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公开(公告)号：US07078217B2
公开(公告)日：2006-07-18
申请号：US10354983
申请日：2003-01-31
申请人： Christopher J. Corcoran , Michael J. Agostino , Edward R. LaVallie , Carl R. Flannery , Lisa A. Collins-Racie
发明人： Christopher J. Corcoran , Michael J. Agostino , Edward R. LaVallie , Carl R. Flannery , Lisa A. Collins-Racie
CPC分类号： C12N9/6421 , A61K2039/505
摘要： Novel aggrecanase proteins and the nucleotide sequences encoding them as well as processes for producing them are disclosed. Methods of identifying and developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.
摘要翻译： 公开了新型聚蛋白聚糖蛋白聚糖蛋白和编码它们的核苷酸序列以及其制备方法。 还公开了鉴定和发展聚蛋白聚糖蛋白酶的抑制剂和用于治疗由聚集蛋白聚糖蛋白降解特征的病症的酶的抗体的方法。
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公开(公告)号：US20080139452A1
公开(公告)日：2008-06-12
申请号：US12000468
申请日：2007-12-13
申请人： Kenneth Jacobs , John M. McCoy , Edward R. LaVallie , Lisa A. Collins-Racie , David Merberg , Michael J. Agostino , Robert Steininger , Vikki Spaulding , Gordon G. Wong , Hilary F. Clark , Kim Fechtel , Cheryl Evans , Maurice Treacy
发明人： Kenneth Jacobs , John M. McCoy , Edward R. LaVallie , Lisa A. Collins-Racie , David Merberg , Michael J. Agostino , Robert Steininger , Vikki Spaulding , Gordon G. Wong , Hilary F. Clark , Kim Fechtel , Cheryl Evans , Maurice Treacy
CPC分类号： C07K16/18 , A61K38/00 , C07K14/435 , C07K14/47
摘要： Novel polynucleotides and the proteins encoded thereby are disclosed.
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公开(公告)号：US07344861B2
公开(公告)日：2008-03-18
申请号：US11395249
申请日：2006-04-03
申请人： Kenneth Jacobs , John M. McCoy , Edward R. LaVallie , Lisa A. Collins-Racie , David Merberg , Michael J. Agostino , Robert J. Steininger, II , Vikki Spaulding , Gordon G. Wong , Hilary F. Clark , Kim Fechtel , Cheryl Evans , Maurice Treacy
发明人： Kenneth Jacobs , John M. McCoy , Edward R. LaVallie , Lisa A. Collins-Racie , David Merberg , Michael J. Agostino , Robert J. Steininger, II , Vikki Spaulding , Gordon G. Wong , Hilary F. Clark , Kim Fechtel , Cheryl Evans , Maurice Treacy
CPC分类号： C07K16/18 , A61K38/00 , C07K14/435 , C07K14/47
摘要： Novel polynucleotides and the proteins encoded thereby are disclosed.
摘要翻译： 公开了新的多核苷酸和由此编码的蛋白质。
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公开(公告)号：US07223858B2
公开(公告)日：2007-05-29
申请号：US11488340
申请日：2006-07-18
申请人： Katy E. Georgiadis , Tara K. Crawford , Kathleen N. Tomkinson , Lisa A. Collins-Racie , Christopher J. Corcoran , Bethany A. Freeman , Edward R. LaVallie
发明人： Katy E. Georgiadis , Tara K. Crawford , Kathleen N. Tomkinson , Lisa A. Collins-Racie , Christopher J. Corcoran , Bethany A. Freeman , Edward R. LaVallie
CPC分类号： C12N9/6421
摘要： Truncated aggrecanase proteins and nucleotides sequences encoding them as well as processes for producing them are disclosed. Additionally, aggrecanases with amino acid mutations that lead to increased stability and expression levels in comparison with wild-type or native aggrecanases are also disclosed. Aggrecanases of the invention are especially useful for development of compositions for treatment of diseases such as osteoarthritis. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.
