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公开(公告)号：US20110118433A1
公开(公告)日：2011-05-19
申请号：US12943145
申请日：2010-11-10
CPC分类号： C12P7/62 , C07C51/347 , C07C67/42 , C07C227/06 , C07C227/08 , C12N1/16 , C12N9/004 , C12N9/0042 , C12P7/42 , C12P7/625 , C12P13/04 , C12Y101/01001
摘要： The invention relates to genetically engineered Candida tropicalis cells, use thereof and a method of production of ω-hydroxycarboxylic acids and ω-hydroxycarboxylic acid esters.
摘要翻译： 本发明涉及基因工程的热带假丝酵母细胞，其用途和生产ω-羟基羧酸和ω-羟基羧酸酯的方法。
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公开(公告)号：US09580732B2
公开(公告)日：2017-02-28
申请号：US14233505
申请日：2012-07-17
申请人： Markus Pötter , Thomas Haas , Jan Christoph Pfeffer , Arne Skerra , Wolfgang Kroutil , Alexandra Lerchner , Johann H. Sattler , Steffen Schaffer , Katharina Christin Tauber
发明人： Markus Pötter , Thomas Haas , Jan Christoph Pfeffer , Arne Skerra , Wolfgang Kroutil , Alexandra Lerchner , Johann H. Sattler , Steffen Schaffer , Katharina Christin Tauber
IPC分类号： C12P13/00
CPC分类号： C12P13/001 , Y02P20/582
摘要： A method including the steps a) providing a primary alcohol of the formula HO—(CH2)x—R1, where R1 is —OH, —SH, —NH2 or —COOR2; x is at least 3; and R2 is H, alkyl or aryl, b) oxidizing the primary alcohol by contacting it with an NAD(P)+-dependent alcohol dehydrogenase, and c) contacting the oxidation product of step a) with a transaminase, where the NAD(P)+-alcohol dehydrogenase and/or the transaminase is a recombinant or isolated enzyme. A whole cell catalyst for carrying out the method. The use of such a whole cell catalyst for oxidizing a primary alcohol.
摘要翻译： 一种方法，包括步骤a）提供式HO-（CH 2）x -R 1的伯醇，其中R 1是-OH，-SH，-NH 2或-COOR 2; x至少为3; 并且R2是H，烷基或芳基，b）通过使其与NAD（P）+依赖性醇脱氢酶接触来氧化伯醇，和c）使步骤a）的氧化产物与转氨酶接触，其中NAD ）+ - 醇脱氢酶和/或转氨酶是重组或分离的酶。 用于实施该方法的全细胞催化剂。 使用这种全细胞催化剂来氧化伯醇。
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公开(公告)号：US20140242646A1
公开(公告)日：2014-08-28
申请号：US14233505
申请日：2012-07-17
申请人： Markus Pötter , Thomas Haas , Jan Christoph Pfeffer , Arne Skerra , Wolfgang Kroutil , Alexandra Lerchner , Johann H. Sattler , Steffen Schaffer , Katharina Christin Tauber
发明人： Markus Pötter , Thomas Haas , Jan Christoph Pfeffer , Arne Skerra , Wolfgang Kroutil , Alexandra Lerchner , Johann H. Sattler , Steffen Schaffer , Katharina Christin Tauber
IPC分类号： C12P13/00
CPC分类号： C12P13/001 , Y02P20/582
摘要： The present invention relates to a method comprising the steps a) providing a primary alcohol of the formula HO—(CH2)x—R1, wherein R1 is selected from the group consisting of —OH, —SH, —NH2 and —COOR2, x is at least 3 and R2 is selected from the group consisting of H, alkyl and aryl, b) oxidizing the primary alcohol by contacting it with an NAD(P)+-dependent alcohol dehydrogenase, and c) contacting the oxidation product of step a) with a transaminase, wherein the NAD(P)+-alcohol dehydrogenase and/or the transaminase is a recombinant or isolated enzyme, to a whole cell catalyst for carrying out the method, and to the use of such a whole cell catalyst for oxidizing a primary alcohol.
摘要翻译： 本发明涉及包括以下步骤的方法：a）提供式HO-（CH 2）x -R 1的伯醇，其中R 1选自-OH，-SH，-NH 2和-COOR 2，x 至少3，R2选自H，烷基和芳基，b）通过使其与NAD（P）+依赖性醇脱氢酶接触来氧化伯醇，和c）使步骤a的氧化产物 ）与转氨酶，其中NAD（P）+ - 醇脱氢酶和/或转氨酶是重组或分离的酶，用于实施该方法的全细胞催化剂，以及使用这种全细胞催化剂进行氧化 一个小酒精。
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公开(公告)号：US10071951B2
公开(公告)日：2018-09-11
申请号：US14000028
申请日：2011-12-01
申请人： Frank Erhardt , Thomas Haas , Martin Roos , Daniel Demicoli , Markus Pötter , Anja Schubert , Jan Christoph Pfeffer , Thomas Tacke , Harald Häger , Andreas Pfennig , Marie-Dominique Przybylski-Freund
发明人： Frank Erhardt , Thomas Haas , Martin Roos , Daniel Demicoli , Markus Pötter , Anja Schubert , Jan Christoph Pfeffer , Thomas Tacke , Harald Häger , Andreas Pfennig , Marie-Dominique Przybylski-Freund
IPC分类号： B01D11/00 , B01J39/04 , C07C67/62 , B01D11/04 , B01J39/16 , C07C227/40 , C07C229/08 , C02F1/26 , C02F1/42 , C02F101/34
CPC分类号： C07C67/62 , B01D11/0492 , B01J39/04 , B01J39/16 , C02F1/26 , C02F2001/425 , C02F2101/34 , C07C227/40 , C07C229/08
摘要： The present application relates to a process for removing an organic compound having one or more positive charges from an aqueous solution, comprising the steps a) provision of the aqueous solution comprising the organic compound and of a hydrophobic organic solution which comprises a liquid cation exchanger, where the liquid cation exchanger is hydrophobic, and where the liquid cation exchanger has one or more negative charges and an overall negative charge, b) contacting the aqueous solution and the organic solution, and c) separating off the organic solution from the aqueous solution.
