公开(公告)号：US09012088B2

公开(公告)日：2015-04-21

申请号：US12918864

申请日：2008-08-07

申请人： Eun Suok Oh ,  Young Min Kim ,  Ok Sun Kim ,  Min Ah Kang

发明人： Eun Suok Oh ,  Young Min Kim ,  Ok Sun Kim ,  Min Ah Kang

IPC分类号： H01M4/02 ,  H01M4/134 ,  H01M4/04 ,  H01M4/133 ,  H01M4/136 ,  H01M4/1393 ,  H01M4/1395 ,  H01M4/1397 ,  H01M4/62 ,  H01M4/66 ,  H01M10/052

CPC分类号： H01M4/134 ,  H01M4/0404 ,  H01M4/133 ,  H01M4/136 ,  H01M4/1393 ,  H01M4/1395 ,  H01M4/1397 ,  H01M4/621 ,  H01M4/622 ,  H01M4/624 ,  H01M4/625 ,  H01M4/626 ,  H01M4/661 ,  H01M10/052 ,  H01M2004/021 ,  H01M2004/027 ,  Y02E60/122

摘要： An anode composition for a lithium secondary battery is provided. The anode composition comprises an anode active material, a conductive material, and an acrylonitrile-acrylic acid copolymer with a high molecular weight as a binder. The acrylonitrile-acrylic acid copolymer has a molar ratio of acrylonitrile to acrylic acid of 1:0.01-2. Further provided are a method for preparing the anode composition and a lithium secondary battery using the anode composition. The binder has improved resistance to an electrolyte solution due to its enhanced adhesive strength. In addition, the use of the anode composition prevents the active material layer from being peeled off or separated from a current collector during charge and discharge to achieve improved capacity and cycle life characteristics of the battery.

摘要翻译： 提供了一种用于锂二次电池的阳极组合物。 阳极组合物包含阳极活性材料，导电材料和具有高分子量的丙烯腈 - 丙烯酸共聚物作为粘合剂。 丙烯腈 - 丙烯酸共聚物的丙烯腈与丙烯酸的摩尔比为1:0.01-2。 还提供了制备阳极组合物的方法和使用阳极组合物的锂二次电池。 粘合剂由于其增强的粘合强度而改善了对电解质溶液的耐受性。 此外，使用阳极组合物可防止活性物质层在充放电期间从集电体剥离或分离，以实现电池的改善的容量和循环寿命特性。

公开(公告)号：US20110003207A1

公开(公告)日：2011-01-06

申请号：US12918864

申请日：2008-08-07

申请人： Eun Suok Oh ,  Young Min Kim ,  Ok Sun Kim ,  Min Ah Kang

发明人： Eun Suok Oh ,  Young Min Kim ,  Ok Sun Kim ,  Min Ah Kang

IPC分类号： H01M4/583 ,  H01B1/12 ,  H01B1/24 ,  H01B1/22 ,  H01M4/02 ,  H01M4/58 ,  H01M4/04

CPC分类号： H01M4/134 ,  H01M4/0404 ,  H01M4/133 ,  H01M4/136 ,  H01M4/1393 ,  H01M4/1395 ,  H01M4/1397 ,  H01M4/621 ,  H01M4/622 ,  H01M4/624 ,  H01M4/625 ,  H01M4/626 ,  H01M4/661 ,  H01M10/052 ,  H01M2004/021 ,  H01M2004/027 ,  Y02E60/122

摘要： An anode composition for a lithium secondary battery is provided. The anode composition comprises an anode active material, a conductive material, and an acrylonitrile-acrylic acid copolymer with a high molecular weight as a binder. The acrylonitrile-acrylic acid copolymer has a molar ratio of acrylonitrile to acrylic acid of 1:0.01-2. Further provided are a method for preparing the anode composition and a lithium secondary battery using the anode composition. The binder has improved resistance to an electrolyte solution due to its enhanced adhesive strength. In addition, the use of the anode composition prevents the active material layer from being peeled off or separated from a current collector during charge and discharge to achieve improved capacity and cycle life characteristics of the battery.

摘要翻译： 提供了一种用于锂二次电池的阳极组合物。 阳极组合物包含阳极活性材料，导电材料和具有高分子量的丙烯腈 - 丙烯酸共聚物作为粘合剂。 丙烯腈 - 丙烯酸共聚物的丙烯腈与丙烯酸的摩尔比为1:0.01-2。 还提供了制备阳极组合物的方法和使用阳极组合物的锂二次电池。 粘合剂由于其增强的粘合强度而改善了对电解质溶液的耐受性。 此外，使用阳极组合物可防止活性物质层在充放电期间从集电体剥离或分离，以实现电池的改善的容量和循环寿命特性。

公开(公告)号：US09075066B2

公开(公告)日：2015-07-07

申请号：US12679879

申请日：2009-04-21

申请人： Hee Gu Lee ,  Eun Young Song ,  Min Ah Kang ,  Jong Tae Kim ,  Jae Wha Kim ,  Young Il Yeom ,  Seon Young Kim ,  Kyung Chan Park

发明人： Hee Gu Lee ,  Eun Young Song ,  Min Ah Kang ,  Jong Tae Kim ,  Jae Wha Kim ,  Young Il Yeom ,  Seon Young Kim ,  Kyung Chan Park

IPC分类号： G01N33/53 ,  G01N33/574 ,  C12Q1/68

CPC分类号： G01N33/57446 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N2500/04

摘要： The present invention relates to a biomarker for gastric cancer, CST1 (cysteine proteinase inhibitor, type 2 family), DCC1 (Defective in sister chromatid cohesion homolog 1), IFITM1 (interferon induced transmembrane protein 1) or MELK (maternal embryonic leucine zipper kinase). More particularly, the present invention relates to a diagnostic composition for gastric cancer comprising an agent measuring the expression level of CST1, DCC1, IFITM1 or MELK, a kit comprising the composition, a method for detecting the marker, and a method for screening a therapeutic agent for gastric cancer using the marker.

