公开(公告)号：US20140154715A1

公开(公告)日：2014-06-05

申请号：US14233068

申请日：2012-07-06

申请人： Marc Hubert Mercken ,  Marianne Borgers ,  Marc, Maria, Pierre, Pelagie Vandermeeren ,  Bianca Julia J Van Broeck

发明人： Marc Hubert Mercken ,  Marianne Borgers ,  Marc, Maria, Pierre, Pelagie Vandermeeren ,  Bianca Julia J Van Broeck

IPC分类号： G01N33/577 ,  C07K16/18

CPC分类号： G01N33/577 ,  C07K16/18

摘要： The present invention provides monoclonal antibodies which specifically recognize the shorter Aβ peptides obtained after cleavage of the APP protein mediated by γ-secretase, i.e. the Aβ-peptide fragments Aβ1-37, Aβ3-37, Aβ3p-37, Aβ1-37 and Aβ11p-37, and other like fragments ending at the 37th amino acid of APP, hereinafter also referred to as the Aβx-37 peptides. It further provides hybridoma cells producing the monoclonal antibodies as well as methods for producing the antibodies and the hybridoma cells; and an immunoassay for an Aβx-37 peptide by a competitive method or a sandwich method using the antibody of the present invention; and methods for measuring the level of Aβx-37 peptides in a sample, such as a biological sample.

摘要翻译： 本发明提供特异性识别较短A和Bgr的单克隆抗体。 在由γ-分泌酶介导的APP蛋白切割后获得的肽，即A＆bgr;肽片段A＆bgr; 1-37，A＆bgr; 3-37，A＆bgr; 3p-37，A＆bgr; 1-37和A＆bgr; 11p-37 ，以及以APP的第37个氨基酸终止的其他类似片段，以下也称为A＆bgr; x-37肽。 其进一步提供产生单克隆抗体的杂交瘤细胞以及产生抗体和杂交瘤细胞的方法; 以及使用本发明的抗体的竞争方法或夹心方法对A＆bgr; x-37肽的免疫测定; 以及用于测量样品（例如生物样品）中A＆bgr x-37肽水平的方法。

公开(公告)号：US20100109208A1

公开(公告)日：2010-05-06

申请号：US12263915

申请日：2008-11-03

申请人： Claude Marc Hubert ,  Michael John Layland ,  Lee A. Tichenor ,  Michael Ray Aten ,  Ron Long

发明人： Claude Marc Hubert ,  Michael John Layland ,  Lee A. Tichenor ,  Michael Ray Aten ,  Ron Long

IPC分类号： B29C70/44

CPC分类号： B29C70/446 ,  B29C33/48 ,  B29C70/54 ,  B29L2031/3076 ,  Y10S425/06 ,  Y10T29/49895 ,  Y10T29/49904

摘要： A multi-segment tool and tooling system for vacuum forming a composite part. A tool can include a first tool having first and second surfaces. A second tool can have an opening positioned on a first tool in a location other than the first surface or the second surface. The first tool and second tool can receive at least a portion of a preform composite. The first tool can have a vacuum barrier attached to the first surface and to the second surface encapsulating the preform composite and the second tool. A tooling system can include a first tool having a core and a base with a core extending upwards from the base. A second tool can be positioned upon the core where the core extends above the second tool. A vacuum barrier sealed to the base and the core can include a composite, the first tool and the second tool.

