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    VACCINE COMPOSITIONS FOR THE TREATMENT OF DENGUE FEVER AND USES THEREOF
    1.
    发明申请
    VACCINE COMPOSITIONS FOR THE TREATMENT OF DENGUE FEVER AND USES THEREOF 审中-公开
    用于治疗登革热的疫苗组合物及其用途

    公开(公告)号：US20110262472A1

    公开(公告)日：2011-10-27

    申请号：US12989186

    申请日：2009-04-22

    申请人： Martin Bachmann ,  Adrian Huber ,  Lidia Ivanova ,  Martin Bachmann

    发明人： Martin Bachmann ,  Adrian Huber ,  Lidia Ivanova ,  Martin Bachmann

    IPC分类号： A61K39/12 ,  A61P31/14

    CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/385 ,  A61K2039/5258 ,  A61K2039/55505 ,  A61K2039/6075 ,  A61K2039/62 ,  A61K2039/64 ,  A61K2039/70 ,  C12N2770/24122 ,  C12N2770/24134 ,  C12N2795/18123 ,  Y02A50/386

    摘要： The invention provides compositions, vaccine compositions and pharmaceutical compositions for the treatment, amelioration and/or prevention of dengue fever. The compositions, vaccine compositions and pharmaceutical compositions of the invention comprise a virus-like particle of an RNA bacteriophage and at least one antigen, wherein said at least one antigen is a dengue antigen. When administered to an animal, preferably to a human, said compositions, vaccine compositions and pharmaceutical compositions induce efficient immune responses, in particular antibody responses, wherein typically and preferably said antibody responses are directed against dengue virus, preferably against dengue virus of any one of serotypes 1 to 4. Thus, the invention further provides methods of treating, ameliorating and/or preventing dengue virus infection by way of active immunization against domain III of the dengue virus envelope protein E, or against antigenic fragments thereof.

    摘要翻译： 本发明提供用于治疗，改善和/或预防登革热的组合物，疫苗组合物和药物组合物。 本发明的组合物，疫苗组合物和药物组合物包含RNA噬菌体和至少一种抗原的病毒样颗粒，其中所述至少一种抗原是登革热抗原。 当给予动物，优选给人时，所述组合物，疫苗组合物和药物组合物诱导有效的免疫应答，特别是抗体应答，其中通常且优选地所述抗体应答针对登革热病毒，优选针对登革热病毒， 因此，本发明还提供了通过针对登革病毒包膜蛋白E的结构域III的主动免疫或其抗原性片段来治疗，改善和/或预防登革病毒感染的方法。

    INFLUENZA HEMAGGLUTININ COMPOSITIONS AND USES THEREOF
    2.
    发明申请
    INFLUENZA HEMAGGLUTININ COMPOSITIONS AND USES THEREOF 审中-公开
    流感嗜血红蛋白组合物及其用途

    公开(公告)号：US20120263743A1

    公开(公告)日：2012-10-18

    申请号：US13318099

    申请日：2010-04-30

    申请人： Martin Bachmann ,  Andrea Jegerlehner ,  Philippe Saudan

    发明人： Martin Bachmann ,  Andrea Jegerlehner ,  Philippe Saudan

    IPC分类号： A61K39/145 ,  A61P31/16 ,  A61P37/04 ,  C07K14/11

    CPC分类号： A61K47/6901 ,  A61K47/646

    摘要： The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides compositions, vaccine compositions and pharmaceutical compositions for the treatment, amelioration and/or prevention of influenza. The compositions, vaccine compositions and pharmaceutical compositions of the invention comprise a virus-like particle of an RNA bacteriophage and at least one antigen, wherein said at least one antigen is an ectodomain of an influenza virus hemagglutinin protein or a fragment of said ectodomain of an influenza virus hemagglutinin protein. When administered to an animal, preferably to a human, said compositions, vaccine compositions and pharmaceutical compositions efficiently induce immune responses, in particular antibody responses, wherein typically and preferably said antibody responses are directed against influenza virus. Thus, the invention further provides methods of treating, ameliorating and/or preventing influenza virus infection.

