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1.发明申请RADIO FREQUENCY ENERGY TRANSMISSION DEVICE FOR THE ABLATION OF BIOLOGICAL TISSUES 审中-公开用于消除生物组织的无线电频率能量传输装置公开(公告)号：US20090082762A1
公开(公告)日：2009-03-26
申请号：US11858736
申请日：2007-09-20
IPC分类号： A61B18/18
CPC分类号： A61B18/14 , A61B18/18 , A61B18/1815 , A61B2017/00243 , A61B2018/00577 , H01Q11/08
摘要： A radio frequency energy transmission device comprises a hollow coaxial electrically conductive cable adapted for conduction of radio frequency (RF) energy, particularly microwave energy, for the ablation of biological tissue. The hollow cable has a proximal end and a distal end and comprises coaxial inner and outer conductors extending substantially the entire length of the cable from the proximal end to a distal end portion of the cable. The inner conductor comprises an elongated electrically conductive tubular member having a hollow, axially extending lumen, and the outer conductor comprises an elongated electrically conductive tubular member disposed in a substantially coaxial relationship over at least a portion of the inner conductor. Dielectricity to impede conduction between the inner and outer conductors is introduced with a vacuum or dielectric medium disposed between the inner and outer conductors. An ablating member, which delivers radio frequency energy, particularly microwave energy, to body tissue is disposed at a distal end portion of the cable. The ablating member can be a helical coil, a monopole of a microstrip circuit.
摘要翻译： 射频能量传输装置包括适于传导射频（RF）能量，特别是微波能量的中空同轴导电电缆，用于生物组织的消融。 中空电缆具有近端和远端，并且包括同轴的内部和外部导体，其基本上从电缆的近端延伸到电缆的远端部分的整个长度。 内导体包括具有中空的轴向延伸的内腔的细长的导电管状构件，并且外导体包括在内导体的至少一部分上以基本上同轴的关系设置的细长的导电管状构件。 导电内阻和外导体之间的导通电介质被设置在内导体和外导体之间的真空或电介质介质。 将电波能量特别是微波能量的消融部件设置在电缆的远端部分。 烧蚀构件可以是螺旋线圈，微带电路的单极子。
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公开(公告)号：US07004938B2
公开(公告)日：2006-02-28
申请号：US10306757
申请日：2002-11-27
IPC分类号： A61B18/18
CPC分类号： H01Q1/42 , A61B18/1492 , A61B2017/003 , A61B2017/00867 , A61B2018/00357 , A61B2018/00839 , C08L2201/12
摘要： A RF catheter system includes a catheter with a proximal portion, a distal portion having a distal end and a lumen extending from the proximal portion to the distal portion. Inner and outer coaxially aligned conductors extend within the catheter and are coaxial with the lumen. A deflectable catheter guide is disposed within the catheter lumen and extends proximally within the catheter lumen and terminates distally of the distal end of the catheter to define a biological ablation pathway. A radio-frequency antenna is disposed at the distal portion of the catheter and is in electrical communication with the inner and outer coaxially aligned conductors. The radio-frequency antenna is adaptable to receive and transmit radio-frequency energy for ablating biological tissue along the ablation pathway.
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3.发明授权Preformed catheter set for use with a linear ablation system to produce ablation lines in the left and right atrium for treatment of atrial fibrillation 有权用于线性消融系统的预成型导管组，用于在左心房和右心房产生消融线，用于治疗房颤公开(公告)号：US06941953B2
公开(公告)日：2005-09-13
申请号：US10772861
申请日：2004-02-06
CPC分类号： A61B18/1492 , A61B2018/183
摘要： A preformed catheter set for production of linear ablation lines in the left and right atrium for treatment of atrial fibrillation includes at least a first catheter including a pre-shaped distal segment having a distal linear ablation antenna and a U-shaped curve portion proximal to the distal linear ablation antenna.
