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    Dendrimer conjugates
    1.
    发明授权
    Dendrimer conjugates 有权

    公开(公告)号：US08445528B2

    公开(公告)日：2013-05-21

    申请号：US13547929

    申请日：2012-07-12

    Applicant: James R. Baker, Jr. ,  Xue-min Cheng ,  Thommey P. Thomas ,  Baohua Mark Huang

    Inventor： James R. Baker, Jr. ,  Xue-min Cheng ,  Thommey P. Thomas ,  Baohua Mark Huang

    IPC: A61K31/403 ,  A61K31/485 ,  C07D209/12 ,  C07D471/04

    CPC classification number: C07D305/08

    Abstract: The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy.

    Representing de-duplicated file data
    2.
    发明授权
    Representing de-duplicated file data 有权
    表示取消复制的文件数据

    公开(公告)号：US08396839B1

    公开(公告)日：2013-03-12

    申请号：US12803393

    申请日：2010-06-25

    Applicant: Mark Huang

    Inventor： Mark Huang

    IPC: G06F17/30

    CPC classification number: G06F17/30156

    Abstract: A subset of de-duplicated is outputted. In some embodiments, the output includes a subset of data stored in de-duplicated form in a plurality of containers each including a plurality of data segments comprising the data. For each container that includes one or more data segments comprising the subset, a corresponding container data is included in the output. Each container may include one or more segments not included in the subset. For each container the corresponding container data of which is included in the output, a corresponding value in a data structure including for each container stored on the de-duplicated storage system a data value indicating whether or not the corresponding container data has been included in the output is updated.

    Abstract translation: 输出一个去重复的子集。 在一些实施例中，输出包括在多个容器中以重复形式存储的数据子集，每个容器包括包括数据的多个数据段。 对于包括包括该子集的一个或多个数据段的每个容器，相应的容器数据被包括在输出中。 每个容器可以包括不包括在子集中的一个或多个段。 对于包含在输出中的对应的容器数据的每个容器，在数据结构中包括对存储在去重复存储系统上的每个容器的相应值，指示对应的容器数据是否已被包括在数据结构中的数据值 输出更新。

    Dendrimer conjugates
    3.
    发明授权
    Dendrimer conjugates 有权
    树枝状结合物

    公开(公告)号：US08252834B2

    公开(公告)日：2012-08-28

    申请号：US12403179

    申请日：2009-03-12

    Applicant: James R. Baker, Jr. ,  Xue-min Cheng ,  Thommey P. Thomas ,  Baohua Mark Huang

    Inventor： James R. Baker, Jr. ,  Xue-min Cheng ,  Thommey P. Thomas ,  Baohua Mark Huang

    IPC: A61K31/403 ,  A61K31/485 ,  C07D209/12 ,  C07D471/04

    CPC classification number: C07D305/08

    Abstract: The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy.

    Abstract translation: 本发明涉及新的治疗和诊断树枝状大分子。 特别地，本发明涉及树枝状大分子 - 连接体缀合物，其合成方法，包含缀合物的组合物，以及利用缀合物的系统和方法（例如，在诊断和/或治疗设置（例如，用于递送 治疗，成像和/或靶向剂（例如，在疾病（例如癌症）诊断和/或治疗，疼痛治疗等中））。因此，本发明的树枝状大分子 - 接头缀合物还可包含一种或多种 用于靶向，成像，感测和/或提供治疗或诊断材料和/或监测治疗反应的组分。

    DENDRIMER CONJUGATES
    5.
    发明申请
    DENDRIMER CONJUGATES 有权
    DENDRIMER联合

    公开(公告)号：US20090287005A1

    公开(公告)日：2009-11-19

    申请号：US12403179

    申请日：2009-03-12

    Applicant: James R. Baker, JR. ,  Xue-min Cheng ,  Thommey P. Thomas ,  Baohua Mark Huang

    Inventor： James R. Baker, JR. ,  Xue-min Cheng ,  Thommey P. Thomas ,  Baohua Mark Huang

    IPC: C07D305/08

    CPC classification number: C07D305/08

    Abstract: The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy.

