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公开(公告)号：US09295391B1
公开(公告)日：2016-03-29
申请号：US09709162
申请日：2000-11-10
CPC分类号： A61B5/0059 , A61B1/00096 , A61B1/0017 , A61B1/043 , A61B1/07 , A61B5/0062 , A61B5/0071 , A61B5/0084 , G02B21/0036 , G02B21/0048 , G02B21/0064
摘要： A spectrally encoded endoscopic probe having high resolution and small diameter comprising at least one flexible optical fiber; an energy source; a grating through which said energy is transmitted such that the energy spectrum is dispersed; a lens for focusing the dispersed energy spectrum onto a sample such that the impingement spot for each wavelength is a separate position on the sample, the wavelength spectrum defining a wavelength encoded axis; means for mechanically scanning the sample with focused energy in a direction perpendicular to the wavelength encoded axis; a means for receiving energy reflected from the sample; and, a means for detecting the received reflected energy. The probe grating and lens delivers a beam of multi-spectral light having spectral components extending in one dimension across a target region and which is moved to scan in another direction. The reflected spectrum is measured to provide two dimensional imaging of the region.
摘要翻译： 一种具有高分辨率和小直径的光谱编码内窥镜探针，包括至少一个柔性光纤; 能源; 所述能量通过所述光栅传播，使得能谱被分散; 用于将分散的能谱聚焦到样品上的透镜，使得每个波长的冲击点是样品上的分离位置，所述波长谱定义波长编码轴; 用于在垂直于波长编码轴的方向上以聚焦能量机械扫描样品的装置; 用于接收样品反射的能量的方法; 以及用于检测所接收的反射能量的装置。 探测光栅和透镜提供具有在一个维度上延伸穿过目标区域并且被移动以沿另一个方向扫描的光谱分量的多光谱光束。 测量反射光谱以提供该区域的二维成像。
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公开(公告)号：US20110275899A1
公开(公告)日：2011-11-10
申请号：US13187106
申请日：2011-07-20
IPC分类号： A61B1/06
CPC分类号： A61B5/0059 , A61B1/00096 , A61B1/0017 , A61B1/043 , A61B1/07 , A61B5/0062 , A61B5/0071 , A61B5/0084 , G02B21/0036 , G02B21/0048 , G02B21/0064
摘要： A spectrally encoded endoscopic probe having high resolution and small diameter comprising at least one flexible optical fiber; an energy source; a grating through which said energy is transmitted such that the energy spectrum is dispersed; a lens for focusing the dispersed energy spectrum onto a sample such that the impingement spot for each wavelength is a separate position on the sample, the wavelength spectrum defining a wavelength encoded axis; means for mechanically scanning the sample with focused energy in a direction perpendicular to the wavelength encoded axis; a means for receiving energy reflected from the sample; and, a means for detecting the received reflected energy. The probe grating and lens delivers a beam of multi-spectral light having spectral components extending in one dimension across a target region and which is moved to scan in another direction. The reflected spectrum is measured to provide two dimensional imaging of the region.
摘要翻译： 一种具有高分辨率和小直径的光谱编码内窥镜探针，包括至少一个柔性光纤; 能源; 所述能量通过所述光栅传播，使得能谱被分散; 用于将分散的能谱聚焦到样品上的透镜，使得每个波长的冲击点是样品上的分离位置，所述波长谱定义波长编码轴; 用于在垂直于波长编码轴的方向上以聚焦能量机械扫描样品的装置; 用于接收样品反射的能量的方法; 以及用于检测所接收的反射能量的装置。 探测光栅和透镜提供具有在一个维度上延伸穿过目标区域并且被移动以沿另一个方向扫描的光谱分量的多光谱光束。 测量反射光谱以提供该区域的二维成像。
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3.发明申请System and Method for Identifying Tissue Using Low-Coherence Interferometry 审中-公开使用低相干干涉法识别组织的系统和方法公开(公告)号：US20110092823A1
公开(公告)日：2011-04-21
申请号：US12839165
申请日：2010-07-19
申请人： Guillermo J. Tearney , Milen Stefanov Shishkov , Nicursor V. Iftimia , Brett E. Bouma , Martha Pitman
发明人： Guillermo J. Tearney , Milen Stefanov Shishkov , Nicursor V. Iftimia , Brett E. Bouma , Martha Pitman
IPC分类号： A61B6/00
CPC分类号： A61B5/6852 , A61B5/0066 , A61B5/415 , A61B5/416 , A61B5/418 , A61B5/6848
摘要： An apparatus for needle biopsy with real time tissue differentiation using one dimensional interferometric ranging imaging, comprising a biopsy device having a barrel and a needle, an optical fiber inserted in the needle, and a fiber optic imaging system connected to the optical fiber. The imaging system obtains images and compares the optical properties and patterns to a database of normalized tissue sample images to determine different tissue types. The physician performing the biopsy obtains feedback via a feedback unit associated with the biopsy device and which is connected to the imaging system. The feedback unit can provide visual, audible or vibratory feedback as to tissue type encountered when the needle is inserted toward the target tissue. The feedback unit can be programmed for different biopsy procedures so that the user can actuate a button to select a display or other feedback mechanism for the desired procedure and anticipated tissue to be encountered.
