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公开(公告)号：US20120237519A1
公开(公告)日：2012-09-20
申请号：US13472818
申请日：2012-05-16
IPC分类号： C12N15/40 , C12Q1/70 , G01N33/53 , A61K39/42 , A61K39/12 , C07K16/10 , C12N15/63 , C12P21/02 , G01N33/569 , A61P31/14 , C12N1/19 , C12N1/15 , C12N5/10 , C12N1/21 , C07K14/08
CPC分类号： C12Q1/701 , A61K39/00 , A61K39/12 , A61K2039/53 , C07K14/005 , C12N7/00 , C12N2770/24321 , C12N2770/24322 , C12N2770/24334 , C12Q2600/136 , G01N33/56983 , G01N2333/18 , G01N2469/20
摘要： The application relates to a pestivirus, designated PMC virus, that is associated with porcine myocarditis syndrome, and the gene and protein sequences derived therefrom. The application further relates to detection methods, vaccine therapeutics, and diagnostic methods using the PMC virus or gene/protein sequences derived therefrom.
摘要翻译： 该应用涉及与猪心肌炎综合征相关的瘟病毒，称为PMC病毒，以及由其衍生的基因和蛋白质序列。 该应用还涉及使用PMC病毒的检测方法，疫苗治疗剂和诊断方法或由其衍生的基因/蛋白质序列。
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公开(公告)号：US08202977B2
公开(公告)日：2012-06-19
申请号：US12298026
申请日：2007-04-20
CPC分类号： C12Q1/701 , A61K39/00 , A61K39/12 , A61K2039/53 , C07K14/005 , C12N7/00 , C12N2770/24321 , C12N2770/24322 , C12N2770/24334 , C12Q2600/136 , G01N33/56983 , G01N2333/18 , G01N2469/20
摘要： The application relates to a pestivirus, designated PMC virus, that is associated with porcine myocarditis syndrome, and the gene and protein sequences derived therefrom. The application further relates to detection methods, vaccine therapeutics, and diagnostic methods using the PMC virus or gene/protein sequences derived therefrom.
摘要翻译： 该应用涉及与猪心肌炎综合征相关的瘟病毒，称为PMC病毒，以及由其衍生的基因和蛋白质序列。 该应用还涉及使用PMC病毒的检测方法，疫苗治疗剂和诊断方法或由其衍生的基因/蛋白质序列。
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公开(公告)号：US20090136536A1
公开(公告)日：2009-05-28
申请号：US12198572
申请日：2008-08-26
IPC分类号： A61K39/00
CPC分类号： C07K14/43563 , A61K39/00 , A61K39/385 , A61K2039/552 , A61K2039/55577 , A61K2039/57 , A61K2039/6043 , C12N2710/14043 , C12N2770/24334
摘要： A method is provided of producing an immunogenic complex comprising a heat shock protein (hsp) coupled to a heterologous antigenic polypeptide, which method comprises: (a) expressing the antigenic polypeptide in a cell which cell has been subjected to a stimulus which causes the induction of a heat shock response in said cells; and (b) recovering the antigenic polypeptide coupled to one or more hsps from said cell or the culture medium. Also provided are immunogenic compositions comprising a heat shock protein (hsp) derived from a non-mammalian eukaryote coupled to a heterologous antigenic polypeptide which composition is capable of inducing an immune response to said antigenic polypeptide in a human or animal.
摘要翻译： 提供了一种产生包含与异源抗原多肽偶联的热休克蛋白（hsp）的免疫原性复合物的方法，该方法包括：（a）在细胞中表达抗原多肽，所述细胞已经经受了引起诱导的刺激 在所述细胞中产生热休克反应; 和（b）从所述细胞或培养基中回收与一种或多种hsps偶联的抗原性多肽。 还提供了包含衍生自与异源抗原多肽偶联的非哺乳动物真核生物的热休克蛋白（hsp）的免疫原性组合物，该组合物能够诱导人或动物中所述抗原性多肽的免疫应答。
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公开(公告)号：US20100203063A1
公开(公告)日：2010-08-12
申请号：US12298026
申请日：2007-04-20
IPC分类号： A61K39/42 , C07H21/02 , C07H21/04 , C07K14/005 , C12Q1/70 , G01N33/53 , C12Q1/68 , C12P21/04 , A61K39/12 , A61K31/7088 , A61K38/16 , C12N15/63 , C12N5/10 , C12P21/06 , A61P31/12
CPC分类号： C12Q1/701 , A61K39/00 , A61K39/12 , A61K2039/53 , C07K14/005 , C12N7/00 , C12N2770/24321 , C12N2770/24322 , C12N2770/24334 , C12Q2600/136 , G01N33/56983 , G01N2333/18 , G01N2469/20
摘要： The application relates to a pestivirus, designated PMC virus, that is associated with porcine myocarditis syndrome, and the gene and protein sequences derived therefrom. The application further relates to detection methods, vaccine therapeutics, and diagnostic methods using the PMC virus or gene/protein sequences derived therefrom.
