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公开(公告)号：US20150011773A1
公开(公告)日：2015-01-08
申请号：US14115471
申请日：2012-04-30
申请人： Mathias Berndt , Andre Muller , Heribert Schmitt-Willich , Timo Stellfeld , Georg Kettschau , Thomas Brumby , Keith Graham , Lutz Lehmann , Jorma Hassfeld , Martin Kruger
发明人： Mathias Berndt , Andre Muller , Heribert Schmitt-Willich , Timo Stellfeld , Georg Kettschau , Thomas Brumby , Keith Graham , Lutz Lehmann , Jorma Hassfeld , Martin Kruger
IPC分类号： C07D249/06 , C07D213/69 , C07C271/22 , C07C229/24 , C07D213/65 , C07C309/73
CPC分类号： C07D249/06 , A61K51/0406 , C07B59/00 , C07B2200/05 , C07C229/24 , C07C229/36 , C07C229/42 , C07C271/22 , C07C309/73 , C07C2601/04 , C07D213/55 , C07D213/61 , C07D213/65 , C07D213/69 , C07D319/06
摘要： This invention relates to novel compounds suitable for labeling by 18F and to the corresponding 18F labeled compounds themselves, 19F-fluorinated analogues thereof and their use as reference standards, methods of preparing such compounds, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging by Positron Emission Tomography (PET).
摘要翻译： 本发明涉及适用于通过18F和相应的18F标记的化合物本身或其相应的18F-氟化的类似物进行标记的新化合物及其作为参考标准物的用途，制备此类化合物的方法，包含这些化合物的组合物，包含这些化合物或组合物的试剂盒，以及 这些化合物，组合物或试剂盒用于通过正电子发射断层扫描（PET）进行诊断成像的用途。
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公开(公告)号：US09238631B2
公开(公告)日：2016-01-19
申请号：US14115471
申请日：2012-04-30
申请人： Mathias Berndt , Andre Muller , Heribert Schmitt-Willich , Timo Stellfeld , Georg Kettschau , Thomas Brumby , Keith Graham , Lutz Lehmann , Jorma Haβfeld , Martin Kruger
发明人： Mathias Berndt , Andre Muller , Heribert Schmitt-Willich , Timo Stellfeld , Georg Kettschau , Thomas Brumby , Keith Graham , Lutz Lehmann , Jorma Haβfeld , Martin Kruger
IPC分类号： A61K31/44 , C07D213/72 , C07D249/06 , A61K51/04 , C07B59/00 , C07C229/36 , C07C229/42 , C07C271/22 , C07C309/73 , C07D213/55 , C07D213/61 , C07D213/65 , C07D319/06 , C07C229/24 , C07D213/69
CPC分类号： C07D249/06 , A61K51/0406 , C07B59/00 , C07B2200/05 , C07C229/24 , C07C229/36 , C07C229/42 , C07C271/22 , C07C309/73 , C07C2601/04 , C07D213/55 , C07D213/61 , C07D213/65 , C07D213/69 , C07D319/06
摘要： This invention relates to novel compounds suitable for labeling by 18F and to the corresponding 18F labeled compounds themselves, 19F-fluorinated analogs thereof and their use as reference standards, methods of preparing such compounds, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging by Positron Emission Tomography (PET).
