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公开(公告)号：US20120121538A1
公开(公告)日：2012-05-17
申请号：US13318701
申请日：2010-05-03
IPC分类号： A61K39/165 , A61K38/20 , A61P31/14 , A61K39/295 , C12N15/63 , C12N1/21 , C12N5/10 , A61P37/04 , A61P33/06
CPC分类号： A61K39/165 , A61K35/13 , A61K38/2013 , A61K39/0015 , A61K39/015 , A61K39/12 , A61K2039/5256 , A61K2039/53 , A61K2039/54 , A61K2039/55566 , A61K2039/55588 , A61K2039/575 , A61K2039/70 , C12N7/00 , C12N2760/18421 , C12N2760/18434 , C12N2760/18442 , C12N2760/18443 , Y02A50/412
摘要： A combined measles-malaria vaccine containing different attenuated recombinant measles-malaria vectors comprising a heterologous nucleic acid encoding several Plasmodium falciparum antigens is described. Preferably, it relates to viral vectors that comprise nucleic acids encoding the circumsporozoite (CS) protein of P. falciparum, the merozoite surface protein 1 (MSP-1) of P. falciparum, and its derivatives (p-42; p-83-30-38) in its glycosylated and secreted forms, and apical membrane antigen1 (AMA1) of P. falciparum, in its anchored or secreted form. The viral vector stems from an attenuated measles virus, based on a strain that is used as a vaccine and is efficient in delivering the gene of interest and that binds to and infects the relevant immune cells efficiently.
摘要翻译： 描述了包含编码几种恶性疟原虫抗原的异源核酸的包含不同的减毒重组麻疹 - 疟疾载体的麻疹 - 疟疾综合疫苗。 优选地，其涉及包含编码恶性疟原虫的环子孢子（CS）蛋白，恶性疟原虫的裂殖子表面蛋白1（MSP-1）及其衍生物（p-42; p-83- 30-38）以其糖基化和分泌形式，以及恶性疟原虫的顶端膜抗原1（AMA1）以其锚定或分泌形式。 病毒载体源自减毒的麻疹病毒，其基于用作疫苗的菌株，并且有效地传递感兴趣的基因并且有效地结合并感染相关的免疫细胞。
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2.发明申请公开(公告)号：US20120003264A1
公开(公告)日：2012-01-05
申请号：US13175307
申请日：2011-07-01
CPC分类号： C12N15/86 , A01N63/00 , A01N63/02 , A61K39/00 , A61K39/12 , A61K39/165 , A61K48/00 , A61K2039/51 , A61K2039/525 , C07K14/005 , C07K2319/00 , C07K2319/02 , C12N7/00 , C12N2760/18421 , C12N2760/18422 , C12N2760/18434 , C12N2760/18443 , C12N2760/20222 , C12N2760/20241 , C12N2840/203 , C12N2840/44
摘要： The present invention relates, in general, to a methodology for the generation of nonsegmented negative-strand RNA viruses (Pringle, 1991) from cloned deoxyribonucleic acid (cDNA). Such rescued viruses are suitable for use as vaccines, or alternatively, as plasmids in somatic gene therapy applications. The invention also relates to cDNA molecules suitable as tools in this methodology and to helper cell lines allowing the direct rescue of such viruses. Measles virus (MV) is used as a mode for other representatives of the Mononegavirales, in particular the family Paramyxoviridae.
