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1.发明授权Dengue and West Nile viruses proteins and genes coding the foregoing, and their use in vaccinal, therapeutic and diagnostic applications 有权登革热和西尼罗病毒蛋白质和编码前述的基因，以及它们在疫苗，治疗和诊断应用中的应用公开(公告)号：US08859240B2
公开(公告)日：2014-10-14
申请号：US12476304
申请日：2009-06-02
CPC分类号： A61K39/12 , A61K38/00 , A61K39/00 , A61K2039/5256 , A61K2039/53 , C07K14/005 , C07K14/1825 , C12N15/86 , C12N2760/18443 , C12N2770/24122 , C12Q1/701 , Y02A50/386 , Y02A50/394 , Y02A50/53
摘要： The present invention relates to the development of viral vectors expressing different immunogens from the West Nile Encephalitis Virus (WNV) or the Dengue virus which are able to induce protective humoral and cellular immune responses against WNV or Dengue virus infections. More specifically, the present invention relates to three (3) antigens from WNV (the secreted envelope glycoprotein (E), the heterodimer glycoproteins (pre-M-E) and the NSI protein) and from Dengue virus (the secreted envelope glycoprotein (e), the heterodimer glycoproteins (pre-m-e) and the nsl protein) and their use in vaccinal, therapeutic and diagnostic applications.
摘要翻译： 本发明涉及表达来自西尼罗河脑炎病毒（WNV）或登革热病毒的不同免疫原的病毒载体的开发，其能够诱导针对WNV或登革热病毒感染的保护性体液和细胞免疫应答。 更具体地，本发明涉及来自WNV（分泌的包膜糖蛋白（E），异二聚体糖蛋白（pre-ME）和NSI蛋白）和登革病毒（分泌的包膜糖蛋白（e））的三（3）个抗原， 异二聚体糖蛋白（pre-me）和nsl蛋白）及其在疫苗，治疗和诊断应用中的应用。
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2.发明申请CHIMERIC POLY PEPTIDES AND THE THERAPEUTIC USE THEREOF AGAINST A FLAVIVIRIDAE INFECTION 有权CHICERIC POLY PEPTIDES及其对FLAVIVIRIDIDA感染的治疗用途公开(公告)号：US20120201825A1
公开(公告)日：2012-08-09
申请号：US13089705
申请日：2011-04-19
申请人： Frederic TANGY , Marianne Lucas-Hourani , Erika Navarro-Sanchez , Marie-Pascale Frenkiel , Hugues Bedouelle , Chantal Combredet , Philippe Despres
发明人： Frederic TANGY , Marianne Lucas-Hourani , Erika Navarro-Sanchez , Marie-Pascale Frenkiel , Hugues Bedouelle , Chantal Combredet , Philippe Despres
IPC分类号： A61K39/395 , C12P21/06 , C12N15/63 , A61K38/00 , A61P31/12 , C07K14/18 , C07K16/10 , C07H21/04 , A61P37/04 , A61K39/12 , A61K31/7088
CPC分类号： C07K14/005 , A61K38/00 , A61K39/12 , A61K39/165 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , A61K2039/55 , A61K2039/55505 , C07K2319/00 , C07K2319/04 , C12N7/00 , C12N15/86 , C12N2760/18434 , C12N2760/18443 , C12N2770/24122 , C12N2770/24134 , C12N2770/24171 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394
摘要： The invention relates to building a chimeric polypeptide used for preventing or treating a Flaviviridae infection. The use of the inventive chimeric polypeptide for producing recombinant viral vectors such as a measles living viral vector is also disclosed.