    摘要翻译： 本发明涉及医药，公共卫生，免疫学，分子生物学和病毒学领域。 本发明提供用于治疗，改善和/或预防流感的组合物，疫苗组合物和药物组合物。 本发明的组合物，疫苗组合物和药物组合物包含RNA噬菌体和至少一种抗原的病毒样颗粒，其中所述至少一种抗原是流感病毒血凝素蛋白的胞外域或所述胞外域的片段 流感病毒血凝素蛋白。 当给予动物，优选给人时，所述组合物，疫苗组合物和药物组合物有效诱导免疫应答，特别是抗体应答，其中通常且优选所述抗体应答针对流感病毒。 因此，本发明还提供了治疗，改善和/或预防流感病毒感染的方法。

    User of Interleukin-1 Conjugates in the Treatment of Diabetes
    3.
    发明申请
    User of Interleukin-1 Conjugates in the Treatment of Diabetes 审中-公开
    白细胞介素-1缀合物在糖尿病治疗中的用户

    公开(公告)号：US20110318300A1

    公开(公告)日：2011-12-29

    申请号：US12921038

    申请日：2009-03-05

    申请人： Martin Bachmann ,  Gunther Spohn

    发明人： Martin Bachmann ,  Gunther Spohn

    IPC分类号： A61K38/20 ,  A61P3/10

    CPC分类号： C07K14/545 ,  A61K38/2006 ,  A61K2039/5258 ,  C12N2795/18123

    摘要： The invention provides compositions, pharmaceutical compositions and vaccines for the treatment, amelioration and/or prophylaxis of diabetes, preferably of type II diabetes. The compositions, pharmaceutical compositions and vaccines of the invention comprise a core particle and an antigen, wherein said antigen comprises an interleukin-1 (IL-1) molecule. When administered to an animal, preferably to a human, said compositions, pharmaceutical compositions, and vaccines induce efficient immune responses, in particular antibody responses, wherein typically and preferably said antibody responses are directed against IL-1. Thus, the invention provides methods of treating, ameliorating or preventing diabetes, preferably type II diabetes, by way of active immunization against IL-1.

    摘要翻译： 本发明提供用于治疗，改善和/或预防糖尿病，优选II型糖尿病的组合物，药物组合物和疫苗。 本发明的组合物，药物组合物和疫苗包含核心颗粒和抗原，其中所述抗原包含白细胞介素-1（IL-1）分子。 当施用于动物，优选给人时，所述组合物，药物组合物和疫苗诱导有效的免疫应答，特别是抗体应答，其中通常且优选地所述抗体应答针对IL-1。 因此，本发明提供了通过对IL-1的主动免疫来治疗，改善或预防糖尿病，优选II型糖尿病的方法。

    Interleukin-1 Conjugates and Uses Thereof
    4.
    发明申请
    Interleukin-1 Conjugates and Uses Thereof 审中-公开
    白细胞介素-1共轭体及其用途

    公开(公告)号：US20110027220A1

    公开(公告)日：2011-02-03

    申请号：US11992731

    申请日：2006-09-28

    申请人： Martin Bachmann ,  Gunther Spohn ,  Alain Tissot

    发明人： Martin Bachmann ,  Gunther Spohn ,  Alain Tissot

    IPC分类号： A61K39/00 ,  C07K14/54 ,  A61P25/00 ,  A61P19/00 ,  A61P19/06 ,  A61P9/10 ,  A61P37/08 ,  A61P29/00

    CPC分类号： C07K14/545 ,  A61K38/00 ,  A61K2039/5258 ,  A61K2039/6075 ,  C07K14/005 ,  C07K2319/00 ,  C12N7/00 ,  C12N2795/18122 ,  C12N2795/18123

    摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen array, wherein the antigen is an IL-1 protein, an IL-1 mutein or an IL-1 fragment. More specifically, the invention provides a composition comprising a virus-like particle, and at least one IL-1 protein, IL-1 mutein or at least one IL-1 fragment linked thereto. The invention also provides a process for producing the composition. The compositions of the invention are useful in the production of vaccines for the treatment of inflammatory diseases, and chronic autoimmune diseases, genetic diseases and cardiovascular diseases. The composition of the invention efficiently induces immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.

