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公开(公告)号:US20050112568A1
公开(公告)日:2005-05-26
申请号:US10480068
申请日:2002-06-03
申请人: Lori Friedman , Gregory Plowman , Mercia Belvin , Helen Francis-Lang , Danxi Li , Roel Funke
发明人: Lori Friedman , Gregory Plowman , Mercia Belvin , Helen Francis-Lang , Danxi Li , Roel Funke
IPC分类号: A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P9/00 , A61P35/00 , A61P43/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/02 , C12Q1/25 , C12Q1/42 , C12Q1/48 , C12Q1/527 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , G01N33/567 , G01N33/573 , G01N33/574 , G01N33/68
CPC分类号: G01N33/68 , C12Q1/42 , C12Q1/485 , C12Q1/527 , C12Q1/6886 , C12Q2600/158 , G01N33/5011 , G01N33/5017 , G01N33/5308 , G01N33/573 , G01N33/574 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/57449 , G01N33/5748 , G01N33/57484 , G01N33/57496 , G01N33/6872 , G01N2333/4739 , G01N2333/705 , G01N2333/82 , G01N2333/912 , G01N2333/988 , G01N2500/00 , G01N2500/04 , G01N2500/10 , G01N2510/00
摘要: Human DGK genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53,comprising screening for agents that modulate the activity of DKG are provided.
摘要翻译: 人DGK基因被鉴定为p53途径的调节剂,因此是与缺陷型p53功能相关的病症的治疗靶点。 提供了鉴定p53调节剂的方法,包括筛选调节DKG活性的试剂。