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公开(公告)号：US20140087466A1
公开(公告)日：2014-03-27
申请号：US13784216
申请日：2013-03-04
申请人： Frances S. Ligler , André A. Adams , Michael Daniele , David R. Mott , Peter B. Howell, JR. , Stephanie Fertig , Aron Bobrowski
发明人： Frances S. Ligler , André A. Adams , Michael Daniele , David R. Mott , Peter B. Howell, JR. , Stephanie Fertig , Aron Bobrowski
CPC分类号： C12N5/0697 , A61F2240/001 , B01J19/0093 , B01J2219/00783 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/0093 , B01J2219/00936 , B01L3/502707 , B01L3/502746 , B01L3/502776 , B01L2200/0636 , B01L2200/10 , B01L2200/12 , B01L2300/0838 , B01L2300/0887 , B01L2300/12 , B01L2300/16 , B01L2400/0487 , B01L2400/084 , B29D99/0078 , B29K2995/0056 , B29K2995/006 , B29L2009/00 , B29L2023/00 , C12M21/08 , C12M25/10 , C12M25/12 , C12M25/14 , C12N5/0602 , G02B6/032 , G02B2006/0325
摘要： A fiber includes one or more layers of polymer surrounding a central lumen, and living animal cells disposed within the lumen and/or within at least one of the one or more layers, wherein the fiber has an outer diameter of between 5 and 8000 microns and wherein each individual layer of polymer has a thickness of between 0.1 and 250 microns. Also disclosed are model tissues including such fibers, and method of making such fibers. The fibers can serve as synthetic blood vessels, ducts, or nerves.
摘要翻译： 纤维包括围绕中心腔的一层或多层聚合物，以及设置在内腔内和/或在一层或多层中的至少一层内的活动动物细胞，其中纤维的外径为5至8000微米， 其中每个单独的聚合物层具有0.1至250微米的厚度。 还公开了包括这种纤维的模型组织，以及制造这种纤维的方法。 纤维可以用作合成血管，导管或神经。
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公开(公告)号：US20150328636A1
公开(公告)日：2015-11-19
申请号：US14789440
申请日：2015-07-01
CPC分类号： C12N5/0697 , A61F2240/001 , B01J19/0093 , B01J2219/00783 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/0093 , B01J2219/00936 , B01L3/502707 , B01L3/502746 , B01L3/502776 , B01L2200/0636 , B01L2200/10 , B01L2200/12 , B01L2300/0838 , B01L2300/0887 , B01L2300/12 , B01L2300/16 , B01L2400/0487 , B01L2400/084 , B29D99/0078 , B29K2995/0056 , B29K2995/006 , B29L2009/00 , B29L2023/00 , C12M21/08 , C12M25/10 , C12M25/12 , C12M25/14 , C12N5/0602 , G02B6/032 , G02B2006/0325
摘要： A fiber includes one or more layers of polymer surrounding a central lumen, and living animal cells disposed within the lumen and/or within at least one of the one or more layers, wherein the fiber has an outer diameter of between 5 and 8000 microns and wherein each individual layer of polymer has a thickness of between 0.1 and 250 microns. Also disclosed are model tissues including such fibers, and method of making such fibers. The fibers can serve as synthetic blood vessels, ducts, or nerves.
摘要翻译： 纤维包括围绕中心腔的一层或多层聚合物，以及设置在内腔内和/或在一层或多层中的至少一层内的活动动物细胞，其中纤维的外径为5至8000微米， 其中每个单独的聚合物层具有0.1至250微米的厚度。 还公开了包括这种纤维的模型组织，以及制造这种纤维的方法。 纤维可以用作合成血管，导管或神经。
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公开(公告)号：US20150322408A1
公开(公告)日：2015-11-12
申请号：US14789269
申请日：2015-07-01
IPC分类号： C12N5/071
CPC分类号： C12N5/0697 , A61F2240/001 , B01J19/0093 , B01J2219/00783 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/0093 , B01J2219/00936 , B01L3/502707 , B01L3/502746 , B01L3/502776 , B01L2200/0636 , B01L2200/10 , B01L2200/12 , B01L2300/0838 , B01L2300/0887 , B01L2300/12 , B01L2300/16 , B01L2400/0487 , B01L2400/084 , B29D99/0078 , B29K2995/0056 , B29K2995/006 , B29L2009/00 , B29L2023/00 , C12M21/08 , C12M25/10 , C12M25/12 , C12M25/14 , C12N5/0602 , G02B6/032 , G02B2006/0325
摘要： A fiber includes one or more layers of polymer surrounding a central lumen, and living animal cells disposed within the lumen and/or within at least one of the one or more layers, wherein the fiber has an outer diameter of between 5 and 8000 microns and wherein each individual layer of polymer has a thickness of between 0.1 and 250 microns. Also disclosed are model tissues including such fibers, and method of making such fibers. The fibers can serve as synthetic blood vessels, ducts, or nerves.
