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1.发明申请SYSTEMS AND METHODS FOR INTRAVENOUS DRUG MANAGEMENT USING IMMITTANCE SPECTROSCOPY 审中-公开使用轻度光谱进行静脉内药物治疗的系统和方法公开(公告)号：US20140375324A1
公开(公告)日：2014-12-25
申请号：US14457937
申请日：2014-08-12
申请人： Leonid F. MATSIEV , Michael J. WEICKERT , James W. BENNETT , Matthew F. SMITH , Svetlana LITVINTSEVA , Kit BLANKE
发明人： Leonid F. MATSIEV , Michael J. WEICKERT , James W. BENNETT , Matthew F. SMITH , Svetlana LITVINTSEVA , Kit BLANKE
IPC分类号： G01N27/02 , G01N27/416
CPC分类号： G01N27/026 , A61M5/142 , A61M2205/0244 , A61M2205/3306 , A61M2205/3313 , A61M2205/3553 , A61M2205/3561 , A61M2205/6018 , G01N27/4166 , Y02A90/26
摘要： Described herein are devices, systems, and methods for determining the composition of liquids, including the identity of one or more drugs in the liquid, the concentration of the drug, and the type of diluent using immittance spectroscopy. These devices, systems and methods are particularly useful for describing the identity and, in some variations, concentration of one or more components of a medical liquid such as intravenous fluid. In particular, described herein are devices, systems and methods that may operate in low ionic strength diluents. Also described are methods of recognizing complex immittance spectrograph patterns to determine the composition of a liquid by pattern recognition.
摘要翻译： 本文描述了用于确定液体组成的装置，系统和方法，包括液体中一种或多种药物的特性，药物的浓度以及使用导纳光谱法的稀释剂类型。 这些装置，系统和方法对于描述身份以及在一些变型中特别可用于浓缩医疗液体如静脉内液体的一种或多种组分。 特别地，本文描述了可以在低离子强度稀释剂中操作的装置，系统和方法。 还描述了通过模式识别来识别复合导纳光谱仪图案以确定液体的组成的方法。
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2.发明申请SYSTEMS AND METHODS FOR INTRAVENOUS DRUG MANAGEMENT USING IMMITTANCE SPECTROSCOPY 有权使用轻度光谱进行静脉内药物治疗的系统和方法公开(公告)号：US20120065617A1
公开(公告)日：2012-03-15
申请号：US13229597
申请日：2011-09-09
申请人： Leonid F. Matsiev , Michael J. Weickert , James W. Bennett , Matthew F. Smith , Svetlana Litvintseva , Kit Blanke
发明人： Leonid F. Matsiev , Michael J. Weickert , James W. Bennett , Matthew F. Smith , Svetlana Litvintseva , Kit Blanke
CPC分类号： G01N27/026 , A61M5/142 , A61M2205/0244 , A61M2205/3306 , A61M2205/3313 , A61M2205/3553 , A61M2205/3561 , A61M2205/6018 , G01N27/4166 , Y02A90/26
摘要： Described herein are devices, systems, and methods for determining the composition of liquids, including the identity of one or more drugs in the liquid, the concentration of the drug, and the type of diluent using immittance spectroscopy. These devices, systems and methods are particularly useful for describing the identity and, in some variations, concentration of one or more components of a medical liquid such as intravenous fluid. In particular, described herein are devices, systems and methods that may operate in low ionic strength diluents. Also described are methods of recognizing complex immittance spectrograph patterns to determine the composition of a liquid by pattern recognition.
摘要翻译： 本文描述了用于确定液体组成的装置，系统和方法，包括液体中一种或多种药物的特性，药物的浓度以及使用导纳光谱法的稀释剂类型。 这些装置，系统和方法对于描述身份以及在一些变型中特别可用于浓缩医疗液体如静脉内液体的一种或多种组分。 特别地，本文描述了可以在低离子强度稀释剂中操作的装置，系统和方法。 还描述了通过模式识别来识别复合导纳光谱仪图案以确定液体的组成的方法。
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3.发明授权公开(公告)号：US07049406B2
公开(公告)日：2006-05-23
申请号：US10107871
申请日：2002-03-27
申请人： Michael J Weickert , Christopher B Glascock , Antony J Mathews , Douglas D Lemon , Daniel H Doherty , John S Olson
发明人： Michael J Weickert , Christopher B Glascock , Antony J Mathews , Douglas D Lemon , Daniel H Doherty , John S Olson
IPC分类号： C07K14/00
CPC分类号： C07K14/805 , A61K38/00
摘要： The invention relates to novel recombinant hemoglobins having reduced nitric oxide scavenging and/or increased high soluble expression. The invention further relates to methods of increasing the soluble expression of recombinant hemoglobin by adding exogenous hemin in molar excess of the heme binding sites of recombinant hemoglobin.
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4.发明授权Systems and methods for the identification of compounds in medical fluids using admittance spectroscopy 有权使用导纳光谱法鉴定医用液体中化合物的系统和方法公开(公告)号：US09173600B2
公开(公告)日：2015-11-03
申请号：US12796567
申请日：2010-06-08
IPC分类号： G01N27/06 , G01N30/96 , G01N27/12 , G01N27/60 , A61B5/145 , A61B5/00 , A61M5/172 , G01N27/02 , A61B5/1455
CPC分类号： A61B5/145 , A61B5/14557 , A61B5/4839 , A61B5/7267 , A61M5/172 , A61M2205/3523 , A61M2205/3592 , G01N27/026
摘要： Described herein are devices, systems, and methods for determining the composition of fluids, and particularly for describing the identity and concentration of one or more components of a medical fluid such as intravenous fluid. These devices, systems and methods take multiple complex admittance measurements from a fluid sample in order to identify the identity and the concentration of components of the fluid. The identity and concentration of all of the components of the solution may be simultaneously and rapidly determined. In some variations, additional measurement or sensing modalities may be used in addition to admittance spectroscopy, including optical, thermal, chemical, etc.