    Abstract translation: 本发明涉及新的治疗和诊断树枝状大分子。 特别地，本发明涉及树枝状大分子 - 连接体缀合物，其合成方法，包含缀合物的组合物，以及利用缀合物的系统和方法（例如，在诊断和/或治疗设置（例如，用于递送 治疗，成像和/或靶向剂（例如，在疾病（例如癌症）诊断和/或治疗，疼痛治疗等中））。因此，本发明的树枝状大分子 - 接头缀合物还可包含一种或多种 用于靶向，成像，感测和/或提供治疗或诊断材料和/或监测治疗反应的组分。

    Storing differences between precompressed and recompressed data files
    7.
    发明授权
    Storing differences between precompressed and recompressed data files 有权
    存储预压缩和重新压缩的数据文件之间的差异

    公开(公告)号：US09026505B1

    公开(公告)日：2015-05-05

    申请号：US13329072

    申请日：2011-12-16

    Applicant: Mark Huang

    Inventor： Mark Huang

    IPC: G06F7/02 ,  G06F17/30

    CPC classification number: G06F17/30153 ,  G06F17/30106 ,  G06F17/3015 ,  G06F17/30156 ,  G06F17/30162

    Abstract: A system comprises a processor and a memory. The processor is configured to decompress a precompressed file; recompress the decompressed file; and determine a difference file. The memory is coupled to the processor and configured to provide the processor with instructions.

    Abstract translation: 系统包括处理器和存储器。 处理器被配置为解压缩预压缩的文件; 重新压缩解压文件; 并确定差异文件。 存储器耦合到处理器并且被配置为向处理器提供指令。

    Efficient backup replication
    8.
    发明授权
    Efficient backup replication 有权
    高效备份复制

    公开(公告)号：US08972678B2

    公开(公告)日：2015-03-03

    申请号：US13332474

    申请日：2011-12-21

    Applicant: Mark Huang

    Inventor： Mark Huang

    IPC: G06F12/16

    CPC classification number: G06F11/1435 ,  G06F11/1451 ,  G06F11/1453 ,  G06F11/1456 ,  G06F11/1464 ,  G06F11/202 ,  G06F11/2094 ,  G06F2201/83 ,  G06F2201/84

    Abstract: A system for backup replication comprises a processor and a memory. The processor is configured to determine data present in a most recent backup not present in a previous backup; transmit an extent specification; and transmit data segment fingerprints of the one or more data segments. The memory is coupled to the processor and is configured to provide the processor with instructions.

    Abstract translation: 用于备份复制的系统包括处理器和存储器。 处理器被配置为确定存在于先前备份中不存在的最新备份中的数据; 传输范围规范; 并发送一个或多个数据段的数据段指纹。 存储器耦合到处理器并且被配置为向处理器提供指令。

    Medical device having bonding regions and method of making the same
    9.
    发明授权
    Medical device having bonding regions and method of making the same 有权
    具有接合区域的医疗器械及其制造方法

    公开(公告)号：US08535806B2

    公开(公告)日：2013-09-17

    申请号：US12888091

    申请日：2010-09-22

    Applicant: I Mark Huang ,  Michael V. Williamson

    Inventor： I Mark Huang ,  Michael V. Williamson

    IPC: B32B9/04 ,  B32B27/00 ,  B32B15/04 ,  B32B15/00 ,  B32B9/00

    CPC classification number: B32B9/04 ,  C04B37/00 ,  C09J5/02 ,  C09J5/06 ,  C09J2400/166 ,  Y10T156/10 ,  Y10T428/12979 ,  Y10T428/31504 ,  Y10T428/31544 ,  Y10T428/31678

    Abstract: Medical devices having bonded joints are disclosed. The bonded joints include two surfaces bonded by a layer of phenoxy resin therebetween. In the preferred embodiments, bonded surfaces include materials that are suitable for medical devices. Most preferably, Nitinol includes at least one bonded surface, however, other preferred materials may include, but are not limited to cobalt chromium, stainless steel, titanium, tantalum, and plastic. An intraluminal device including a plurality of locations with a phenoxy resin layer is also disclosed wherein the phenoxy resin further includes a radioopaque additive, a lubricious additive, or both radioopaque and lubricious additives. Also disclosed is an intraluminal device having contiguous heterogeneous structural elements of metallic members and non-metallic sections that are bonded together by a layer of phenoxy resin therebetween.

    Abstract translation: 公开了具有接合接头的医疗器械。 接合接头包括两层，它们之间通过一层苯氧树脂结合。 在优选实施例中，接合表面包括适合于医疗装置的材料。 最优选地，镍钛诺包括至少一个键合表面，然而，其它优选的材料可以包括但不限于钴铬，不锈钢，钛，钽和塑料。 还公开了一种包括具有苯氧基树脂层的多个位置的管腔内装置，其中所述苯氧基树脂还包括不透射线添加剂，润滑添加剂或放射性不透明和润滑添加剂两者。 还公开了一种具有金属构件和非金属部分的连续异质结构元件的管腔内装置，其通过其间的一层苯氧基树脂结合在一起。

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