摘要翻译： 用于真空成型复合部件的多段工具和加工系统。 工具可以包括具有第一和第二表面的第一工具。 第二工具可以具有位于除了第一表面或第二表面之外的位置处的第一工具上的开口。 第一工具和第二工具可以容纳预制件复合材料的至少一部分。 第一工具可以具有附接到第一表面的真空阻挡层和封装预型件复合材料和第二工具的第二表面。 工具系统可以包括具有芯的第一工具和具有从基部向上延伸的芯的基部。 第二工具可以定位在芯部上，其中芯部在第二工具上方延伸。 密封到基部和芯部的真空屏障可以包括复合材料，第一工具和第二工具。

公开(公告)号：US07183288B2

公开(公告)日：2007-02-27

申请号：US10493454

申请日：2002-10-29

申请人： Eddy Jean Edgard Freyne ,  Peter Jacobus Johannes Antonius Buijnsters ,  Marc Willems ,  Werner Constant Johan Embrechts ,  Jean Fernand Armand Lacrampe ,  Herwig Josephus Margareta Janssen, legal representative ,  Paul Peter Maria Janssen, legal representative ,  Graziella Maria Constantina Janssen, legal representative ,  Jasmine Josée Werner Janssen, legal representative ,  Maroussia Godelieve Frank Janssen, legal representative ,  Theodora Joanna Francisca Arts ,  Paulus Joannes Lewi ,  Jan Heeres ,  Marc René de Jonge ,  Lucien Maria Henricus Koymans ,  Frederik Frans Desiré Daeyaert ,  Michael Joseph Kukla ,  Hugo Alfons Gabriel Geerts ,  Rony Maria Nuydens ,  Marc Hubert Mercken ,  Donald William Ludovici

发明人： Paul Adriaan Jan Janssen, deceased

IPC分类号： A61K31/505 ,  C07D239/42

CPC分类号： C07D213/81 ,  C07D213/82 ,  C07D239/42 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

摘要： This invention concerns a compound of formula a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein ring A represents a 6-membered heterocycle; R1 is hydrogen; aryl; formyl; C1-6alkylcarbonyl; optionally substituted C1-6alkyl; C1-6alkyloxycarbonyl; optionally substituted C1-6alkyloxyC1-6alkylcarbonyl; X is a direct bond or a linker atom or group; Z is O or S; R2 is hydrogen, C1-10alkyl, C2-10alkenyl, C2-10alkynyl, a carbocycle or a heterocycle, each of said groups may optionally be substituted; R3 is hydrogen; hydroxy; halo; optionally substituted C1-6alkyl or C2-6alkenyl or C2-6alkynyl; C1-6alkyloxy; C1-6alkylthio; C1-6alkyloxycarbonyl; C1-6alkylcarbonyloxy; carboxyl; cyano; nitro; amino; mono- or di(C1-6alkyl)amino; polyhaloC1-6alkyl; polyhaloC1-6alkyloxy; polyhaloC1-6alkylthio; R21; R21—C1-6alkyl; R21—O—; R21—S—; R21—C(═O)—; R21—S(═O)p—; R7—S(═O)p—; R7—S(═O)p—NH—; R21—S(═O)p—NH—; R7—C(═O)—; —NHC(═O)H; —C(═O)NHNH2; R7—C(═O)—NH—; R21—C(═O)—NH—; —C(═NH)R7; —C(═NH)R21; R4a or R4b each independently represent hydrogen, R8, —Y1—NR9—Y2—NR10R11, —Y1—NR9—Y1—R8, —Y1—NR9R10; provided that —X—R2 and/or R3 is other than hydrogen; their use, pharmaceutical compositions comprising them and processes for their preparation.

公开(公告)号：USD531955S1

公开(公告)日：2006-11-14

申请号：US29243857

申请日：2005-12-01

申请人： Sebastien Willy Fontaine ,  Sebastien Morin ,  Kenneth Jenner Powell ,  Vincent Dominique Rion ,  Michel Marguerite Walther Ghislan Constant ,  Edouard Leon Hoffmann ,  Marc Hubert

设计人： Sebastien Willy Fontaine ,  Sebastien Morin ,  Kenneth Jenner Powell ,  Vincent Dominique Rion ,  Michel Marguerite Walther Ghislan Constant ,  Edouard Leon Hoffmann ,  Marc Hubert

