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1.发明申请HEME-BINDING PHOTOACTIVE POLYPEPTIDES AND METHODS OF USE THEREOF 审中-公开HEME-BINDING PHOTOID POLYPEPTIDES及其使用方法公开(公告)号：US20110243849A1
公开(公告)日：2011-10-06
申请号：US13077686
申请日：2011-03-31
申请人： Michael A. Marletta , Michael B. Winter , Emily J. McLaurin , Steven Y. Reece , Charles Olea, JR. , Daniel G. Nocera
发明人： Michael A. Marletta , Michael B. Winter , Emily J. McLaurin , Steven Y. Reece , Charles Olea, JR. , Daniel G. Nocera
IPC分类号： A61K49/00 , C07K14/795 , C07K14/805 , C07K14/80 , C12N9/96 , C12P21/00 , G01N21/75 , C12N13/00 , C07K19/00 , B82Y15/00
CPC分类号： C07K14/80 , A61K41/0071 , B82Y15/00 , C07K14/795 , C07K14/805 , G01N33/52
摘要： The present disclosure provides photoactive polypeptides. A subject photoactive polypeptide is useful in a variety of applications, which are also provided.
摘要翻译： 本公开提供光活性多肽。 受试者光活性多肽在各种应用中是有用的，其也被提供。
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公开(公告)号：US20100266673A1
公开(公告)日：2010-10-21
申请号：US12302004
申请日：2007-05-21
IPC分类号： A61K38/16 , A61K9/127 , A61P9/00 , A61P9/12 , A61P13/12 , C07K14/00 , C07H21/04 , C12N15/63 , C12N5/10 , C12P21/00
CPC分类号： C07K14/47 , A61K38/00 , C07K14/195 , C07K14/33 , C07K14/435 , C07K14/43545 , C07K14/43563 , C07K14/43581 , Y02A50/469 , Y02A50/471 , Y02A50/478 , Y10T436/102499
摘要： H-NOX proteins are mutated to exhibit improved or optimal kinetic and thermodynamic properties for blood gas NO delivery. The engineered H-NOX proteins comprise mutations that impart altered NO or 02 ligand-binding relative to the corresponding wild-type H-NOX domain, and are operative as physiologically compatible mammalian blood NO gas carriers. The invention also provides pharmaceutical compositions, kits, and methods that use wild-type or mutant H-NOX proteins for the treatment of any condition for which delivery of NO is beneficial.
摘要翻译： H-NOX蛋白被突变以表现出改善的或最佳的动力学和热力学性质用于血气NO递送。 工程化的H-NOX蛋白质包含相对于相应的野生型H-NOX结构域赋予改变的NO或O 2配体结合的突变，并且作为生理上相容的哺乳动物血液NO气体载体起作用。 本发明还提供了使用野生型或突变型H-NOX蛋白质用于治疗NO的递送有益的任何病症的药物组合物，试剂盒和方法。
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公开(公告)号：US08404631B2
公开(公告)日：2013-03-26
申请号：US12302002
申请日：2007-05-21
申请人： Stephen P. L. Cary , Elizabeth M. Boon , Emily Weinert , Jonathan A. Winger , Michael A. Marletta
发明人： Stephen P. L. Cary , Elizabeth M. Boon , Emily Weinert , Jonathan A. Winger , Michael A. Marletta
IPC分类号： C07K14/00
CPC分类号： C07K14/47 , A61K38/00 , C07K14/195 , C07K14/33 , C07K14/435 , C07K14/43545 , C07K14/43563 , C07K14/43581 , Y02A50/469 , Y02A50/471 , Y02A50/478 , Y10T436/102499
摘要： H-NOX proteins are mutated to exhibit improved or optimal kinetic and thermodynamic properties for blood gas O2 delivery. The engineered H-NOX proteins comprise mutations that impart altered O2 or NO ligand-binding relative to the corresponding wild-type H-NOX domain, and are operative as physiologically compatible mammalian blood O2 gas carriers. The invention also provides pharmaceutical compositions, kits, and methods that use wild-type or mutant H-NOX proteins for the treatment of any condition for which delivery of O2 is beneficial.
