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    Capture Probes Immobilizable Via L-Nucleotide Tail
    1.
    发明申请
    Capture Probes Immobilizable Via L-Nucleotide Tail 有权
    捕获探针可通过L-核苷酸尾部固定

    公开(公告)号：US20130260368A1

    公开(公告)日：2013-10-03

    申请号：US13823551

    申请日：2011-09-16

    Applicant: Reinhold Pollner ,  Mehrdad Majlessi ,  Susan Yamagata ,  Michael M. Becker ,  Mark Reynolds ,  Lyle Arnold

    Inventor： Reinhold Pollner ,  Mehrdad Majlessi ,  Susan Yamagata ,  Michael M. Becker ,  Mark Reynolds ,  Lyle Arnold

    IPC: C12Q1/70

    CPC classification number: C12Q1/707 ,  C12Q1/6837 ,  C12Q1/703 ,  Y02A50/53 ,  Y02A50/54 ,  C12Q2525/161

    Abstract: The invention provides chimeric capture probes immobilizable via an L-nucleic acid tail that can bind to a complementary L-nucleic acid in an immobilized probe. The capture probes are useful for capturing a target nucleic acid from a sample. The L-nucleic acid in the tail of the capture probe bind to the complementary L-nucleic acid in the immobilized probe with similar affinity as would otherwise equivalent D-nucleic acids. However, the L-nucleic acid of the capture probe tail and immobilized probes do not form stable duplexes with D-nucleic acids present in the sample containing the target nucleic acid. Binding of nucleic acids in the sample directly to immobilized probe or to the tail of the capture probe is reduced or eliminated increasing the sensitivity and/or specificity of the assay.

    Abstract translation: 本发明提供了通过可以在固定化探针中结合互补L-核酸的L-核酸尾部固定的嵌合捕获探针。 捕获探针可用于从样品中捕获靶核酸。 捕获探针尾部的L-核酸与固定化探针中的互补L-核酸结合，具有与否则相当于D-核酸的亲和力。 然而，捕获探针尾和固定化探针的L-核酸不与存在于含有靶核酸的样品中的D-核酸形成稳定的双链体。 将样品中的核酸直接与捕获探针的固定化探针或尾部的结合降低或消除，增加了测定的灵敏度和/或特异性。

    TOOLS AND TECHNIQUES FOR ORIGINAL DIGITAL FILES
    3.
    发明申请
    TOOLS AND TECHNIQUES FOR ORIGINAL DIGITAL FILES 审中-公开
    原始数字文件的工具和技术

    公开(公告)号：US20080021936A1

    公开(公告)日：2008-01-24

    申请号：US11840723

    申请日：2007-08-17

    Applicant: Mark Reynolds

    Inventor： Mark Reynolds

    IPC: G06F17/00

    CPC classification number: G06F21/64 ,  G06F8/71 ,  G06F2221/2101 ,  G06F2221/2111

    Abstract: The present invention provides tools and techniques for distinguishing a file from any or all copies of the file that may exist. One method ascertains (204) the actual physical location of the file (512) and associates (214) that physical location with the file as the claimed physical location (516) of the file. The file's originality status may then be determined (104) by finding (304) the location claim, reading (306) from it the claimed physical location associated with the file, ascertaining (308) the actual physical location of the file, and comparing (310) the locations. If the claimed and actual locations are identical, then the file is the original file it claims to be. If there is disparity between the claimed physical location recited for or by the file and the actual physical location of the file, then it is not the original file it claims to be.

    Abstract translation: 本发明提供用于区分文件与可能存在的文件的任何或所有副本的工具和技术。 一种方法确定（204）文件的实际物理位置（512）并将物理位置与该文件相关联（214）作为文件的所声明的物理位置（516）。 然后可以通过找到（304）位置声明，从其读取（306）与文件相关联的所声明的物理位置来确定（308）文件的实际物理位置，并且（ 310）位置。 如果所声明的和实际的位置相同，则该文件是其声称的原始文件。 如果所声明的文件所述的物理位置与文件的实际物理位置之间存在差异，则它不是原始文件。

    System for coupling a shaft to an outer shaft sleeve
    5.
    发明授权
    System for coupling a shaft to an outer shaft sleeve 失效
    将轴连接到外轴套的系统