摘要翻译： 一种使用一维干涉测量成像的实时组织分化的针活检装置，包括具有镜筒和针的活检装置，插入针中的光纤以及连接到光纤的光纤成像系统。 成像系统获得图像并将光学性质和图案与标准化组织样本图像的数据库进行比较，以确定不同的组织类型。 执行活组织检查的医师通过与活检装置相关联的反馈单元获得反馈，并且连接到成像系统。 反馈单元可以提供关于当针朝向目标组织插入时遇到的组织类型的视觉，听觉或振动反馈。 反馈单元可以被编程用于不同的活检程序，使得用户可以致动按钮以选择用于期望的程序和所期望的组织的显示器或其他反馈机构。
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4.发明授权公开(公告)号：US07761139B2
公开(公告)日：2010-07-20
申请号：US10765430
申请日：2004-01-26
申请人： Guillermo J. Tearney , Milen Stefanov Shishkov , Nicusor V. Iftimia , Brett E. Bouma , Martha Pitman
发明人： Guillermo J. Tearney , Milen Stefanov Shishkov , Nicusor V. Iftimia , Brett E. Bouma , Martha Pitman
IPC分类号： A61B5/00
CPC分类号： A61B5/6852 , A61B5/0066 , A61B5/415 , A61B5/416 , A61B5/418 , A61B5/6848
摘要： An apparatus for needle biopsy with real time tissue differentiation using one dimensional interferometric ranging imaging, comprising a biopsy device having a barrel and a needle, an optical fiber inserted in the needle, and a fiber optic imaging system connected to the optical fiber. The imaging system obtains images and compares the optical properties and patterns to a database of normalized tissue sample images to determine different tissue types. The physician performing the biopsy obtains feedback via a feedback unit associated with the biopsy device and which is connected to the imaging system. The feedback unit can provide visual, audible or vibratory feedback as to tissue type encountered when the needle is inserted toward the target tissue. The feedback unit can be programmed for different biopsy procedures so that the user can actuate a button to select a display or other feedback mechanism for the desired procedure and anticipated tissue to be encountered.
摘要翻译： 一种使用一维干涉测量成像的实时组织分化的针活检装置，包括具有镜筒和针的活检装置，插入针中的光纤以及连接到光纤的光纤成像系统。 成像系统获得图像并将光学性质和图案与标准化组织样本图像的数据库进行比较，以确定不同的组织类型。 执行活组织检查的医师通过与活检装置相关联的反馈单元获得反馈，并且连接到成像系统。 反馈单元可以提供关于当针朝向目标组织插入时遇到的组织类型的视觉，听觉或振动反馈。 反馈单元可以被编程用于不同的活检程序，使得用户可以致动按钮以选择用于期望的程序和所期望的组织的显示器或其他反馈机构。
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5.发明申请METHODS, SYSTEMS, ARRANGEMENTS AND COMPUTER-ACCESSIBLE MEDIUM FOR PROVIDING MICRO-OPTICAL COHERENCE TOMOGRAPHY PROCEDURES 审中-公开方法，系统，安排和计算机可访问介质，用于提供微光学相干计算机程序公开(公告)号：US20150253240A1
公开(公告)日：2015-09-10
申请号：US14240938
申请日：2012-08-27
申请人： Steven M. Rowe , Guillermo J. Tearney , Brett Eugene Bouma , Linbo Liu , Eric J. Sorscher , Kengyeh Ken Chu , Bradford James Diephuis , Eric James Wilsterman , Gregory Andrew Dierksen
发明人： Steven M. Rowe , Guillermo J. Tearney , Brett Eugene Bouma , Linbo Liu , Eric J. Sorscher , Kengyeh Ken Chu , Bradford James Diephuis , Eric James Wilsterman , Gregory Andrew Dierksen
CPC分类号： G01N21/17 , G01B9/02044 , G01B9/0205 , G01B9/02091 , G01J3/45 , G01J9/02 , G01N15/0205 , G01N15/14 , G01N21/35 , G01N21/45 , G01N21/4788 , G01N21/4795 , G01N21/6458 , G01N21/6486 , G01N29/00 , G01N2021/653 , G01N2021/655
摘要： Exemplary apparatus and method can be provided for obtaining data regarding a plurality of samples. For example, using at least one arrangement, it is possible to receive interferometric information that is based on radiations provided from a reference and the samples that are provided in respective chambers. Alternatively and/or in addition, based on the interferometric information, it is possible to discriminate between agents to identify a particular agent that affects a particular function within at least one of the samples.
