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1.发明申请METHOD FOR AEROBICALLY PRODUCING ALANINE OR A COMPOUND PRODUCED USING ALANINE 有权用于生产亚麻酸的方法或使用阿兰生产的化合物公开(公告)号：US20150111254A1
公开(公告)日：2015-04-23
申请号：US14390133
申请日：2013-03-25
申请人： Hans-Georg Hennemann , Steffen Schaffer , Mirja Wessel , Markus Pötter , Jan Christoph Pfeffer , Thomas Haas , Jasmin Corthals , Eva-Maria Eckl , Silvana Roeder , Wolfgang Kroutil , Arne Skerra
发明人： Hans-Georg Hennemann , Steffen Schaffer , Mirja Wessel , Markus Pötter , Jan Christoph Pfeffer , Thomas Haas , Jasmin Corthals , Eva-Maria Eckl , Silvana Roeder , Wolfgang Kroutil , Arne Skerra
IPC分类号： C12P13/06
CPC分类号： C12P13/06 , C12P13/005
摘要： The problem addressed by the invention is solved in a first aspect by a method for producing alanine or a compound produced using alanine, having the steps of (a) providing a cell which expresses a recombinant alanine dehydrogenase or a variant thereof, (b) cultivating the cell under aerobic conditions in the presence of an inorganic nitrogen source in an aqueous phase, and (c) bringing the cell into contact with an organic phase, said cell being a prokaryotic or a lower eukaryotic cell.
摘要翻译： 本发明解决的问题在第一方面通过一种制备丙氨酸或使用丙氨酸生产的化合物的方法来解决，该方法具有以下步骤：（a）提供表达重组丙氨酸脱氢酶的细胞或其变体，（b）培养 在有氧条件下在无水氮源存在下在水相中，和（c）使细胞与有机相接触，所述细胞是原核或低等真核细胞。
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公开(公告)号：US08153408B2
公开(公告)日：2012-04-10
申请号：US12278464
申请日：2007-01-31
IPC分类号： C12P7/26
CPC分类号： C12P41/004 , C12P7/36
摘要： A process for the racemization of an optically active alpha-hydroxyketone by incubating said alpha-hydroxyketone in the presence of an acetoin racemase of Lactobacillus.
摘要翻译： 通过在乳杆菌的乙偶姻消旋酶存在下温育所述α-羟基酮来使光学活性α-羟基酮外消旋化的方法。
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3.发明申请公开(公告)号：US20090098623A1
公开(公告)日：2009-04-16
申请号：US12297804
申请日：2007-04-19
申请人： Rainer Sturmer , Wolfgang Kroutil , Kurt Faber , Christian Gruber
发明人： Rainer Sturmer , Wolfgang Kroutil , Kurt Faber , Christian Gruber
IPC分类号： C12P7/04
CPC分类号： C12P7/02
摘要： A method for racemizing optically active secondary alcohols by incubating these alcohols with at least one alcohol dehydrogenase of the E.C. 1.1.1. class.
摘要翻译： 通过将这些醇与E.C.1.1.1的至少一种醇脱氢酶一起孵育来使旋光性仲醇外消旋化的方法。 类。
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公开(公告)号：US20090221046A1
公开(公告)日：2009-09-03
申请号：US12278464
申请日：2007-01-31
IPC分类号： C12P7/26
CPC分类号： C12P41/004 , C12P7/36
摘要： A process for the racemisation of an optically active alpha-hydroxyketone by incubating said alpha-hydroxyketone in the presence of an acetoin racemase of Lactobacillus.
