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公开(公告)号：US20120009604A1
公开(公告)日：2012-01-12
申请号：US13197242
申请日：2011-08-03
申请人： Jean-Michel ITIER , Marie-Christine MULTON , Gwénaëlle RET , Jean-Marie STUTZMANN , Florence WAHL
发明人： Jean-Michel ITIER , Marie-Christine MULTON , Gwénaëlle RET , Jean-Marie STUTZMANN , Florence WAHL
CPC分类号： G01N33/6893 , G01N33/6872 , G01N33/6896 , G01N2333/4703 , G01N2500/04 , G01N2500/10
摘要： The invention concerns the use of whole or part of the GRF1 protein, or of cells expressing whole or part of the GRF1 protein, in methods for detecting compounds for preventing and/or treating pathologies or disorders of the central nervous system involving neuronal death, such as apoptosis, or related to leptin metabolism. The pathologies of the central nervous system are in particular cerebral ischemia, Parkinson's disease or Alzheimer's disease.
摘要翻译： 本发明涉及使用全部或部分GRF1蛋白或表达全部或部分GRF1蛋白的细胞在检测用于预防和/或治疗涉及神经元死亡的中枢神经系统的病症或病症的化合物的方法中的应用，例如 作为凋亡，或与瘦素代谢有关。 中枢神经系统的病理特别是脑缺血，帕金森病或阿尔茨海默病。
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2.发明授权Net, a transcription factor of the TCF family, as regulator of angiogenic factor expression 有权Net，TCF家族的转录因子，作为血管生成因子表达的调节因子公开(公告)号：US07537887B2
公开(公告)日：2009-05-26
申请号：US10415181
申请日：2001-10-23
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/072 , A01K2217/075 , A01K2267/0375 , A01K2267/0393 , A61K38/1709 , G01N33/6872 , G01N2500/00
摘要： The present invention relates to the regulation of the activity of NET (ERP/SAP-2) protein and to compounds which modify or regulate NET protein activity. The invention further relates to methods of screening for agonists or antagonists of NET in order to identify new pro-angiogenic or anti-angiogenic compounds and to therapeutic uses of these compounds. The invention also relates to transgenic animals bearing mutations in NET gene.
摘要翻译： 本发明涉及NET（ERP / SAP-2）蛋白的活性调节以及修饰或调节NET蛋白活性的化合物。 本发明还涉及筛选NET的激动剂或拮抗剂以鉴定新的促血管生成或抗血管生成化合物的方法以及这些化合物的治疗用途。 本发明还涉及带有NET基因突变的转基因动物。
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公开(公告)号：US20050250143A1
公开(公告)日：2005-11-10
申请号：US11105864
申请日：2005-04-14
CPC分类号： C07K14/4702 , A61K48/00 , C07K2319/00 , C12N2799/021
摘要： The present invention relates to a novel protein of the MEKK signal transduction pathway, and the gene encoding it. The invention further relates to diagnostic and therapeutic uses of the protein or the gene, and to methods of screening for agonists or antagonists of the protein, particularly with respect to MEKK activity. In particular, the invention provides a gene encoding MIF1, the MIF1 protein, and antibodies that specifically bind MIF1. MIF1 and the MIF1 gene can be used in screening assays, particularly to identify agonists and antagonists of MIF1 interaction with MEKK, and thus modulators of the MEKK signal pathway. MIF1 gene (or cDNA) can also be delivered to cells, e.g., for in vitro screening or testing, or in vivo or ex vivo for gene therapy.
摘要翻译： 本发明涉及MEKK信号转导途径的新蛋白质及其编码基因。 本发明还涉及蛋白质或基因的诊断和治疗用途，以及筛选蛋白质的激动剂或拮抗剂的方法，特别是关于MEKK活性的方法。 特别地，本发明提供编码MIF1，MIF1蛋白的基因和特异性结合MIF1的抗体。 MIF1和MIF1基因可用于筛选试验，特别是鉴定MIF1与MEKK相互作用的激动剂和拮抗剂，从而鉴定MEKK信号通路的调节剂。 也可将MIF1基因（或cDNA）递送至细胞，例如用于体外筛选或检测，或体内或离体进行基因治疗。
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公开(公告)号：US07364871B2
公开(公告)日：2008-04-29
申请号：US11105864
申请日：2005-04-14
CPC分类号： C07K14/4702 , A61K48/00 , C07K2319/00 , C12N2799/021
摘要： The present invention relates to a novel protein of the MEKK signal transduction pathway, and the gene encoding it. The invention further relates to diagnostic and therapeutic uses of the protein or the gene, and to methods of screening for agonists or antagonists of the protein, particularly with respect to MEKK activity. In particular, the invention provides a gene encoding MIF1, the MIF1 protein, and antibodies that specifically bind MIF1. MIF1 and the MIF1 gene can be used in screening assays, particularly to identify agonists and antagonists of MIF1 interaction with MEKK, and thus modulators of the MEKK signal pathway. MIF1 gene (or cDNA) can also be delivered to cells, e.g., for in vitro screening or testing, or in vivo or ex vivo for gene therapy.
