Fet sensor with specially configured gate electrode for the highly sensitive detection of analytes
    1.
    发明授权
    Fet sensor with specially configured gate electrode for the highly sensitive detection of analytes 失效
    用特殊配置的栅电极对传感器进行高灵敏度的分析物检测

    公开(公告)号:US07632670B2

    公开(公告)日:2009-12-15

    申请号:US10499751

    申请日:2002-12-14

    IPC分类号: C12M1/34

    摘要: Disclosed is a sensor comprising a substrate, a source contact region, a drain contact region, and the gate oxide of a transistor. A gate electrode is disposed between the gate oxide and a detection electrode made of a nonconducting material. The contact area Asens between the gate electrode and the detection electrode is larger than the contact area Agate between the gate electrode and the gate oxide, whereby the receptor can be immobilized on the surface of the detection electrode in a technically simple manner while the small contact area Agate between the gate electrode and the transistor provides for high sensitivity for detecting the analyte. According to the inventive method for detecting at least one analyte, at least one analyte is brought into contact with a receptor immobilized at the detection electrode so as to modify the electrical charge at the surface of the detection electrode. The analyte is detected by detecting the modified voltage in the transistor.

    摘要翻译: 公开了一种传感器,其包括晶体管的基板,源极接触区域,漏极接触区域和栅极氧化物。 栅电极设置在栅极氧化物和由不导电材料制成的检测电极之间。 栅电极和检测电极之间的接触面积Asens大于栅电极和栅极氧化物之间的接触面积玛瑙,由此可以以技术上简单的方式将受体固定在检测电极的表面上,同时小接触 栅电极和晶体管之间的区域玛瑙提供了用于检测分析物的高灵敏度。 根据用于检测至少一种分析物的本发明的方法,至少一种分析物与固定在检测电极处的受体接触,以便改变检测电极表面的电荷。 通过检测晶体管中的修改的电压来检测分析物。

    Fet sensor with specially configured gate electrode for the highly sensitive detection of analytes
    2.
    发明申请
    Fet sensor with specially configured gate electrode for the highly sensitive detection of analytes 失效
    用特殊配置的栅电极对传感器进行高灵敏度的分析物检测

    公开(公告)号:US20050040483A1

    公开(公告)日:2005-02-24

    申请号:US10499751

    申请日:2002-12-14

    摘要: Disclosed is a sensor comprising a substrate, a source contact region, a drain contact region, and the gate oxide of a transistor. A gate electrode is disposed between the gate oxide and a detection electrode made of a nonconducting material. The contact area Asens between the gate electrode and the detection electrode is larger than the contact area Agate between the gate electrode and the gate oxide, whereby the receptor can be immobilized on the surface of the detection electrode in a technically simple manner while the small contact area Agate between the gate electrode and the transistor provides for high sensitivity for detecting the analyte. According to the inventive method for detecting at least one analyte, at least one analyte is brought into contact with a receptor immobilized at the detection electrode so as to modify the electrical charge at the surface of the detection electrode. The analyte is detected by detecting the modified voltage in the transistor.

    摘要翻译: 公开了一种传感器,其包括晶体管的基板,源极接触区域,漏极接触区域和栅极氧化物。 栅电极设置在栅极氧化物和由不导电材料制成的检测电极之间。 栅电极和检测电极之间的接触面积Asens大于栅电极和栅极氧化物之间的接触面积玛瑙,由此可以以技术上简单的方式将受体固定在检测电极的表面上,同时小接触 栅电极和晶体管之间的区域玛瑙提供了用于检测分析物的高灵敏度。 根据用于检测至少一种分析物的本发明的方法,使至少一种分析物与固定在检测电极上的受体接触,以便改变检测电极表面的电荷。 通过检测晶体管中的修改的电压来检测分析物。