公开(公告)号：US20110092823A1

公开(公告)日：2011-04-21

申请号：US12839165

申请日：2010-07-19

申请人： Guillermo J. Tearney ,  Milen Stefanov Shishkov ,  Nicursor V. Iftimia ,  Brett E. Bouma ,  Martha Pitman

发明人： Guillermo J. Tearney ,  Milen Stefanov Shishkov ,  Nicursor V. Iftimia ,  Brett E. Bouma ,  Martha Pitman

IPC分类号： A61B6/00

CPC分类号： A61B5/6852 ,  A61B5/0066 ,  A61B5/415 ,  A61B5/416 ,  A61B5/418 ,  A61B5/6848

摘要： An apparatus for needle biopsy with real time tissue differentiation using one dimensional interferometric ranging imaging, comprising a biopsy device having a barrel and a needle, an optical fiber inserted in the needle, and a fiber optic imaging system connected to the optical fiber. The imaging system obtains images and compares the optical properties and patterns to a database of normalized tissue sample images to determine different tissue types. The physician performing the biopsy obtains feedback via a feedback unit associated with the biopsy device and which is connected to the imaging system. The feedback unit can provide visual, audible or vibratory feedback as to tissue type encountered when the needle is inserted toward the target tissue. The feedback unit can be programmed for different biopsy procedures so that the user can actuate a button to select a display or other feedback mechanism for the desired procedure and anticipated tissue to be encountered.

摘要翻译： 一种使用一维干涉测量成像的实时组织分化的针活检装置，包括具有镜筒和针的活检装置，插入针中的光纤以及连接到光纤的光纤成像系统。 成像系统获得图像并将光学性质和图案与标准化组织样本图像的数据库进行比较，以确定不同的组织类型。 执行活组织检查的医师通过与活检装置相关联的反馈单元获得反馈，并且连接到成像系统。 反馈单元可以提供关于当针朝向目标组织插入时遇到的组织类型的视觉，听觉或振动反馈。 反馈单元可以被编程用于不同的活检程序，使得用户可以致动按钮以选择用于期望的程序和所期望的组织的显示器或其他反馈机构。

公开(公告)号：US09295391B1

公开(公告)日：2016-03-29

申请号：US09709162

申请日：2000-11-10

申请人： Guillermo J. Tearney ,  Brett Eugene Bouma ,  Milen Stefanov Shishkov ,  Jonathan Jay Rosen

发明人： Guillermo J. Tearney ,  Brett Eugene Bouma ,  Milen Stefanov Shishkov ,  Jonathan Jay Rosen

IPC分类号： A61B6/00 ,  A61B5/00

CPC分类号： A61B5/0059 ,  A61B1/00096 ,  A61B1/0017 ,  A61B1/043 ,  A61B1/07 ,  A61B5/0062 ,  A61B5/0071 ,  A61B5/0084 ,  G02B21/0036 ,  G02B21/0048 ,  G02B21/0064

摘要： A spectrally encoded endoscopic probe having high resolution and small diameter comprising at least one flexible optical fiber; an energy source; a grating through which said energy is transmitted such that the energy spectrum is dispersed; a lens for focusing the dispersed energy spectrum onto a sample such that the impingement spot for each wavelength is a separate position on the sample, the wavelength spectrum defining a wavelength encoded axis; means for mechanically scanning the sample with focused energy in a direction perpendicular to the wavelength encoded axis; a means for receiving energy reflected from the sample; and, a means for detecting the received reflected energy. The probe grating and lens delivers a beam of multi-spectral light having spectral components extending in one dimension across a target region and which is moved to scan in another direction. The reflected spectrum is measured to provide two dimensional imaging of the region.

摘要翻译： 一种具有高分辨率和小直径的光谱编码内窥镜探针，包括至少一个柔性光纤; 能源; 所述能量通过所述光栅传播，使得能谱被分散; 用于将分散的能谱聚焦到样品上的透镜，使得每个波长的冲击点是样品上的分离位置，所述波长谱定义波长编码轴; 用于在垂直于波长编码轴的方向上以聚焦能量机械扫描样品的装置; 用于接收样品反射的能量的方法; 以及用于检测所接收的反射能量的装置。 探测光栅和透镜提供具有在一个维度上延伸穿过目标区域并且被移动以沿另一个方向扫描的光谱分量的多光谱光束。 测量反射光谱以提供该区域的二维成像。

