：US698330

申请日：1985-02-05

Applicant: Ludwig Ross ,  Danuta Grabowski ,  Burkhard Speit ,  Volkmar Geiler

Inventor： Ludwig Ross ,  Danuta Grabowski ,  Burkhard Speit ,  Volkmar Geiler

IPC: C03C3/07 ,  C03C4/00 ,  G02C7/00 ,  C03C3/102 ,  C03C13/02

CPC classification number: C03C4/0028 ,  C03C3/07 ,  Y10S501/901 ,  Y10S501/903

Abstract: High PbO-content glass in the optical range of flint and heavy flint glasses from the system SiO.sub.2 --PbO--M.sub.2 O wherein M.sub.2 O=alkali metal oxides, said glass having a minimum PbO content of 30 wt. % and a minimum M.sub.2 O content of 0.5 wt. %, are provided with enhanced chemical stability without loss of the desired optical position by replacing a portion of the SiO.sub.2 and PbO such that the glass contains 1.5-6 wt. % (TiO.sub.2 +ZrO.sub.2) and the ratio of TiO.sub.2 :ZrO.sub.2 is about 0.3-2.0.

Abstract translation: 来自系统SiO2-PbO-M2O的火石和重的燧石玻璃的光学范围内的高PbO含量玻璃，其中M 2 O =碱金属氧化物，所述玻璃具有30重量％的最小PbO含量。 ％和最小M2O含量为0.5wt。 ％，通过更换SiO 2和PbO的一部分使得玻璃含有1.5-6wt。％的化学稳定性而不损失所需的光学位置。 ％（TiO 2 + ZrO 2），TiO 2：ZrO 2的比例为约0.3-2.0。

公开(公告)号：US4719186A

公开(公告)日：1988-01-12

申请号：US854715

申请日：1986-04-16

Applicant: Karl Mennemann ,  Georg Gliemeroth ,  Ludwig Ross ,  Burkhard Speit ,  Volkmar Geiler ,  Hans-Georg Krolla ,  Lothar Meckel

Inventor： Karl Mennemann ,  Georg Gliemeroth ,  Ludwig Ross ,  Burkhard Speit ,  Volkmar Geiler ,  Hans-Georg Krolla ,  Lothar Meckel

IPC: C03C3/091 ,  C03C3/093 ,  C03C3/095 ,  C03C3/097 ,  C03C3/115 ,  C03C3/118 ,  C03C4/00

CPC classification number: C03C3/097 ,  C03C3/091 ,  C03C3/093 ,  C03C3/095 ,  C03C3/115 ,  C03C3/118 ,  Y10S501/903

Abstract: An optical and ophthalmic glass with high refractive index, high Abbe number and low density, which is distinguished by good chemical stability, good crystallization behavior and capability of chemical hardening, comprises (in % by weight):______________________________________ SiO.sub.2 50-63 B.sub.2 O.sub.3 4-8 Al.sub.2 O.sub.3 1-2 Li.sub.2 O 4-8 Na.sub.2 O 4-8 K.sub.2 O 3-7 sum of M.sub.2 O 11-20 (M = Li, Na, K) MgO 0.5-2 CaO 2-5 sum of MO 0-3 (M = Mg, Ca) TiO.sub.2 8-12.5 ZrO.sub.2 1-3 F.sup.- 0-1 As.sub.2 O.sub.3 0.05-0.15 (optional refining agent) Sb.sub.2 O.sub.3 0.0-0.2 (optional refining agent) ______________________________________

Abstract translation: 具有良好化学稳定性，良好的结晶行为和化学硬化能力的高折射率，高阿贝数和低密度的光学和眼镜玻璃包含（重量％）：-SiO 2 50-63 -B 2 O 3 -8-Al2O3 1-2 -Li2O 4-8 -Na2O 4-8-K2O 3-7 - M2O 11-20 - （M = Li，Na，K）-MgO 0.5-2 -CaO 2-5 - 总和MO 0-3 - （M = Mg，Ca）-TiO2 8-12.5 -ZrO2 1-3 -F-0-1 -As2O3 0.05-0.15 - （任选的精制剂）-Sb2O3 0.0-0.2 - （可选精炼 代理） -