摘要翻译： H-NOX蛋白被突变以表现出改善的或最佳的动力学和热力学性质用于血液中氧气输送。 工程化的H-NOX蛋白质包含相对于相应的野生型H-NOX结构域赋予改变的O 2或NO配体结合的突变，并且作为生理上相容的哺乳动物血液氧气载体起作用。 本发明还提供了使用野生型或突变型H-NOX蛋白质治疗任何有利于O 2递送的条件的药物组合物，试剂盒和方法。
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公开(公告)号：US20150266931A1
公开(公告)日：2015-09-24
申请号：US14490597
申请日：2014-09-18
IPC分类号： C07K14/195 , C07K14/33 , C07K14/435
CPC分类号： C07K14/47 , A61K38/00 , C07K14/195 , C07K14/33 , C07K14/435 , C07K14/43545 , C07K14/43563 , C07K14/43581 , Y02A50/469 , Y02A50/471 , Y02A50/478 , Y10T436/102499
摘要： H-NOX proteins are mutated to exhibit improved or optimal kinetic and thermodynamic properties for blood gas NO delivery. The engineered H-NOX proteins comprise mutations that impart altered NO or O2 ligand-binding relative to the corresponding wild-type H-NOX domain, and are operative as physiologically compatible mammalian blood NO gas carriers. The invention also provides pharmaceutical compositions, kits, and methods that use wild-type or mutant H-NOX proteins for the treatment of any condition for which delivery of NO is beneficial.
摘要翻译： H-NOX蛋白被突变以表现出改善的或最佳的动力学和热力学性质用于血气NO递送。 工程化的H-NOX蛋白质包含相对于相应的野生型H-NOX结构域赋予改变的NO或O 2配体结合的突变，并且作为生理上相容的哺乳动物血液NO气体载体起作用。 本发明还提供了使用野生型或突变型H-NOX蛋白质用于治疗NO的递送有益的任何病症的药物组合物，试剂盒和方法。
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公开(公告)号：US20140073012A1
公开(公告)日：2014-03-13
申请号：US14008525
申请日：2012-04-04
IPC分类号： C12P19/00
CPC分类号： C12P19/14 , C07K2319/00 , C12N9/0006 , C12N9/2437 , C12P19/00 , C12P19/02 , C13K1/02 , D21C5/005
摘要： The present disclosure provides compositions and methods related to the degradation of cellulose and cellulose-containing materials. CDH-heme domain polypeptides and GH61 polypeptides and related polynucleotides and compositions are provided herein. Additionally, methods related to CDH-heme domain polypeptides, GH61 polypeptides, and related polynucleotides and compositions, are provided herein
摘要翻译： 本公开提供了与纤维素和含纤维素材料的降解有关的组合物和方法。 本文提供CDH-血红素结构域多肽和GH61多肽及相关多核苷酸和组合物。 此外，本文提供了与CDH-血红素结构域多肽，GH61多肽以及相关多核苷酸和组合物相关的方法
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6.发明授权Post-transcriptional regulation of RNA-related processes using encoded protein-binding RNA aptamers 有权使用编码蛋白结合RNA适体的RNA相关过程的转录后调控公开(公告)号：US09125931B2
公开(公告)日：2015-09-08
申请号：US12755121
申请日：2010-04-06
IPC分类号： C07H21/04 , C12N15/63 , A61K31/713 , C12N15/115 , A61K31/70
CPC分类号： A61K31/713 , C12N15/115 , C12N2310/16
摘要： In vitro SELEX has been used to discover high affinity RNA aptamers interacting with the tetracycline repressor protein in a tetracycline-dependent manner. Using in silico RNA folding predictions to guide the design of both aptamer truncations and mutants, minimized tetracycline repressor protein high affinity binding aptamers have been defined. Using one such aptamer, inducible post-transcriptional regulation in vivo has been demonstrated that is predicated on a direct interaction between a tetracycline repressor protein and a RNA aptamer element. These aptamer components can be integrated in any organism to inducibly regulate RNA translation of a gene of interest.
摘要翻译： 已经使用体外SELEX发现以四环素依赖的方式与四环素阻遏蛋白相互作用的高亲和力RNA适体。 使用电脑RNA折叠预测来指导适体截短和突变体的设计，最小化四环素阻遏蛋白高亲和力结合适配体已被定义。 已经证明使用一种这样的适体，体内可诱导的转录后调控是以四环素阻遏物蛋白和RNA适体元件之间的直接相互作用为前提的。 这些适配子组分可以整合到任何生物体中以诱导调节目的基因的RNA翻译。
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公开(公告)号：US08569022B2
公开(公告)日：2013-10-29
申请号：US13813153
申请日：2011-06-23
IPC分类号： C12P7/58
CPC分类号： C12P19/02 , A23K10/14 , A23K50/30 , A23K50/75 , C11D3/386 , C12N9/18 , C12P7/58 , C12P2201/00 , C12Y101/03004 , C12Y101/99018 , C12Y301/01017 , D21C5/00 , D21C5/005
摘要： The present disclosure relates to hydrolysis of hexose-δ-lactones by use of an S. thermophile extracellular aldonolactonase. In particular the present disclosure relates to compositions including a S. thermophile extracellular aldonolactonase and methods of use thereof.
