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    RADIO FREQUENCY-BASED CATHETER SYSTEM WITH IMPROVED DEFLECTION AND STEERING MECHANISMS
    1.
    发明申请
    RADIO FREQUENCY-BASED CATHETER SYSTEM WITH IMPROVED DEFLECTION AND STEERING MECHANISMS 有权
    具有改进的偏转和转向机构的无线电频率导管系统

    公开(公告)号：US20110009858A1

    公开(公告)日：2011-01-13

    申请号：US12877887

    申请日：2010-09-08

    申请人： Theodore C. Ormsby ,  Ming-Fan Law ,  George L. Leung

    发明人： Theodore C. Ormsby ,  Ming-Fan Law ,  George L. Leung

    IPC分类号： A61B18/18

    CPC分类号： H01Q1/42 ,  A61B18/1492 ,  A61B2017/003 ,  A61B2017/00867 ,  A61B2018/00357 ,  A61B2018/00839 ,  C08L2201/12

    摘要： A RF catheter system includes a catheter with a proximal portion, a distal portion having a distal end and a lumen extending from the proximal portion to the distal portion. Inner and outer coaxially aligned conductors extend within the catheter and are coaxial with the lumen. A deflectable catheter guide is disposed within the catheter lumen and extends proximally within the catheter lumen and terminates distally of the distal end of the catheter to define a biological ablation pathway. A radio-frequency antenna is disposed at the distal portion of the catheter and is in electrical communication with the inner and outer coaxially aligned conductors. The radio-frequency antenna is adaptable to receive and transmit radio-frequency energy for ablating biological tissue along the ablation pathway.

    摘要翻译： RF导管系统包括具有近端部分的导管，远侧部分具有远端，以及从近端部分延伸到远端部分的内腔。 内部和外部同轴对准的导体在导管内延伸并且与内腔同轴。 导管导管设置在导管内腔内并且在导管内腔内向近侧延伸并且终止于导管远端的远端以限定生物消融通路。 射频天线设置在导管的远端部分并且与内部和外部同轴对齐的导体电连通。 射频天线适于接收和发射用于沿着消融路径烧蚀生物组织的射频能量。

    Radio-frequency-based catheter system with improved deflection and steering mechanisms
    2.
    发明授权
    Radio-frequency-based catheter system with improved deflection and steering mechanisms 有权
    射频导管系统具有改进的偏转和转向机制

    公开(公告)号：US07815637B2

    公开(公告)日：2010-10-19

    申请号：US11359808

    申请日：2006-02-22

    申请人： Theodore C. Ormsby ,  Ming-Fan Law ,  George L. Leung

    发明人： Theodore C. Ormsby ,  Ming-Fan Law ,  George L. Leung

    IPC分类号： A61B18/18

    CPC分类号： H01Q1/42 ,  A61B18/1492 ,  A61B2017/003 ,  A61B2017/00867 ,  A61B2018/00357 ,  A61B2018/00839 ,  C08L2201/12

    摘要： A RF catheter system includes a catheter with a proximal portion, a distal portion having a distal end and a lumen extending from the proximal portion to the distal portion. Inner and outer coaxially aligned conductors extend within the catheter and are coaxial with the lumen. A deflectable catheter guide is disposed within the catheter lumen and extends proximally within the catheter lumen and terminates distally of the distal end of the catheter to define a biological ablation pathway. A radio-frequency antenna is disposed at the distal portion of the catheter and is in electrical communication with the inner and outer coaxially aligned conductors. The radio-frequency antenna is adaptable to receive and transmit radio-frequency energy for ablating biological tissue along the ablation pathway.

