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公开(公告)号：US20140087466A1
公开(公告)日：2014-03-27
申请号：US13784216
申请日：2013-03-04
申请人： Frances S. Ligler , André A. Adams , Michael Daniele , David R. Mott , Peter B. Howell, JR. , Stephanie Fertig , Aron Bobrowski
发明人： Frances S. Ligler , André A. Adams , Michael Daniele , David R. Mott , Peter B. Howell, JR. , Stephanie Fertig , Aron Bobrowski
CPC分类号： C12N5/0697 , A61F2240/001 , B01J19/0093 , B01J2219/00783 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/0093 , B01J2219/00936 , B01L3/502707 , B01L3/502746 , B01L3/502776 , B01L2200/0636 , B01L2200/10 , B01L2200/12 , B01L2300/0838 , B01L2300/0887 , B01L2300/12 , B01L2300/16 , B01L2400/0487 , B01L2400/084 , B29D99/0078 , B29K2995/0056 , B29K2995/006 , B29L2009/00 , B29L2023/00 , C12M21/08 , C12M25/10 , C12M25/12 , C12M25/14 , C12N5/0602 , G02B6/032 , G02B2006/0325
摘要： A fiber includes one or more layers of polymer surrounding a central lumen, and living animal cells disposed within the lumen and/or within at least one of the one or more layers, wherein the fiber has an outer diameter of between 5 and 8000 microns and wherein each individual layer of polymer has a thickness of between 0.1 and 250 microns. Also disclosed are model tissues including such fibers, and method of making such fibers. The fibers can serve as synthetic blood vessels, ducts, or nerves.
摘要翻译： 纤维包括围绕中心腔的一层或多层聚合物，以及设置在内腔内和/或在一层或多层中的至少一层内的活动动物细胞，其中纤维的外径为5至8000微米， 其中每个单独的聚合物层具有0.1至250微米的厚度。 还公开了包括这种纤维的模型组织，以及制造这种纤维的方法。 纤维可以用作合成血管，导管或神经。
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公开(公告)号：US10208289B2
公开(公告)日：2019-02-19
申请号：US14789269
申请日：2015-07-01
IPC分类号： C12N5/071 , B29D99/00 , B01J19/00 , B01L3/00 , G02B6/032 , C12M3/00 , C12M1/12 , B29L9/00 , B29L23/00
摘要： A fiber includes one or more layers of polymer surrounding a central lumen, and living animal cells disposed within the lumen and/or within at least one of the one or more layers, wherein the fiber has an outer diameter of between 5 and 8000 microns and wherein each individual layer of polymer has a thickness of between 0.1 and 250 microns. Also disclosed are model tissues including such fibers, and method of making such fibers. The fibers can serve as synthetic blood vessels, ducts, or nerves.
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公开(公告)号：US20150328636A1
公开(公告)日：2015-11-19
申请号：US14789440
申请日：2015-07-01
CPC分类号： C12N5/0697 , A61F2240/001 , B01J19/0093 , B01J2219/00783 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/0093 , B01J2219/00936 , B01L3/502707 , B01L3/502746 , B01L3/502776 , B01L2200/0636 , B01L2200/10 , B01L2200/12 , B01L2300/0838 , B01L2300/0887 , B01L2300/12 , B01L2300/16 , B01L2400/0487 , B01L2400/084 , B29D99/0078 , B29K2995/0056 , B29K2995/006 , B29L2009/00 , B29L2023/00 , C12M21/08 , C12M25/10 , C12M25/12 , C12M25/14 , C12N5/0602 , G02B6/032 , G02B2006/0325
摘要： A fiber includes one or more layers of polymer surrounding a central lumen, and living animal cells disposed within the lumen and/or within at least one of the one or more layers, wherein the fiber has an outer diameter of between 5 and 8000 microns and wherein each individual layer of polymer has a thickness of between 0.1 and 250 microns. Also disclosed are model tissues including such fibers, and method of making such fibers. The fibers can serve as synthetic blood vessels, ducts, or nerves.
摘要翻译： 纤维包括围绕中心腔的一层或多层聚合物，以及设置在内腔内和/或在一层或多层中的至少一层内的活动动物细胞，其中纤维的外径为5至8000微米， 其中每个单独的聚合物层具有0.1至250微米的厚度。 还公开了包括这种纤维的模型组织，以及制造这种纤维的方法。 纤维可以用作合成血管，导管或神经。
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公开(公告)号：US20150322408A1
公开(公告)日：2015-11-12
申请号：US14789269
申请日：2015-07-01
IPC分类号： C12N5/071
CPC分类号： C12N5/0697 , A61F2240/001 , B01J19/0093 , B01J2219/00783 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/0093 , B01J2219/00936 , B01L3/502707 , B01L3/502746 , B01L3/502776 , B01L2200/0636 , B01L2200/10 , B01L2200/12 , B01L2300/0838 , B01L2300/0887 , B01L2300/12 , B01L2300/16 , B01L2400/0487 , B01L2400/084 , B29D99/0078 , B29K2995/0056 , B29K2995/006 , B29L2009/00 , B29L2023/00 , C12M21/08 , C12M25/10 , C12M25/12 , C12M25/14 , C12N5/0602 , G02B6/032 , G02B2006/0325
摘要： A fiber includes one or more layers of polymer surrounding a central lumen, and living animal cells disposed within the lumen and/or within at least one of the one or more layers, wherein the fiber has an outer diameter of between 5 and 8000 microns and wherein each individual layer of polymer has a thickness of between 0.1 and 250 microns. Also disclosed are model tissues including such fibers, and method of making such fibers. The fibers can serve as synthetic blood vessels, ducts, or nerves.
