公开(公告)号：US07034135B2

公开(公告)日：2006-04-25

申请号：US10116422

申请日：2002-04-04

Applicant: John Bertin ,  Weiye Wang ,  Maria Blatcher

Inventor： John Bertin ,  Weiye Wang ,  Maria Blatcher

IPC: C07H21/04 ,  C07H21/02 ,  C12P21/06 ,  C12P21/04

CPC classification number: C07K14/47 ,  C07K2319/00

Abstract: Novel NBS-2, NBS-3, PYRIN-12/NBS-4, and NBS-5 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated NBS-2, NBS-3, PYRIN-12/NBS-4, and NBS-5 proteins, the invention further provides NBS-2, NBS-3, PYRIN-12/NBS-4, and NBS-5 fusion proteins, antigenic peptides and anti-NBS-2, anti-NBS-3, anti-PYRIN-12/NBS-4, and anti-NBS-5 antibodies. The invention also provides NBS-2, NBS-3, PYRIN-12/NBS-4, and NBS-5 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a NBS-2, NBS-3, PYRIN-12/NBS-4, or NBS-5 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

Abstract translation: 公开了新型NBS-2，NBS-3，PYRIN-12 / NBS-4和NBS-5多肽，蛋白质和核酸分子。 除了分离的NBS-2，NBS-3，PYRIN-12 / NBS-4和NBS-5蛋白外，本发明还提供了NBS-2，NBS-3，PYRIN-12 / NBS-4和NBS-5 融合蛋白，抗原肽和抗NBS-2，抗NBS-3，抗PYRIN-12 / NBS-4和抗NBS-5抗体。 本发明还提供了NBS-2，NBS-3，PYRIN-12 / NBS-4和NBS-5核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞 和其中引入或破坏NBS-2，NBS-3，PYRIN-12 / NBS-4或NBS-5基因的非人转基因动物。 还提供利用本发明组合物的诊断，筛选和治疗方法。

公开(公告)号：US07041643B2

公开(公告)日：2006-05-09

申请号：US10124498

申请日：2002-04-17

Applicant: John Bertin ,  Weiye Wang ,  Maria Blatcher

Inventor： John Bertin ,  Weiye Wang ,  Maria Blatcher

IPC: A61K38/00 ,  C07K1/00 ,  C07K14/00

CPC classification number: C07K14/47 ,  A61K38/00 ,  C07K14/4702 ,  C07K14/4747 ,  Y10T436/143333

Abstract: Novel PYRIN-2, PYRIN-3, PYRIN-5, PYRIN-6, PYRIN-7, PYRIN-8, PYRIN-10, and PYRIN-11 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated PYRIN-2, PYRIN-3, PYRIN-5, PYRIN-6, PYRIN-7, PYRIN-8, PYRIN-10, and PYRIN-11 proteins, the invention further provides PYRIN-2, PYRIN-3, PYRIN-5, PYRIN-6, PYRIN-7, PYRIN-8, PYRIN-10, and PYRIN-11 fusion proteins, antigenic peptides and anti-PYRIN-2, -PYRIN-3, -PYRIN-5, -PYRIN-6, -PYRIN-7, -PYRIN-8, -PYRIN-10, and -PYRIN-11 antibodies. The invention also provides PYRIN-2, PYRIN-3, PYRIN-5, PYRIN-6, PYRIN-7, PYRIN-8, PYRIN-10, and PYRIN-11 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a PYRIN-2, PYRIN-3, PYRIN-5, PYRIN-6, PYRIN-7, PYRIN-8, PYRIN-10, or PYRIN-11 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