摘要翻译： 本公开内容涉及通过使用嗜热菌嗜热细胞外aldonolactonase水解己糖-δ-内酯。 特别地，本公开涉及包含嗜热链球菌细胞外α-淀粉酶的组合物及其使用方法。
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公开(公告)号：US08404632B2
公开(公告)日：2013-03-26
申请号：US12302004
申请日：2007-05-21
IPC分类号： C07K14/00
CPC分类号： C07K14/47 , A61K38/00 , C07K14/195 , C07K14/33 , C07K14/435 , C07K14/43545 , C07K14/43563 , C07K14/43581 , Y02A50/469 , Y02A50/471 , Y02A50/478 , Y10T436/102499
摘要： H-NOX proteins are mutated to exhibit improved or optimal kinetic and thermodynamic properties for blood gas NO delivery. The engineered H-NOX proteins comprise mutations that impart altered NO or O2 ligand-binding relative to the corresponding wild-type H-NOX domain, and are operative as physiologically compatible mammalian blood NO gas carriers. The invention also provides pharmaceutical compositions, kits, and methods that use wild-type or mutant H-NOX proteins for the treatment of any condition for which delivery of NO is beneficial.
摘要翻译： H-NOX蛋白被突变以表现出改善的或最佳的动力学和热力学性质用于血气NO递送。 工程化的H-NOX蛋白质包含相对于相应的野生型H-NOX结构域赋予改变的NO或O 2配体结合的突变，并且作为生理上相容的哺乳动物血液NO气体载体起作用。 本发明还提供了使用野生型或突变型H-NOX蛋白质用于治疗NO的递送有益的任何病症的药物组合物，试剂盒和方法。
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公开(公告)号：US20100285104A1
公开(公告)日：2010-11-11
申请号：US12302002
申请日：2007-05-21
申请人： Stephen P. L. Cary , Elizabeth M. Boon , Emily Weinert , Jonathan A. Winger , Michael A. Marletta
发明人： Stephen P. L. Cary , Elizabeth M. Boon , Emily Weinert , Jonathan A. Winger , Michael A. Marletta
IPC分类号： A61K9/127 , C12P21/06 , C12N5/10 , C12N5/02 , C12N15/63 , G01N31/00 , A61K38/00 , C07K14/435 , C07H21/04 , C07K14/195
CPC分类号： C07K14/47 , A61K38/00 , C07K14/195 , C07K14/33 , C07K14/435 , C07K14/43545 , C07K14/43563 , C07K14/43581 , Y02A50/469 , Y02A50/471 , Y02A50/478 , Y10T436/102499
摘要： H-NOX proteins are mutated to exhibit improved or optimal kinetic and thermodynamic properties for blood gas O2 delivery. The engineered H-NOX proteins comprise mutations that impart altered O2 or NO ligand-binding relative to the corresponding wild-type H-NOX domain, and are operative as physiologically compatible mammalian blood O2 gas carriers. The invention also provides pharmaceutical compositions, kits, and methods that use wild-type or mutant H-NOX proteins for the treatment of any condition for which delivery of O2 is beneficial.
摘要翻译： H-NOX蛋白被突变以表现出改善的或最佳的动力学和热力学性质用于血液中氧气输送。 工程化的H-NOX蛋白质包含相对于相应的野生型H-NOX结构域赋予改变的O 2或NO配体结合的突变，并且作为生理上相容的哺乳动物血液氧气载体起作用。 本发明还提供了使用野生型或突变型H-NOX蛋白质治疗任何有利于O 2递送的条件的药物组合物，试剂盒和方法。
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公开(公告)号：US20130196396A1
公开(公告)日：2013-08-01
申请号：US13813153
申请日：2011-06-23
IPC分类号： C12P7/58
CPC分类号： C12P19/02 , A23K10/14 , A23K50/30 , A23K50/75 , C11D3/386 , C12N9/18 , C12P7/58 , C12P2201/00 , C12Y101/03004 , C12Y101/99018 , C12Y301/01017 , D21C5/00 , D21C5/005
摘要： The present disclosure relates to hydrolysis of hexose-δ-lactones by use of an S. thermophile extracellular aldonolactonase. In particular the present disclosure relates to compositions including a S. thermophile extracellular aldonolactonase and methods of use thereof.
摘要翻译： 本公开内容涉及通过使用嗜热菌嗜热细胞外aldonolactonase水解己糖-δ-内酯。 特别地，本公开涉及包含嗜热链球菌细胞外α-淀粉酶的组合物及其使用方法。
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