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    Methods for Enhancing Antibody Activity
    1.
    发明申请
    Methods for Enhancing Antibody Activity 审中-公开
    增强抗体活性的方法

    公开(公告)号：US20080009038A1

    公开(公告)日：2008-01-10

    申请号：US10582413

    申请日：2004-12-10

    申请人： Toshihiko Ohtomo ,  Naohiro Yabuta ,  Hiroyuki Tsunoda ,  Masayuki Tsuchiya

    发明人： Toshihiko Ohtomo ,  Naohiro Yabuta ,  Hiroyuki Tsunoda ,  Masayuki Tsuchiya

    IPC分类号： C12P21/00 ,  C07K16/00

    CPC分类号： C07K16/00 ,  C07K16/18 ,  C07K2317/622 ,  C07K2317/75

    摘要： Anti-human Mp1 antibodies were isolated and purified, and then single-chain anti-human Mp1 antibodies were prepared using genetic engineering techniques. The antibodies were found to exhibit a high agonistic activity. This shows that the activity of an antibody can be enhanced by making the antibody into a single-chain polypeptide that comprises two or more heavy chain variable regions and two or more light chain variable regions linked via linkers.

    摘要翻译： 分离和纯化抗人Mp1抗体，然后使用遗传工程技术制备单链抗人Mp1抗体。 发现抗体表现出高的激动作用。 这表明通过将抗体制成包含两个或多个重链可变区和通过接头连接的两个或更多个轻链可变区的单链多肽，可以增强抗体的活性。

    Screening methods for biologically active ligands
    6.
    发明授权
    Screening methods for biologically active ligands 失效
    生物活性配体的筛选方法

    公开(公告)号：US07732133B2

    公开(公告)日：2010-06-08

    申请号：US10333103

    申请日：2001-07-17

    申请人： Naohiro Yabuta ,  Hideki Adachi ,  Yasushi Shimonaka ,  Kunihiro Hattori

    发明人： Naohiro Yabuta ,  Hideki Adachi ,  Yasushi Shimonaka ,  Kunihiro Hattori

    IPC分类号： G01Q1/68 ,  G01Q33/53 ,  G01N33/566 ,  C12P21/04 ,  C12N15/00

    CPC分类号： G01N33/566 ,  G01N2500/00

    摘要： In the case when there are two objective biological activities, and the aim is to isolate a compound having at least one biological activity, the present inventors developed an assay method wherein a common detection marker is utilized for separately detecting the presence or absence of each of the biological activities. The present inventors discovered that a compound having at least one of two or more distinct biological activities can be efficiently and conveniently detected by simultaneously assaying at least one test sample or more by the above-mentioned method. Furthermore, for a test sample that proved to be positive by the detection method, they found that it is possible to efficiently and conveniently screen for a test sample having an objective specific biological activity by combining with a method wherein an individual activity of a test sample can be detected to specify the biological activity.

    摘要翻译： 在存在两个目标生物活性的情况下，目的是分离具有至少一种生物活性的化合物时，本发明人开发了一种测定方法，其中使用常见的检测标记来分别检测每种化合物的存在或不存在 生物活动。 本发明人发现通过上述方法同时测定至少一种测试样品，可有效地方便地检测具有两种或更多种不同生物活性中至少一种的化合物。 此外，对于通过检测方法证实为阳性的测试样品，他们发现可以通过结合其中测试样品的单独活性的方法有效和方便地筛选具有客观特异性生物活性的测试样品 可以检测到指定生物活性。