Abstract translation: 公开了新的PYRIN-2，PYRIN-3，PYRIN-5，PYRIN-6，PYRIN-7，PYRIN-8，PYRIN-10和PYRIN-11多肽，蛋白质和核酸分子。 除了分离的PYRIN-2，PYRIN-3，PYRIN-5，PYRIN-6，PYRIN-7，PYRIN-8，PYRIN-10和PYRIN-11蛋白外，本发明还提供了PYRIN-2，PYRIN-3， PYRIN-5，PYRIN-6，PYRIN-7，PYRIN-8，PYRIN-10和PYRIN-11融合蛋白，抗原肽和抗PYRIN-2，-PYRIN-3，-PYRIN-5，-PYRIN-6 ，-PYRIN-7，-PYRIN-8，-PYRIN-10和-PYRIN-11抗体。 本发明还提供了含有PYRIN-2，PYRIN-3，PYRIN-5，PYRIN-6，PYRIN-7，PYRIN-8，PYRIN-10和PYRIN-11核酸分子的重组表达载体， 本发明中已经引入了表达载体的宿主细胞和非人转基因动物，其中PYRIN-2，PYRIN-3，PYRIN-5，PYRIN-6，PYRIN-7，PYRIN-8，PYRIN-10或 PYRIN-11基因已被引入或破坏。 还提供利用本发明组合物的诊断，筛选和治疗方法。

公开(公告)号：US20050191624A1

公开(公告)日：2005-09-01

申请号：US10116422

申请日：2002-04-04

Applicant: John Bertin ,  Weiye Wang ,  Maria Blatcher

Inventor： John Bertin ,  Weiye Wang ,  Maria Blatcher

IPC: C07K14/47 ,  C12Q1/00 ,  C07H21/04 ,  C12Q1/68

CPC classification number: C07K14/47 ,  C07K2319/00

Abstract: Novel NBS-2, NBS-3, PYRIN-12/NBS-4, and NBS-5 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated NBS-2, NBS-3, PYRIN-12/NBS-4, and NBS-5 proteins, the invention further provides NBS-2, NBS-3, PYRIN-12/NBS-4, and NBS-5 fusion proteins, antigenic peptides and anti-NBS-2, anti-NBS-3, anti-PYRIN-12/NBS-4, and anti-NBS-5 antibodies. The invention also provides NBS-2, NBS-3, PYRIN-12/NBS-4, and NBS-5 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a NBS-2, NBS-3, PYRIN-12/NBS-4, or NBS-5 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

Abstract translation: 公开了新型NBS-2，NBS-3，PYRIN-12 / NBS-4和NBS-5多肽，蛋白质和核酸分子。 除了分离的NBS-2，NBS-3，PYRIN-12 / NBS-4和NBS-5蛋白外，本发明还提供了NBS-2，NBS-3，PYRIN-12 / NBS-4和NBS-5 融合蛋白，抗原肽和抗NBS-2，抗NBS-3，抗PYRIN-12 / NBS-4和抗NBS-5抗体。 本发明还提供了NBS-2，NBS-3，PYRIN-12 / NBS-4和NBS-5核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞 和其中引入或破坏NBS-2，NBS-3，PYRIN-12 / NBS-4或NBS-5基因的非人转基因动物。 还提供利用本发明组合物的诊断，筛选和治疗方法。

公开(公告)号：US20070031860A1

公开(公告)日：2007-02-08

申请号：US11396960

申请日：2006-04-03

Applicant: Maria Blatcher ,  Brian Bates ,  Janet Paulsen

Inventor： Maria Blatcher ,  Brian Bates ,  Janet Paulsen

IPC: C12Q1/68 ,  G01N33/567 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705 ,  C07K16/28

CPC classification number: C07K14/70571 ,  A01K2217/075

Abstract: The present invention is based on the identification of a G-protein coupled receptor (GPCR) that is expressed predominantly in the brain and placenta and nucleic acid molecules that encoded the GPCR, which is referred to herein as the hCAR protein and hCAR gene respectively (for human Constitutively Active Receptor). Based on this identification, the present invention provides: (1) isolated hCAR protein; (2) isolated nucleic acid molecules that encode an hCAR protein; (3) antibodies that selectively bind to the hCAR protein; (4) methods of isolating allelic variants of the hCAR protein and gene; (5) methods of identifying cells and tissues that express the hCAR protein/gene; (6) methods of identifying agents and cellular compounds that bind to the hCAR protein; (7) methods of identifying agents that modulate the expression of the hCAR gene; and (8) methods of modulating the activity of the hCAR protein in a cell or organism.