摘要翻译： 本文描述了用于确定流体组成的装置，系统和方法，特别是用于描述诸如静脉内流体的医用流体的一种或多种组分的特性和浓度。 这些装置，系统和方法从流体样品进行多次复杂的导纳测量，以便识别流体的组分的身份和浓度。 可以同时快速地确定溶液的所有组分的特性和浓度。 在一些变型中，除导纳光谱外，还可以使用额外的测量或感测方式，包括光学，热学，化学等。
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5.发明授权Hemoglobin mutants with increased soluble expression and/or reduced nitric oxide scavenging 失效具有增加的可溶性表达和/或减少的一氧化氮清除的血红蛋白突变体公开(公告)号：US06455676B1
公开(公告)日：2002-09-24
申请号：US09403208
申请日：2000-04-25
申请人： Michael J. Weickert , Christopher B. Glascock , Antony J. Mathews , Douglas D. Lemon , Daniel H. Doherty , John S. Olson
发明人： Michael J. Weickert , Christopher B. Glascock , Antony J. Mathews , Douglas D. Lemon , Daniel H. Doherty , John S. Olson
IPC分类号： C07K14805
CPC分类号： C07K14/805 , A61K38/00
摘要： The invention relates to novel recombinant hemoglobins having reduced nitric oxide scavenging and/or increased high soluble expression. The invention further relates to methods of increasing the soluble expression of recombinant hemoglobin by adding exogenous hemin in molar excess of the heme binding sites of recombinant hemoglobin.
摘要翻译： 本发明涉及具有减少的一氧化氮清除和/或增加的高可溶性表达的新型重组血红蛋白。 本发明还涉及通过在重组血红蛋白的血红素结合位点的摩尔过量中加入外源血红素来增加重组血红蛋白的可溶性表达的方法。
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6.发明授权Systems and methods for intravenous drug management using immittance spectroscopy 有权使用导纳光谱法进行静脉药物管理的系统和方法公开(公告)号：US08838395B2
公开(公告)日：2014-09-16
申请号：US13229597
申请日：2011-09-09
申请人： Leonid F. Matsiev , Michael J. Weickert , James W. Bennett , Matthew F. Smith , Svetlana Litvintseva , Kit Blanke
发明人： Leonid F. Matsiev , Michael J. Weickert , James W. Bennett , Matthew F. Smith , Svetlana Litvintseva , Kit Blanke
IPC分类号： G01N31/00
CPC分类号： G01N27/026 , A61M5/142 , A61M2205/0244 , A61M2205/3306 , A61M2205/3313 , A61M2205/3553 , A61M2205/3561 , A61M2205/6018 , G01N27/4166 , Y02A90/26
摘要： Described herein are devices, systems, and methods for determining the composition of liquids, including the identity of one or more drugs in the liquid, the concentration of the drug, and the type of diluent using immittance spectroscopy. These devices, systems and methods are particularly useful for describing the identity and, in some variations, concentration of one or more components of a medical liquid such as intravenous fluid. In particular, described herein are devices, systems and methods that may operate in low ionic strength diluents. Also described are methods of recognizing complex immittance spectrograph patterns to determine the composition of a liquid by pattern recognition.
摘要翻译： 本文描述了用于确定液体组成的装置，系统和方法，包括液体中一种或多种药物的特性，药物的浓度以及使用导纳光谱法的稀释剂类型。 这些装置，系统和方法对于描述身份以及在一些变型中特别可用于浓缩医疗液体如静脉内液体的一种或多种组分。 特别地，本文描述了可以在低离子强度稀释剂中操作的装置，系统和方法。 还描述了通过模式识别来识别复合导纳光谱仪图案以确定液体的组成的方法。
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7.发明申请SYSTEMS AND METHODS FOR THE IDENTIFICATION OF COMPOUNDS IN MEDICAL FLUIDS USING ADMITTANCE SPECTROSCOPY 有权用化学光谱法鉴定医用液体中化合物的系统和方法公开(公告)号：US20100305499A1
公开(公告)日：2010-12-02
申请号：US12796567
申请日：2010-06-08
CPC分类号： A61B5/145 , A61B5/14557 , A61B5/4839 , A61B5/7267 , A61M5/172 , A61M2205/3523 , A61M2205/3592 , G01N27/026
摘要： Described herein are devices, systems, and methods for determining the composition of fluids, and particularly for describing the identity and concentration of one or more components of a medical fluid such as intravenous fluid. These devices, systems and methods take multiple complex admittance measurements from a fluid sample in order to identify the identity and the concentration of components of the fluid. The identity and concentration of all of the components of the solution may be simultaneously and rapidly determined. In some variations, additional measurement or sensing modalities may be used in addition to admittance spectroscopy, including optical, thermal, chemical, etc.
摘要翻译： 本文描述了用于确定流体组成的装置，系统和方法，特别是用于描述诸如静脉内流体的医用流体的一种或多种组分的特性和浓度。 这些装置，系统和方法从流体样品进行多次复杂的导纳测量，以便识别流体的组分的身份和浓度。 可以同时快速地确定溶液的所有组分的特性和浓度。 在一些变型中，除导纳光谱外，还可以使用额外的测量或感测方式，包括光学，热学，化学等。
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