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1.发明授权Method of producing fibrin-specific antibodies using soluble fibrin polymers as an immunogen 失效使用可溶性纤维蛋白聚合物作为免疫原产生纤维蛋白特异性抗体的方法
公开(公告)号：US5837540A
公开(公告)日：1998-11-17
申请号：US672611
申请日：1996-06-28
摘要： The subject invention relates to a method for producing antibodies using as an immunogen a composition comprising soluble crosslinked DesAABB fibrin polymers and soluble non-crosslinked DesAABB fibrin polymers. The invention provides a method for producing fibrin-specific antibodies which, for the purposes of the present invention, are defined as antibodies that specifically bind to soluble crosslinked DesAABB fibrin polymers and soluble non-crosslinked DesAABB fibrin polymers, but which do not specifically bind to: (a) fibrinogen, (b) plasmin-derived fibrinogen degradation products, (c) DesAA fibrin monomers, (d) DesAA fibrin polymers, (e) DesAABB fibrin monomers, (f) crosslinked fibrinogen, (g) DesAA fibrin monomer-fibrinogen complex, and (h) plasmin-derived fibrin degradation products.
摘要翻译： 本发明涉及使用免疫原产生抗体的方法，该组合物包含可溶性交联的DesAABB纤维蛋白聚合物和可溶性非交联的DesAABB纤维蛋白聚合物。 本发明提供了一种生产纤维蛋白特异性抗体的方法，对于本发明的目的，其定义为与可溶性交联的DesAABB纤维蛋白聚合物和可溶性非交联的DesAABB纤维蛋白聚合物特异性结合但不特异性结合 ：（a）纤维蛋白原，（b）纤溶酶原纤维蛋白原降解产物，（c）DesAA纤维蛋白单体，（d）DesAA纤维蛋白聚合物，（e）DesAABB纤维蛋白单体，（f）交联纤维蛋白原，（g） 纤维蛋白原复合物和（h）纤溶酶原纤维蛋白降解产物。
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2.发明授权公开(公告)号：US07981261B2
公开(公告)日：2011-07-19
申请号：US11605840
申请日：2006-11-28
申请人： Tijana Rajh , YuPo Lin , Nada Dimitrijevic , Seth W. Snyder , Norman F. Sather
发明人： Tijana Rajh , YuPo Lin , Nada Dimitrijevic , Seth W. Snyder , Norman F. Sather
IPC分类号： C25B9/00
CPC分类号： C01B3/042 , C01B3/503 , C01B13/0207 , C01B13/0255 , C01B2203/041 , C01B2203/0465 , C01B2203/047 , C01B2203/0475 , C01B2210/0053 , H01M8/0606 , Y02E60/364 , Y02P20/134 , Y02P20/135 , Y02P30/30
摘要： The invention provides a system for separating oppositely-charged charge carriers, the substrate comprising a semiconductor; a ligand in electrical communication with said semiconductor; an ion-exchange resin attached to the semiconductor; an ion-exchange membrane; and an electrical conduit attaching said resin to said membrane. Also provided is a method for producing hydrogen gas, comprising: inducing charge separation in semiconductor particles so as to produce electrons and holes; oxidizing water with the holes to produce oxygen ions and protons, wherein the protons are sequestered from the oxygen ions as the protons are produced; and directing the sequestered protons to a cathode. The invention also provides a method to produce electricity comprising, inducing charge separation in semiconductor particles so as to produce electrons and holes, and completing the circuit with an electron hole transporter.
摘要翻译： 本发明提供了一种用于分离带正电荷的电荷载体的系统，所述衬底包括半导体; 与所述半导体电连通的配体; 附着在半导体上的离子交换树脂; 离子交换膜; 以及将所述树脂附着到所述膜上的电导管。 还提供了一种生产氢气的方法，包括：在半导体颗粒中诱导电荷分离以产生电子和空穴; 用空穴氧化水以产生氧离子和质子，其中当产生质子时，质子与氧离子隔离; 并将螯合的质子引导到阴极。 本发明还提供一种产生电的方法，包括：在半导体颗粒中诱导电荷分离以产生电子和空穴，并用电子空穴传输器完成电路。
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公开(公告)号：US20100078066A1
公开(公告)日：2010-04-01
申请号：US12489001
申请日：2009-06-22
CPC分类号： H01L51/4226 , H01L51/0036 , Y02E10/549 , Y02P70/521
摘要： A hybrid photovoltaic cell comprising a composite substrate of a nanotube or nanorod array of metal oxide infiltrated with a monomer precursor and subsequently polymerized in situ via UV irradiation. In an embodiment, the photovoltaic cell comprises an electron accepting TiO2 nanotube array infiltrated with a photo-sensitive electron donating conjugated polymer. The conjugated polymer may be formed in situ through UV irradiation polymerizing a monomer precursor such as 2,5-diiodothiophene (DIT).