Abstract translation: 本发明基于主要在脑和胎盘中表达的G蛋白偶联受体（GPCR）的鉴定和编码GPCR的核酸分子（分别在本文中称为hCAR蛋白和hCAR基因） 对于人类组成型活性受体）。 基于该鉴定，本发明提供：（1）分离的hCAR蛋白; （2）编码hCAR蛋白的分离的核酸分子; （3）选择性结合hCAR蛋白的抗体; （4）分离hCAR蛋白和基因的等位基因变体的方法; （5）鉴定表达hCAR蛋白/基因的细胞和组织的方法; （6）鉴定与hCAR蛋白结合的试剂和细胞化合物的方法; （7）鉴定调节hCAR基因表达的试剂的方法; 和（8）调节细胞或生物体中hCAR蛋白活性的方法。

公开(公告)号：US07160695B2

公开(公告)日：2007-01-09

申请号：US10066521

申请日：2002-01-31

Applicant: John Bertin ,  Weiye Wang ,  Maria Blatcher

Inventor： John Bertin ,  Weiye Wang ,  Maria Blatcher

IPC: C12N15/00 ,  C12N5/00 ,  C12N15/63 ,  C07H21/04

CPC classification number: C07K14/47 ,  A61K38/00

Abstract: Novel PYRIN-2, PYRIN-3, PYRIN-5, PYRIN-6, PYRIN-7, PYRIN-8, PYRIN-10, and PYRIN-11 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated PYRIN-2, PYRIN-3, PYRIN-5, PYRIN-6, PYRIN-7, PYRIN-8, PYRIN-10, and PYRIN-11 proteins, the invention further provides PYRIN-2, PYRIN-3, PYRIN-5, PYRIN-6, PYRIN-7, PYRIN-8, PYRIN-10, and PYRIN-11 fusion proteins, antigenic peptides and anti-PYRIN-2, -PYRIN-3, -PYRIN-5, -PYRIN-6, -PYRIN-7, -PYRIN-8, -PYRIN-10, and -PYRIN-11 antibodies. The invention also provides PYRIN-2, PYRIN-3, PYRIN-5, PYRIN-6, PYRIN-7, PYRIN-8, PYRIN-10, and PYRIN-11 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a PYRIN-2, PYRIN-3, PYRIN-5, PYRIN-6, PYRIN-7, PYRIN-8, PYRIN-10, or PYRIN-11 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

Abstract translation: 公开了新的PYRIN-2，PYRIN-3，PYRIN-5，PYRIN-6，PYRIN-7，PYRIN-8，PYRIN-10和PYRIN-11多肽，蛋白质和核酸分子。 除了分离的PYRIN-2，PYRIN-3，PYRIN-5，PYRIN-6，PYRIN-7，PYRIN-8，PYRIN-10和PYRIN-11蛋白外，本发明还提供了PYRIN-2，PYRIN-3， PYRIN-5，PYRIN-6，PYRIN-7，PYRIN-8，PYRIN-10和PYRIN-11融合蛋白，抗原肽和抗PYRIN-2，-PYRIN-3，-PYRIN-5，-PYRIN-6 ，-PYRIN-7，-PYRIN-8，-PYRIN-10和-PYRIN-11抗体。 本发明还提供了含有PYRIN-2，PYRIN-3，PYRIN-5，PYRIN-6，PYRIN-7，PYRIN-8，PYRIN-10和PYRIN-11核酸分子的重组表达载体， 本发明中已经引入了表达载体的宿主细胞和非人转基因动物，其中PYRIN-2，PYRIN-3，PYRIN-5，PYRIN-6，PYRIN-7，PYRIN-8，PYRIN-10或 PYRIN-11基因已被引入或破坏。 还提供利用本发明组合物的诊断，筛选和治疗方法。

