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    Methods for determining therapeutic index from gene expression profiles
    1.
    发明申请
    Methods for determining therapeutic index from gene expression profiles 失效

    公开(公告)号：US20070275407A1

    公开(公告)日：2007-11-29

    申请号：US11879161

    申请日：2007-07-16

    申请人： Matthew Marton ,  Roland Stoughton

    发明人： Matthew Marton ,  Roland Stoughton

    IPC分类号： C12Q1/68 ,  C12Q1/18 ,  G01N33/566

    CPC分类号： C12Q1/6883 ,  C12Q1/025 ,  C12Q1/18 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/5005 ,  G01N33/5088 ,  G06F19/20 ,  G06F19/70

    摘要： This invention provides methods for determining drug specificity, therapeutic index and effective doses for individual patients. According to the methods of the invention, graded levels of drug are applied to a biological sample or a patient. A plurality of cellular constituents are measured to determine the activity of the drug on a target pathway and at least one off-target pathway. A drug specificity is determined by comparing the target and off target activities of the drug. A therapeutic concentration (or dose) is defined as a concentration (or dose) of the drug that induces certain response in the target pathway. A toxic concentration (or dose) is defined as a concentration (or dose) of the drug that induces certain response in the off target pathway. Therapeutic index is the ratio of the toxic concentration over therapeutic concentration. Methods are also provided to determine an effective dose of a drug for a patient by measuring the activity of the drug on the particular patient.

    Methods for determining therapeutic index from gene expression profiles
    3.
    发明授权
    Methods for determining therapeutic index from gene expression profiles 失效
    从基因表达谱确定治疗指数的方法

    公开(公告)号：US07254487B2

    公开(公告)日：2007-08-07

    申请号：US09823322

    申请日：2001-04-02

    申请人： Matthew Marton ,  Roland Stoughton

    发明人： Matthew Marton ,  Roland Stoughton

    IPC分类号： G01N33/48 ,  G01N31/00 ,  A01N37/18 ,  A01N43/04 ,  C12Q1/00 ,  C12Q1/68 ,  C12Q1/70 ,  C12P21/06

    CPC分类号： C12Q1/6883 ,  C12Q1/025 ,  C12Q1/18 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/5005 ,  G01N33/5088 ,  G06F19/20 ,  G06F19/70

    摘要： This invention provides methods for determining drug specificity, therapeutic index and effective doses for individual patients. According to the methods of the invention, graded levels of drug are applied to a biological sample or a patient. A plurality of cellular constituents are measured to determine the activity of the drug on a target pathway and at least one off-target pathway. A drug specificity is determined by comparing the target and off target activities of the drug. A therapeutic concentration (or dose) is defined as a concentration (or dose) of the drug that induces certain response in the target pathway. A toxic concentration (or dose) is defined as a concentration (or dose) of the drug that induces certain response in the off target pathway. Therapeutic index is the ratio of the toxic concentration over therapeutic concentration. Methods are also provided to determine an effective dose of a drug for a patient by measuring the activity of the drug on the particular patient.

    摘要翻译： 本发明提供用于确定个体患者的药物特异性，治疗指数和有效剂量的方法。 根据本发明的方法，将分级药物施用于生物样品或患者。 测量多个细胞成分以确定药物在靶途径和至少一个脱靶途径上的活性。 通过比较药物的靶标和脱靶活性来确定药物特异性。 治疗浓度（或剂量）被定义为在目标途径中诱导一定反应的药物的浓度（或剂量）。 毒性浓度（或剂量）被定义为在脱靶途径中诱导某些反应的药物的浓度（或剂量）。 治疗指标是毒性浓度与治疗浓度的比值。 还提供了通过测量特定患者上的药物的活性来确定患者药物的有效剂量的方法。

    Manufacture and use of non-standard size microarray slides
    4.
    发明申请
    Manufacture and use of non-standard size microarray slides 审中-公开
    制造和使用非标尺寸的微阵列幻灯片

    公开(公告)号：US20060141507A1

    公开(公告)日：2006-06-29

    申请号：US11287808

    申请日：2005-11-28

    申请人： Mel Kronick ,  Bernett Saunders ,  Matthew Marton ,  John Hinchcliffe ,  Dianne Rees ,  Carol Schembri

    发明人： Mel Kronick ,  Bernett Saunders ,  Matthew Marton ,  John Hinchcliffe ,  Dianne Rees ,  Carol Schembri

    IPC分类号： C12Q1/68 ,  G01N33/53 ,  G06F19/00 ,  C12M1/34

    CPC分类号： B01L9/52 ,  B01J2219/00531 ,  B01J2219/00547 ,  B01J2219/00608 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00662 ,  B01L3/508 ,  B01L2300/0636 ,  B01L2300/0819 ,  B01L2300/0822 ,  G02B21/34 ,  Y10T436/25 ,  Y10T436/2575

    摘要： Methods and devices are disclosed for microarray analysis. In one embodiment a method is disclosed for processing a non-standard size slide having an array of chemical compounds attached to a surface of the slide. A sample is exposed to the surface of the non-standard size slide wherein components in the sample bind to the chemical compounds on the surface of the slide. The sample and the slide are incubated under conditions for carrying out the binding reactions, and the surface of the non-standard size slide is examined for the results of the binding reactions. Prior to the exposing step or the incubating step or the examining step, the non-standard size slide is placed into a slide holder comprising a slide-holding section a slide-holding section adapted to dispose the non-standard size slide to a processing instrument in a manner similar to that for a standard size slide. The non-standard size slide may also include an identifier such as a bar code.