摘要翻译： 一种混合光伏电池，其包含纳米管或纳米棒阵列的金属氧化物的复合衬底，所述金属氧化物浸入单体前体中，随后通过UV照射原位聚合。 在一个实施方案中，光伏电池包括渗透有感光电子给予共轭聚合物的电子接受TiO 2纳米管阵列。 共轭聚合物可以通过UV照射原位形成聚合单体前体如2,5-二碘噻吩（DIT）。
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4.发明申请公开(公告)号：US20070105013A1
公开(公告)日：2007-05-10
申请号：US11605840
申请日：2006-11-28
申请人： Tijana Rajh , YuPo Lin , Nada Dimitrijevic , Seth Snyder , Norman Sather
发明人： Tijana Rajh , YuPo Lin , Nada Dimitrijevic , Seth Snyder , Norman Sather
IPC分类号： H01M4/00
CPC分类号： C01B3/042 , C01B3/503 , C01B13/0207 , C01B13/0255 , C01B2203/041 , C01B2203/0465 , C01B2203/047 , C01B2203/0475 , C01B2210/0053 , H01M8/0606 , Y02E60/364 , Y02P20/134 , Y02P20/135 , Y02P30/30
摘要： The invention provides a system for separating oppositely-charged charge carriers, the substrate comprising a semiconductor; a ligand in electrical communication with said semiconductor; an ion-exchange resin attached to the semiconductor; an ion-exchange membrane; and an electrical conduit attaching said resin to said membrane. Also provided is a method for producing hydrogen gas, comprising: inducing charge separation in semiconductor particles so as to produce electrons and holes; oxidizing water with the holes to produce oxygen ions and protons, wherein the protons are sequestered from the oxygen ions as the protons are produced; and directing the sequestered protons to a cathode. The invention also provides a method to produce electricity comprising, inducing charge separation in semiconductor particles so as to produce electrons and holes, and completing the circuit with an electron hole transporter.
摘要翻译： 本发明提供了一种用于分离带正电荷的电荷载体的系统，所述衬底包括半导体; 与所述半导体电连通的配体; 附着在半导体上的离子交换树脂; 离子交换膜; 以及将所述树脂附着到所述膜上的电导管。 还提供了一种生产氢气的方法，包括：在半导体颗粒中诱导电荷分离以产生电子和空穴; 用空穴氧化水以产生氧离子和质子，其中当产生质子时，质子与氧离子隔离; 并将螯合的质子引导到阴极。 本发明还提供一种产生电的方法，包括：在半导体颗粒中诱导电荷分离以产生电子和空穴，并用电子空穴传输器完成电路。
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公开(公告)号：US10525146B2
公开(公告)日：2020-01-07
申请号：US16385519
申请日：2019-04-16
发明人： Tijana Rajh , Elena A. Rozhkova , Harry C. Fry , Nada Dimitrijevic , Tamara Koritarov , Bartosz Gryzbowski
摘要： A nanostructure comprises a MOX NP and a bidentate ligand on a surface of the MOX NP. A cancer recognition molecule is covalent coupled to the surface of the MOX NP via the bidentate ligand. A biocatalyst is also coupled to the surface of the MOX nanoparticle via the bidentate ligand. The cancer recognition molecule includes a structure configured to selectively recognize a corresponding antigen on a surface of a cancer cell and bind to the antigen. The biocatalyst is structured to selectively catalyze the oxidation of a light emitting compound to produce photons. The photons transform the MOX NPs into an excited state such that the MOX NPs generate reactive oxygen species (ROS) in the vicinity of the cancer cells in the excited state. The reactive oxygen species lyse or cause apoptosis in the cancer cells in situ. The biocatalyst includes luciferase and the light emitting compound includes luciferin.