公开(公告)号：US20110275899A1

公开(公告)日：2011-11-10

申请号：US13187106

申请日：2011-07-20

申请人： Guillermo J. Tearney ,  Brett Eugene Bouma ,  Milen Stefanov Shishkov ,  Jonathan Jay Rosen

发明人： Guillermo J. Tearney ,  Brett Eugene Bouma ,  Milen Stefanov Shishkov ,  Jonathan Jay Rosen

IPC分类号： A61B1/06

CPC分类号： A61B5/0059 ,  A61B1/00096 ,  A61B1/0017 ,  A61B1/043 ,  A61B1/07 ,  A61B5/0062 ,  A61B5/0071 ,  A61B5/0084 ,  G02B21/0036 ,  G02B21/0048 ,  G02B21/0064

摘要： A spectrally encoded endoscopic probe having high resolution and small diameter comprising at least one flexible optical fiber; an energy source; a grating through which said energy is transmitted such that the energy spectrum is dispersed; a lens for focusing the dispersed energy spectrum onto a sample such that the impingement spot for each wavelength is a separate position on the sample, the wavelength spectrum defining a wavelength encoded axis; means for mechanically scanning the sample with focused energy in a direction perpendicular to the wavelength encoded axis; a means for receiving energy reflected from the sample; and, a means for detecting the received reflected energy. The probe grating and lens delivers a beam of multi-spectral light having spectral components extending in one dimension across a target region and which is moved to scan in another direction. The reflected spectrum is measured to provide two dimensional imaging of the region.

摘要翻译： 一种具有高分辨率和小直径的光谱编码内窥镜探针，包括至少一个柔性光纤; 能源; 所述能量通过所述光栅传播，使得能谱被分散; 用于将分散的能谱聚焦到样品上的透镜，使得每个波长的冲击点是样品上的分离位置，所述波长谱定义波长编码轴; 用于在垂直于波长编码轴的方向上以聚焦能量机械扫描样品的装置; 用于接收样品反射的能量的方法; 以及用于检测所接收的反射能量的装置。 探测光栅和透镜提供具有在一个维度上延伸穿过目标区域并且被移动以沿另一个方向扫描的光谱分量的多光谱光束。 测量反射光谱以提供该区域的二维成像。

公开(公告)号：US07761139B2

公开(公告)日：2010-07-20

申请号：US10765430

申请日：2004-01-26

申请人： Guillermo J. Tearney ,  Milen Stefanov Shishkov ,  Nicusor V. Iftimia ,  Brett E. Bouma ,  Martha Pitman

发明人： Guillermo J. Tearney ,  Milen Stefanov Shishkov ,  Nicusor V. Iftimia ,  Brett E. Bouma ,  Martha Pitman

IPC分类号： A61B5/00

CPC分类号： A61B5/6852 ,  A61B5/0066 ,  A61B5/415 ,  A61B5/416 ,  A61B5/418 ,  A61B5/6848

摘要： An apparatus for needle biopsy with real time tissue differentiation using one dimensional interferometric ranging imaging, comprising a biopsy device having a barrel and a needle, an optical fiber inserted in the needle, and a fiber optic imaging system connected to the optical fiber. The imaging system obtains images and compares the optical properties and patterns to a database of normalized tissue sample images to determine different tissue types. The physician performing the biopsy obtains feedback via a feedback unit associated with the biopsy device and which is connected to the imaging system. The feedback unit can provide visual, audible or vibratory feedback as to tissue type encountered when the needle is inserted toward the target tissue. The feedback unit can be programmed for different biopsy procedures so that the user can actuate a button to select a display or other feedback mechanism for the desired procedure and anticipated tissue to be encountered.

摘要翻译： 一种使用一维干涉测量成像的实时组织分化的针活检装置，包括具有镜筒和针的活检装置，插入针中的光纤以及连接到光纤的光纤成像系统。 成像系统获得图像并将光学性质和图案与标准化组织样本图像的数据库进行比较，以确定不同的组织类型。 执行活组织检查的医师通过与活检装置相关联的反馈单元获得反馈，并且连接到成像系统。 反馈单元可以提供关于当针朝向目标组织插入时遇到的组织类型的视觉，听觉或振动反馈。 反馈单元可以被编程用于不同的活检程序，使得用户可以致动按钮以选择用于期望的程序和所期望的组织的显示器或其他反馈机构。