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公开(公告)号:US20120264217A1
公开(公告)日:2012-10-18
申请号:US13444338
申请日:2012-04-11
申请人: Martin L. Moore , Anne Hotard
发明人: Martin L. Moore , Anne Hotard
CPC分类号: C12N7/00 , C12N15/86 , C12N2760/18543 , C12N2760/18552 , C12N2800/204 , C12N2800/50
摘要: In certain embodiments, the disclosure relates to vectors containing bacterial nucleic acid sequences and a paramyxovirus gene. Typically, the expression vector comprises a bacterial artificial chromosome (BAC), and a nucleic acid sequence comprising a respiratory syncytial virus (RSV) gene in operable combination with a regulatory element and optionally a reporter gene.
摘要翻译: 在某些实施方案中,本发明涉及含有细菌核酸序列和副粘病毒基因的载体。 通常,表达载体包含细菌人造染色体(BAC)和包含呼吸道合胞病毒(RSV)基因的核酸序列,其与调控元件和任选的报道基因可操作地组合。
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公开(公告)号:US10227569B2
公开(公告)日:2019-03-12
申请号:US13444338
申请日:2012-04-11
申请人: Martin L. Moore , Anne Hotard
发明人: Martin L. Moore , Anne Hotard
IPC分类号: A61K39/215 , A61K39/225 , C07H21/04 , C12N15/00 , C12N7/00 , C12N15/86
摘要: In certain embodiments, the disclosure relates to vectors containing bacterial nucleic acid sequences and a paramyxovirus gene. Typically, the expression vector comprises a bacterial artificial chromosome (BAC), and a nucleic acid sequence comprising a respiratory syncytial virus (RSV) gene in operable combination with a regulatory element and optionally a reporter gene.
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公开(公告)号:US20140255441A1
公开(公告)日:2014-09-11
申请号:US14236618
申请日:2012-07-31
IPC分类号: C07K14/37 , C07K14/005 , C07K14/195
CPC分类号: C07K14/005 , A61K38/00 , A61K39/12 , A61K39/145 , A61K2039/5258 , A61K2039/543 , A61K2039/55516 , A61K2039/6068 , A61K2039/64 , C07K14/195 , C07K14/255 , C07K2319/02 , C07K2319/03 , C07K2319/42 , C07K2319/735 , C07K2319/75 , C12N7/00 , C12N2710/14043 , C12N2760/16122 , C12N2760/16123 , C12N2760/16134 , C12N2760/18522 , C12N2760/18523 , C12N2760/18534 , C12N2799/026
摘要: This disclosure relates to immunogenic compositions and methods of enhancing an immune response to an antigen. In certain embodiments, the disclosure relates to virus-like carries comprising a TLR5 agonist on the exterior without an antigen.
摘要翻译: 本公开涉及增强对抗原的免疫应答的免疫原性组合物和方法。 在某些实施方案中,本公开涉及在外部没有抗原的包含TLR5激动剂的病毒样载体。
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