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公开(公告)号:US20120289591A1
公开(公告)日:2012-11-15
申请号:US13510361
申请日:2010-11-17
IPC分类号: A61K31/19 , A61K31/201 , A61K31/202 , A61K31/194 , A01P1/00 , A61K31/375 , A01N37/02 , A01N37/06 , A61P31/04 , A61K31/20 , A61K31/191
CPC分类号: A61K31/20 , A61K8/06 , A61K8/361 , A61K8/553 , A61K9/0014 , A61K9/107 , A61K31/201 , A61K31/685 , A61K47/12 , A61K47/24 , A61K2800/74 , A61Q11/00 , A61K2300/00
摘要: The invention concerns antimicrobial compositions comprising free fatty acids emulsified with membrane lipids or hydrolysed derivatives thereof, and pharmaceutical formulations comprising same. The compositions can be used in the treatment or prophylaxis of microbial infections. They can also regulate the rate of blood clotting rendering them suitable for incorporation in catheter locking solutions and for use in wound care.
摘要翻译: 本发明涉及包含用膜脂质或其水解衍生物乳化的游离脂肪酸的抗微生物组合物和包含其的药物制剂。 组合物可用于治疗或预防微生物感染。 它们还可以调节血液凝固的速率,使其适合纳入导管锁定溶液并用于伤口护理。
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公开(公告)号:US20150157720A1
公开(公告)日:2015-06-11
申请号:US14623850
申请日:2015-02-17
CPC分类号: A61K31/20 , A61K8/06 , A61K8/361 , A61K8/553 , A61K9/0014 , A61K9/107 , A61K31/201 , A61K31/685 , A61K47/12 , A61K47/24 , A61K2800/74 , A61Q11/00 , A61K2300/00
摘要: The invention concerns antimicrobial compositions comprising free fatty acids emulsified with membrane lipids or hydrolysed derivatives thereof, and pharmaceutical formulations comprising same. The compositions can be used in the treatment of prophylaxis of microbial infections. They can also regulate the rate of blood clotting rendering them suitable for incorporation in catheter locking solutions and for use in wound care.
摘要翻译: 本发明涉及包含用膜脂质或其水解衍生物乳化的游离脂肪酸的抗微生物组合物和包含其的药物制剂。 该组合物可用于预防微生物感染的治疗。 它们还可以调节血液凝固的速率,使其适合纳入导管锁定溶液并用于伤口护理。
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公开(公告)号:US20100317734A1
公开(公告)日:2010-12-16
申请号:US12734929
申请日:2008-12-04
申请人: Michael Anthony Folan , Colm O'Brien , Colum Dunne
发明人: Michael Anthony Folan , Colm O'Brien , Colum Dunne
CPC分类号: A61K45/06 , A61K31/19 , A61K35/20 , A61K2300/00
摘要: An antimicrobial composition comprising a blend of two or more natural free fatty acids derivable from milk serum lipid, the free fatty acids being selected from: butyric (C4); caproic (C6); caprylic (C8); capric (C10); lauric (C12); myristic (C14); palmitic (C 16): palmitoleic 5 (C16:1); stearic (C1 8); oleic (C18:1); linoleic (Cl 8:2); linolenic (C18:3); and esterified derivatives thereof, and a milk, protein as an emulsifying agent for the free fatty acids wherein at least 35% of the total lipid content comprises free fatty acids selected from one or more of: butyric, caproic, caprylic, capric and lauric.