    摘要翻译： RF导管系统包括具有近端部分的导管，远侧部分具有远端，以及从近端部分延伸到远端部分的内腔。 内部和外部同轴对准的导体在导管内延伸并且与内腔同轴。 导管导管设置在导管内腔内并且在导管内腔内向近侧延伸并且终止于导管远端的远端以限定生物消融通路。 射频天线设置在导管的远端部分并且与内部和外部同轴对齐的导体电连通。 射频天线适于接收和发射用于沿着消融路径烧蚀生物组织的射频能量。

    Radio-frequency based catheter system and hollow co-axial cable for ablation of body tissues
    3.
    发明授权
    Radio-frequency based catheter system and hollow co-axial cable for ablation of body tissues 有权
    射频导管系统和空心同轴电缆，用于身体组织的消融

    公开(公告)号：US06663625B1

    公开(公告)日：2003-12-16

    申请号：US09459058

    申请日：1999-12-11

    申请人： Theodore C. Ormsby ,  George L. Leung ,  Ming-Fan Law

    发明人： Theodore C. Ormsby ,  George L. Leung ,  Ming-Fan Law

    IPC分类号： A61B1818

    CPC分类号： A61B18/18 ,  A61B18/1492 ,  A61B18/1815 ,  A61B90/39 ,  A61B2017/003 ,  A61B2018/00839 ,  A61B2018/1407 ,  A61B2018/1437 ,  A61B2018/1861

    摘要： An improved radio-frequency catheter system for ablating biological tissues of a body vessel in a patient including a catheter, a deployable antenna guide disposed at the distal portion of the catheter and a radio-frequency (“RF”) antenna mounted on the antenna guide. The RF antenna includes a axial passageway to accommodate the antenna guide, and is adapted to receive and transmit RF energy for tissue ablation. Upon deployment, the antenna guide acquires a loop configuration which establishes line contact with the body vessel conformable to its internal contour to prescribe the precise and affixed tissue ablation pathway despite body vessel movements. The RF antenna is carried by the antenna guide to be deployed along the established tissue ablation pathway. Alignment of the loop with the desired tissue ablation pathway is facilitated with the use of radio-opaque markers and intracardiac electrodes mounted along the antenna guide. The catheter, as well as the antenna can be provided with steering or deflection mechanism for navigation through the body vessel passageways. A hollow co-axial cable is provided for the delivery of RF energy.

    摘要翻译： 一种用于消除患者体内血管的生物组织的改进的射频导管系统，包括导管，布置在导管的远端部分的可展开天线引导件和安装在天线导向器上的射频（“RF”）天线 。 RF天线包括用于容纳天线引导件的轴向通道，并且适于接收和发射用于组织消融的RF能量。 在部署时，天线引导件获得环路配置，其与身体容器建立线接触，其符合其内部轮廓，以规定精确且固定的组织消融路径，尽管身体血管移动。 RF天线由天线引导器携带，沿着建立的组织消融路径进行部署。 通过使用沿着天线导向器安装的不透射线的标记和心内电极，便于环路与期望的组织消融路径的对准。 导管以及天线可以设置有用于通过身体血管通道导航的转向或偏转机构。 提供中空的同轴电缆用于传送RF能量。

    Radio frequency-based catheter system with improved deflection and steering mechanisms
    6.
    发明授权
    Radio frequency-based catheter system with improved deflection and steering mechanisms 有权
    射频导管系统具有改进的偏转和转向机制

    公开(公告)号：US08152799B2

    公开(公告)日：2012-04-10

    申请号：US12877887

    申请日：2010-09-08

    申请人： Theodore C. Ormsby ,  Ming-Fan Law ,  George L. Leung

    发明人： Theodore C. Ormsby ,  Ming-Fan Law ,  George L. Leung

    IPC分类号： A61B18/18

    CPC分类号： H01Q1/42 ,  A61B18/1492 ,  A61B2017/003 ,  A61B2017/00867 ,  A61B2018/00357 ,  A61B2018/00839 ,  C08L2201/12

    摘要： A RF catheter system includes a catheter with a proximal portion, a distal portion having a distal end and a lumen extending from the proximal portion to the distal portion. Inner and outer coaxially aligned conductors extend within the catheter and are coaxial with the lumen. A deflectable catheter guide is disposed within the catheter lumen and extends proximally within the catheter lumen and terminates distally of the distal end of the catheter to define a biological ablation pathway. A radio-frequency antenna is disposed at the distal portion of the catheter and is in electrical communication with the inner and outer coaxially aligned conductors. The radio-frequency antenna is adaptable to receive and transmit radio-frequency energy for ablating biological tissue along the ablation pathway.