公开(公告)号：US20100255006A1

公开(公告)日：2010-10-07

申请号：US12627191

申请日：2009-11-30

Applicant: JOHN BERTIN ,  WEIYE WANG ,  MARIA BLATCHER

Inventor： JOHN BERTIN ,  WEIYE WANG ,  MARIA BLATCHER

IPC: A61K39/395 ,  C07K16/18 ,  A61K31/7088 ,  A61K38/17 ,  A61P29/00 ,  A61P35/00 ,  C07H21/04 ,  C07K14/47 ,  C12N15/63 ,  A61P35/04 ,  A61P31/04 ,  A61P31/10 ,  A61P33/00 ,  A61P31/12 ,  A61K38/45 ,  C12N5/10 ,  C12N9/12 ,  C12P21/02 ,  C12Q1/48 ,  G01N33/566 ,  G01N33/53 ,  C07K14/00 ,  G01N33/50

CPC classification number: C07K14/47 ,  A61K38/00 ,  C07K14/4702 ,  C07K14/4747 ,  Y10T436/143333

Abstract: Novel PYRIN-2, PYRIN-3, PYRIN-5, PYRIN-6, PYRIN-7, PYRIN-8, PYRIN-10, and PYRIN-11 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated PYRIN-2, PYRIN-3, PYRIN-5, PYRIN-6, PYRIN-7, PYRIN-8, PYRIN-10, and PYRIN-11 proteins, the invention further provides PYRIN-2, PYRIN-3, PYRIN-5, PYRIN-6, PYRIN-7, PYRIN-8, PYRIN-10, and PYRIN-11 fusion proteins, antigenic peptides and anti-PYRIN-2, -PYRIN-3, -PYRIN-5, -PYRIN-6, -PYRIN-7, -PYRIN-8, -PYRIN-10, and -PYRIN-11 antibodies. The invention also provides PYRIN-2, PYRIN-3, PYRIN-5, PYRIN-6, PYRIN-7, PYRIN-8, PYRIN-10, and PYRIN-11 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a PYRIN-2, PYRIN-3, PYRIN-5, PYRIN-6, PYRIN-7, PYRIN-8, PYRIN-10, or PYRIN-11 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

Abstract translation: 公开了新的PYRIN-2，PYRIN-3，PYRIN-5，PYRIN-6，PYRIN-7，PYRIN-8，PYRIN-10和PYRIN-11多肽，蛋白质和核酸分子。 除了分离的PYRIN-2，PYRIN-3，PYRIN-5，PYRIN-6，PYRIN-7，PYRIN-8，PYRIN-10和PYRIN-11蛋白外，本发明还提供了PYRIN-2，PYRIN-3， PYRIN-5，PYRIN-6，PYRIN-7，PYRIN-8，PYRIN-10和PYRIN-11融合蛋白，抗原肽和抗PYRIN-2，-PYRIN-3，-PYRIN-5，-PYRIN-6 ，-PYRIN-7，-PYRIN-8，-PYRIN-10和-PYRIN-11抗体。 本发明还提供了含有PYRIN-2，PYRIN-3，PYRIN-5，PYRIN-6，PYRIN-7，PYRIN-8，PYRIN-10和PYRIN-11核酸分子的重组表达载体， 本发明中已经引入了表达载体的宿主细胞和非人转基因动物，其中PYRIN-2，PYRIN-3，PYRIN-5，PYRIN-6，PYRIN-7，PYRIN-8，PYRIN-10或 PYRIN-11基因已被引入或破坏。 还提供利用本发明组合物的诊断，筛选和治疗方法。

公开(公告)号：US07648963B2

公开(公告)日：2010-01-19

申请号：US11346858

申请日：2006-02-01

Applicant: John Bertin ,  Weiye Wang ,  Maria Blatcher

Inventor： John Bertin ,  Weiye Wang ,  Maria Blatcher

IPC: C07H21/02

CPC classification number: C07K14/47 ,  A61K38/00 ,  C07K14/4702 ,  C07K14/4747 ,  Y10T436/143333

