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18 条记录 (耗时 0.014 秒)

    Stilbene derivatives for ADP-ribosyl cyclase inhibitors
    3.
    发明授权
    Stilbene derivatives for ADP-ribosyl cyclase inhibitors 有权
    ADP-核糖基环化酶抑制剂的二苯乙烯衍生物

    公开(公告)号：US08314082B2

    公开(公告)日：2012-11-20

    申请号：US13149166

    申请日：2011-05-31

    申请人： Uh-Hyun Kim ,  Ho-Jeong Kwon ,  Mie-Jae Im ,  Seon-Young Kim ,  Kwang-Hyun Park ,  So-Young Rah ,  Tae-Sik Nam ,  Byung-Ju Kim ,  Gul Rukhsana

    发明人： Uh-Hyun Kim ,  Ho-Jeong Kwon ,  Mie-Jae Im ,  Seon-Young Kim ,  Kwang-Hyun Park ,  So-Young Rah ,  Tae-Sik Nam ,  Byung-Ju Kim ,  Gul Rukhsana

    IPC分类号： A61K31/05

    CPC分类号： C07C245/08 ,  C07C39/215

    摘要： The present disclosure relates to bisphenyl compounds that are useful for inhibiting the ADP-ribosyl cyclase (ADPR-cyclase). More particularly, the disclosed compounds can be used for treatment and prevention of hypertension, hypertensive cardiac hypertrophy, diabetes, and diabetic nephropathy, in which pathogenesis ADPR-cyclase is involved. The compounds and compositions of the invention can be used for treatment and prevention of cardiovascular disease and related disease states, particularly, hypertension or diabetes related disorders, such as, hypertensive cardiac hypertrophy, diabetic nephropathy, and the like.

    摘要翻译： 本公开涉及可用于抑制ADP-核糖基环化酶（ADPR-环化酶）的双苯基化合物。 更具体地，所公开的化合物可用于治疗和预防涉及发病机制ADPR-环化酶的高血压，高血压心脏肥大，糖尿病和糖尿病性肾病。 本发明的化合物和组合物可用于治疗和预防心血管疾病和相关疾病状态，特别是高血压或糖尿病相关疾病，例如高血压心脏肥大，糖尿病性肾病等。

    SNP FOR PREDICTING THE SENSITIVITY TO ANTICANCER TARGETED THERAPEUTIC FORMULATION
    6.
    发明申请
    SNP FOR PREDICTING THE SENSITIVITY TO ANTICANCER TARGETED THERAPEUTIC FORMULATION 审中-公开
    用于预测抗精神病药物治疗药物灵敏度的SNP

    公开(公告)号：US20130190200A1

    公开(公告)日：2013-07-25

    申请号：US13704423

    申请日：2010-12-08

    申请人： Jin Cheon Kim ,  Yong Sung Kim ,  Seon Young Kim ,  Dong Hyung Cho

    发明人： Jin Cheon Kim ,  Yong Sung Kim ,  Seon Young Kim ,  Dong Hyung Cho

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/156

    摘要： The present invention relates to a single nucleotide polymorphism (SNP) for predicting the sensitivity to an anticancer targeted therapeutic formulation, a polynucleotide containing the same, and a method for predicting the sensitivity to an anticancer targeted therapeutic formulation. According to the present invention, it is possible to predict the sensitivity of each individual to a certain anticancer targeted therapeutic formulation, using a small amount of a sample taken from a patient and thus to select a most suitable targeted therapeutic formulation over the entire duration of treatment for the patient.

    摘要翻译： 本发明涉及用于预测对抗癌靶向治疗制剂的敏感性的单核苷酸多态性（SNP），含有该制剂的多核苷酸，以及预测对抗癌靶向治疗剂型的敏感性的方法。 根据本发明，可以使用少量来自患者的样品来预测每个个体对某种抗癌靶向治疗剂型的敏感性，从而在整个持续时间内选择最合适的靶向治疗制剂 治疗病人。

    Regenerator and cryocooler using the same
    8.
    发明授权
    Regenerator and cryocooler using the same 有权
    再生器和低温冷冻机使用相同

    公开(公告)号：US07275375B2

    公开(公告)日：2007-10-02

    申请号：US10965918

    申请日：2004-10-18

    申请人： Seon-Young Kim

    发明人： Seon-Young Kim

    IPC分类号： F25B9/00 ,  F28D17/00

    CPC分类号： F25B9/14 ,  F25B2309/001 ,  F25B2309/003 ,  F25B2309/1415

    摘要： A regenerator includes a casing including a connection channel for making a high temperature part and a cooling part communicate with each other; and a thermal energy storage material inserted in the connection channel of the casing and made of an aramid fiber which stores/radiates heat of a working fluid flowing through the connection channel. A cryocooler includes the regenerator. Accordingly, regeneration performance of storing heat included in the working fluid and transmitting the stored heat to a working fluid is improved, and simultaneously a weight is decreased, thereby minimizing abrasion of components.

    摘要翻译： 再生器包括：壳体，其包括用于使高温部件和冷却部件相互连通的连接通道; 以及插入在壳体的连接通道中并由芳族聚酰胺纤维制成的热能储存材料，其存储/辐射流过连接通道的工作流体的热量。 一个低温冷却器包括再生器。 因此，提高了包含在工作流体中并将储存的热量传递到工作流体的再生性能，并且同时减轻了重量，从而使部件的磨损最小化。

    Regenerator and cryocooler using the same
    9.
    发明申请
    Regenerator and cryocooler using the same 有权
    再生器和低温冷冻机使用相同

    公开(公告)号：US20050223715A1

    公开(公告)日：2005-10-13

    申请号：US10965918

    申请日：2004-10-18

    申请人： Seon-Young Kim

    发明人： Seon-Young Kim

    IPC分类号： F25B9/00 ,  C09K5/08 ,  F25B9/14

    CPC分类号： F25B9/14 ,  F25B2309/001 ,  F25B2309/003 ,  F25B2309/1415

    摘要： A regenerator includes a casing including a connection channel for making a high temperature part and a cooling part communicate with each other; and a thermal energy storage material inserted in the connection channel of the casing and made of an aramid fiber which stores/radiates heat of a working fluid flowing through the connection channel. A cryocooler includes the regenerator. Accordingly, regeneration performance of storing heat included in the working fluid and transmitting the stored heat to a working fluid is improved, and simultaneously a weight is decreased, thereby minimizing abrasion of components.

    摘要翻译： 再生器包括：壳体，其包括用于使高温部件和冷却部件相互连通的连接通道; 以及插入在壳体的连接通道中并由芳族聚酰胺纤维制成的热能储存材料，其存储/辐射流过连接通道的工作流体的热量。 一个低温冷却器包括再生器。 因此，提高了包含在工作流体中并将储存的热量传递到工作流体的再生性能，并且同时减轻了重量，从而使部件的磨损最小化。