摘要翻译： 本发明涉及适合于通过18F和相应的18F标记的化合物本身，其19F-氟化类似物及其作为参考标准物的用途，制备这些化合物的方法，包含这些化合物的组合物，包含这些化合物或组合物的试剂盒和 这些化合物，组合物或试剂盒用于通过正电子发射断层扫描（PET）进行诊断成像的用途。
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![Novel [F-18]-labelled L-glutamic acid and L-glutamine derivatives (II), their use and processes for their preparation](/abs-image/US/2011/05/05/US20110104057A1/abs.jpg.150x150.jpg)
3.发明申请Novel [F-18]-labelled L-glutamic acid and L-glutamine derivatives (II), their use and processes for their preparation 审中-公开新型[F-18] - 标签L-谷氨酸和L-谷氨酰胺衍生物（II），其用途及其制备方法公开(公告)号：US20110104057A1
公开(公告)日：2011-05-05
申请号：US12993289
申请日：2009-05-13
申请人： Ludger Dinkelborg , Keith Graham , Mathias Berndt , Norman Koglin , Heribert Schmitt-Willich , Matthias Friebe , Lutz Lehmann
发明人： Ludger Dinkelborg , Keith Graham , Mathias Berndt , Norman Koglin , Heribert Schmitt-Willich , Matthias Friebe , Lutz Lehmann
IPC分类号： A61K49/08 , A61K31/4015 , A61K31/27 , A61K31/20 , A61K31/198 , C07D207/22 , C07C205/56 , C07C271/22 , C07C229/36 , C07C59/31 , C07C229/24 , A61P35/00
CPC分类号： C07D207/28 , A61K51/0402 , C07B59/00 , C07C229/24 , C07C229/28 , C07C229/36 , C07C271/22 , C07C2601/04 , Y02P20/55
摘要： What is described are the compounds and the synthesis of [F-18]-labelled L-glutamic acid, [F-18]-labelled L-glutamate, their derivatives of the formula (I) and their use.
摘要翻译： 描述了[F-18]标记的L-谷氨酸，[F-18] - 标签的L-谷氨酸，其式（I）的衍生物及其用途的化合物和合成。
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公开(公告)号：US20080292548A1
公开(公告)日：2008-11-27
申请号：US11851910
申请日：2007-09-07
申请人： Lutz Lehmann , Ananth Srinivasan , Thomas Brumby , Detlef Suelzle , Timo Stellfeld , Keith Graham , Mylene Karramkam , Simon Ametamey
发明人： Lutz Lehmann , Ananth Srinivasan , Thomas Brumby , Detlef Suelzle , Timo Stellfeld , Keith Graham , Mylene Karramkam , Simon Ametamey
IPC分类号： A61K51/08 , C07K5/117 , A61K38/07 , C07K7/06 , A61K38/08 , C07H19/073 , A61K31/7072
CPC分类号： C07K14/6555 , A61K51/088 , C07K14/57545
摘要： The present invention relates to novel compounds suitable for or already radiolabeled with 18F, methods of making such compounds and use of such compounds for diagnostic imaging. Such labeled compounds are characterized by Formula II, wherein the substituents G, Q, L, Y and U have the meaning as defined in the specification and claims.
摘要翻译： 本发明涉及适用于或已经用18F放射性标记的新化合物，制备这种化合物的方法和用于诊断成像的这些化合物的用途。 这些标记的化合物由式II表征，其中取代基G，Q，L，Y和U具有如说明书和权利要求书中所定义的含义。
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公开(公告)号：US08557776B2
公开(公告)日：2013-10-15
申请号：US11851910
申请日：2007-09-07
申请人： Lutz Lehmann , Ananth Srinivasan , Thomas Brumby , Detlef Suelzle , Timo Stellfeld , Keith Graham , Mylene Tania Karramkam , Simon Ametamey
发明人： Lutz Lehmann , Ananth Srinivasan , Thomas Brumby , Detlef Suelzle , Timo Stellfeld , Keith Graham , Mylene Tania Karramkam , Simon Ametamey
CPC分类号： C07K14/6555 , A61K51/088 , C07K14/57545
摘要： The present invention relates to novel compounds suitable for or already radiolabeled with 18F, methods of making such compounds and use of such compounds for diagnostic imaging. Such labeled compounds are characterized by Formula II, wherein the substituents G, Q, L, Y and U have the meaning as defined in the specification and claims.