摘要翻译： 本发明涉及胃癌生物标志物，CST1（半胱氨酸蛋白酶抑制剂，2型家族），DCC1（姐妹染色单体内聚同系物1缺陷），IFITM1（干扰素诱导的跨膜蛋白1）或MELK（母体白蛋白亮氨酸拉链激酶） 。 更具体地，本发明涉及用于胃癌的诊断组合物，其包含测量CST1，DCC1，IFITM1或MELK的表达水平的试剂，包含该组合物的试剂盒，用于检测标记物的方法和用于筛选治疗 使用标记的胃癌药物。

公开(公告)号：US20110201512A1

公开(公告)日：2011-08-18

申请号：US12822556

申请日：2010-06-24

申请人： Hee Gu Lee ,  Eun Young Song ,  Young II Yeom ,  Jae Wha Kim ,  Jong Tae Kim ,  Kyung Sook Chung ,  Mi Sun Won ,  Hyun Hyo Suh ,  Joo Woong Park ,  Min Ah Kang

发明人： Hee Gu Lee ,  Eun Young Song ,  Young II Yeom ,  Jae Wha Kim ,  Jong Tae Kim ,  Kyung Sook Chung ,  Mi Sun Won ,  Hyun Hyo Suh ,  Joo Woong Park ,  Min Ah Kang

IPC分类号： C40B30/04 ,  C12Q1/68 ,  G01N33/574

CPC分类号： G01N33/57419 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158

摘要： The present invention relates to a method for detecting a colon cancer in a human, comprising the steps of: (a) providing a biological sample from the human; and (b) detecting the level of a ATAD2 nucleic acid or a ATAD2 protein in the biological sample, relative to the level of the ATAD2 nucleic acid or the ATAD2 protein in a control sample from a normal human, wherein an increased level of the ATAD2 nucleic acid or the ATAD2 protein in the biological sample compared to the control sample indicates that the human has the colon cancer. The biomarker of this invention was identified using normal colon tissue, colon cancer tissue and metastatic cancer tissue derived from a colon cancer patient. Therefore, the accuracy and reliability of the present biomarker for colon cancer and/or metastasis are much more significantly improved. In addition, the biomarker of this invention permits to identify and predict colon cancer or metastasis in an accurate manner.

摘要翻译： 本发明涉及一种检测人类结肠癌的方法，包括以下步骤：（a）从人体提供生物样品; 相对于来自正常人的对照样品中的ATAD2核酸或ATAD2蛋白的水平，检测生物样品中ATAD2核酸或ATAD2蛋白的水平，其中ATAD2的升高水平 与对照样品相比，生物样品中的核酸或ATAD2蛋白表明人类具有结肠癌。 使用来自结肠癌患者的正常结肠组织，结肠癌组织和转移性癌组织鉴定本发明的生物标志物。 因此，目前用于结肠癌和/或转移的生物标志物的准确性和可靠性大大提高。 此外，本发明的生物标志物允许以准确的方式鉴定和预测结肠癌或转移。

公开(公告)号：US20110152106A1

公开(公告)日：2011-06-23

申请号：US12679879

申请日：2009-04-21

申请人： Hee Gu Lee ,  Eun Young Song ,  Min Ah Kang ,  Jong Tae Kim ,  Eun Hwa Choi ,  Hyo Ran Yoon ,  Jae Wha Kim

发明人： Hee Gu Lee ,  Eun Young Song ,  Min Ah Kang ,  Jong Tae Kim ,  Eun Hwa Choi ,  Hyo Ran Yoon ,  Jae Wha Kim

IPC分类号： C40B30/00 ,  C07H21/00 ,  C07K16/00 ,  C12Q1/68 ,  C40B40/06 ,  C40B40/10 ,  G01N33/53

CPC分类号： G01N33/57446 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N2500/04

摘要： The present invention relates to a biomarker for gastric cancer, CST1 (cysteine proteinase inhibitor, type 2 family), DCC1 (Defective in sister chromatid cohesion homolog 1), IFITM1 (interferon induced transmembrane protein 1) or MELK (maternal embryonic leucine zipper kinase). More particularly, the present invention relates to a diagnostic composition for gastric cancer comprising an agent measuring the expression level of CST1, DCC1, IFITM1 or MELK, a kit comprising the composition, a method for detecting the marker, and a method for screening a therapeutic agent for gastric cancer using the marker.

摘要翻译： 本发明涉及胃癌生物标志物，CST1（半胱氨酸蛋白酶抑制剂，2型家族），DCC1（姐妹染色单体内聚同系物1缺陷），IFITM1（干扰素诱导的跨膜蛋白1）或MELK（母体白蛋白亮氨酸拉链激酶） 。 更具体地，本发明涉及用于胃癌的诊断组合物，其包含测量CST1，DCC1，IFITM1或MELK的表达水平的试剂，包含该组合物的试剂盒，用于检测标记物的方法和用于筛选治疗 使用标记的胃癌药物。