摘要翻译： 本发明涉及MEKK信号转导途径的新蛋白质及其编码基因。 本发明还涉及蛋白质或基因的诊断和治疗用途，以及筛选蛋白质的激动剂或拮抗剂的方法，特别是关于MEKK活性的方法。 特别地，本发明提供编码MIF1，MIF1蛋白的基因和特异性结合MIF1的抗体。 MIF1和MIF1基因可用于筛选测定，特别是鉴定MIF1与MEKK相互作用的激动剂和拮抗剂，从而鉴定MEKK信号通路的调节剂。 也可将MIF1基因（或cDNA）递送至细胞，例如用于体外筛选或测试，或体内或离体进行基因治疗。
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公开(公告)号：US20050100972A1
公开(公告)日：2005-05-12
申请号：US10344223
申请日：2001-08-07
申请人： Jean-Michel Itier , Marie-Christine Multon , Gwenaelle Ret , Jean-Marie Stutzmann , Florence Wahl
发明人： Jean-Michel Itier , Marie-Christine Multon , Gwenaelle Ret , Jean-Marie Stutzmann , Florence Wahl
IPC分类号： G01N33/50 , C12N1/19 , C12N15/09 , C12Q1/04 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/68 , G01N33/569
CPC分类号： G01N33/6893 , G01N33/6872 , G01N33/6896 , G01N2333/4703 , G01N2500/04 , G01N2500/10
摘要： The invention concerns the use of whole or part of the GRF1 protein, or of cells expressing whole or part of the GRF1 protein, in methods for detecting compounds for preventing and/or treating pathologies or disorders of the central nervous system involving neuronal death, such as apoptosis, or related to leptin metabolism. The pathologies of the central nervous system are in particular cerebral ischemia, Parkinson's disease or Alzheimer's disease.
摘要翻译： 本发明涉及使用全部或部分GRF1蛋白或表达全部或部分GRF1蛋白的细胞在检测用于预防和/或治疗涉及神经元死亡的中枢神经系统的病症或病症的化合物的方法中的应用，例如 作为凋亡，或与瘦素代谢有关。 中枢神经系统的病理特别是脑缺血，帕金森病或阿尔茨海默病。
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6.发明授权Method for identifying an antagonist of guanine nucleotide releasing factor 1 有权鉴定鸟嘌呤核苷酸释放因子1拮抗剂的方法公开(公告)号：US08852878B2
公开(公告)日：2014-10-07
申请号：US13197242
申请日：2011-08-03
申请人： Jean-Michel Itier , Marie-Christine Multon , Gwénaëlle Ret , Jean-Marie Stutzmann , Florence Wahl
发明人： Jean-Michel Itier , Marie-Christine Multon , Gwénaëlle Ret , Jean-Marie Stutzmann , Florence Wahl
IPC分类号： G01N33/53 , G01N33/567 , G01N33/68
CPC分类号： G01N33/6893 , G01N33/6872 , G01N33/6896 , G01N2333/4703 , G01N2500/04 , G01N2500/10
摘要： The invention concerns the use of whole or part of the GRF1 protein, or of cells expressing whole or part of the GRF1 protein, in methods for detecting compounds for preventing and/or treating pathologies or disorders of the central nervous system involving neuronal death, such as apoptosis, or related to leptin metabolism. The pathologies of the central nervous system are in particular cerebral ischemia, Parkinson's disease or Alzheimer's disease.
摘要翻译： 本发明涉及使用全部或部分GRF1蛋白或表达全部或部分GRF1蛋白的细胞在检测用于预防和/或治疗涉及神经元死亡的中枢神经系统的病症或病症的化合物的方法中的应用，例如 作为凋亡，或与瘦素代谢有关。 中枢神经系统的病理特别是脑缺血，帕金森病或阿尔茨海默病。
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7.发明授权MEKK1 (serine threonine kinases)-interacting FHA (forkhead associated domain) protein 1 (M1F1) 失效蛋白1（M1F1）的MEKK1（丝氨酸苏氨酸激酶） - 相互作用的FHA（叉头相关结构域）公开(公告)号：US06890733B1
公开(公告)日：2005-05-10
申请号：US09744125
申请日：1999-07-21
CPC分类号： C07K14/4702 , A61K48/00 , C07K2319/00 , C12N2799/021
摘要： The present invention relates to a novel protein of the MEKK signal transduction pathway, and the gene encoding it. The invention further relates to diagnostic and therapeutic uses of the protein or the gene, and to methods of screening for agonists or antagonists of the protein, particularly with respect to MEKK activity. In particular, the invention provides a gene encoding MIF1, the MIF1 protein, and antibodies that specifically bind MIF1. MIF1 and the MIF1 gene can be used in screening assays, particularly to identify agonists and antagonists of MIF1 interaction with MEKK, and thus modulators of the MEKK signal pathway. MIF1 gene (or cDNA) can also be delivered to cells, e.g., for in vitro screening or testing, or in vivo or ex vivo for gene therapy.
摘要翻译： 本发明涉及MEKK信号转导途径的新蛋白质及其编码基因。 本发明还涉及蛋白质或基因的诊断和治疗用途，以及筛选蛋白质的激动剂或拮抗剂的方法，特别是关于MEKK活性的方法。 特别地，本发明提供编码MIF1，MIF1蛋白的基因和特异性结合MIF1的抗体。 MIF1和MIF1基因可用于筛选测定，特别是鉴定MIF1与MEKK相互作用的激动剂和拮抗剂，从而鉴定MEKK信号通路的调节剂。 也可将MIF1基因（或cDNA）递送至细胞，例如用于体外筛选或测试，或体内或离体进行基因治疗。
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