摘要翻译： 本发明涉及构建用于预防或治疗黄病毒科感染的嵌合多肽。 还公开了本发明的嵌合多肽用于产生重组病毒载体如麻疹活病毒载体的用途。
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公开(公告)号：US20100099854A1
公开(公告)日：2010-04-22
申请号：US12112366
申请日：2008-04-30
申请人： PHILIPPE DESPRES , VINCENT DEUBEL , JEAN-LOUIS GUENET , MARIE-THERESE DROUET , MERTYN MALKINSON , CAROLINE BANET , MARIE-PASCALE FRENKIEL , MARIE-PIERRE COURAGEOT , FASSELI COULIBALY , ADELINE CATTEAU , MARIE FLAMAND , PATRICK WEBER , PIERRE-EMMANUEL CECCALDI
发明人： PHILIPPE DESPRES , VINCENT DEUBEL , JEAN-LOUIS GUENET , MARIE-THERESE DROUET , MERTYN MALKINSON , CAROLINE BANET , MARIE-PASCALE FRENKIEL , MARIE-PIERRE COURAGEOT , FASSELI COULIBALY , ADELINE CATTEAU , MARIE FLAMAND , PATRICK WEBER , PIERRE-EMMANUEL CECCALDI
IPC分类号： C07K16/00
CPC分类号： C12N7/00 , A01K67/027 , A01K2267/02 , A61K39/00 , C07K14/005 , C12N2770/24121 , C12Q1/701 , G01N33/56983 , Y02A50/394
摘要： Neuroinvasive and neurovirulent strain of the West Nile virus, named IS-98-ST1, nucleic acid molecules derived from its genome, proteins and peptides encoded by said nucleic acid molecules, and uses thereof.
摘要翻译： 西尼罗河病毒的神经侵袭性和神经毒力毒株，命名为IS-98-ST1，源自其基因组的核酸分子，由所述核酸分子编码的蛋白质和肽及其用途。
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公开(公告)号：US08715693B2
公开(公告)日：2014-05-06
申请号：US13423161
申请日：2012-03-16
申请人： Philippe Despres , Vincent Deubel , Jean-Louis Guenet , Marie-Thérèse Drouet , Mertyn Malkinson , Caroline Banet , Marie-Pascale Frenkiel , Marie-Pierre Courageot , Fasséli Coulibaly , Adeline Catteau , Marie Flamand , Patrick Weber , Pierre-Emmanuel Ceccaldi
发明人： Philippe Despres , Vincent Deubel , Jean-Louis Guenet , Marie-Thérèse Drouet , Mertyn Malkinson , Caroline Banet , Marie-Pascale Frenkiel , Marie-Pierre Courageot , Fasséli Coulibaly , Adeline Catteau , Marie Flamand , Patrick Weber , Pierre-Emmanuel Ceccaldi
CPC分类号： C12N7/00 , A01K67/027 , A01K2267/02 , A61K39/00 , C07K14/005 , C12N2770/24121 , C12Q1/701 , G01N33/56983 , Y02A50/394
摘要： Neuroinvasive and neurovirulent strain of the West Nile virus, named IS-98-ST1, nucleic acid molecules derived from its genome, proteins and peptides encoded by said nucleic acid molecules, and uses thereof.
摘要翻译： 西尼罗河病毒的神经侵袭性和神经毒力毒株，命名为IS-98-ST1，源自其基因组的核酸分子，由所述核酸分子编码的蛋白质和肽及其用途。
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公开(公告)号：US20120266261A1
公开(公告)日：2012-10-18
申请号：US13423161
申请日：2012-03-16
申请人： Philippe Despres , Vincent Deubel , Jean-Louis Guenet , Marie-Thérèse Drouet , Mertyn Malkinson , Caroline Banet , Marie-Pascale Frenkiel , Marie-Pierre Courageot , Fasséli Coulibaly , Adeline Catteau , Marie Flamand , Patrick Weber , Pierre-Emmanuel Ceccaldi
发明人： Philippe Despres , Vincent Deubel , Jean-Louis Guenet , Marie-Thérèse Drouet , Mertyn Malkinson , Caroline Banet , Marie-Pascale Frenkiel , Marie-Pierre Courageot , Fasséli Coulibaly , Adeline Catteau , Marie Flamand , Patrick Weber , Pierre-Emmanuel Ceccaldi
IPC分类号： C12N7/00 , C12N5/10 , C12N15/40 , A01K67/027 , C07H21/04 , C07K14/18 , C07K16/10 , C12N15/85 , C12Q1/70
CPC分类号： C12N7/00 , A01K67/027 , A01K2267/02 , A61K39/00 , C07K14/005 , C12N2770/24121 , C12Q1/701 , G01N33/56983 , Y02A50/394
摘要： Neuroinvasive and neurovirulent strain of the West Nile virus, named IS-98-ST1, nucleic acid molecules derived from its genome, proteins and peptides encoded by said nucleic acid molecules, and uses thereof.