公开(公告)号：US4526874A

公开(公告)日：1985-07-02

申请号：US488951

申请日：1983-04-27

Applicant: Danuta Grabowski geb. Marszalek ,  Ludwig Ross ,  Volkmar Geiler ,  Karl Mennemann

Inventor： Danuta Grabowski geb. Marszalek ,  Ludwig Ross ,  Volkmar Geiler ,  Karl Mennemann

IPC: C03C3/064 ,  C03C3/066 ,  C03C3/072 ,  C03C3/089 ,  C03C3/091 ,  C03C3/08 ,  C03C3/10 ,  C03C3/30

CPC classification number: C03C3/091 ,  C03C3/064 ,  C03C3/066 ,  C03C3/089 ,  Y10S501/901 ,  Y10S501/903

Abstract: An optical glass with the familiar optical position of n.sub.d >1.70 and v.sub.d >22, which differs from the familiar optical glasses of the optical position due to its lower density and good chemical stability, and is composed of (in percent by weight): SiO.sub.2 25-42, TiO.sub.2 15-35, B.sub.2 O.sub.3 0.5-7, BaO 3-13, CaO 1-3, Nb.sub.2 O.sub.5 1-20, GeO.sub.2 0-2, Al.sub.2 O.sub.3 0-4, Na.sub.2 O 7.5-15, Li.sub.2 O 0-9, K.sub.2 O 2-10, SrO 0-6, ZnO 0-5, ZrO.sub.2 0-3, and WO.sub.3 0-3.

Abstract translation: 具有熟悉的光学位置nd> 1.70和vd> 22的光学玻璃，由于其较低的密度和良好的化学稳定性而与光学位置的熟悉的光学眼镜不同，并且由（以重量百分比计）组成：SiO 2 25-42，TiO2 15-35，B 2 O 3 0.5-7，BaO 3-13，CaO 1-3，Nb 2 O 5 1-20，GeO 2 0-2，Al 2 O 3 0-4，Na 2 O 7.5-15，Li 2 O 0-9，K 2 O 2-10，SrO 0-6，ZnO 0-5，ZrO 2 0-3和WO 3 0-3。

公开(公告)号：US4508834A

公开(公告)日：1985-04-02

申请号：US465410

申请日：1983-02-10

Applicant: Georg Gliemeroth ,  Ludwig Ross ,  Burkhard Speit ,  Volkmar Geiler ,  Hans-Georg Krolla ,  Lothar Meckel

Inventor： Georg Gliemeroth ,  Ludwig Ross ,  Burkhard Speit ,  Volkmar Geiler ,  Hans-Georg Krolla ,  Lothar Meckel

IPC: G02C7/00 ,  C03C3/062 ,  C03C3/064 ,  C03C3/066 ,  C03C3/04 ,  C03C3/02 ,  C03C3/16

CPC classification number: C03C3/064 ,  C03C3/062 ,  C03C3/066 ,  Y10S501/903

Abstract: A spectacle glass which is colorless in the visible spectrum range, not transmissive in the ultraviolet spectrum range below 350 nm, has a refractive index n.sub.d higher than 1.56 and an Abbe number of more than 45, and which has an extremely low density, has the following composition (in % by weight):______________________________________ 12-40 P.sub.2 O.sub.5 13-34 Al.sub.2 O.sub.3 8-30 SiO.sub.2 0-16 B.sub.2 O.sub.3 4-12 TiO.sub.2 0-4 ZrO.sub.2 2-18 CaO 0-4 MgO 0-15 Na.sub.2 O 0-11 K.sub.2 O 0-6 Li.sub.2 O 0-12 Nb.sub.2 O.sub.5 0-8 ZnO. ______________________________________

Abstract translation: 在可见光谱范围内无色的眼镜玻璃，在350nm以下的紫外光谱范围内不透射，其折射率nd高于1.56，阿贝数大于45，具有极低密度， 以下组成（重量％）：-12-40 P2O5 -13-34 Al2O3 -8-30 SiO2 -0-16 B2O3 -4-12 TiO2 -0-4 ZrO2-2-18 CaO -0-4 MgO - 0-15 Na2O -0-11 K2O -0-6 Li2O -0-12 Nb2O5 -0-8 ZnO。 -