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    ANTI-INFLAMMATORY FACTORS
    1.
    发明申请
    ANTI-INFLAMMATORY FACTORS 审中-公开
    抗炎因素

    公开(公告)号：US20130052198A1

    公开(公告)日：2013-02-28

    申请号：US13638368

    申请日：2011-03-29

    申请人： John Miles Milwid ,  Biju Parekkadan ,  Martin Leon Yarmush ,  Matthew LI

    发明人： John Miles Milwid ,  Biju Parekkadan ,  Martin Leon Yarmush ,  Matthew LI

    IPC分类号： A61K38/45 ,  C12Q1/37 ,  A61K39/395 ,  A61P29/00 ,  A61K38/17 ,  A61K38/22 ,  G01N33/566 ,  C40B30/04

    CPC分类号： A61K38/1709 ,  G01N33/6893 ,  Y02A50/414 ,  Y02A50/421

    摘要： The present invention provides particular anti-inflammatory factors, compositions containing them, methods of making, identifying, and/or characterizing them, and methods of using them. In some embodiments, provided factors are expressed by human bone marrow stromal cells (MSC). In some embodiments, provided factors are characterized by an ability, when contacted with mammalian leukocytes in culture, to alter production of at least one inflammatory or anti-inflammatory agent by the mammalian leukocytes. In some embodiments, provided factors include GALNT1 polypeptides, LGALS3BP polypeptides, MFAP5 polypeptides, PENK polypeptides and/or HAPLN1 polypeptides. In some embodiments, provided factors are useful in the inhibition of inflammatory agents, in the promotion of anti-inflammatory agents, and/or for the treatment of subjects suffering from or susceptible to a disease, disorder or condition characterized by inflammation.

    摘要翻译： 本发明提供特定的抗炎因素，含有它们的组合物，制备，鉴定和/或表征它们的方法，以及使用它们的方法。 在一些实施方案中，提供的因子由人骨髓基质细胞（MSC）表达。 在一些实施方案中，所提供的因子的特征在于当与培养物中的哺乳动物白细胞接触以改变哺乳动物白细胞产生至少一种炎症或抗炎药物时的能力。 在一些实施方案中，所提供的因子包括GALNT1多肽，LGALS3BP多肽，MFAP5多肽，PENK多肽和/或HAPLN1多肽。 在一些实施方案中，所提供的因子可用于抑制炎症因子，促进抗炎药和/或用于治疗患有或易患有以炎症为特征的疾病，病症或病症的受试者。

    Methods for common authentication and authorization across independent networks
    4.
    发明授权
    Methods for common authentication and authorization across independent networks 有权
    独立网络通用认证和授权方法

    公开(公告)号：US07774828B2

    公开(公告)日：2010-08-10

    申请号：US10401595

    申请日：2003-03-31

    申请人： David Benenati ,  Peretz Moshes Feder ,  Nancy Yushan Lee ,  Silvia Martin-Leon ,  Reuven Shapira

    发明人： David Benenati ,  Peretz Moshes Feder ,  Nancy Yushan Lee ,  Silvia Martin-Leon ,  Reuven Shapira

    IPC分类号： H04L29/08

    CPC分类号： H04L63/0815 ,  H04L63/0884 ,  H04W12/04 ,  H04W12/06 ,  H04W80/00 ,  H04W80/04

    摘要： Common authentication and authorization (AA) between networks having disparate access technologies may enable a seamless user transition between the networks. A set of AA credentials from a user attempting to gain access to one of the networks may be received, and a subscriber database of another of the networks may be used to verify the set of AA credentials. A communication protocol common to the networks may be used. Additionally, the user may employ a single set of authentication and authorization (AA) credentials, usable over multiple communication protocol layers. Further, a user may perform a single authentication and authorization (AA) operation when roaming across two or more networks by gathering user's key material during an AA challenge and reply session at a data link layer. The gathered material may be used for an AA challenge at an upper network layer or another network as the user transitions between networks.

    摘要翻译： 具有不同接入技术的网络之间的通用认证和授权（AA）可以实现网络之间无缝的用户转换。 可以接收到来自尝试访问其中一个网络的用户的一组AA凭证，并且可以使用另一个网络的订户数据库来验证该组AA凭证。 可以使用网络通用的通信协议。 另外，用户可以采用可以在多个通信协议层上使用的一组认证和授权（AA）证书。 此外，当在数据链路层的AA挑战和应答会话期间收集用户的密钥材料时，用户可以在两个或更多个网络上漫游时执行单个认证和授权（AA）操作。 当用户在网络之间转换时，所收集的材料可以用于上网络层或另一网络处的AA质询。

    Injection of bone marrow-derived conditioned medium for angiogenesis
    5.
    发明申请
    Injection of bone marrow-derived conditioned medium for angiogenesis 审中-公开
    注射用于血管生成的骨髓来源的条件培养基