摘要翻译： 通过在乳杆菌的乙酰丁酰消旋酶存在下温育所述α-羟基酮来使光学活性的α-羟基酮消旋化的方法。
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5.发明授权公开(公告)号：US07569375B2
公开(公告)日：2009-08-04
申请号：US10666205
申请日：2003-09-18
申请人： Wolfgang Stampfer , Birgit Kosjek , Wolfgang Kroutil , Kurt Faber , Jürgen Eck , Frank Niehaus
发明人： Wolfgang Stampfer , Birgit Kosjek , Wolfgang Kroutil , Kurt Faber , Jürgen Eck , Frank Niehaus
CPC分类号： C12N9/0006 , C12P7/04 , C12P41/002
摘要： The invention relates to biocatalysts showing alcohol dehydrogenase activity obtainable from Rhodococcus ruber, their preparation, their use in the oxidation of secondary alcohols and/or the reduction of ketones, as well as nucleic acids coding for these alcohol dehydrogenases and microorganisms transformed with nucleic acids coding for these biocatalysts and their use for producing the biocatalyst or oxidizing secondary alcohols and/or reducing ketones.
摘要翻译： 本发明涉及显示可从红球菌获得的醇脱氢酶活性的生物催化剂，它们的制备，它们在仲醇氧化中的用途和/或还原酮，以及编码这些醇脱氢酶的核酸和用编码的核酸转化的微生物 这些生物催化剂及其用于生产生物催化剂或氧化仲醇和/或还原酮的用途。
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公开(公告)号：US09580732B2
公开(公告)日：2017-02-28
申请号：US14233505
申请日：2012-07-17
申请人： Markus Pötter , Thomas Haas , Jan Christoph Pfeffer , Arne Skerra , Wolfgang Kroutil , Alexandra Lerchner , Johann H. Sattler , Steffen Schaffer , Katharina Christin Tauber
发明人： Markus Pötter , Thomas Haas , Jan Christoph Pfeffer , Arne Skerra , Wolfgang Kroutil , Alexandra Lerchner , Johann H. Sattler , Steffen Schaffer , Katharina Christin Tauber
IPC分类号： C12P13/00
CPC分类号： C12P13/001 , Y02P20/582
摘要： A method including the steps a) providing a primary alcohol of the formula HO—(CH2)x—R1, where R1 is —OH, —SH, —NH2 or —COOR2; x is at least 3; and R2 is H, alkyl or aryl, b) oxidizing the primary alcohol by contacting it with an NAD(P)+-dependent alcohol dehydrogenase, and c) contacting the oxidation product of step a) with a transaminase, where the NAD(P)+-alcohol dehydrogenase and/or the transaminase is a recombinant or isolated enzyme. A whole cell catalyst for carrying out the method. The use of such a whole cell catalyst for oxidizing a primary alcohol.
摘要翻译： 一种方法，包括步骤a）提供式HO-（CH 2）x -R 1的伯醇，其中R 1是-OH，-SH，-NH 2或-COOR 2; x至少为3; 并且R2是H，烷基或芳基，b）通过使其与NAD（P）+依赖性醇脱氢酶接触来氧化伯醇，和c）使步骤a）的氧化产物与转氨酶接触，其中NAD ）+ - 醇脱氢酶和/或转氨酶是重组或分离的酶。 用于实施该方法的全细胞催化剂。 使用这种全细胞催化剂来氧化伯醇。
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公开(公告)号：US20140308717A1
公开(公告)日：2014-10-16
申请号：US14237121
申请日：2012-07-27
申请人： Thomas Haas , Markus Poetter , Jan Christoph Pfeffer , Wolfgang Kroutil , Arne Skerra , Alexandra Lerchner , Katharina Christin Tauber , Johann H. Sattler , Steffen Schaffer
发明人： Thomas Haas , Markus Poetter , Jan Christoph Pfeffer , Wolfgang Kroutil , Arne Skerra , Alexandra Lerchner , Katharina Christin Tauber , Johann H. Sattler , Steffen Schaffer
CPC分类号： C12P13/001 , C12N9/0006 , C12N9/1096 , C12N15/63 , C12P13/005 , C12P13/04 , C12P17/04 , C12Y101/01001 , C12Y206/01 , C12Y206/01018
摘要： The present invention relates to a method comprising the steps a) providing a secondary alcohol, b) oxidizing the secondary alcohol by contacting it with an NAD(P)+-dependent alcohol dehydrogenase and c) contacting the oxidation product of step a) with a transaminase, wherein the NAD(P)+-dependent alcohol dehydrogenase and/or the transaminase is a recombinant or isolated enzyme, to a whole cell catalyst for carrying out the method, and to the use of such a whole cell catalyst for oxidizing a secondary alcohol.