摘要翻译： 可以提供示例性的装置和方法来获得关于多个样本的数据。 例如，使用至少一种布置，可以接收基于从参考提供的辐射和在各个室中提供的样本的干涉信息。 可选地和/或另外，基于干涉信息，可以区分代理以识别影响至少一个样本内的特定功能的特定代理。
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6.发明申请APPARATUS AND METHOD FOR OBTAINING AND PROVIDING IMAGING INFORMATION ASSOCIATED WITH AT LEAST ONE PORTION OF A SAMPLE, AND EFFECTING SUCH PORTION(S) 有权用于获取和提供与至少一个样品部分相关的成像信息的装置和方法，以及影响这些部分公开(公告)号：US20130066215A1
公开(公告)日：2013-03-14
申请号：US13614459
申请日：2012-09-13
IPC分类号： A61B1/07
CPC分类号： A61B1/07 , A61B5/0066 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B18/22 , A61B2017/00061
摘要： Exemplary apparatus and process can be provided for imaging information associated with at least one portion of a sample. For example, (i) first different wavelengths of at least one first electro-magnetic radiation can be provided within a first wavelength range provided on the portion of the sample so as to determine at least one first transverse location of the portion, and (ii) second different wavelengths of at least one second electro-magnetic radiation within a second wavelength range can be provided on the portion so as to determine at least one second transverse location of the portion. The first and second ranges can east partially overlap on the portion. Further, a relative phase between at least one third electro-magnetic radiation electro-magnetic radiation being returned from the sample and at least one fourth electro-magnetic radiation returned from a reference can be obtained to determine a relative depth location of the portion.
摘要翻译： 可以提供示例性装置和过程用于与样品的至少一部分相关联的成像信息。 例如，（i）可在提供在样品部分上的第一波长范围内提供至少一个第一电磁辐射的第一不同波长，以便确定该部分的至少一个第一横向位置，和（ii ）可以在该部分上提供在第二波长范围内的至少一个第二电磁辐射的第二不同波长，以便确定该部分的至少一个第二横向位置。 第一和第二范围可以在该部分上部分重叠。 此外，可以获得从样品返回的至少一个第三电磁辐射电磁辐射与从基准返回的至少一个第四电磁辐射之间的相对相位，以确定该部分的相对深度位置。
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7.发明申请公开(公告)号：US20110255561A1
公开(公告)日：2011-10-20
申请号：US13003983
申请日：2009-07-14
IPC分类号： H01S3/10
摘要： Exemplary embodiments of apparatus according to the present disclosure are provided. For example, an apparatus for providing electromagnetic radiation to a structure can be provided. In one exemplary embodiment, the apparatus can provide at least one electromagnetic radiation, and include at least one first arrangement which can be configured to generate the electromagnetic radiation(s) having at least one wavelength that varies over time. The exemplary apparatus can also include at least one second arrangement which can be configured to power the first arrangement(s) independently from an external power source. In another exemplary embodiment the apparatus can include at least one particular arrangement which is configured to generate the electromagnetic radiation(s) having at least one wavelength that varies over time. The particular arrangement(s) can include a resonant cavity that has a roundtrip optical transit time of approximately less than 0.7 nsec.
摘要翻译： 提供了根据本公开的装置的示例性实施例。 例如，可以提供用于向结构提供电磁辐射的装置。 在一个示例性实施例中，该装置可以提供至少一个电磁辐射，并且包括至少一个第一布置，其可被配置为产生具有随时间变化的至少一个波长的电磁辐射。 示例性装置还可以包括至少一个第二装置，其可被配置为独立于外部电源为第一装置供电。 在另一个示例性实施例中，装置可以包括至少一个特定布置，其被配置为产生具有随时间变化的至少一个波长的电磁辐射。 具体布置可以包括谐振腔，其具有大约小于0.7纳秒的往返光通过时间。
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公开(公告)号：US08032200B2
公开(公告)日：2011-10-04
申请号：US11534095
申请日：2006-09-21
IPC分类号： A61B5/00
CPC分类号： A61B5/6885 , A61B1/00082 , A61B1/0615 , A61B1/07 , A61B5/0066 , A61B5/0068 , A61B5/0075 , A61B5/0084 , A61B5/02007 , A61B5/7207 , A61B5/7257 , G01N21/49
摘要： The invention relates to methods and systems to optically analyze samples such as tissue based on speckle patterns of microscopic motion, such as Brownian motion.