Abstract: Novel PYRIN-2, PYRIN-3, PYRIN-5, PYRIN-6, PYRIN-7, PYRIN-8, PYRIN-10, and PYRIN-11 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated PYRIN-2, PYRIN-3, PYRIN-5, PYRIN-6, PYRIN-7, PYRIN-8, PYRIN-10, and PYRIN-11 proteins, the invention further provides PYRIN-2, PYRIN-3, PYRIN-5, PYRIN-6, PYRIN-7, PYRIN-8, PYRIN-10, and PYRIN-11 fusion proteins, antigenic peptides and anti-PYRIN-2, -PYRIN-3, -PYRIN-5, -PYRIN-6, -PYRIN-7, -PYRIN-8, -PYRIN-10, and -PYRIN-11 antibodies. The invention also provides PYRIN-2, PYRIN-3, PYRIN-5, PYRIN-6, PYRIN-7, PYRIN-8, PYRIN-10, and PYRIN-11 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a PYRIN-2, PYRIN-3, PYRIN-5, PYRIN-6, PYRIN-7, PYRIN-8, PYRIN-10, or PYRIN-11 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

Abstract translation: 公开了新的PYRIN-2，PYRIN-3，PYRIN-5，PYRIN-6，PYRIN-7，PYRIN-8，PYRIN-10和PYRIN-11多肽，蛋白质和核酸分子。 除了分离的PYRIN-2，PYRIN-3，PYRIN-5，PYRIN-6，PYRIN-7，PYRIN-8，PYRIN-10和PYRIN-11蛋白外，本发明还提供了PYRIN-2，PYRIN-3， PYRIN-5，PYRIN-6，PYRIN-7，PYRIN-8，PYRIN-10和PYRIN-11融合蛋白，抗原肽和抗PYRIN-2，-PYRIN-3，-PYRIN-5，-PYRIN-6 ，-PYRIN-7，-PYRIN-8，-PYRIN-10和-PYRIN-11抗体。 本发明还提供了含有PYRIN-2，PYRIN-3，PYRIN-5，PYRIN-6，PYRIN-7，PYRIN-8，PYRIN-10和PYRIN-11核酸分子的重组表达载体， 本发明中已经引入了表达载体的宿主细胞和非人转基因动物，其中PYRIN-2，PYRIN-3，PYRIN-5，PYRIN-6，PYRIN-7，PYRIN-8，PYRIN-10或 PYRIN-11基因已被引入或破坏。 还提供利用本发明组合物的诊断，筛选和治疗方法。

公开(公告)号：US20090255004A1

公开(公告)日：2009-10-08

申请号：US12397761

申请日：2009-03-04

Applicant: Maria Blatcher ,  Brian Gaither Bates ,  Janet Elizabeth Paulsen

Inventor： Maria Blatcher ,  Brian Gaither Bates ,  Janet Elizabeth Paulsen

IPC: A01K67/027 ,  C12N15/12 ,  C12N15/85 ,  C07K14/47 ,  C07K16/18 ,  G01N33/566 ,  C12Q1/68 ,  C12N5/00

CPC classification number: C07K14/70571 ,  A01K2217/075

Abstract: The present invention is based on the identification of a G-protein coupled receptor (GPCR) that is expressed predominantly in the brain and placenta and nucleic acid molecules that encoded the GPCR, which is referred to herein as the hCAR protein and hCAR gene respectively (for human Constitutively Active Receptor). Based on this identification, the present invention provides: (1) isolated hCAR protein; (2) isolated nucleic acid molecules that encode an hCAR protein; (3) antibodies that selectively bind to the hCAR protein; (4) methods of isolating allelic variants of the hCAR protein and gene; (5) methods of identifying cells and tissues that express the hCAR protein/gene; (6) methods of identifying agents and cellular compounds that bind to the hCAR protein; (7) methods of identifying agents that modulate the expression of the hCAR gene; and (8) methods of modulating the activity of the hCAR protein in a cell or organism.