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公开(公告)号：US09926534B2
公开(公告)日：2018-03-27
申请号：US14789440
申请日：2015-07-01
IPC分类号： C12N5/071 , B29D99/00 , B01J19/00 , B01L3/00 , G02B6/032 , C12M3/00 , C12M1/12 , B29L9/00 , B29L23/00
CPC分类号： C12N5/0697 , A61F2240/001 , B01J19/0093 , B01J2219/00783 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/0093 , B01J2219/00936 , B01L3/502707 , B01L3/502746 , B01L3/502776 , B01L2200/0636 , B01L2200/10 , B01L2200/12 , B01L2300/0838 , B01L2300/0887 , B01L2300/12 , B01L2300/16 , B01L2400/0487 , B01L2400/084 , B29D99/0078 , B29K2995/0056 , B29K2995/006 , B29L2009/00 , B29L2023/00 , C12M21/08 , C12M25/10 , C12M25/12 , C12M25/14 , C12N5/0602 , G02B6/032 , G02B2006/0325
摘要： A fiber includes one or more layers of polymer surrounding a central lumen, and living animal cells disposed within the lumen and/or within at least one of the one or more layers, wherein the fiber has an outer diameter of between 5 and 8000 microns and wherein each individual layer of polymer has a thickness of between 0.1 and 250 microns. Also disclosed are model tissues including such fibers, and method of making such fibers. The fibers can serve as synthetic blood vessels, ducts, or nerves.
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公开(公告)号：US09157060B2
公开(公告)日：2015-10-13
申请号：US13784216
申请日：2013-03-04
CPC分类号： C12N5/0697 , A61F2240/001 , B01J19/0093 , B01J2219/00783 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/0093 , B01J2219/00936 , B01L3/502707 , B01L3/502746 , B01L3/502776 , B01L2200/0636 , B01L2200/10 , B01L2200/12 , B01L2300/0838 , B01L2300/0887 , B01L2300/12 , B01L2300/16 , B01L2400/0487 , B01L2400/084 , B29D99/0078 , B29K2995/0056 , B29K2995/006 , B29L2009/00 , B29L2023/00 , C12M21/08 , C12M25/10 , C12M25/12 , C12M25/14 , C12N5/0602 , G02B6/032 , G02B2006/0325
摘要： A fiber includes one or more layers of polymer surrounding a central lumen, and living animal cells disposed within the lumen and/or within at least one of the one or more layers, wherein the fiber has an outer diameter of between 5 and 8000 microns and wherein each individual layer of polymer has a thickness of between 0.1 and 250 microns. Also disclosed are model tissues including such fibers, and method of making such fibers. The fibers can serve as synthetic blood vessels, ducts, or nerves.
摘要翻译： 纤维包括围绕中心腔的一层或多层聚合物，以及设置在内腔内和/或在一层或多层中的至少一层内的活动动物细胞，其中纤维的外径为5至8000微米， 其中每个单独的聚合物层具有0.1至250微米的厚度。 还公开了包括这种纤维的模型组织，以及制造这种纤维的方法。 纤维可以用作合成血管，导管或神经。
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公开(公告)号：US10208289B2
公开(公告)日：2019-02-19
申请号：US14789269
申请日：2015-07-01
IPC分类号： C12N5/071 , B29D99/00 , B01J19/00 , B01L3/00 , G02B6/032 , C12M3/00 , C12M1/12 , B29L9/00 , B29L23/00
摘要： A fiber includes one or more layers of polymer surrounding a central lumen, and living animal cells disposed within the lumen and/or within at least one of the one or more layers, wherein the fiber has an outer diameter of between 5 and 8000 microns and wherein each individual layer of polymer has a thickness of between 0.1 and 250 microns. Also disclosed are model tissues including such fibers, and method of making such fibers. The fibers can serve as synthetic blood vessels, ducts, or nerves.
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