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公开(公告)号：US20190240347A1
公开(公告)日：2019-08-08
申请号：US16385519
申请日：2019-04-16
申请人： Tijana RAJH , Elena A. ROZHKOVA , Harry C. FRY , Nada DIMITRIJEVIC , Tamara KORITAROV , Bartosz Gryzbowski
发明人： Tijana RAJH , Elena A. ROZHKOVA , Harry C. FRY , Nada DIMITRIJEVIC , Tamara KORITAROV , Bartosz Gryzbowski
CPC分类号： A61K47/6863 , A61K47/6923 , A61K49/12 , C12Q1/66
摘要： A nanostructure comprises a MOX NP and a bidentate ligand on a surface of the MOX NP. A cancer recognition molecule is covalent coupled to the surface of the MOX NP via the bidentate ligand. A biocatalyst is also coupled to the surface of the MOX nanoparticle via the bidentate ligand. The cancer recognition molecule includes a structure configured to selectively recognize a corresponding antigen on a surface of a cancer cell and bind to the antigen. The biocatalyst is structured to selectively catalyze the oxidation of a light emitting compound to produce photons. The photons transform the MOX NPs into an excited state such that the MOX NPs generate reactive oxygen species (ROS) in the vicinity of the cancer cells in the excited state. The reactive oxygen species lyse or cause apoptosis in the cancer cells in situ. The biocatalyst includes luciferase and the light emitting compound includes luciferin.
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公开(公告)号：US08269100B2
公开(公告)日：2012-09-18
申请号：US12489001
申请日：2009-06-22
CPC分类号： H01L51/4226 , H01L51/0036 , Y02E10/549 , Y02P70/521
摘要： A hybrid photovoltaic cell comprising a composite substrate of a nanotube or nanorod array of metal oxide infiltrated with a monomer precursor and subsequently polymerized in situ via UV irradiation. In an embodiment, the photovoltaic cell comprises an electron accepting TiO2 nanotube array infiltrated with a photo-sensitive electron donating conjugated polymer. The conjugated polymer may be formed in situ through UV irradiation polymerizing a monomer precursor such as 2,5-diiodothiophene (DIT).
摘要翻译： 一种混合光伏电池，其包含纳米管或纳米棒阵列的金属氧化物的复合衬底，所述金属氧化物浸入单体前体中，随后通过UV照射原位聚合。 在一个实施方案中，光伏电池包括渗透有感光电子给予共轭聚合物的电子接受TiO 2纳米管阵列。 共轭聚合物可以通过UV照射原位形成聚合单体前体如2,5-二碘噻吩（DIT）。
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公开(公告)号：US20070007512A1
公开(公告)日：2007-01-11
申请号：US11438180
申请日：2006-05-22
申请人： Nada Dimitrijevic , Tijana Rajh , Zoran Saponjic , Bryan Rabatic , David Tiede , Lin Chen , Peter Zapol
发明人： Nada Dimitrijevic , Tijana Rajh , Zoran Saponjic , Bryan Rabatic , David Tiede , Lin Chen , Peter Zapol
CPC分类号： H01L51/0595 , B82Y5/00 , B82Y10/00 , B82Y20/00 , B82Y30/00 , H01L2251/5369
摘要： A method for producing a bio-inorganic conjugate is provided comprising supplying a plurality of inorganic particles that are axially anisotropic; and positioning biomolecules intermediate the particles to form a chain-like structure. Also provided is an organized microscopic structure capable of vectorial electron transport within the structure, comprising a plurality of inorganic oxide particles, each particle having at least two ends; a first molecule covalently attached to each end to form a plurality of constructs; and a second molecule attached to the first molecule so as to link the constructs and form an elongated substrate.
摘要翻译： 提供一种制备生物 - 无机共轭物的方法，包括提供多个轴向各向异性的无机颗粒; 并将生物分子定位在颗粒之间以形成链状结构。 还提供了能够在结构内进行矢量电子传输的有组织的微观结构，包括多个无机氧化物颗粒，每个颗粒具有至少两个末端; 共价连接到每一端以形成多个构建体的第一分子; 和连接到第一分子的第二分子，以便连接构建体并形成细长的底物。
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