    摘要翻译： 公开了用于微阵列分析的方法和装置。 在一个实施方案中，公开了一种用于处理具有附着到载玻片的表面的化学化合物阵列的非标尺寸载玻片的方法。 将样品暴露于非标准尺寸载玻片的表面，其中样品中的组分与载玻片表面上的化合物结合。 将样品和载玻片在进行结合反应的条件下孵育，并检查非标准尺寸载玻片的表面的结合反应结果。 在暴露步骤或孵化步骤或检查步骤之前，将非标准尺寸的载玻片放置在载玻片保持器中，滑动保持器包括滑动保持部分，该滑动保持部分适于将非标准尺寸滑块配置到处理器械 以类似于标准尺寸幻灯片的方式。 非标准尺寸的幻灯片还可以包括诸如条形码的标识符。

    Methods for determining therapeutic index from gene expression profiles
    5.
    发明授权
    Methods for determining therapeutic index from gene expression profiles 失效
    从基因表达谱确定治疗指数的方法

    公开(公告)号：US06222093B1

    公开(公告)日：2001-04-24

    申请号：US09222582

    申请日：1998-12-28

    申请人： Matthew Marton ,  Roland Stoughton

    发明人： Matthew Marton ,  Roland Stoughton

    IPC分类号： G01N3300

    CPC分类号： C12Q1/6883 ,  C12Q1/025 ,  C12Q1/18 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/5005 ,  G01N33/5088 ,  G06F19/20 ,  G06F19/70

    摘要： This invention provides methods for determining drug specificity, therapeutic index and effective doses for individual patients. According to the methods of the invention, graded levels of drug are applied to a biological sample or a patient. A plurality of cellular constituents are measured to determine the activity of the drug on a target pathway and at least one off-target pathway. A drug specificity is determined by comparing the target and off target activities of the drug. A therapeutic concentration (or dose) is defined as a concentration (or dose) of the drug that induces certain response in the target pathway. A toxic concentration (or dose) is defined as a concentration (or dose) of the drug that induces certain response in the off target pathway. Therapeutic index is the ratio of the toxic concentration over therapeutic concentration. Methods are also provided to determine an effective dose of a drug for a patient by measuring the activity of the drug on the particular patient.

    摘要翻译： 本发明提供用于确定个体患者的药物特异性，治疗指数和有效剂量的方法。 根据本发明的方法，将分级药物施用于生物样品或患者。 测量多个细胞成分以确定药物在靶途径和至少一个脱靶途径上的活性。 通过比较药物的靶标和脱靶活性来确定药物特异性。 治疗浓度（或剂量）被定义为在目标途径中诱导一定反应的药物的浓度（或剂量）。 毒性浓度（或剂量）被定义为在脱靶途径中诱导某些反应的药物的浓度（或剂量）。 治疗指标是毒性浓度与治疗浓度的比值。 还提供了通过测量特定患者上的药物的活性来确定患者药物的有效剂量的方法。

    Methods for determining therapeutic index from gene expression profiles
    6.
    发明授权
    Methods for determining therapeutic index from gene expression profiles 失效
    从基因表达谱确定治疗指数的方法

    公开(公告)号：US08560243B2

    公开(公告)日：2013-10-15

    申请号：US11879161

    申请日：2007-07-16

    申请人： Matthew Marton ,  Roland Stoughton

    发明人： Matthew Marton ,  Roland Stoughton

    IPC分类号： G06F17/00 ,  G06F17/11

    CPC分类号： C12Q1/6883 ,  C12Q1/025 ,  C12Q1/18 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/5005 ,  G01N33/5088 ,  G06F19/20 ,  G06F19/70

    摘要： This invention provides methods for determining drug specificity, therapeutic index and effective doses for individual patients. According to the methods of the invention, graded levels of drug are applied to a biological sample or a patient. A plurality of cellular constituents are measured to determine the activity of the drug on a target pathway and at least one off-target pathway. A drug specificity is determined by comparing the target and off target activities of the drug. A therapeutic concentration (or dose) is defined as a concentration (or dose) of the drug that induces certain response in the target pathway. A toxic concentration (or dose) is defined as a concentration (or dose) of the drug that induces certain response in the off target pathway. Therapeutic index is the ratio of the toxic concentration over therapeutic concentration. Methods are also provided to determine an effective dose of a drug for a patient by measuring the activity of the drug on the particular patient.

    摘要翻译： 本发明提供用于确定个体患者的药物特异性，治疗指数和有效剂量的方法。 根据本发明的方法，将分级药物施用于生物样品或患者。 测量多个细胞成分以确定药物在靶途径和至少一个脱靶途径上的活性。 通过比较药物的靶标和脱靶活性来确定药物特异性。 治疗浓度（或剂量）被定义为在目标途径中诱导一定反应的药物的浓度（或剂量）。 毒性浓度（或剂量）被定义为在脱靶途径中诱导某些反应的药物的浓度（或剂量）。 治疗指标是毒性浓度与治疗浓度的比值。 还提供了通过测量特定患者上的药物的活性来确定患者药物的有效剂量的方法。