摘要翻译： 本发明涉及包括以下步骤的方法：a）提供仲醇，b）通过使其与NAD（P）+依赖性醇脱氢酶接触来氧化仲醇，和c）将步骤a）的氧化产物与 转氨酶，其中NAD（P）+依赖性醇脱氢酶和/或转氨酶是重组或分离的酶，用于实施该方法的全细胞催化剂，以及使用这种全细胞催化剂来氧化二级 醇。
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公开(公告)号：US20140242646A1
公开(公告)日：2014-08-28
申请号：US14233505
申请日：2012-07-17
申请人： Markus Pötter , Thomas Haas , Jan Christoph Pfeffer , Arne Skerra , Wolfgang Kroutil , Alexandra Lerchner , Johann H. Sattler , Steffen Schaffer , Katharina Christin Tauber
发明人： Markus Pötter , Thomas Haas , Jan Christoph Pfeffer , Arne Skerra , Wolfgang Kroutil , Alexandra Lerchner , Johann H. Sattler , Steffen Schaffer , Katharina Christin Tauber
IPC分类号： C12P13/00
CPC分类号： C12P13/001 , Y02P20/582
摘要： The present invention relates to a method comprising the steps a) providing a primary alcohol of the formula HO—(CH2)x—R1, wherein R1 is selected from the group consisting of —OH, —SH, —NH2 and —COOR2, x is at least 3 and R2 is selected from the group consisting of H, alkyl and aryl, b) oxidizing the primary alcohol by contacting it with an NAD(P)+-dependent alcohol dehydrogenase, and c) contacting the oxidation product of step a) with a transaminase, wherein the NAD(P)+-alcohol dehydrogenase and/or the transaminase is a recombinant or isolated enzyme, to a whole cell catalyst for carrying out the method, and to the use of such a whole cell catalyst for oxidizing a primary alcohol.
摘要翻译： 本发明涉及包括以下步骤的方法：a）提供式HO-（CH 2）x -R 1的伯醇，其中R 1选自-OH，-SH，-NH 2和-COOR 2，x 至少3，R2选自H，烷基和芳基，b）通过使其与NAD（P）+依赖性醇脱氢酶接触来氧化伯醇，和c）使步骤a的氧化产物 ）与转氨酶，其中NAD（P）+ - 醇脱氢酶和/或转氨酶是重组或分离的酶，用于实施该方法的全细胞催化剂，以及使用这种全细胞催化剂进行氧化 一个小酒精。
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9.发明授权公开(公告)号：US07795004B2
公开(公告)日：2010-09-14
申请号：US12297804
申请日：2007-04-19
申请人： Rainer Stürmer , Wolfgang Kroutil , Kurt Faber , Christian Gruber
发明人： Rainer Stürmer , Wolfgang Kroutil , Kurt Faber , Christian Gruber
IPC分类号： C12P41/00
CPC分类号： C12P7/02
摘要： A method for racemizing optically active secondary alcohols by incubating these alcohols with at least one alcohol dehydrogenase of the E.C. 1.1.1. class.
摘要翻译： 通过将这些醇与E.C.1.1.1的至少一种醇脱氢酶一起孵育来使旋光性仲醇外消旋化的方法。 类。
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公开(公告)号：US09273291B2
公开(公告)日：2016-03-01
申请号：US14241210
申请日：2012-08-09
CPC分类号： C12N9/0073 , C12N9/0069 , C12P7/24 , C12Y114/13069
摘要： The invention relates to an enzyme that comprises or includes a sequence according to SEQ. ID No. 1 or SEQ. ID No. 2, to a method for the production thereof, and to the use thereof as a catalyst in the oxidative cleavage of vinyl aromatics.
摘要翻译： 本发明涉及一种酶，其包含或包含根据SEQ ID NO： ID号1或SEQ。 ID No.2，其制备方法及其在乙烯基芳族化合物的氧化裂解中作为催化剂的用途。
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