公开(公告)号：US06219704B1

公开(公告)日：2001-04-17

申请号：US08974442

申请日：1997-11-20

申请人： Michelle Yoonkyung Kim ,  Asser Nasreldin Tantawi ,  Edward Cholchin So ,  Marc Hubert Willebeek-LeMair

发明人： Michelle Yoonkyung Kim ,  Asser Nasreldin Tantawi ,  Edward Cholchin So ,  Marc Hubert Willebeek-LeMair

IPC分类号： G06F15173

CPC分类号： H04L12/5602 ,  H04L47/11 ,  H04L47/283

摘要： A method and an apparatus adaptively and dynamically deliver multimedia content based on continuously monitored network conditions. Given the temporal relationships among the multimedia items in the multimedia data stream and also the current network condition, the method and apparatus compute a transmission schedule such that the transmission delay and the burstyness of the network bandwidth utilization are minimized, while maintaining the integrity of the multimedia presentation.

摘要翻译： 一种方法和装置，基于连续监视的网络条件自适应地动态地传送多媒体内容。 鉴于多媒体数据流中的多媒体项目之间的时间关系以及当前的网络状况，该方法和装置计算传输调度，使得传输延迟和网络带宽利用的突发性最小化，同时保持 多媒体演示。

公开(公告)号：US5940391A

公开(公告)日：1999-08-17

申请号：US977864

申请日：1997-11-25

申请人： Peter Kenneth Malkin ,  Marc Hubert Willebeek-LeMair ,  Philip Shi-Lung Yu

发明人： Peter Kenneth Malkin ,  Marc Hubert Willebeek-LeMair ,  Philip Shi-Lung Yu

IPC分类号： H04L12/18

CPC分类号： H04L12/185

摘要： A multimedia stream is multicasted. A request to perform the multicast is received. A plurality of distribution nodes are assigned to provide the multicast to a plurality of receivers. The assignment of a node is based on the transformation capabilities of that node. The multicast is then performed and the assigned node performs its transformation. The transformed multicast is distributed to a receiver which is suitable for receiving the transformed multicast.

摘要翻译： 组播多媒体流。 接收到执行多播的请求。 分配多个分发节点以向多个接收机提供多播。 节点的分配基于该节点的转换能力。 然后执行多播，并且分配的节点执行其转换。 转换的多播被分配给适合于接收转换的多播的接收机。

公开(公告)号：US20110261365A1

公开(公告)日：2011-10-27

申请号：US13133934

申请日：2009-12-10

申请人： Stephane Tisserand ,  Marc Hubert ,  Laurent Roux

发明人： Stephane Tisserand ,  Marc Hubert ,  Laurent Roux

IPC分类号： G01J3/45

CPC分类号： G01J3/26 ,  G01J3/02 ,  G01J3/0256 ,  G01J3/10 ,  G01J3/45

摘要： The invention relates to a wavelength spectroscopy device comprising, on a substrate a filter cell CF constituted by two mirrors separated by a spacer membrane, the filter cell being made up of a plurality of interference filters. Furthermore, the device also comprises an emission cell CE comprising a plurality of emission sources, each of said sources being associated with one of said interference filters.

摘要翻译： 本发明涉及一种波长分析装置，在基板上包括由间隔膜隔开的两个反射镜构成的滤光单元CF，滤光单元由多个干涉滤光片构成。 此外，该装置还包括包括多个发射源的发射单元CE，每个所述源与所述干扰滤波器之一相关联。

公开(公告)号：US20110049340A1

公开(公告)日：2011-03-03

申请号：US12863731

申请日：2009-01-20

申请人： Stephane Tisserand ,  Marc Hubert ,  Laurent Roux

发明人： Stephane Tisserand ,  Marc Hubert ,  Laurent Roux

IPC分类号： G01N21/25 ,  G01J3/51

CPC分类号： G01J3/26

摘要： The invention relates to a wavelength spectroscopy device comprising, on a substrate SUB, a filter module made up of two mirrors MIR1, MIR2 that are spaced apart by a spacer membrane SP. The filter module comprises a plurality of interference filters FP1, FP2, FP3, the thickness of said spacer membrane SP being constant for any given filter and varying from one filter to another.