摘要翻译： 本发明涉及适用于或已经用18F放射性标记的新化合物，制备这种化合物的方法和用于诊断成像的这些化合物的用途。 这些标记的化合物由式II表征，其中取代基G，Q，L，Y和U具有如说明书和权利要求书中所定义的含义。
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公开(公告)号：US09017645B2
公开(公告)日：2015-04-28
申请号：US13509062
申请日：2010-11-08
申请人： Heribert Schmitt-Willich , Niels Böhnke , Norman Koglin , Andre Müller , Mathias Berndt , Matthias Friebe , Lutz Lehmann
发明人： Heribert Schmitt-Willich , Niels Böhnke , Norman Koglin , Andre Müller , Mathias Berndt , Matthias Friebe , Lutz Lehmann
IPC分类号： A61B5/055 , C07C271/22 , A61K49/10 , A61K51/04 , C07B59/00 , C07C229/24 , C07C229/30 , C07C255/58
CPC分类号： C07C271/22 , A61K49/10 , A61K51/04 , A61K51/0402 , C07B59/001 , C07B2200/05 , C07C229/24 , C07C229/30 , C07C255/58
摘要： This invention relates to homoglutamic acid derivatives suitable for labeling or already labeled with 18F or 19F, methods of preparing such compounds, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging.
摘要翻译： 本发明涉及适用于标记或已经用18F或19F标记的高谷氨酸衍生物，制备此类化合物的方法，包含这些化合物的组合物，包含这些化合物或组合物的试剂盒以及用于诊断成像的这些化合物，组合物或试剂盒的用途。
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公开(公告)号：US20130071327A1
公开(公告)日：2013-03-21
申请号：US13509062
申请日：2010-11-08
申请人： Heribert Schmitt-Willich , Niels Böhnke , Norman Koglin , Andre Müller , Mathias Berndt , Matthias Friebe , Lutz Lehmann
发明人： Heribert Schmitt-Willich , Niels Böhnke , Norman Koglin , Andre Müller , Mathias Berndt , Matthias Friebe , Lutz Lehmann
IPC分类号： C07C229/24 , C07C255/59 , C07C271/22 , C07C309/73 , C07C269/06 , C07C227/00 , C07C253/00 , C07C269/00 , C07C227/20 , C07C253/30 , C07C229/30 , A61K51/04
CPC分类号： C07C271/22 , A61K49/10 , A61K51/04 , A61K51/0402 , C07B59/001 , C07B2200/05 , C07C229/24 , C07C229/30 , C07C255/58
摘要： This invention relates to homoglutamic acid derivatives suitable for labeling or already labeled with 18F or 19F, methods of preparing such compounds, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging.
摘要翻译： 本发明涉及适于标记或已经用18F或19F标记的高谷氨酸衍生物，制备此类化合物的方法，包含这些化合物的组合物，包含这些化合物或组合物的试剂盒以及用于诊断成像的这些化合物，组合物或试剂盒的用途。
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8.发明申请Triaryl-sulphonium compounds, kit and methods for labeling positron emitting isotopes 审中-公开三芳基锍化合物，用于标记正电子发射同位素的试剂盒和方法公开(公告)号：US20120020881A1
公开(公告)日：2012-01-26
申请号：US13139145
申请日：2009-12-04
申请人： Lutz Lehmann , Timo Stellfeld , Keith Graham , Jessica Becaud , Linjing Mu
发明人： Lutz Lehmann , Timo Stellfeld , Keith Graham , Jessica Becaud , Linjing Mu
IPC分类号： A61K51/08 , C07D277/82 , C07K7/06 , C07H21/02 , C07K5/103 , C07D401/12 , C07C381/12 , C07D271/113 , C07D451/02 , C07D401/06 , C07D211/32 , C07D471/04 , A61K38/08 , A61K38/07 , A61K31/7088 , A61K31/428 , A61K31/496 , A61K31/185 , A61K31/4245 , A61K31/4427 , A61K31/46 , A61K31/517 , A61K31/445 , A61K31/519 , A61P25/00 , A61K51/04
CPC分类号： C07D277/82 , A61K51/065 , A61K51/088 , C07C381/12 , C07D211/32 , C07D213/70 , C07D213/82 , C07D271/113 , C07D277/66 , C07D401/06 , C07D401/12 , C07D451/14 , C07D471/04
摘要： This invention relates to novel compounds suitable for labeling by positron emitting isotopes, such as 18F, 11C, 13N and 15O, through appropriate labeling reagents, such as 18F reagents and methods of preparing such a compound, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging by positron emission tomography (PET).