摘要翻译： 本发明涉及基于诸如布朗运动的微观运动的斑纹图案光学分析诸如组织的样品的方法和系统。
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9.发明授权Methods and systems for performing angle-resolved fourier-domain optical coherence tomography 有权用于进行角度分辨的傅里叶变换光学相干断层扫描的方法和系统公开(公告)号：US07982879B2
公开(公告)日：2011-07-19
申请号：US11677278
申请日：2007-02-21
IPC分类号： G01B9/02
CPC分类号： G01N21/4795 , A61B5/0066 , A61B5/0073 , G01B9/02043 , G01B9/02087 , G01B9/02091 , G01B2290/70 , G01N2021/4714
摘要： Arrangements, apparatus and methods are provided according to exemplary embodiments of the present invention. In particular, at least one first electro-magnetic radiation may be received and at least one second electro-magnetic radiation within a solid angle may be forwarded to a sample. The second electro-magnetic radiation may be associated with the first electro-magnetic radiation. A plurality of third electro-magnetic radiations can be received from the sample which is associated with the second electro-magnetic radiation, and at least one portion of the third electro-magnetic radiation is provided outside a periphery of the solid angle. Signals associated with each of the third electro-magnetic radiations can be simultaneously detected, with the signals being associated with information for the sample at a plurality of depths thereof. The depths can be determined using at least one of the third electro-magnetic radiations without a need to utilize another one of the third electro-magnetic radiations.
摘要翻译： 根据本发明的示例性实施例提供了安排，装置和方法。 特别地，可以接收至少一个第一电磁辐射，并且将立体角内的至少一个第二电磁辐射转发到样品。 第二电磁辐射可以与第一电磁辐射相关联。 可以从与第二电磁辐射相关联的样品接收多个第三电磁辐射，并且第三电磁辐射的至少一部分设置在立体角的外围。 可以同时检测与每个第三电磁辐射相关联的信号，其中信号与样品在其多个深度处的信息相关联。 可以使用第三电磁辐射中的至少一个来确定深度，而不需要利用第三电磁辐射中的另一个。
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10.发明授权Apparatus and method for ranging and noise reduction of low coherence interferometry (LCI) and optical coherence tomography (OCT) signals by parallel detection of spectral bands 有权用于通过光谱带的并行检测的低相干干涉测量（LCI）和光学相干断层扫描（OCT）信号的测距和降噪的装置和方法公开(公告)号：US07903257B2
公开(公告)日：2011-03-08
申请号：US11954794
申请日：2007-12-12
CPC分类号： G01B9/02007 , A61B5/0059 , A61B5/0066 , A61B5/7257 , G01B9/02008 , G01B9/0201 , G01B9/02032 , G01B9/02044 , G01B9/02045 , G01B9/02079 , G01B9/0209 , G01B9/02091 , G01B2290/45 , G01N21/4795
摘要： Apparatus and method for increasing the sensitivity in the detection of optical coherence tomography and low coherence interferometry (“LCI”) signals by detecting a parallel set of spectral bands, each band being a unique combination of optical frequencies. The LCI broad bandwidth source is split into N spectral bands. The N spectral bands are individually detected and processed to provide an increase in the signal-to-noise ratio by a factor of N. Each spectral band is detected by a separate photo detector and amplified. For each spectral band the signal is band pass filtered around the signal band by analog electronics and digitized, or, alternatively, the signal may be digitized and band pass filtered in software. As a consequence, the shot noise contribution to the signal is reduced by a factor equal to the number of spectral bands. The signal remains the same. The reduction of the shot noise increases the dynamic range and sensitivity of the system.
摘要翻译： 通过检测并行的一组光谱带来增加光学相干断层扫描和低相干干涉测量（“LCI”）信号的灵敏度的装置和方法，每个频带是光频率的唯一组合。 LCI宽带宽源分为N个频谱带。 N个光谱带被单独检测和处理，以使信噪比增加N倍。每个光谱带由单独的光检测器检测并被放大。 对于每个光谱带，信号通过模拟电子装置在信号带周围进行带通滤波，并且被数字化，或者，信号可以被数字化并且在软件中进行带通滤波。 结果，对信号的散粒噪声贡献减小了等于光谱带数的因子。 信号保持不变。 喷射噪声的降低增加了系统的动态范围和灵敏度。
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