摘要翻译： 用于在左心房和右心房中产生线性消融线的预成型导管组用于治疗房颤包括至少第一导管，其包括具有远端线性消融天线的预形远端区段和靠近 远端线性消融天线。
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4.发明授权Hollow conductive coaxial cable for radio frequency based tissue ablation system 有权中空导电同轴电缆，用于基于射频的组织消融系统公开(公告)号：US08308722B2
公开(公告)日：2012-11-13
申请号：US11781467
申请日：2007-07-23
申请人： Theodore C. Ormsby , George L. Leung , Gwo Jenn Shen , Peter Chu , Ming Fan Law
发明人： Theodore C. Ormsby , George L. Leung , Gwo Jenn Shen , Peter Chu , Ming Fan Law
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B2017/003 , A61B2018/00839 , A61B2018/00916 , A61B2018/00946 , A61B2018/183
摘要： A hollow coaxial cable adapted for conduction of radio frequency (RF) energy, particularly microwave energy, has a proximal end and a distal end and comprises coaxial inner and outer conductors extending substantially the entire length of the cable from the proximal end to a distal end portion of the cable with a dielectric medium disposed between the inner and outer conductors. The inner conductor comprises an elongated electrically conductive tubular member having a hollow, axially extending lumen, and the outer conductor comprises an elongated electrically conductive tubular member disposed in a substantially coaxial relationship over at least a portion of the inner conductor. An ablating member which delivers radio frequency energy, particularly microwave energy, to body tissue is disposed at a distal end portion of the cable.
摘要翻译： 适于传导射频（RF）能量，特别是微波能量的中空同轴电缆具有近端和远端，并且包括同轴的内部和外部导体，其基本上从近端延伸到远端的整个长度 电缆的一部分，其中介电介质设置在内导体和外导体之间。 内导体包括具有中空的轴向延伸的内腔的细长的导电管状构件，并且外导体包括在内导体的至少一部分上以基本上同轴的关系设置的细长的导电管状构件。 将电波能量，特别是微波能量传送到身体组织的消融部件设置在电缆的远端部分。
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5.发明授权Radio-frequency-based catheter system with improved deflection and steering mechanisms 有权射频导管系统具有改进的偏转和转向机制公开(公告)号：US07815637B2
公开(公告)日：2010-10-19
申请号：US11359808
申请日：2006-02-22
IPC分类号： A61B18/18
CPC分类号： H01Q1/42 , A61B18/1492 , A61B2017/003 , A61B2017/00867 , A61B2018/00357 , A61B2018/00839 , C08L2201/12
摘要： A RF catheter system includes a catheter with a proximal portion, a distal portion having a distal end and a lumen extending from the proximal portion to the distal portion. Inner and outer coaxially aligned conductors extend within the catheter and are coaxial with the lumen. A deflectable catheter guide is disposed within the catheter lumen and extends proximally within the catheter lumen and terminates distally of the distal end of the catheter to define a biological ablation pathway. A radio-frequency antenna is disposed at the distal portion of the catheter and is in electrical communication with the inner and outer coaxially aligned conductors. The radio-frequency antenna is adaptable to receive and transmit radio-frequency energy for ablating biological tissue along the ablation pathway.
摘要翻译： RF导管系统包括具有近端部分的导管，远侧部分具有远端，以及从近端部分延伸到远端部分的内腔。 内部和外部同轴对准的导体在导管内延伸并且与内腔同轴。 导管导管设置在导管内腔内并且在导管内腔内向近侧延伸并且终止于导管远端的远端以限定生物消融通路。 射频天线设置在导管的远端部分并且与内部和外部同轴对齐的导体电连通。 射频天线适于接收和发射用于沿着消融路径烧蚀生物组织的射频能量。
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6.发明授权Radio-frequency based catheter system and hollow co-axial cable for ablation of body tissues 有权射频导管系统和空心同轴电缆，用于身体组织的消融公开(公告)号：US06663625B1
公开(公告)日：2003-12-16
申请号：US09459058
申请日：1999-12-11
IPC分类号： A61B1818
CPC分类号： A61B18/18 , A61B18/1492 , A61B18/1815 , A61B90/39 , A61B2017/003 , A61B2018/00839 , A61B2018/1407 , A61B2018/1437 , A61B2018/1861
摘要： An improved radio-frequency catheter system for ablating biological tissues of a body vessel in a patient including a catheter, a deployable antenna guide disposed at the distal portion of the catheter and a radio-frequency (“RF”) antenna mounted on the antenna guide. The RF antenna includes a axial passageway to accommodate the antenna guide, and is adapted to receive and transmit RF energy for tissue ablation. Upon deployment, the antenna guide acquires a loop configuration which establishes line contact with the body vessel conformable to its internal contour to prescribe the precise and affixed tissue ablation pathway despite body vessel movements. The RF antenna is carried by the antenna guide to be deployed along the established tissue ablation pathway. Alignment of the loop with the desired tissue ablation pathway is facilitated with the use of radio-opaque markers and intracardiac electrodes mounted along the antenna guide. The catheter, as well as the antenna can be provided with steering or deflection mechanism for navigation through the body vessel passageways. A hollow co-axial cable is provided for the delivery of RF energy.