摘要翻译: 一种抗微生物组合物,其包含两种或更多种可衍生自乳清脂质的天然游离脂肪酸的混合物,所述游离脂肪酸选自:丁酸(C4); 己酸(C6); 辛酸(C8); capric(C10); 月桂酸(C12); 肉豆蔻酸(C14); 棕榈酸(C16):棕榈油5(C16:1); 硬脂酸(C1 8); 油酸(C18:1); 亚油酸(C18:2); 亚麻酸(C18:3); 和其酯化衍生物,以及乳蛋白作为游离脂肪酸的乳化剂,其中总脂质含量的至少35%包含选自以下中的一种或多种的游离脂肪酸:丁酸,己酸,辛酸,癸酸和月桂酸。
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公开(公告)号:US5727333A
公开(公告)日:1998-03-17
申请号:US669565
申请日:1996-11-04
IPC分类号: F26B5/06
CPC分类号: F26B5/065
摘要: A process for drying a solution containing the material. The process includes the following steps: (1) subjecting the solution to vacuum-assisted freezing by introducing the solution into an evacuated chamber in the form of a spray, the droplets of which are at a sufficiently low temperature to ensure that they freeze at the vacuum pressure inside the chamber; (2) collecting the frozen droplets of the solution on a collecting surface of the chamber and controlling the temperature of the collecting surface and the pressure within the chamber so that the frozen solvent sublimes from the collected frozen droplets. The collecting surface is prepared by being brought to an initial temperature which is not greater than the melting point of the frozen solution at the initial pressure, which is the pressure within the chamber when the spray is introduced, the temperature of the collecting surface and the pressure within the chamber being maintained throughout the sublimation process so as to prevent partial remelting of the frozen droplets as sublimation occurs
摘要翻译: PCT No.PCT / IE95 / 00013 Sec。 371日期:1996年11月4日 102(e)日期1996年11月4日PCT提交1995年1月31日PCT公布。 公开号WO95 / 22036 日期1995年8月17日一种干燥含有该材料的溶液的方法。 该方法包括以下步骤:(1)通过将溶液以喷雾的形式引入抽真空室中使溶液经真空辅助冷冻,其中液滴处于足够低的温度下,以确保它们在 室内真空压力; (2)将所述溶液的冷冻液滴收集在所述室的收集表面上,并控制所述收集表面的温度和所述室内的压力,使得所述冷冻溶剂从收集的冷冻液滴中升华。 收集表面通过在初始压力下达到不高于冷冻溶液的熔点的初始温度来制备,该初始压力是当引入喷雾时室内的压力,收集表面的温度和 在整个升华过程中保持室内的压力,以防止发生升华时冷冻液滴的部分重熔
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公开(公告)号:US09555116B2
公开(公告)日:2017-01-31
申请号:US14623850
申请日:2015-02-17
IPC分类号: A01N43/08 , A61K31/34 , A61K47/12 , A61K31/20 , A61K31/201 , A61K31/685
CPC分类号: A61K31/20 , A61K8/06 , A61K8/361 , A61K8/553 , A61K9/0014 , A61K9/107 , A61K31/201 , A61K31/685 , A61K47/12 , A61K47/24 , A61K2800/74 , A61Q11/00 , A61K2300/00
摘要: The invention concerns antimicrobial compositions comprising free fatty acids emulsified with membrane lipids or hydrolyzed derivatives thereof, and pharmaceutical formulations comprising same. The compositions can be used in the treatment of prophylaxis of microbial infections. They can also regulate the rate of blood clotting rendering them suitable for incorporation in catheter locking solutions and for use in wound care.
摘要翻译: 本发明涉及包含用膜脂或其水解衍生物乳化的游离脂肪酸的抗微生物组合物和包含其的药物制剂。 该组合物可用于预防微生物感染的治疗。 它们还可以调节血液凝固的速率,使其适合纳入导管锁定溶液并用于伤口护理。
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公开(公告)号:US20170100357A1
公开(公告)日:2017-04-13
申请号:US15384372
申请日:2016-12-20
摘要: The invention concerns antimicrobial compositions comprising free fatty acids emulsified with membrane lipids or hydrolysed derivatives thereof, and pharmaceutical formulations comprising same. The compositions can be used in the treatment of prophylaxis of microbial infections. They can also regulate the rate of blood clotting rendering them suitable for incorporation in catheter locking solutions and for use in wound care.
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公开(公告)号:US06423336B1
公开(公告)日:2002-07-23
申请号:US09308101
申请日:1999-06-24
IPC分类号: A61K968
CPC分类号: A23G4/20 , A23G4/00 , A61K9/0058
摘要: Chewing gum are obtained by entrapping a liquid within a mass of gum, blast freezing the gum and entrapped liquid, and increasing the temperature to just below the melting point of the liquid, causing the liquid crystals to anneal. By manipulating the size and/or morphology of the frozen liquid crystals, one can thereby manipulate the internal structure of the gum. Optionally, the liquid can contain a drug in solution. If the solvent is then removed, the drug is left in the interstices of the gum. The rate of release of the drug from the gum is thus determined by the distribution of the drug within the gum arising from the annealing step. This method of manufacturing a chewing gum avoids the use of elevated temperatures, and is particularly suitable for entrapping thermolabile substances.
摘要翻译: 咀嚼口香糖通过在一定质量的树胶中捕获液体获得,鼓风冷冻口香糖和捕获的液体,并将温度升高到刚好低于液体的熔点,导致液晶退火。 通过操纵冷冻液晶的尺寸和/或形态,可以操纵胶质的内部结构。 任选地,液体可以含有溶液中的药物。 如果溶剂被除去,药物就留在口香糖的空隙中。 因此,药物从口香糖释放的速率由退火步骤产生的胶中药物的分布决定。 这种制造口香糖的方法避免使用升高的温度,并且特别适用于包埋不耐热物质。
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