    摘要翻译： RF导管系统包括具有近端部分的导管，远侧部分具有远端，以及从近端部分延伸到远端部分的内腔。 内部和外部同轴对准的导体在导管内延伸并且与内腔同轴。 导管导管设置在导管内腔内并且在导管内腔内向近侧延伸并且终止于导管远端的远端以限定生物消融通路。 射频天线设置在导管的远端部分并且与内部和外部同轴对齐的导体电连通。 射频天线适于接收和发射用于沿着消融路径烧蚀生物组织的射频能量。

    Radio-frequency based catheter system and method for ablating biological tissues
    7.
    发明授权
    Radio-frequency based catheter system and method for ablating biological tissues 有权
    基于射频的导管系统和消融生物组织的方法

    公开(公告)号：US07070595B2

    公开(公告)日：2006-07-04

    申请号：US10637325

    申请日：2003-08-08

    申请人： Theodore C. Ormsby ,  Ming-Fan Law ,  George L. Leung

    发明人： Theodore C. Ormsby ,  Ming-Fan Law ,  George L. Leung

    IPC分类号： A61B18/04

    CPC分类号： A61B18/1492 ,  A61B18/18 ,  A61B90/39 ,  A61B2017/003 ,  A61B2018/00214 ,  A61B2018/00839 ,  A61B2018/00875 ,  A61B2018/1407 ,  A61B2018/1437

    摘要： A method for biological tissue ablation includes shaping a shapeable RF antenna to accommodate the contour of a body vessel adjacent a biological tissue load; generating a train of radio frequency (RF) energy pulses at an output frequency for transmission in a transmission line to the shapeable RF antenna adjacent the biological tissue load; sensing a reflected signal and a forward signal of the RF energy pulses; and adjusting output frequency of the RF energy pulses to effect a substantial match of transmission line impedance with shapeable RF antenna and biological tissue load impedance.

    摘要翻译： 一种用于生物组织消融的方法包括成形可成形的RF天线以适应与生物组织负载相邻的身体血管的轮廓; 在输出频率处产生一系列射频（RF）能量脉冲，以在传输线路中传输到与生物组织负载相邻的可成形RF天线; 感测RF能量脉冲的反射信号和正向信号; 并调整RF能量脉冲的输出频率，以实现传输线路阻抗与可塑性RF天线和生物组织负载阻抗的实质匹配。

    Radio-frequency based catheter system for ablation of body tissues
    8.
    发明授权
    Radio-frequency based catheter system for ablation of body tissues 有权
    基于射频的导管系统消融人体组织

    公开(公告)号：US06190382B1

    公开(公告)日：2001-02-20

    申请号：US09211188

    申请日：1998-12-14

    申请人： Theodore C. Ormsby ,  George L. Leung ,  Ming-Fan Law

    发明人： Theodore C. Ormsby ,  George L. Leung ,  Ming-Fan Law

    IPC分类号： A61B1804

    CPC分类号： A61B18/18 ,  A61B18/1492 ,  A61B18/1815 ,  A61B90/39 ,  A61B2017/003 ,  A61B2018/00839 ,  A61B2018/1407 ,  A61B2018/1437 ,  A61B2018/1861