    公开(公告)号：US20060051334A1

    公开(公告)日：2006-03-09

    申请号：US11117607

    申请日：2005-04-27

    申请人： Ran Kornowski ,  Shmuel Fuchs ,  Stephen Epstein ,  Martin Leon

    发明人： Ran Kornowski ,  Shmuel Fuchs ,  Stephen Epstein ,  Martin Leon

    IPC分类号： A61K48/00

    CPC分类号： C12N5/0691 ,  A61K35/28 ,  A61K38/1825 ,  A61K38/1866 ,  A61K38/44 ,  A61K48/00 ,  C12N2502/1358 ,  C12Y114/13039 ,  A61K2300/00

    摘要： Methods are provided for promoting formation of collateral blood supply at an ischemic site in tissue by culturing early attaching cells derived from growth of bone marrow aspirate in vitro, collecting early attaching cells produced by the bone marrow culture and injecting conditioned medium produced by culture of the early attaching cells into an ischemic site in heart or limb. The preferred early attaching cells for use in the invention methods are marrow-derived stromal cells. Any donor's bone marrow can be used in preparation of the conditioned medium. Optionally, the early attaching cells can be transfected with an angiogenesis promoting transgene encoding hypoxia inducing factor 1 alpha, a fibroblast growth factor and/or a nitric oxide synthase. Conditioned media containing angiogenic cytokines produced such cells are also provided for injection into tissue, such as heart or peripheral limb muscle, requiring formation of collateral blood supply.

    摘要翻译： 提供了通过体外培养早期粘附来自骨髓吸出物生长的细胞来促进组织缺血部位形成侧支血液供应的方法，收集由骨髓培养产生的早期附着细胞并注入通过培养产生的条件培养基 早期将细胞附着到心脏或肢体的缺血部位。 用于本发明方法的优选早期附着细胞是骨髓来源的基质细胞。 任何供体的骨髓都可用于制备条件培养基。 任选地，可以用编码缺氧诱导因子1α，成纤维细胞生长因子和/或一氧化氮合酶的血管生成促进转基因转染早期附着细胞。 还提供了含有产生这种细胞的血管生成细胞因子的条件培养基用于注射到组织中，例如心脏或外周肢肌，需要形成侧支血液供应。

    Pile and method for installing same
    9.
    发明授权
    Pile and method for installing same 有权
    桩和安装方法

    公开(公告)号：US06368021B1

    公开(公告)日：2002-04-09

    申请号：US09311237

    申请日：1999-05-13

    申请人： Philip Anton Strong ,  Duncan Cuthill ,  Martin Leon Kobiela

    发明人： Philip Anton Strong ,  Duncan Cuthill ,  Martin Leon Kobiela

    IPC分类号： E02D724

    CPC分类号： E21B7/20 ,  E02D7/28

    摘要： A method of drilling and installing a pile in ground comprising the steps of providing a pile, providing a drill bit at an end of the pile rotatable relative to the pile; engaging the ground with the drill bit, and rotating the drill bit relative to the ground and the pile generating a hole into which the pile is received.

    摘要翻译： 一种在地面钻孔和安装桩的方法，包括提供桩的步骤，在桩的端部提供相对于桩可旋转的钻头;将钻头与钻头接合并使钻头相对于地面旋转， 该桩产生一个收集桩的孔。

    Omni-Directional Thrust Vectoring Propulsor
    10.
    发明申请
    Omni-Directional Thrust Vectoring Propulsor 审中-公开
    全向推力向量推测器

    公开(公告)号：US20160221675A1

    公开(公告)日：2016-08-04

    申请号：US15043510

    申请日：2014-08-19

    申请人： Martin Leon Adam

    发明人： Martin Leon Adam

    IPC分类号： B64C27/82 ,  B64C27/605

    CPC分类号： B64C27/82 ,  B64C27/52 ,  B64C27/605 ,  B64C2027/8218 ,  B64C2027/8227 ,  B64C2027/8236

    摘要： A propulsion system comprising independent rotor sub-systems producing a thrust force of a desired magnitude in any desired radial direction from the centre of the propulsion system, driven from a single driveshaft that may be fixed in its position in the vehicle. When the propulsion system is fitted, for example, to a single-main-rotor helicopter in place of the convention anti-torque tail rotor, the helicopter is thereby equipped with a propulsion system that can produce yaw, pitch, the anti-torque lateral thrust for stability in hover, aft thrust or drag as well as the direct forward thrust that will enable the helicopter to fly at higher speeds. The propulsion system may also be applied in other aeronautical systems as well as to marine and industrial systems to impart energy into a fluid and thereby induce movement in that fluid.

    摘要翻译： 推进系统包括独立的转子子系统，该推进系统从推动系统的中心在任何期望的径向方向上产生所需大小的推力，该推进系统可从固定在车辆中的位置的单个驱动轴驱动。 当推进系统例如安装到单主转子直升机以代替常规的抗扭矩尾转子时，直升机由此配备有可产生偏转，俯仰，抗扭矩侧向的推进系统 推力稳定在悬停，后推或拖曳以及直接向前推力，使直升机能够以更高的速度飞行。 推进系统也可以应用于其他航空系统以及海洋和工业系统中，以将能量传递到流体中并由此引起该流体中的运动。