摘要翻译： 该应用涉及与猪心肌炎综合征相关的瘟病毒，称为PMC病毒，以及由其衍生的基因和蛋白质序列。 该应用还涉及使用PMC病毒的检测方法，疫苗治疗剂和诊断方法或由其衍生的基因/蛋白质序列。
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公开(公告)号：US07494785B1
公开(公告)日：2009-02-24
申请号：US10049953
申请日：2000-08-18
IPC分类号： C12P25/00
CPC分类号： C07K14/43563 , A61K39/00 , A61K39/385 , A61K2039/552 , A61K2039/55577 , A61K2039/57 , A61K2039/6043 , C12N2710/14043 , C12N2770/24334
摘要： A method is provided of producing an immunogenic complex comprising a heat shock protein (hsp) coupled to a heterologous antigenic polypeptide, which method comprises: (a) expressing the antigenic polypeptide in a cell which cell has been subjected to a stimulus which causes the induction of a heat shock response in said cells; and (b) recovering the antigenic polypeptide coupled to one or more hsps from said cell or the culture medium. Also provided are immunogenic compositions comprising a heat shock protein (hsp) derived from a non-mammalian eukaryote coupled to a heterologous antigenic polypeptide which composition is capable of inducing an immune response to said antigenic polypeptide in a human or animal.
摘要翻译： 提供了一种产生包含与异源抗原多肽偶联的热休克蛋白（hsp）的免疫原性复合物的方法，该方法包括：（a）在细胞中表达抗原多肽，所述细胞已经经受了引起诱导的刺激 在所述细胞中产生热休克反应; 和（b）从所述细胞或培养基中回收与一种或多种hsps偶联的抗原性多肽。 还提供了包含衍生自与异源抗原多肽偶联的非哺乳动物真核生物的热休克蛋白（hsp）的免疫原性组合物，该组合物能够诱导人或动物中所述抗原性多肽的免疫应答。
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公开(公告)号：US20140037665A1
公开(公告)日：2014-02-06
申请号：US14036412
申请日：2013-09-25
IPC分类号： C07K14/005 , C12Q1/70 , G01N33/569
CPC分类号： C12Q1/701 , A61K39/00 , A61K39/12 , A61K2039/53 , C07K14/005 , C12N7/00 , C12N2770/24321 , C12N2770/24322 , C12N2770/24334 , C12Q2600/136 , G01N33/56983 , G01N2333/18 , G01N2469/20
摘要： The application relates to a pestivirus, designated PMC virus, that is associated with porcine myocarditis syndrome, and the gene and protein sequences derived therefrom. The application further relates to detection methods, vaccine therapeutics, and diagnostic methods using the PMC virus or gene/protein sequences derived therefrom.
摘要翻译： 该应用涉及与猪心肌炎综合征相关的瘟病毒，称为PMC病毒，以及由其衍生的基因和蛋白质序列。 该应用还涉及使用PMC病毒的检测方法，疫苗治疗剂和诊断方法或由其衍生的基因/蛋白质序列。
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公开(公告)号：US08569473B2
公开(公告)日：2013-10-29
申请号：US13472818
申请日：2012-05-16
CPC分类号： C12Q1/701 , A61K39/00 , A61K39/12 , A61K2039/53 , C07K14/005 , C12N7/00 , C12N2770/24321 , C12N2770/24322 , C12N2770/24334 , C12Q2600/136 , G01N33/56983 , G01N2333/18 , G01N2469/20
摘要： The application relates to a pestivirus, designated PMC virus, that is associated with porcine myocarditis syndrome, and the gene and protein sequences derived therefrom. The application further relates to detection methods, vaccine therapeutics, and diagnostic methods using the PMC virus or gene/protein sequences derived therefrom.
摘要翻译： 该应用涉及与猪心肌炎综合征相关的瘟病毒，称为PMC病毒，以及由其衍生的基因和蛋白质序列。 该应用还涉及使用PMC病毒的检测方法，疫苗治疗剂和诊断方法或由其衍生的基因/蛋白质序列。
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