    摘要： An improved radio-frequency catheter system for ablating biological tissues of a body vessel in a patient including a catheter, a deployable antenna guide disposed at the distal portion of the catheter and a radio-frequency (“RF”) antenna mounted on the antenna guide. The RF antenna includes a helical coil which defines an axial passageway to accommodate the antenna guide, and is adapted to receive and transmit RF energy for tissue ablation. Upon deployment, the antenna guide acquires a loop configuration which establishes line contact with the body vessel conformable to its internal contour to prescribe the precise and affixed tissue ablation pathway despite body vessel movements. The RF antenna is carried by the antenna guide to be deployed along the established tissue ablation pathway. Alignment of the loop with the desired tissue ablation pathway is facilitated with the use of radio-opaque markers and intracardiac electrodes mounted along the antenna guide. The catheter system is provided with steering mechanism for navigation through the body vessel passageways.

    摘要翻译： 一种用于消除患者体内血管的生物组织的改进的射频导管系统，包括导管，布置在导管的远端部分的可展开天线引导件和安装在天线导向器上的射频（“RF”）天线 。 RF天线包括螺旋线圈，其限定用于容纳天线引导件的轴向通道，并且适于接收和发送用于组织消融的RF能量。 在部署时，天线引导件获得环路配置，其与身体容器建立线接触，其符合其内部轮廓，以规定精确且固定的组织消融路径，尽管身体血管移动。 RF天线由天线引导器携带，沿着建立的组织消融路径进行部署。 通过使用沿着天线导向器安装的不透射线的标记和心内电极，便于环路与期望的组织消融路径的对准。 导管系统设置有用于通过身体血管通道导航的转向机构。

    Recombinant DNA process utilizing a papilloma virus DNA as a vector
    9.
    发明授权
    Recombinant DNA process utilizing a papilloma virus DNA as a vector 失效
    使用乳头瘤病毒DNA作为载体的重组DNA方法

    公开(公告)号：US4419446A

    公开(公告)日：1983-12-06

    申请号：US221565

    申请日：1980-12-31

    申请人： Peter M. Howley ,  Nava Sarver ,  Ming-Fan Law

    发明人： Peter M. Howley ,  Nava Sarver ,  Ming-Fan Law

    IPC分类号： C12N15/86 ,  C12P21/00 ,  C12N1/00 ,  C12N15/00 ,  C12P19/34

    CPC分类号： C12N15/86 ,  C12N2710/20043

    摘要： A novel method and composition are provided for the replication and expression of exogenous genes in eukaryotic cells. A segment of a papilloma virus genome capable of extrachromosomal replication is linked to the foreign gene(s) using recombinant DNA techniques to provide a biologically functional replicon with a desired phenotypical property. The replicon is inserted into a eukaryotic cell by transformation, and the isolation of transformant provides cells for replication and expression of the DNA molecules present in the modified plasmid. The transforming region of the bovine papilloma virus provides a unique vector in that it provides both the capability of autonomous extrachromosomal replication but also the malignant transformed phenotype. Thus, genes which of themselves provide no selectable phenotypical property can be conveniently and efficiently introduced into eukaryotic cells and the transformants selected. The method is useful in that the foreign DNA is faithfully expressed and the gene products (proteins), such as pro-insulin (an insulin precursor) is synthesized.

    摘要翻译： 提供了一种新颖的方法和组合物，用于在真核细胞中复制和表达外源基因。 使用重组DNA技术将能够染色体外复制的乳头瘤病毒基因片段与外源基因连接，以提供具有所需表型性质的生物功能复制子。 通过转化将复制子插入真核细胞，转化体的分离提供用于复制和表达修饰质粒中存在的DNA分子的细胞。 牛乳头瘤病毒的转化区域提供了独特的载体，因为它提供了自主染色体外复制的能力，而且提供了恶性转化的表型。 因此，本身不提供选择性表型性质的基因可以方便且有效地引入真核细胞并选择转化体。 该方法可用于外来DNA被忠实表达，并且合成基因产物（蛋白质），例如胰岛素前体（胰岛素前体）。