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公开(公告)号：US20090012053A1
公开(公告)日：2009-01-08
申请号：US11901513
申请日：2007-09-18
IPC分类号： A61K31/575 , A61K31/18 , A61K31/195 , A61K31/506 , A61K31/42 , A61P19/02 , C12Q1/68
CPC分类号： A61K31/00 , A61K31/18 , A61K31/195 , A61K31/404 , A61K31/42 , A61K31/513 , A61K31/575 , A61K31/58 , G01N33/6875 , G01N2333/70567 , G01N2800/105
摘要： Disclosed herein are methods of preventing and treating osteoarthritis through the use of LXR agonists.
摘要翻译： 本文公开了通过使用LXR激动剂预防和治疗骨关节炎的方法。
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公开(公告)号：US07625731B2
公开(公告)日：2009-12-01
申请号：US11467138
申请日：2006-08-24
申请人： Lydia Mosyak , Thomas Saltmarsh Rush, III , Stephane Hubert Olland , Edward R. LaVallie , Lisa A. Collins-Racie , Christopher John Corcoran , Stewart Andrews Mackie
发明人： Lydia Mosyak , Thomas Saltmarsh Rush, III , Stephane Hubert Olland , Edward R. LaVallie , Lisa A. Collins-Racie , Christopher John Corcoran , Stewart Andrews Mackie
CPC分类号： C12N9/6421 , C07K2299/00 , C30B7/00
摘要： This invention relates to aggrecanase polypeptides and aggrecanase polypeptide/ligand complexes, crystals of aggrecanase and aggrecanase polypeptide/ligand complexes, and related methods and software systems.
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公开(公告)号：US07615363B2
公开(公告)日：2009-11-10
申请号：US11467135
申请日：2006-08-24
申请人： Lidia Mosyak , Thomas Saltmarsh Rush, III , Xiaotian Zhong , Thomas E. McDonagh , Katy E. Georgiadis , Phaik-Eng Sum , Edward R. LaVallie , Lisa A. Collins-Racie , Christopher John Corcoran , Ravindra Kumar , Tracy Hebert , Stephane Hubert Olland , Stewart Andrews Mackie
发明人： Lidia Mosyak , Thomas Saltmarsh Rush, III , Xiaotian Zhong , Thomas E. McDonagh , Katy E. Georgiadis , Phaik-Eng Sum , Edward R. LaVallie , Lisa A. Collins-Racie , Christopher John Corcoran , Ravindra Kumar , Tracy Hebert , Stephane Hubert Olland , Stewart Andrews Mackie
CPC分类号： C12N9/6421 , C07K2299/00 , C07K2319/00
摘要： This invention relates to aggrecanase polypeptides and aggrecanase polypeptide/ligand complexes, crystals of aggrecanase and aggrecanase polypeptide/ligand complexes, and related methods and software systems.
摘要翻译： 本发明涉及聚集蛋白聚糖酶多肽和聚集蛋白聚糖蛋白聚糖酶多肽/配体复合物，聚集蛋白聚糖蛋白聚糖酶和聚集蛋白聚糖酶多肽/配体复合物的晶体，以及相关的方法和软件系统。
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8.发明授权Protein kinase C zeta as a drug target for arthritis and other inflammatory diseases 失效蛋白激酶Cζ作为关节炎和其他炎性疾病的药物靶点公开(公告)号：US07638482B2
公开(公告)日：2009-12-29
申请号：US10842142
申请日：2004-05-10
CPC分类号： G01N33/564 , G01N33/6872 , G01N2333/91215 , G01N2500/00 , G01N2800/102
摘要： The present invention is based on the discovery that ζPKC expression is increased in the tissues of arthritis patients as compared to normal individuals. Accordingly, the present invention provides methods of diagnosing, prognosing, and monitoring the course of arthritis in a patient based on increased ζPKC gene expression in arthritic tissue. The present invention further provides compounds that inhibit the expression of ζPKC for use as remedies in the treatment of arthritis, including, but not limited to, inhibitory polynucleotides and polypeptides, small molecules, and peptide inhibitors. In addition, the present invention provides pharmaceutical formulations and routes of administration for such remedies, as well as methods for assessing their efficacy.