Abstract translation: 本发明基于主要在脑和胎盘中表达的G蛋白偶联受体（GPCR）的鉴定和编码GPCR的核酸分子（分别在本文中称为hCAR蛋白和hCAR基因） 对于人类组成型活性受体）。 基于该鉴定，本发明提供：（1）分离的hCAR蛋白; （2）编码hCAR蛋白的分离的核酸分子; （3）选择性结合hCAR蛋白的抗体; （4）分离hCAR蛋白和基因的等位基因变体的方法; （5）鉴定表达hCAR蛋白/基因的细胞和组织的方法; （6）鉴定与hCAR蛋白结合的试剂和细胞化合物的方法; （7）鉴定调节hCAR基因表达的试剂的方法; 和（8）调节细胞或生物体中hCAR蛋白活性的方法。

公开(公告)号：US20060270593A1

公开(公告)日：2006-11-30

申请号：US11346858

申请日：2006-02-01

Applicant: John Bertin ,  Weiye Wang ,  Maria Blatcher

Inventor： John Bertin ,  Weiye Wang ,  Maria Blatcher

IPC: A61K38/17 ,  C07K14/82 ,  C07K16/30 ,  C07H21/04 ,  C12P21/06

CPC classification number: C07K14/47 ,  A61K38/00 ,  C07K14/4702 ,  C07K14/4747 ,  Y10T436/143333

Abstract: Novel PYRIN-2, PYRIN-3, PYRIN-5, PYRIN-6, PYRIN-7, PYRIN-8, PYRIN-10, and PYRIN-11 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated PYRIN-2, PYRIN-3, PYRIN-5, PYRIN-6, PYRIN-7, PYRIN-8, PYRIN-10, and PYRIN-11 proteins, the invention further provides PYRIN-2, PYRIN-3, PYRIN-5, PYRIN-6, PYRIN-7, PYRIN-8, PYRIN-10, and PYRIN-11 fusion proteins, antigenic peptides and anti-PYRIN-2, -PYRIN-3, -PYRIN-5, -PYRIN-6, -PYRIN-7, -PYRIN-8, -PYRIN-10, and -PYRIN-11 antibodies. The invention also provides PYRIN-2, PYRIN-3, PYRIN-5, PYRIN-6, PYRIN-7, PYRIN-8, PYRIN-10, and PYRIN-11 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a PYRIN-2, PYRIN-3, PYRIN-5, PYRIN-6, PYRIN-7, PYRIN-8, PYRIN-10, or PYRIN-11 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

Abstract translation: 公开了新的PYRIN-2，PYRIN-3，PYRIN-5，PYRIN-6，PYRIN-7，PYRIN-8，PYRIN-10和PYRIN-11多肽，蛋白质和核酸分子。 除了分离的PYRIN-2，PYRIN-3，PYRIN-5，PYRIN-6，PYRIN-7，PYRIN-8，PYRIN-10和PYRIN-11蛋白外，本发明还提供了PYRIN-2，PYRIN-3， PYRIN-5，PYRIN-6，PYRIN-7，PYRIN-8，PYRIN-10和PYRIN-11融合蛋白，抗原肽和抗PYRIN-2，-PYRIN-3，-PYRIN-5，-PYRIN-6 ，-PYRIN-7，-PYRIN-8，-PYRIN-10和-PYRIN-11抗体。 本发明还提供了含有PYRIN-2，PYRIN-3，PYRIN-5，PYRIN-6，PYRIN-7，PYRIN-8，PYRIN-10和PYRIN-11核酸分子的重组表达载体， 本发明中已经引入了表达载体的宿主细胞和非人转基因动物，其中PYRIN-2，PYRIN-3，PYRIN-5，PYRIN-6，PYRIN-7，PYRIN-8，PYRIN-10或 PYRIN-11基因已被引入或破坏。 还提供利用本发明组合物的诊断，筛选和治疗方法。