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公开(公告)号：US09926534B2
公开(公告)日：2018-03-27
申请号：US14789440
申请日：2015-07-01
IPC分类号： C12N5/071 , B29D99/00 , B01J19/00 , B01L3/00 , G02B6/032 , C12M3/00 , C12M1/12 , B29L9/00 , B29L23/00
CPC分类号： C12N5/0697 , A61F2240/001 , B01J19/0093 , B01J2219/00783 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/0093 , B01J2219/00936 , B01L3/502707 , B01L3/502746 , B01L3/502776 , B01L2200/0636 , B01L2200/10 , B01L2200/12 , B01L2300/0838 , B01L2300/0887 , B01L2300/12 , B01L2300/16 , B01L2400/0487 , B01L2400/084 , B29D99/0078 , B29K2995/0056 , B29K2995/006 , B29L2009/00 , B29L2023/00 , C12M21/08 , C12M25/10 , C12M25/12 , C12M25/14 , C12N5/0602 , G02B6/032 , G02B2006/0325
摘要： A fiber includes one or more layers of polymer surrounding a central lumen, and living animal cells disposed within the lumen and/or within at least one of the one or more layers, wherein the fiber has an outer diameter of between 5 and 8000 microns and wherein each individual layer of polymer has a thickness of between 0.1 and 250 microns. Also disclosed are model tissues including such fibers, and method of making such fibers. The fibers can serve as synthetic blood vessels, ducts, or nerves.
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公开(公告)号：US09157060B2
公开(公告)日：2015-10-13
申请号：US13784216
申请日：2013-03-04
CPC分类号： C12N5/0697 , A61F2240/001 , B01J19/0093 , B01J2219/00783 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/0093 , B01J2219/00936 , B01L3/502707 , B01L3/502746 , B01L3/502776 , B01L2200/0636 , B01L2200/10 , B01L2200/12 , B01L2300/0838 , B01L2300/0887 , B01L2300/12 , B01L2300/16 , B01L2400/0487 , B01L2400/084 , B29D99/0078 , B29K2995/0056 , B29K2995/006 , B29L2009/00 , B29L2023/00 , C12M21/08 , C12M25/10 , C12M25/12 , C12M25/14 , C12N5/0602 , G02B6/032 , G02B2006/0325
摘要： A fiber includes one or more layers of polymer surrounding a central lumen, and living animal cells disposed within the lumen and/or within at least one of the one or more layers, wherein the fiber has an outer diameter of between 5 and 8000 microns and wherein each individual layer of polymer has a thickness of between 0.1 and 250 microns. Also disclosed are model tissues including such fibers, and method of making such fibers. The fibers can serve as synthetic blood vessels, ducts, or nerves.
摘要翻译： 纤维包括围绕中心腔的一层或多层聚合物，以及设置在内腔内和/或在一层或多层中的至少一层内的活动动物细胞，其中纤维的外径为5至8000微米， 其中每个单独的聚合物层具有0.1至250微米的厚度。 还公开了包括这种纤维的模型组织，以及制造这种纤维的方法。 纤维可以用作合成血管，导管或神经。
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7.发明授权公开(公告)号：US10429376B2
公开(公告)日：2019-10-01
申请号：US12992225
申请日：2009-05-13
摘要： Microdevices are disclosed to efficiently, accurately, and rapidly isolate and enumerate rare cells, such as circulating tumor cells, from liquids such as whole blood. The system employs multiple parallel meandering channels having a width on the order of 1-2 cell diameters. The microdevices can be produced at low-cost, may readily be automated, and in many instances may be used without pre-processing of the sample. They may be used to isolate and enumerate rare cells, including for example the detection and diagnosis of cancers, cancer staging, or evaluating the effectiveness of a therapeutic intervention, or detecting pathogenic bacteria. The device may optionally be used to nondestructively capture and later to release target cells.
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8.发明申请Microfluidic Isolation of Tumor Cells or Other Rare Cells from Whole Blood or Other Liquids 审中-公开来自全血或其他液体的肿瘤细胞或其他罕见细胞的微流控分离公开(公告)号：US20120100521A1
公开(公告)日：2012-04-26
申请号：US12992225
申请日：2009-05-13
CPC分类号： G01N33/49 , B01L3/5027 , B01L2300/0645 , B01L2300/0816 , B01L2300/0864 , B01L2300/0883 , G01N15/1459 , G01N15/1484 , G01N33/4915 , G01N2015/1006
摘要： Microdevices are disclosed to efficiently, accurately, and rapidly isolate and enumerate rare cells, such as circulating tumor cells, from liquids such as whole blood. The system employs multiple parallel meandering channels having a width on the order of 1-2 cell diameters. The microdevices can be produced at low-cost, may readily be automated, and in many instances may be used without pre-processing of the sample. They may be used to isolate and enumerate rare cells, including for example the detection and diagnosis of cancers, cancer staging, or evaluating the effectiveness of a therapeutic intervention, or detecting pathogenic bacteria. The device may optionally be used to nondestructively capture and later to release target cells.
摘要翻译： 公开了微装置，以从诸如全血的液体中有效地，准确地并快速地分离和枚举诸如循环肿瘤细胞的稀有细胞。 该系统采用多个平行的曲折通道，其宽度为1-2个单元直径。 微型器件可以以低成本生产，可以容易地自动化，并且在许多情况下可以使用，而不需要对样品进行预处理。 它们可用于分离和枚举稀有细胞，包括例如癌症的检测和诊断，癌症分期或评估治疗干预的有效性或检测病原菌。 该装置可以可选地用于非破坏性地捕获和稍后释放靶细胞。
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