    摘要翻译： 本发明涉及分子生物学，病毒学，免疫学和医学领域。 本发明提供了包含有序重复抗原阵列的组合物，其中抗原是IL-1蛋白，IL-1突变蛋白或IL-1片段。 更具体地，本发明提供了包含病毒样颗粒和至少一种IL-1蛋白，IL-1突变蛋白或与其连接的至少一个IL-1片段的组合物。 本发明还提供了一种制备该组合物的方法。 本发明的组合物可用于生产用于治疗炎性疾病，慢性自身免疫性疾病，遗传性疾病和心血管疾病的疫苗。 本发明的组合物有效诱导免疫应答，特别是抗体应答。 此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

    CAT allergen conjugates and uses thereof
    5.
    发明授权
    CAT allergen conjugates and uses thereof 有权
    CAT过敏原共轭物及其用途

    公开(公告)号：US07767212B2

    公开(公告)日：2010-08-03

    申请号：US11886577

    申请日：2006-03-17

    申请人： Martin Bachmann ,  Monika Bauer ,  Klaus Dietmeier ,  Nicole Schmitz ,  Stephan Utzinger

    发明人： Martin Bachmann ,  Monika Bauer ,  Klaus Dietmeier ,  Nicole Schmitz ,  Stephan Utzinger

    IPC分类号： A61K39/35 ,  A61K39/385 ,  C12N7/00 ,  C07K19/00 ,  C07K17/06

    CPC分类号： A61K47/48776 ,  A61K39/35 ,  A61K47/6901 ,  A61K2039/5258 ,  A61K2039/55505 ,  C07K14/005 ,  C07K2319/00

    摘要： The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides compositions comprising a virus-like particle (VLP) or a virus particle and at least one antigen, particularly at least one feline antigen, and more particularly at least one feline antigen that is a human allergen. In certain embodiments, the antigen is a Fel d1 antigen or a fragment thereof, covalently linked to the VLP. The invention also provides methods for producing the compositions. The compositions of the invention induce efficient immune responses, in particular antibody responses, in mammals, particularly humans. The compositions and methods of the invention are useful in the production of vaccines, in particular for the treatment and/or prevention of allergies to cat dander and other cat antigens and allergens.

    摘要翻译： 本发明涉及医药，公共卫生，免疫学，分子生物学和病毒学领域。 本发明提供包含病毒样颗粒（VLP）或病毒颗粒和至少一种抗原，特别是至少一种猫科动物抗原，更特别是至少一种作为人类变应原的猫科动物抗原的组合物。 在某些实施方案中，抗原是与VLP共价连接的Fel d1抗原或其片段。 本发明还提供了用于制备组合物的方法。 本发明的组合物在哺乳动物，特别是人类中诱导有效的免疫应答，特别是抗体应答。 本发明的组合物和方法可用于疫苗的制备，特别是用于治疗和/或预防猫皮屑和其它猫抗原和变应原的过敏。

    Carrier Conjugates Of Tnf-Peptides
    6.
    发明申请
    Carrier Conjugates Of Tnf-Peptides 审中-公开
    Tnf肽的载体结合体

    公开(公告)号：US20080019991A1

    公开(公告)日：2008-01-24

    申请号：US11628243

    申请日：2005-06-02

    申请人： Martin Bachmann ,  Patrik Maurer ,  Gunther Spohn

    发明人： Martin Bachmann ,  Patrik Maurer ,  Gunther Spohn

    IPC分类号： A61K39/00 ,  A61K45/00 ,  C12N7/01

    CPC分类号： C12N7/00 ,  A61K47/646 ,  A61K47/6901 ,  A61K2039/5258 ,  C07K14/525 ,  C07K2319/00 ,  C12N2710/00023 ,  C12N2730/10123 ,  C12N2795/00023

    摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a modified virus-like particle (VLP) comprising a VLP and a particular peptide derived from a polypeptide from the TNF-superfamily linked thereto. The invention also provides a process for producing the modified VLP. The modified VLPs of the invention are useful in the production of vaccines for the treatment of autoimmune diseases and bone-related diseases and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.

    摘要翻译： 本发明涉及分子生物学，病毒学，免疫学和医学领域。 本发明提供了包含来自与其连接的TNF-超家族的多肽的VLP和特定肽的经修饰的病毒样颗粒（VLP）。 本发明还提供了用于生产修饰的VLP的方法。 本发明的经修饰的VLP可用于生产用于治疗自身免疫疾病和骨相关疾病的疫苗，并有效诱导免疫应答，特别是抗体应答。 此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。