摘要翻译： 西尼罗河病毒的神经侵袭性和神经毒力毒株，命名为IS-98-ST1，源自其基因组的核酸分子，由所述核酸分子编码的蛋白质和肽及其用途。
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公开(公告)号：US07390495B2
公开(公告)日：2008-06-24
申请号：US10956085
申请日：2004-10-04
申请人： Philippe Despres , Vincent Deubel , Jean-Louis Guenet , Marie-Therese Drouet , Mertyn Malkinson , Caroline Banet , Marie-Pascale Frenkiel , Marie-Pierre Courageot , Fasseli Coulibaly , Adeline Catteau , Marie Flamand , Patrick Weber , Pierre-Emmanuel Ceccaldi
发明人： Philippe Despres , Vincent Deubel , Jean-Louis Guenet , Marie-Therese Drouet , Mertyn Malkinson , Caroline Banet , Marie-Pascale Frenkiel , Marie-Pierre Courageot , Fasseli Coulibaly , Adeline Catteau , Marie Flamand , Patrick Weber , Pierre-Emmanuel Ceccaldi
CPC分类号： C12N7/00 , A01K67/027 , A01K2267/02 , A61K39/00 , C07K14/005 , C12N2770/24121 , C12Q1/701 , G01N33/56983 , Y02A50/394
摘要： Neuroinvasive and neurovirulent strain of the West Nile virus, named IS-98-ST1, nucleic acid molecules derived from its genome, proteins and peptides encoded by said nucleic acid molecules, and uses thereof.
摘要翻译： 西尼罗河病毒的神经侵袭性和神经毒力毒株，命名为IS-98-ST1，源自其基因组的核酸分子，由所述核酸分子编码的蛋白质和肽及其用途。
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公开(公告)号：US20050164170A1
公开(公告)日：2005-07-28
申请号：US10956085
申请日：2004-10-04
申请人： Philippe Despres , Vincent Deubel , Jean-Louis Guenet , Marie-Therese Drouet , Mertyn Malkinson , Caroline Banet , Marie-Pascale Frenkiel , Marie-Pierre Courageot , Fasseli Coulibaly , Adeline Catteau , Marie Flamand , Patrick Weber , Pierre-Emmanuel Ceccaldi
发明人： Philippe Despres , Vincent Deubel , Jean-Louis Guenet , Marie-Therese Drouet , Mertyn Malkinson , Caroline Banet , Marie-Pascale Frenkiel , Marie-Pierre Courageot , Fasseli Coulibaly , Adeline Catteau , Marie Flamand , Patrick Weber , Pierre-Emmanuel Ceccaldi
CPC分类号： C12N7/00 , A01K67/027 , A01K2267/02 , A61K39/00 , C07K14/005 , C12N2770/24121 , C12Q1/701 , G01N33/56983 , Y02A50/394
摘要： Neuroinvasive and neurovirulent strain of the West Nile virus, named IS-98-ST1, nucleic acid molecules derived from its genome, proteins and peptides encoded by said nucleic acid molecules, and uses thereof.
摘要翻译： 西尼罗河病毒的神经侵袭性和神经毒力毒株，命名为IS-98-ST1，源自其基因组的核酸分子，由所述核酸分子编码的蛋白质和肽及其用途。
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公开(公告)号：US09657276B2
公开(公告)日：2017-05-23
申请号：US14230776
申请日：2014-03-31
申请人： Despres Philippe , Vincent Deubel , Jean-Louis Guenet , Marie-Therese Drouet , Mertyn Malkinson , Caroline Banet , Marie-Pascale Frenkiel , Marie-Pierre Courageot , Fasseli Coulibaly , Adeline Catteau , Marie Flamand , Patrick Weber , Pierre-Emmanuel Ceccaldi
发明人： Despres Philippe , Vincent Deubel , Jean-Louis Guenet , Marie-Therese Drouet , Mertyn Malkinson , Caroline Banet , Marie-Pascale Frenkiel , Marie-Pierre Courageot , Fasseli Coulibaly , Adeline Catteau , Marie Flamand , Patrick Weber , Pierre-Emmanuel Ceccaldi
IPC分类号： C12N7/00 , C07K14/005 , A61K39/00 , A01K67/027 , C12Q1/70 , G01N33/569
CPC分类号： C12N7/00 , A01K67/027 , A01K2267/02 , A61K39/00 , C07K14/005 , C12N2770/24121 , C12Q1/701 , G01N33/56983 , Y02A50/394
摘要： Neuroinvasive and neurovirulent strain of the West Nile virus, named IS-98-ST1, nucleic acid molecules derived from its genome, proteins and peptides encoded by said nucleic acid molecules, and uses thereof.
