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    Control system and process for application of energy to airway walls and other mediums
    1.
    发明授权
    Control system and process for application of energy to airway walls and other mediums 有权
    控制系统和能量应用于气道壁和其他介质的过程

    公开(公告)号：US08888769B2

    公开(公告)日：2014-11-18

    申请号：US12944238

    申请日：2010-11-11

    申请人： Michael Biggs ,  Roger A. Stern ,  Christopher J. Danek

    发明人： Michael Biggs ,  Roger A. Stern ,  Christopher J. Danek

    IPC分类号： A61B18/10 ,  A61N1/06 ,  A61N1/40 ,  A61B18/00

    CPC分类号： A61N1/06 ,  A61B18/14 ,  A61B2018/00541 ,  A61N1/40

    摘要： The present invention includes a system for delivering energy to an airway wall of a lung comprising an energy delivering apparatus and a PID controller having one or more variable gain factors which are rest after energy deliver has begun. The energy delivering apparatus may include a flexible elongated member and a distal expandable basket having at least one electrode for transferring energy to the airway wall and at least one temperature sensor for measuring temperature. The PID controller determines a new power set point base on an error between a preset temperature and the measured temperature. The algorithm can be Pi+1=Pi+G(αei+βei−1+γei−2) where α, β and γ are preset values and α is from 1 to 2; β is from −1 to −2; and γ is from −0.5 to 0.5. In another variation, the controller is configured to shut down if various measured parameters are exceeded such as, for example, energy, impedance, temperature, temperature differences, activation time and combinations thereof. Methods for treating a target medium using a PID algorithm are also provided.

    摘要翻译： 本发明包括一种用于向肺气道壁输送能量的系统，包括能量输送装置和具有一个或多个可变增益因子的PID控制器，所述可变增益因子在能量传递开始之后休息。 能量输送装置可以包括柔性细长构件和远端可膨胀篮，其具有用于将能量传递到气道壁的至少一个电极和用于测量温度的至少一个温度传感器。 PID控制器根据预设温度和测量温度之间的误差确定新的功率设定点。 该算法可以是Pi + 1 = Pi + G（αei+＆bgr; ei-1 +γei-2）其中α，＆bgr; γ为预设值，α为1〜2; ＆bgr 从-1到-2; γ为-0.5〜0.5。 在另一变型中，控制器被配置为如果超过各种测量参数，例如能量，阻抗，温度，温差，激活时间及其组合，则关闭。 还提供了使用PID算法处理目标介质的方法。

    Modification of airways by application of energy
    6.
    发明授权
    Modification of airways by application of energy 有权
    通过应用能源改变航空公司

    公开(公告)号：US07198635B2

    公开(公告)日：2007-04-03

    申请号：US10414253

    申请日：2003-04-14

    申请人： Christopher James Danek ,  Michael Biggs ,  Keith M. Burger ,  Bryan Loomas ,  Thomas Keast ,  Dave Haugaard

    发明人： Christopher James Danek ,  Michael Biggs ,  Keith M. Burger ,  Bryan Loomas ,  Thomas Keast ,  Dave Haugaard

    IPC分类号： A61B18/18 ,  A61F2/00 ,  A61N1/00

    CPC分类号： A61B18/1492 ,  A61B18/08 ,  A61B18/1477 ,  A61B2017/00084 ,  A61B2017/00123 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00541 ,  A61B2018/00791 ,  A61B2018/00982 ,  A61B2018/046 ,  A61B2018/1467 ,  A61B2018/1475 ,  A61B2018/1497 ,  A61B2090/3614 ,  A61N1/06 ,  A61N1/403 ,  A61N5/00

    摘要： This relates to methods and devices for treating reversible chronic obstructive pulmonary disease, and more particularly, relates to a device for exchanging energy with airway tissue such as that found in the airway of human lungs. The exchange of energy with this airway tissue in the airways reduces the ability of the air ways to constrict and/or reduces the resistance within the airway to the flow of air through the airway. This also relates to a method for decreasing responsiveness or decreasing resistance to airflow of airways involves the transfer of energy to or from the airway walls to prevent or reduce airway constriction and other symptoms of lung diseases. The treatment reduces the ability of the airway to contract during an acute narrowing of the airways, reduces mucus plugging of the airways, and/or increases the airway diameter. The methods according to the present invention provide a longer duration and/or more effective treatment for lung diseases than currently used drug treatments, and obviate patient compliance issues. This also includes additional steps that reduce the ability of the lung to produce at least one of the symptoms of reversible obstructive pulmonary disease and to reduce the resistance to the flow of air through a lung.