摘要翻译： 本发明基于与正常个体相比，关节炎患者组织中zetaPKC表达增加的发现。 因此，本发明提供了基于关节炎组织中增加的zetaPKC基因表达来诊断，预测和监测患者关节炎过程的方法。 本发明还提供抑制zetaPKC表达用作治疗关节炎的药物的化合物，包括但不限于抑制性多核苷酸和多肽，小分子和肽抑制剂。 此外，本发明提供了药物制剂和用于此类治疗方法的给药途径，以及评估其疗效的方法。
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9.发明申请PROTEIN KINASE C ZETA AS A DRUG TARGET FOR ARTHRITIS AND OTHER INFLAMMATORY DISEASES 审中-公开蛋白激酶C ZETA作为ARTHRITIS和其他炎症疾病的药物目标公开(公告)号：US20100062448A1
公开(公告)日：2010-03-11
申请号：US12616484
申请日：2009-11-11
IPC分类号： C12Q1/68 , C12Q1/02 , C12Q1/48 , A61K31/7088 , C07H21/02
CPC分类号： G01N33/564 , G01N33/6872 , G01N2333/91215 , G01N2500/00 , G01N2800/102
摘要： The present invention is based on the discovery that ζPKC expression is increased in the tissues of arthritis patients as compared to normal individuals. Accordingly, the present invention provides methods of diagnosing, prognosing, and monitoring the course of arthritis in a patient based on increased ζPKC gene expression in arthritic tissue. The present invention further provides compounds that inhibit the expression of ζPKC for use as remedies in the treatment of arthritis, including, but not limited to, inhibitory polynucleotides and polypeptides, small molecules, and peptide inhibitors. In addition, the present invention provides pharmaceutical formulations and routes of administration for such remedies, as well as methods for assessing their efficacy.
摘要翻译： 本发明基于与正常个体相比，关节炎患者组织中ζPKC表达增加的发现。 因此，本发明提供了基于关节炎组织中ζPKC基因表达增加来诊断，预测和监测患者关节炎过程的方法。 本发明进一步提供抑制ζPKC表达用于治疗关节炎的药物的化合物，包括但不限于抑制性多核苷酸和多肽，小分子和肽抑制剂。 此外，本发明提供了药物制剂和用于此类治疗方法的给药途径，以及评估其疗效的方法。
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公开(公告)号：US07118902B2
公开(公告)日：2006-10-10
申请号：US10628432
申请日：2003-07-29
申请人： Christopher John Corcoran , Carl R. Flannery , Weilan Zeng , Lisa A. Racie , Thomas McDonagh , Bethany A. Freeman , Katy E. Georgiadis , Edward R. LaVallie
发明人： Christopher John Corcoran , Carl R. Flannery , Weilan Zeng , Lisa A. Racie , Thomas McDonagh , Bethany A. Freeman , Katy E. Georgiadis , Edward R. LaVallie
CPC分类号： C12N9/6489 , A61K2039/505
摘要： The present invention relates to modified ADAMTS4 proteins having improved stability comparing to the corresponding native, unmodified proteins. The modified ADAMTS4 proteins can be expressed and isolated in large quantities, thus allowing further characterization of the proteins, such as crystallographic and enzyme kinetic studies. The purified, stable proteins would also facilitate the production of anti-ADAMTS antibodies and the development of inhibitors to ADAMTS enzymes.
摘要翻译： 本发明涉及与相应的天然未修饰蛋白相比具有改进的稳定性的修饰的ADAMTS4蛋白。 修饰的ADAMTS4蛋白可以大量表达和分离，从而进一步表征蛋白质，如晶体学和酶动力学研究。 纯化的稳定蛋白质也有助于抗ADAMTS抗体的产生和ADAMTS酶抑制剂的开发。
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