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9.发明申请DENGUE AND WEST NILE VIRUSES PROTEINS AND GENES CODING THE FOREGOING, AND THEIR USE IN VACCINAL, THERAPEUTIC AND DIAGNOSTIC APPLICATIONS 有权登革热和西尼氏病毒蛋白质和基因编码前体及其在疫苗，治疗和诊断应用中的应用公开(公告)号：US20130089558A1
公开(公告)日：2013-04-11
申请号：US12476304
申请日：2009-06-02
CPC分类号： A61K39/12 , A61K38/00 , A61K39/00 , A61K2039/5256 , A61K2039/53 , C07K14/005 , C07K14/1825 , C12N15/86 , C12N2760/18443 , C12N2770/24122 , C12Q1/701 , Y02A50/386 , Y02A50/394 , Y02A50/53
摘要： The present invention relates to the development of viral vectors expressing different immunogens from the West Nile Encephalitis Virus (WNV) or the Dengue virus which are able to induce protective humoral and cellular immune responses against WNV or Dengue virus infections. More specifically, the present invention relates to three (3) antigens from WNV (the secreted envelope glycoprotein (E), the heterodimer glycoproteins (pre-M-E) and the NSI protein) and from Dengue virus (the secreted envelope glycoprotein (e), the heterodimer glycoproteins (pre-m-e) and the nsl protein) and their use in vaccinal, therapeutic and diagnostic applications.
摘要翻译： 本发明涉及表达来自西尼罗河脑炎病毒（WNV）或登革热病毒的不同免疫原的病毒载体的开发，其能够诱导针对WNV或登革热病毒感染的保护性体液和细胞免疫应答。 更具体地，本发明涉及来自WNV（分泌的包膜糖蛋白（E），异二聚体糖蛋白（pre-ME）和NSI蛋白）和登革病毒（分泌的包膜糖蛋白（e））的三（3）个抗原， 异二聚体糖蛋白（pre-me）和nsl蛋白）及其在疫苗，治疗和诊断应用中的应用。
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10.发明授权Dengue and West Nile viruses proteins and genes coding the foregoing, and their use in vaccinal, therapeutic and diagnostic applications 有权登革热和西尼罗病毒蛋白质和编码前述的基因，以及它们在疫苗，治疗和诊断应用中的应用公开(公告)号：US07556812B2
公开(公告)日：2009-07-07
申请号：US11210960
申请日：2005-08-25
CPC分类号： A61K39/12 , A61K38/00 , A61K39/00 , A61K2039/5256 , A61K2039/53 , C07K14/005 , C07K14/1825 , C12N15/86 , C12N2760/18443 , C12N2770/24122 , C12Q1/701 , Y02A50/386 , Y02A50/394 , Y02A50/53
摘要： The present invention relates to the development of viral vectors expressing different immunogens from the West Nile Encephalitis Virus (WNV) or the Dengue virus which are able to induce protective humoral and cellular immune responses against WNV or Dengue virus infections. More specifically, the present invention relates to three (3) antigens from WNV (the secreted envelope glycoprotein (E), the heterodimer glycoproteins (pre-M-E) and the NSI protein) and from Dengue virus (the secreted envelope glycoprotein (e), the heterodimer glycoproteins (pre- m-e) and the nsl protein) and their use in vaccinal, therapeutic and diagnostic applications.
摘要翻译： 本发明涉及表达来自西尼罗河脑炎病毒（WNV）或登革热病毒的不同免疫原的病毒载体的开发，其能够诱导针对WNV或登革热病毒感染的保护性体液和细胞免疫应答。 更具体地，本发明涉及来自WNV（分泌的包膜糖蛋白（E），异二聚体糖蛋白（pre-ME）和NSI蛋白）和登革病毒（分泌的包膜糖蛋白（e））的三（3）个抗原， 异二聚体糖蛋白（pre me）和nsl蛋白）及其在疫苗，治疗和诊断应用中的应用。
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