    摘要翻译： 这涉及用于治疗可逆性慢性阻塞性肺疾病的方法和装置，更具体地涉及用于与例如人肺气道中发现的气道组织交换能量的装置。 与气道中的这种气道组织的能量交换降低了气道收缩和/或降低气道内通过气道的空气流动的阻力的能力。 这也涉及一种降低呼吸道反应性或降低气道阻力的方法，涉及将气体转移到气道壁或从气道壁传递，以防止或减少气道收缩和其他肺部疾病症状。 该治疗降低了在气道急性变窄期间气道收缩的能力，减少气道的粘液堵塞和/或增加气道直径。 根据本发明的方法提供比目前使用的药物治疗更长的持续时间和/或更有效的肺部疾病治疗，并且消除患者依从性问题。 这还包括额外的步骤，其降低肺产生可逆性阻塞性肺疾病的至少一种症状的能力并降低对通过肺的空气流动的抵抗力。

    CONTROL SYSTEM AND PROCESS FOR APPLICATION OF ENERGY TO AIRWAY WALLS AND OTHER MEDIUMS
    8.
    发明申请
    CONTROL SYSTEM AND PROCESS FOR APPLICATION OF ENERGY TO AIRWAY WALLS AND OTHER MEDIUMS 有权
    能源对航空公司和其他媒体应用的控制系统和过程

    公开(公告)号：US20060247726A1

    公开(公告)日：2006-11-02

    申请号：US11458074

    申请日：2006-07-17

    申请人： Michael BIGGS ,  Roger STERN ,  Christopher DANEK

    发明人： Michael BIGGS ,  Roger STERN ,  Christopher DANEK

    IPC分类号： A61N1/00

    CPC分类号： A61N1/06 ,  A61B18/14 ,  A61B2018/00541 ,  A61N1/40

    摘要： The present invention includes a system for delivering energy to an airway wall of a lung comprising an energy delivering apparatus and a PID controller having one or more variable gain factors which are rest after energy deliver has begun. The energy delivering apparatus may include a flexible elongated member and a distal expandable basket having at least one electrode for transferring energy to the airway wall and at least one temperature sensor for measuring temperature. The PID controller determines a new power set point base on an error between a preset temperature and the measured temperature. The algorithm can be Pii+1=Pi+G(αei+βei-1+γei-2) where α, β and γ are preset values and a is from 1 to 2; β is from −1 to −2; and 7 is from −0.5 to 0-5. In another variation, the controller is configured to shut down if various measured parameters are exceeded such as, for example, energy, impedance, temperature, temperature differences, activation time and combinations thereof. Methods for treating a target medium using a PID algorithm are also provided.

    摘要翻译： 本发明包括一种用于向肺气道壁输送能量的系统，包括能量输送装置和具有一个或多个可变增益因子的PID控制器，所述可变增益因子在能量传递开始之后休息。 能量输送装置可以包括柔性细长构件和远端可膨胀篮，其具有用于将能量传递到气道壁的至少一个电极和用于测量温度的至少一个温度传感器。 PID控制器根据预设温度和测量温度之间的误差确定新的功率设定点。 该算法可以是Pi + i + 1 + P（i + 1）+＆Sigma; i = 其中α，β和γ是预设值，a是1至2; β为-1至-2; 7为-0.5〜0-5。 在另一变型中，控制器被配置为如果超过各种测量参数，例如能量，阻抗，温度，温差，激活时间及其组合，则关闭。 还提供了使用PID算法处理目标介质的方法。