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公开(公告)号：US09200043B2
公开(公告)日：2015-12-01
申请号：US13642412
申请日：2011-03-15
申请人： Markus Pötter , Andreas Schmid , Bruno Bühler , Hans-Georg Hennemann , Mattijs Kamiel Julsing , Steffen Schaffer , Thomas Haas , Manfred Schrewe , Sjef Cornelissen , Martin Roos , Harald Häger
发明人： Markus Pötter , Andreas Schmid , Bruno Bühler , Hans-Georg Hennemann , Mattijs Kamiel Julsing , Steffen Schaffer , Thomas Haas , Manfred Schrewe , Sjef Cornelissen , Martin Roos , Harald Häger
CPC分类号： C07K14/21 , C12P7/02 , C12P7/24 , C12P7/42 , C12P7/62 , C12P7/6436 , C12Y114/15003
摘要： The invention provides a biocatalytic process for oxidation of organic compounds with the aid of an alkL gene product, and microorganisms used in this process.
摘要翻译： 本发明提供了借助于alkL基因产物和在该方法中使用的微生物来氧化有机化合物的生物催化方法。
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6.发明申请METHOD FOR AEROBICALLY PRODUCING ALANINE OR A COMPOUND PRODUCED USING ALANINE 有权用于生产亚麻酸的方法或使用阿兰生产的化合物公开(公告)号：US20150111254A1
公开(公告)日：2015-04-23
申请号：US14390133
申请日：2013-03-25
申请人： Hans-Georg Hennemann , Steffen Schaffer , Mirja Wessel , Markus Pötter , Jan Christoph Pfeffer , Thomas Haas , Jasmin Corthals , Eva-Maria Eckl , Silvana Roeder , Wolfgang Kroutil , Arne Skerra
发明人： Hans-Georg Hennemann , Steffen Schaffer , Mirja Wessel , Markus Pötter , Jan Christoph Pfeffer , Thomas Haas , Jasmin Corthals , Eva-Maria Eckl , Silvana Roeder , Wolfgang Kroutil , Arne Skerra
IPC分类号： C12P13/06
CPC分类号： C12P13/06 , C12P13/005
摘要： The problem addressed by the invention is solved in a first aspect by a method for producing alanine or a compound produced using alanine, having the steps of (a) providing a cell which expresses a recombinant alanine dehydrogenase or a variant thereof, (b) cultivating the cell under aerobic conditions in the presence of an inorganic nitrogen source in an aqueous phase, and (c) bringing the cell into contact with an organic phase, said cell being a prokaryotic or a lower eukaryotic cell.
摘要翻译： 本发明解决的问题在第一方面通过一种制备丙氨酸或使用丙氨酸生产的化合物的方法来解决，该方法具有以下步骤：（a）提供表达重组丙氨酸脱氢酶的细胞或其变体，（b）培养 在有氧条件下在无水氮源存在下在水相中，和（c）使细胞与有机相接触，所述细胞是原核或低等真核细胞。
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公开(公告)号：US20140054224A1
公开(公告)日：2014-02-27
申请号：US14000028
申请日：2011-12-01
申请人： Frank Erhardt , Thomas Haas , Martin Roos , Daniel Demicoli , Markus Pötter , Anja Schubert , Jan Christoph Pfeffer , Thomas Tacke , Harald Häger , Andreas Pfennig , Marie-Dominique Przybylski-Freund
发明人： Frank Erhardt , Thomas Haas , Martin Roos , Daniel Demicoli , Markus Pötter , Anja Schubert , Jan Christoph Pfeffer , Thomas Tacke , Harald Häger , Andreas Pfennig , Marie-Dominique Przybylski-Freund
CPC分类号： C07C67/62 , B01D11/0492 , B01J39/04 , B01J39/16 , C02F1/26 , C02F2001/425 , C02F2101/34 , C07C227/40 , C07C229/08
摘要： The present application relates to a process for removing an organic compound having one or more positive charges from an aqueous solution, comprising the steps a) provision of the aqueous solution comprising the organic compound and of a hydrophobic organic solution which comprises a liquid cation exchanger, where the liquid cation exchanger is hydrophobic, and where the liquid cation exchanger has one or more negative charges and an overall negative charge, b) contacting the aqueous solution and the organic solution, and c) separating off the organic solution from the aqueous solution.
摘要翻译： 本申请涉及从水溶液中除去具有一个或多个正电荷的有机化合物的方法，包括以下步骤：a）提供包含有机化合物的水溶液和包含液体阳离子交换剂的疏水性有机溶液， 其中液体阳离子交换剂是疏水性的，并且其中液体阳离子交换剂具有一个或多个负电荷和总负电荷，b）使该水溶液和有机溶液接触，和c）从该水溶液中分离有机溶液。
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