摘要翻译： 一种用于消除患者体内血管的生物组织的改进的射频导管系统，包括导管，布置在导管的远端部分的可展开天线引导件和安装在天线导向器上的射频（“RF”）天线 。 RF天线包括用于容纳天线引导件的轴向通道，并且适于接收和发射用于组织消融的RF能量。 在部署时，天线引导件获得环路配置，其与身体容器建立线接触，其符合其内部轮廓，以规定精确且固定的组织消融路径，尽管身体血管移动。 RF天线由天线引导器携带，沿着建立的组织消融路径进行部署。 通过使用沿着天线导向器安装的不透射线的标记和心内电极，便于环路与期望的组织消融路径的对准。 导管以及天线可以设置有用于通过身体血管通道导航的转向或偏转机构。 提供中空的同轴电缆用于传送RF能量。
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7.发明授权
公开(公告)号：US4419446A
公开(公告)日：1983-12-06
申请号：US221565
申请日：1980-12-31
申请人： Peter M. Howley , Nava Sarver , Ming-Fan Law
发明人： Peter M. Howley , Nava Sarver , Ming-Fan Law
CPC分类号： C12N15/86 , C12N2710/20043
摘要： A novel method and composition are provided for the replication and expression of exogenous genes in eukaryotic cells. A segment of a papilloma virus genome capable of extrachromosomal replication is linked to the foreign gene(s) using recombinant DNA techniques to provide a biologically functional replicon with a desired phenotypical property. The replicon is inserted into a eukaryotic cell by transformation, and the isolation of transformant provides cells for replication and expression of the DNA molecules present in the modified plasmid. The transforming region of the bovine papilloma virus provides a unique vector in that it provides both the capability of autonomous extrachromosomal replication but also the malignant transformed phenotype. Thus, genes which of themselves provide no selectable phenotypical property can be conveniently and efficiently introduced into eukaryotic cells and the transformants selected. The method is useful in that the foreign DNA is faithfully expressed and the gene products (proteins), such as pro-insulin (an insulin precursor) is synthesized.
摘要翻译： 提供了一种新颖的方法和组合物，用于在真核细胞中复制和表达外源基因。 使用重组DNA技术将能够染色体外复制的乳头瘤病毒基因片段与外源基因连接，以提供具有所需表型性质的生物功能复制子。 通过转化将复制子插入真核细胞，转化体的分离提供用于复制和表达修饰质粒中存在的DNA分子的细胞。 牛乳头瘤病毒的转化区域提供了独特的载体，因为它提供了自主染色体外复制的能力，而且提供了恶性转化的表型。 因此，本身不提供选择性表型性质的基因可以方便且有效地引入真核细胞并选择转化体。 该方法可用于外来DNA被忠实表达，并且合成基因产物（蛋白质），例如胰岛素前体（胰岛素前体）。
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8.发明申请RADIO FREQUENCY-BASED CATHETER SYSTEM WITH IMPROVED DEFLECTION AND STEERING MECHANISMS 有权具有改进的偏转和转向机构的无线电频率导管系统公开(公告)号：US20110009858A1
公开(公告)日：2011-01-13
申请号：US12877887
申请日：2010-09-08
IPC分类号： A61B18/18
CPC分类号： H01Q1/42 , A61B18/1492 , A61B2017/003 , A61B2017/00867 , A61B2018/00357 , A61B2018/00839 , C08L2201/12
摘要： A RF catheter system includes a catheter with a proximal portion, a distal portion having a distal end and a lumen extending from the proximal portion to the distal portion. Inner and outer coaxially aligned conductors extend within the catheter and are coaxial with the lumen. A deflectable catheter guide is disposed within the catheter lumen and extends proximally within the catheter lumen and terminates distally of the distal end of the catheter to define a biological ablation pathway. A radio-frequency antenna is disposed at the distal portion of the catheter and is in electrical communication with the inner and outer coaxially aligned conductors. The radio-frequency antenna is adaptable to receive and transmit radio-frequency energy for ablating biological tissue along the ablation pathway.