摘要翻译： 本发明一般涉及从克隆的脱氧核糖核酸（cDNA）产生非分段负链RNA病毒（Pringle，1991）的方法。 这种被拯救的病毒适合用作疫苗，或者作为体细胞基因治疗应用中的质粒。 本发明还涉及适合作为该方法中的工具的cDNA分子以及帮助直接拯救这些病毒的细胞系。 麻疹病毒（MV）被用作Mononegavirales的其他代表，特别是副粘病毒科的一种模式。
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3.发明授权Host cells comprising cDNA corresponding to the antigenome of nonsegmented negative strand RNA viruses, further encoding antigenically active proteins 失效宿主细胞包含对应于非分段负链RNA病毒的抗原组的cDNA，进一步编码抗原活性蛋白质公开(公告)号：US07402429B1
公开(公告)日：2008-07-22
申请号：US09011425
申请日：1996-08-09
CPC分类号： C12N15/86 , A01N63/00 , A01N63/02 , A61K39/00 , A61K39/12 , A61K39/165 , A61K48/00 , A61K2039/51 , A61K2039/525 , C07K14/005 , C07K2319/00 , C07K2319/02 , C12N7/00 , C12N2760/18421 , C12N2760/18422 , C12N2760/18434 , C12N2760/18443 , C12N2760/20222 , C12N2760/20241 , C12N2840/203 , C12N2840/44
摘要： The present invention relates, in general, to a methodology for the generation or nonsegmented negative-strand RNA viruses (Pringle, 1991) from cloned deoxyribonucleic acid (cDNA). Such rescued viruses are suitable for use as vaccines, or alternatively, as plasmids in somatic gene therapy applications. The invention also relates to cDNA molecules suitable as tools in this methodology and to helper cell lines allowing the direct rescue of such viruses. Measles virus (MV) is used as a model for other representatives of the Mononegavirales, in particular the family Paramyxoviridae.
摘要翻译： 本发明一般涉及从克隆的脱氧核糖核酸（cDNA）产生或非分段的负链RNA病毒（Pringle，1991）的方法。 这种被拯救的病毒适合用作疫苗，或者作为体细胞基因治疗应用中的质粒。 本发明还涉及适合作为该方法中的工具的cDNA分子以及帮助直接拯救这些病毒的细胞系。 麻疹病毒（MV）被用作Mononegavirales的其他代表，特别是副粘病毒科的模型。
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公开(公告)号：US09119815B2
公开(公告)日：2015-09-01
申请号：US13318701
申请日：2010-05-03
IPC分类号： C12N15/00 , A61K39/165 , A61K39/015 , A61K38/20 , C12N7/00 , A61K35/13 , A61K39/00
CPC分类号： A61K39/165 , A61K35/13 , A61K38/2013 , A61K39/0015 , A61K39/015 , A61K39/12 , A61K2039/5256 , A61K2039/53 , A61K2039/54 , A61K2039/55566 , A61K2039/55588 , A61K2039/575 , A61K2039/70 , C12N7/00 , C12N2760/18421 , C12N2760/18434 , C12N2760/18442 , C12N2760/18443 , Y02A50/412
摘要： A combined measles-malaria vaccine containing different attenuated recombinant measles-malaria vectors comprising a heterologous nucleic acid encoding several Plasmodium falciparum antigens is described. Preferably, it relates to viral vectors that comprise nucleic acids encoding the circumsporozoite (CS) protein of P. falciparum, the merozoite surface protein 1 (MSP-1) of P. falciparum, and its derivatives (p-42; p-83-30-38) in its glycosylated and secreted forms, and apical membrane antigen1 (AMA1) of P. falciparum, in its anchored or secreted form. The viral vector stems from an attenuated measles virus, based on a strain that is used as a vaccine and is efficient in delivering the gene of interest and that binds to and infects the relevant immune cells efficiently.