摘要翻译： 本发明涉及适用于通过正电子发射同位素（如18F，11C，13N和150）通过合适的标记试剂如18F试剂进行标记的新型化合物及其制备方法，包含这些化合物的组合物，包含这些化合物的试剂盒 或这些化合物，组合物或试剂盒的组合物和用途，用于通过正电子发射断层摄影（PET）进行诊断成像。
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![[F-18]-LABELED L-GLUTAMIC ACID, [F-18]-LABELED L-GLUTAMINE, DERIVATIVES THEREOF AND USE THEREOF AND PROCESSES FOR THEIR PREPARATION](/abs-image/US/2010/08/26/US20100217011A1/abs.jpg.150x150.jpg)
9.发明申请[F-18]-LABELED L-GLUTAMIC ACID, [F-18]-LABELED L-GLUTAMINE, DERIVATIVES THEREOF AND USE THEREOF AND PROCESSES FOR THEIR PREPARATION 审中-公开[F-18] -L-氨基酸，[F-18] -L-谷氨酰胺，其衍生物及其用途及其制备方法公开(公告)号：US20100217011A1
公开(公告)日：2010-08-26
申请号：US12513112
申请日：2007-10-30
申请人： Ludger Dinkelborg , Matthias Friebe , Nikolaevna Raisa Krasikowa , Yuri Belokon , Fedorovna Olga Kuznetsova , Keith Graham , Lutz Lehmann , Mathias Berndt
发明人： Ludger Dinkelborg , Matthias Friebe , Nikolaevna Raisa Krasikowa , Yuri Belokon , Fedorovna Olga Kuznetsova , Keith Graham , Lutz Lehmann , Mathias Berndt
IPC分类号： C07F15/04 , C07D207/24 , C07D207/16 , C07C229/24 , C07C227/16
CPC分类号： A61K51/0402 , C07B59/001 , C07B2200/05 , C07C227/16 , C07C229/24 , C07C251/24 , C07C271/22 , C07C309/66 , C07C309/73 , C07D207/16 , C07D207/26 , C07D207/28 , C07F15/045
摘要： The compounds and the synthesis of [F-18]-labeled L-glutamic acid, [F-18]-labeled L-glutamate, their derivatives as set forth in formula (I) and their uses are described.
摘要翻译： 描述了[F-18]标记的L-谷氨酸[F-18] - 标记的L-谷氨酸酯，式（I）所示的衍生物及其用途的化合物和合成。
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10.发明申请Piperazine Derivatives for Binding and Imaging Amyloid Plaques and Their Use 审中-公开哌嗪衍生物用于结合和成像淀粉样斑块及其用途公开(公告)号：US20110250135A1
公开(公告)日：2011-10-13
申请号：US13063532
申请日：2009-09-04
申请人： Heribert Schmitt-Willich , Ulrike Röhn , Matthias Friebe , Lutz Lehmann , Ansgar Fitzner , Sabine Krause , Damian Brockschnieder , Thomas Dyrks , Andrea Thiele , Ulf Bömer , Ursula Mönning , Tobias Heinrich
发明人： Heribert Schmitt-Willich , Ulrike Röhn , Matthias Friebe , Lutz Lehmann , Ansgar Fitzner , Sabine Krause , Damian Brockschnieder , Thomas Dyrks , Andrea Thiele , Ulf Bömer , Ursula Mönning , Tobias Heinrich
IPC分类号： A61K51/04 , C07D403/04 , C07D241/04 , C07D403/12 , A61P25/28 , A61K31/497 , A61K49/00 , A61K49/04 , A61K49/10 , C40B30/04 , A61K31/4965
CPC分类号： C07D239/42 , C07D209/24 , C07D213/81 , C07D213/82 , C07D295/185 , C07D405/12
摘要： The invention relates to compounds of formula I, their synthesis and their use, in particular for detecting amyloid deposits in a patient.
摘要翻译： 本发明涉及式I化合物，其合成及其用途，特别是用于检测患者中的淀粉样沉积物。
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