摘要翻译： RF导管系统包括具有近端部分的导管，远侧部分具有远端，以及从近端部分延伸到远端部分的内腔。 内部和外部同轴对准的导体在导管内延伸并且与内腔同轴。 导管导管设置在导管内腔内并且在导管内腔内向近侧延伸并且终止于导管远端的远端以限定生物消融通路。 射频天线设置在导管的远端部分并且与内部和外部同轴对齐的导体电连通。 射频天线适于接收和发射用于沿着消融路径烧蚀生物组织的射频能量。
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9.发明授权Radio frequency-based catheter system with improved deflection and steering mechanisms 有权射频导管系统具有改进的偏转和转向机制公开(公告)号：US08152799B2
公开(公告)日：2012-04-10
申请号：US12877887
申请日：2010-09-08
IPC分类号： A61B18/18
CPC分类号： H01Q1/42 , A61B18/1492 , A61B2017/003 , A61B2017/00867 , A61B2018/00357 , A61B2018/00839 , C08L2201/12
摘要： A RF catheter system includes a catheter with a proximal portion, a distal portion having a distal end and a lumen extending from the proximal portion to the distal portion. Inner and outer coaxially aligned conductors extend within the catheter and are coaxial with the lumen. A deflectable catheter guide is disposed within the catheter lumen and extends proximally within the catheter lumen and terminates distally of the distal end of the catheter to define a biological ablation pathway. A radio-frequency antenna is disposed at the distal portion of the catheter and is in electrical communication with the inner and outer coaxially aligned conductors. The radio-frequency antenna is adaptable to receive and transmit radio-frequency energy for ablating biological tissue along the ablation pathway.
摘要翻译： RF导管系统包括具有近端部分的导管，远侧部分具有远端，以及从近端部分延伸到远端部分的内腔。 内部和外部同轴对准的导体在导管内延伸并且与内腔同轴。 导管导管设置在导管内腔内并且在导管内腔内向近侧延伸并且终止于导管远端的远端以限定生物消融通路。 射频天线设置在导管的远端部分并且与内部和外部同轴对齐的导体电连通。 射频天线适于接收和发射用于沿着消融路径烧蚀生物组织的射频能量。
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10.发明授权Radio-frequency based catheter system and method for ablating biological tissues 有权基于射频的导管系统和消融生物组织的方法公开(公告)号：US07594913B2
公开(公告)日：2009-09-29
申请号：US11479259
申请日：2006-06-30
申请人： Theodore C. Ormsby , George L. Leung , Gwo Jenn Shen , Peter Chu , Ming Fan Law
发明人： Theodore C. Ormsby , George L. Leung , Gwo Jenn Shen , Peter Chu , Ming Fan Law
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B18/18 , A61B18/1815 , A61B2017/00256 , A61B2017/003 , A61B2018/00666 , A61B2018/00678 , A61B2018/00702 , A61B2018/00779 , A61B2018/00785 , A61B2018/00791 , A61B2018/00946
摘要： A radio-frequency based catheter system and method for ablating biological tissues within the body vessel of a patient comprises a radio-frequency (“RF”) generator for selectively generating a high frequency RF energy signal in a deployable catheter having an RF transmission line, an RF antenna mounted on the distal portion of the catheter, and a temperature sensor also mounted on a distal portion of the catheter for detecting temperature adjacent an ablation site. A control system adjusts the RF energy signal so that the detected temperature is at or close to a selected temperature setting or within a selected temperature range.
摘要翻译： 用于消除患者体内血液中的生物组织的基于射频的导管系统和方法包括：射频（“RF”）发生器，用于在具有RF传输线的可展开导管中选择性地产生高频RF能量信号， 安装在导管的远端部分上的RF天线，以及也安装在导管的远端部分上的温度传感器，用于检测消融部位附近的温度。 控制系统调节RF能量信号，使得检测到的温度处于或接近所选择的温度设置或者在选定的温度范围内。
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