摘要翻译： 描述了包含编码几种恶性疟原虫抗原的异源核酸的包含不同的减毒重组麻疹 - 疟疾载体的麻疹 - 疟疾综合疫苗。 优选地，其涉及包含编码恶性疟原虫的环子孢子（CS）蛋白，恶性疟原虫的裂殖子表面蛋白1（MSP-1）及其衍生物（p-42; p-83- 30-38）以其糖基化和分泌形式，以及恶性疟原虫的顶端膜抗原1（AMA1）以其锚定或分泌形式。 病毒载体源自减毒的麻疹病毒，其基于用作疫苗的菌株，并且有效地传递感兴趣的基因并且有效地结合并感染相关的免疫细胞。
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5.发明授权CDNA corresponding to the antigenome of nonsegmented negative strand RNA viruses, and process for the production of such viruses encoding additional antigenically active proteins 有权对应于非分段负链RNA病毒的抗原组的CDNA以及编码另外的抗原活性蛋白质的这种病毒的生产方法公开(公告)号：US08158416B2
公开(公告)日：2012-04-17
申请号：US13175307
申请日：2011-07-01
IPC分类号： C12N15/00 , A01N63/00 , A01N65/00 , A61K39/12 , A61K39/155 , A61K39/165 , A61K48/00
CPC分类号： C12N15/86 , A01N63/00 , A01N63/02 , A61K39/00 , A61K39/12 , A61K39/165 , A61K48/00 , A61K2039/51 , A61K2039/525 , C07K14/005 , C07K2319/00 , C07K2319/02 , C12N7/00 , C12N2760/18421 , C12N2760/18422 , C12N2760/18434 , C12N2760/18443 , C12N2760/20222 , C12N2760/20241 , C12N2840/203 , C12N2840/44
摘要： The present invention relates, in general, to a methodology for the generation of nonsegmented negative-strand RNA viruses (Pringle, 1991) from cloned deoxyribonucleic acid (cDNA). Such rescued viruses are suitable for use as vaccines, or alternatively, as plasmids in somatic gene therapy applications. The invention also relates to cDNA molecules suitable as tools in this methodology and to helper cell lines allowing the direct rescue of such viruses. Measles virus (MV) is used as a mode for other representatives of the Mononegavirales, in particular the family Paramyxoviridae.
摘要翻译： 本发明一般涉及从克隆的脱氧核糖核酸（cDNA）产生非分段负链RNA病毒（Pringle，1991）的方法。 这种被拯救的病毒适合用作疫苗，或者作为体细胞基因治疗应用中的质粒。 本发明还涉及适合作为该方法中的工具的cDNA分子以及帮助直接拯救这些病毒的细胞系。 麻疹病毒（MV）被用作Mononegavirales的其他代表，特别是副粘病毒科的一种模式。
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6.发明授权cDNA corresponding to the antigenome of nonsegmented negative stranded RNA viruses and process for the production of such viruses 有权对应于非分段负链RNA病毒的反向单元的cDNA和用于产生这种病毒的方法公开(公告)号：US07993924B2
公开(公告)日：2011-08-09
申请号：US11899492
申请日：2007-09-06
IPC分类号： A01N63/00 , A01N65/00 , A61K39/12 , A61K39/155 , A61K39/165 , A61K48/00 , C12N15/00
CPC分类号： C12N15/86 , A01N63/00 , A01N63/02 , A61K39/00 , A61K39/12 , A61K39/165 , A61K48/00 , A61K2039/51 , A61K2039/525 , C07K14/005 , C07K2319/00 , C07K2319/02 , C12N7/00 , C12N2760/18421 , C12N2760/18422 , C12N2760/18434 , C12N2760/18443 , C12N2760/20222 , C12N2760/20241 , C12N2840/203 , C12N2840/44
摘要： The present invention relates, in general, to a methodology for the generation of nonsegmented negative-strand RNA viruses (Pringle, 1991) from cloned deoxyribonucleic acid (cDNA). Such rescued viruses are suitable for use as vaccines, or alternatively, as plasmids in somatic gene therapy applications. The invention also relates to cDNA molecules suitable as tools in this methodology and to helper cell lines allowing the direct rescue of such viruses. Measles virus (MV) is used as a mode for other representatives of the Mononegavirales, in particular the family Paramyxoviridae.