摘要翻译： 本发明涉及一种波长分析装置，在基板SUB上包括由隔离膜SP隔开的两个反射镜MIR1，MIR2构成的滤光模块。 滤波器模块包括多个干涉滤光器FP1，FP2，FP3，所述间隔膜SP的厚度对于任何给定的滤光器是恒定的，并且从一个滤光片到另一滤光片。

公开(公告)号：USD559767S1

公开(公告)日：2008-01-15

申请号：US29263944

申请日：2006-08-01

申请人： Maurice Graas ,  Marco Joseph Eicher ,  Sebastien Morin ,  Xavier Sebastien Benoit Fraipont ,  Jerome Marcel Germain Delu ,  Sebastien Willy Fontaine ,  Kenneth Jenner Powell ,  Vincent Dominique Claude Rion ,  Francois Baumard ,  Marc Hubert ,  Thierry Vincent Joseph Martin Botman ,  Andre Hardy ,  Josepha Beaubras

设计人： Maurice Graas ,  Marco Joseph Eicher ,  Sebastien Morin ,  Xavier Sebastien Benoit Fraipont ,  Jerome Marcel Germain Delu ,  Sebastien Willy Fontaine ,  Kenneth Jenner Powell ,  Vincent Dominique Claude Rion ,  Francois Baumard ,  Marc Hubert ,  Thierry Vincent Joseph Martin Botman ,  Andre Hardy ,  Josepha Beaubras

公开(公告)号：US08911731B2

公开(公告)日：2014-12-16

申请号：US14233068

申请日：2012-07-06

申请人： Marc Hubert Mercken ,  Marianne Borgers ,  Marc Maria Pierre Pelagie Vandermeeren ,  Bianca Julia J Van Broeck

发明人： Marc Hubert Mercken ,  Marianne Borgers ,  Marc Maria Pierre Pelagie Vandermeeren ,  Bianca Julia J Van Broeck

IPC分类号： A61K39/395 ,  C07K14/47 ,  A61K48/00 ,  A61K38/10 ,  C07K16/18 ,  G01N33/577

CPC分类号： G01N33/577 ,  C07K16/18

摘要： The present invention provides monoclonal antibodies which specifically recognize the shorter Aβ peptides obtained after cleavage of the APP protein mediated by γ-secretase, i.e. the Aβ-peptide fragments Aβ1-37, Aβ3-37, Aβ3p-37, Aβ1-37 and Aβ11p-37, and other like fragments ending at the 37th amino acid of APP, hereinafter also referred to as the Aβx-37 peptides. It further provides hybridoma cells producing the monoclonal antibodies as well as methods for producing the antibodies and the hybridoma cells; and an immunoassay for an Aβx-37 peptide by a competitive method or a sandwich method using the antibody of the present invention; and methods for measuring the level of Aβx-37 peptides in a sample, such as a biological sample.

摘要翻译： 本发明提供特异性识别较短A和Bgr的单克隆抗体。 在由γ-分泌酶介导的APP蛋白切割后获得的肽，即A＆bgr;肽片段A＆bgr; 1-37，A＆bgr; 3-37，A＆bgr; 3p-37，A＆bgr; 1-37和A＆bgr; 11p-37 ，以及以APP的第37个氨基酸终止的其他类似片段，以下也称为A＆bgr; x-37肽。 其进一步提供产生单克隆抗体的杂交瘤细胞以及产生抗体和杂交瘤细胞的方法; 以及使用本发明的抗体的竞争方法或夹心方法对A＆bgr; x-37肽的免疫测定; 以及用于测量样品（例如生物样品）中A＆bgr x-37肽水平的方法。