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    DIAGNOSTIC CARTRIDGES HAVING FLEXIBLE SEALS
    1.
    发明申请
    DIAGNOSTIC CARTRIDGES HAVING FLEXIBLE SEALS 审中-公开

    公开(公告)号：US20190009271A1

    公开(公告)日：2019-01-10

    申请号：US16129094

    申请日：2018-09-12

    申请人： Nanosphere, Inc.

    发明人： Tom WESTBERG ,  Bruce RICHARDSON ,  Ryan GRISWOLD ,  Chris LEWIS

    IPC分类号： B01L3/00

    摘要： Disclosed are cartridges and modules that may be utilized in diagnostic systems and methods. The cartridge includes a flexible seal that caps the cartridge. The flexible seal has an opening for a pipette tip, and the flexible seal is configured to create a sealed environment when a pipette tip is positioned in the opening of the flexible seal and when the pipette tip is moved in the X-axis, Y-axis, and Z-axis.

    Diagnostic cartridges having flexible seals
    2.
    发明授权
    Diagnostic cartridges having flexible seals 有权

    公开(公告)号：US10092906B2

    公开(公告)日：2018-10-09

    申请号：US15819168

    申请日：2017-11-21

    申请人： Nanosphere, Inc.

    发明人： Tom Westberg ,  Bruce Richardson ,  Ryan Griswold ,  Chris Lewis

    IPC分类号： B01L3/00

    摘要： Disclosed are cartridges and modules that may be utilized in diagnostic systems and methods. The cartridge includes a flexible seal that caps the cartridge. The flexible seal has an opening for a pipette tip, and the flexible seal is configured to create a sealed environment when a pipette tip is positioned in the opening of the flexible seal and when the pipette tip is moved in the X-axis, Y-axis, and Z-axis.

    Nanoparticle polyanion conjugates and methods of use thereof in detecting analytes
    3.
    发明申请
    Nanoparticle polyanion conjugates and methods of use thereof in detecting analytes 有权
    纳米粒子聚阴离子共轭物及其在检测分析物中的应用方法

    公开(公告)号：US20040053222A1

    公开(公告)日：2004-03-18

    申请号：US10612422

    申请日：2003-07-02

    申请人： Nanosphere, Inc.

    发明人： James J. Storhoff ,  Robert L. Letsinger ,  Susan R. Hagenow

    IPC分类号： C12Q001/70 ,  C12Q001/68 ,  G01N033/53

    CPC分类号： G01N33/588 ,  B82Y15/00 ,  G01N33/54346 ,  G01N33/54353 ,  G01N33/545 ,  G01N2333/726 ,  Y10S977/702 ,  Y10T428/2982

    摘要： This invention provides polyanionic polymer conjugates containing non-nucleotide polyanionic polymers that are useful in detecting target analytes such as proteins or small molecules. The invention also provides nanoparticles bound to polyanionic polymer conjugates and methods of preparation and use thereof. The polyanionic polymer conjugates have the formula:LnullOnullnullPO2nullOnullZnullOnullnnullPO2nullOnullXwherein n ranges from 1 to 200; L represents a moiety comprising a functional group for attaching the polyanion polymer to the nanoparticle surface; Z represents a bridging group, and X represents Q, Xnull or nullQnullXnull, wherein Q represents a functional group for attaching a recognition probe to the polyanion polymer, and Xnull represents a recognition probe.

    摘要翻译： 本发明提供含有非核苷酸聚阴离子聚合物的聚阴离子聚合物缀合物，其可用于检测目标分析物如蛋白质或小分子。 本发明还提供结合聚阴离子聚合物共轭物的纳米颗粒及其制备和使用方法。 聚阴离子聚合物共轭物具有下式：L-O- [PO2-O-Z-O] n-PO2-O-X，其中n为1至200; L表示包含用于将聚阴离子聚合物附着到纳米颗粒表面的官能团的部分; Z表示桥连基，X表示Q，X'或-Q-X'，其中Q表示用于将识别探针附着到聚阴离子聚合物上的官能团，X'表示识别探针。

    DIAGNOSTIC CARTRIDGES HAVING FLEXIBLE SEALS
    7.
    发明申请
    DIAGNOSTIC CARTRIDGES HAVING FLEXIBLE SEALS 有权
    具有柔性密封的诊断盒

    公开(公告)号：US20150298120A1

    公开(公告)日：2015-10-22

    申请号：US14693470

    申请日：2015-04-22

    申请人： Nanosphere, Inc.

    发明人： Tom Westberg ,  Bruce Richardson ,  Ryan Griswold ,  Chris Lewis

    IPC分类号： B01L3/00

    CPC分类号： B01L3/50853 ,  B01L2200/0689 ,  B01L2200/16 ,  B01L2300/042 ,  B01L2300/044 ,  B01L2300/046 ,  B01L2300/123

    摘要： Disclosed are cartridges and modules that may be utilized in diagnostic systems and methods. The cartridge includes a flexible seal that caps the cartridge. The flexible seal has an opening for a pipette tip, and the flexible seal is configured to create a sealed environment when a pipette tip is positioned in the opening of the flexible seal and when the pipette tip is moved in the X-axis, Y-axis, and Z-axis.

    摘要翻译： 公开了可用于诊断系统和方法的盒和模块。 盒包括用于盖住盒的柔性密封件。 柔性密封件具有用于移液管末端的开口，并且柔性密封件构造成当移液管末端定位在柔性密封件的开口中时并且当移液管尖端在X轴上移动时产生密封环境，Y- 轴和Z轴。