摘要翻译： 本发明一般涉及从克隆的脱氧核糖核酸（cDNA）产生非分段负链RNA病毒（Pringle，1991）的方法。 这种被拯救的病毒适合用作疫苗，或者作为体细胞基因治疗应用中的质粒。 本发明还涉及适合作为该方法中的工具的cDNA分子以及帮助直接拯救这些病毒的细胞系。 麻疹病毒（MV）被用作Mononegavirales的其他代表，特别是副粘病毒科的一种模式。
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公开(公告)号：US07851214B2
公开(公告)日：2010-12-14
申请号：US11320487
申请日：2005-12-27
IPC分类号： C12N15/00 , A01N63/00 , A01N65/00 , A61K48/00 , A61K39/12 , A61K39/155 , A61K39/165
CPC分类号： C12N15/86 , A01N63/00 , A01N63/02 , A61K39/00 , A61K39/12 , A61K39/165 , A61K48/00 , A61K2039/51 , A61K2039/525 , C07K14/005 , C07K2319/00 , C07K2319/02 , C12N7/00 , C12N2760/18421 , C12N2760/18422 , C12N2760/18434 , C12N2760/18443 , C12N2760/20222 , C12N2760/20241 , C12N2840/203 , C12N2840/44
摘要： The present invention relates, in general, to a methodology or the generation of nonsegmented negative-strand RNA viruses (Pringle, 1991) from cloned deoxyribonucleic acid (cDNA). Such rescued viruses are suitable for use as vaccines, or alternatively, as plasmids in somatic gene therapy applications. The invention also relates to cDNA molecules suitable as tools in this methodology and to helper cell lines allowing the direct rescue of such viruses. Measles virus (MV) is used as a model for other representatives of the Mononegavirales, in particular the family Paramyxoviridae.
摘要翻译： 本发明一般涉及克隆的脱氧核糖核酸（cDNA）的方法或生成非分段负链RNA病毒（Pringle，1991）。 这种被拯救的病毒适合用作疫苗，或者作为体细胞基因治疗应用中的质粒。 本发明还涉及适合作为该方法中的工具的cDNA分子以及帮助直接拯救这些病毒的细胞系。 麻疹病毒（MV）被用作Mononegavirales的其他代表，特别是副粘病毒科的模型。
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8.发明申请cDNA Corresponding to the antigenome of nonsegmented negative stranded RNA viruses and process for the production of such viruses 有权cDNA对应于非分段负链RNA病毒的反义单元和生产这种病毒的方法公开(公告)号：US20080124803A1
公开(公告)日：2008-05-29
申请号：US11899492
申请日：2007-09-06
CPC分类号： C12N15/86 , A01N63/00 , A01N63/02 , A61K39/00 , A61K39/12 , A61K39/165 , A61K48/00 , A61K2039/51 , A61K2039/525 , C07K14/005 , C07K2319/00 , C07K2319/02 , C12N7/00 , C12N2760/18421 , C12N2760/18422 , C12N2760/18434 , C12N2760/18443 , C12N2760/20222 , C12N2760/20241 , C12N2840/203 , C12N2840/44
摘要： The present invention relates, in general, to a methodology for the generation of nonsegmented negative-strand RNA viruses (Pringle, 1991) from cloned deoxyribonucleic acid (cDNA). Such rescued viruses are suitable for use as vaccines, or alternatively, as plasmids in somatic gene therapy applications. The invention also relates to cDNA molecules suitable as tools in this methodology and to helper cell lines allowing the direct rescue of such viruses. Measles virus (MV) is used as a mode for other representatives of the Mononegavirales, in particular the family Paramyxoviridae.
摘要翻译： 本发明一般涉及从克隆的脱氧核糖核酸（cDNA）产生非分段负链RNA病毒（Pringle，1991）的方法。 这种被拯救的病毒适合用作疫苗，或者作为体细胞基因治疗应用中的质粒。 本发明还涉及适合作为该方法中的工具的cDNA分子以及帮助直接拯救这些病毒的细胞系。 麻疹病毒（MV）被用作Mononegavirales的其他代表，特别是副粘病毒科的一种模式。
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