    公开(公告)号：US06371723B1

    公开(公告)日：2002-04-16

    申请号：US09641825

    申请日：2000-08-17

    Applicant: Lloyd Grant ,  Mark Reynolds

    Inventor： Lloyd Grant ,  Mark Reynolds

    IPC: F01D102

    CPC classification number: F04D29/043 ,  F04D7/065 ,  Y10T29/49885

    Abstract: Disclosed is a shaft system particularly adapted for use in molten metal applications, such as injecting impellers, submersible molten metal pumps, and others. Embodiments of the shaft system contemplated by this invention very generally including a base shaft with an outer surface, a shaft sleeve composed of material adapted to be used in a molten metal environment, the shaft sleeve having an inner surface approximately corresponding in size to the outer surface of the shaft and located approximately concentrically around the shaft; and a shaft coupler between the outer surface of the shaft and the inner surface of the shaft sleeve; wherein the shaft sleeve is securely attached to the shaft by the expansion of the shaft coupler relative to the shaft and the shaft sleeve.

    Abstract translation: 公开了一种特别适用于熔融金属应用的轴系统，例如喷射叶轮，潜水熔融金属泵等。 本发明设想的轴系的实施例非常通常包括具有外表面的基轴，由适于在熔融金属环境中使用的材料构成的轴套，所述轴套具有大致对应于外部尺寸的内表面 轴的表面并且大致同心地围绕轴定位; 以及在所述轴的外表面和所述轴套的内表面之间的轴联接器; 其中所述轴套通过所述轴联接器相对于所述轴和所述轴套的膨胀而牢固地附接到所述轴。

    Auto purchase system and method
    7.
    发明授权
    Auto purchase system and method 失效

    公开(公告)号：US07024373B1

    公开(公告)日：2006-04-04

    申请号：US09461603

    申请日：1999-12-15

    Applicant: Kris Reynolds ,  Mark Reynolds ,  Anthony H. Handal

    Inventor： Kris Reynolds ,  Mark Reynolds ,  Anthony H. Handal

    IPC: G06F17/60

    CPC classification number: G06Q20/12 ,  G06Q30/02 ,  G06Q30/0258 ,  G06Q30/06 ,  G06Q30/0635

    Abstract: The inventive communications system dedicated to the sale of first items in conjunction with the establishment of a second, preferably long-term, commercial relationship between the consumer of the first items and sellers of second items is disclosed. A central processing unit is located on the premises of a website operator. In accordance with the invention, a memory is associated with the central processing unit. The memory holds a number of interactive pages for transfer to the central processing unit. At least one of the interactive pages has at least one button associated with a consumer decision. That page further comprises information respecting a choice signified by actuation of the button. A database is coupled to the central processing unit. The database contains information respecting the cost of at least one selectable first item, information respecting at least one selectable sales condition associated with at least one second item, and information respecting discounts on the first item associated with the second item when associated with the sales condition. A modem subsystem is coupled to the central processing unit and connects the computer of a consumer to the central processing unit through a publicly accessible digital information network. The modem has the capability of transmitting a page with an interactive button to the computer of the customer. The modem is also capable of receiving and responding to an actuation of the interactive button and sending a signal indicating the actuation and an associated consumer decision to the central processing unit. A plurality of data lines connect the central processing unit through the modem subsystem to a financial institution coupling information respecting the consumer decision whereby the financial institution may make a financing decision, and coupling information respecting the financing decision from the financial institution to the central processing unit indicating completion of a transaction, the modem subsystem coupling information respecting completion of the transaction to the consumer.

    Treatment and system for nicotine withdrawal
    9.
    发明授权
    Treatment and system for nicotine withdrawal 失效

    公开(公告)号：US06645470B1

    公开(公告)日：2003-11-11

    申请号：US10072822

    申请日：2002-02-08

    Applicant: Mark Reynolds

    Inventor： Mark Reynolds

    IPC: A61K968

    CPC classification number: A61K31/465

    Abstract: A kit and associated method in which symptoms of nicotine withdrawal syndrome are relieved as well as addressing the associated weight gain issues and craving for sweets by combining nicotine replacement therapy with complementary dosages of xylitol.

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