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    Monoclonal antibody inducing apoptosis
    2.
    发明授权
    Monoclonal antibody inducing apoptosis 失效
    单克隆抗体诱导细胞凋亡

    公开(公告)号：US07531643B2

    公开(公告)日：2009-05-12

    申请号：US10355236

    申请日：2003-01-31

    申请人： Naoshi Fukushima ,  Shinsuke Uno

    发明人： Naoshi Fukushima ,  Shinsuke Uno

    IPC分类号： C07K16/00 ,  A61K39/395

    CPC分类号： C07K16/2839 ,  A61K2039/505

    摘要： The monoclonal antibodies of this invention are antibodies that specifically recognize human Integrin Associated Protein, and the antigens that induce apoptosis of nucleated blood cells having human Integrin Associated Protein. Accordingly, they are useful as antibodies that recognize human Integrin Associated Protein for its distinction and identification, while also having an action of inducing apoptosis of nucleated blood cells; these properties can be utilized to prepare useful therapeutic agents in the field of treatment for myeloid leukemia and lymphoid leukemia.

    摘要翻译： 本发明的单克隆抗体是特异性识别人整联蛋白相关蛋白的抗体，以及诱导具有人整联蛋白相关蛋白的有核血细胞凋亡的抗原。 因此，它们可用作识别人整联蛋白相关蛋白以鉴别和鉴定的抗体，同时还具有诱导有核血细胞凋亡的作用; 这些性质可用于制备骨髓性白血病和淋巴样白血病治疗领域的有用治疗剂。

    Method of screening apoptosis inducing substances
    4.
    发明授权
    Method of screening apoptosis inducing substances 失效
    筛选凋亡诱导物质的方法

    公开(公告)号：US06579692B1

    公开(公告)日：2003-06-17

    申请号：US09147004

    申请日：1998-09-08

    申请人： Naoshi Fukushima

    发明人： Naoshi Fukushima

    IPC分类号： C12Q102

    CPC分类号： C07K14/70596 ,  A61K38/00 ,  C07K14/4747

    摘要： The present invention provides a method of screening substances having property of causing apoptosis, and relates to a method of screening substances having property of causing apoptosis characterized by using cells which are expressing IAP (Integrin Associated Protein), and the relates to above screening method, wherein the cells used are myeloid cells, and relates to pharmaceutical compositions containing as the active ingredient the substances obtained by the above method, and the present invention makes it possible to differentiate, identify and screen readily and highly efficiently the substances, such as antibodies and the like, that have property of causing apoptosis on myeloid cells by using cells which are expressing IAP while using specific binding reactions of the substances, and the above specific substances thus obtained can be used by virtue of their characteristics as the active ingredient of pharmaceutical compositions such as anticancer agents and medicines for myelocytic leukemia and the like.

    摘要翻译： 本发明提供一种筛选具有引起细胞凋亡的物质的方法，涉及一种筛选具有使细胞表达IAP（整联蛋白相关蛋白）特征在于凋亡特性的物质的方法，涉及上述筛选方法， 其中所使用的细胞是骨髓细胞，并且涉及含有通过上述方法获得的物质作为活性成分的药物组合物，并且本发明使得可以容易且高效地区分，鉴定和筛选诸如抗体和 其具有通过使用表达IAP的细胞同时使用物质的特异性结合反应而引起细胞凋亡的性质，以及由此获得的上述特定物质可以由于其作为药物组合物的活性成分的特性而使用 如抗癌剂和骨髓药物 白血病等。

    Monoclonal antibodies having property of causing apoptosis
    5.
    发明授权
    Monoclonal antibodies having property of causing apoptosis 失效
    具有引起细胞凋亡的单克隆抗体

    公开(公告)号：US5840344A

    公开(公告)日：1998-11-24

    申请号：US605059

    申请日：1996-04-15

    申请人： Naoshi Fukushima

    发明人： Naoshi Fukushima

    IPC分类号： A61K38/00 ,  A61K39/395 ,  C07K16/00 ,  C07K16/28 ,  C12N5/20 ,  C12N5/22 ,  C12N15/16 ,  C12P21/08 ,  C12N5/06 ,  C12N5/12

    CPC分类号： C07K16/28 ,  A61K38/00

    摘要： It is the objective and purpose of the present invention to provide a monoclonal antibody having the property of causing apoptosis on myeloid cells. This invention relates to a monoclonal antibody having the property of causing apoptosis on myeloid cells, and fragments thereof, and furthermore relates to a hybridoma producing the monoclonal antibody. Since the monoclonal antibodies of the present invention are useful as antibodies recognizing and identifying antigens causing apoptosis on myeloid cells specifically and besides have the property of causing apoptosis on myeloid cells, they may be used as medicine useful in the field of remedies for myelocytic leukemia utilizing the property.

    摘要翻译： PCT No.PCT / JP94 / 01453 Sec。 371日期：1996年4月15日 102（e）日期1996年4月15日PCT 1994年9月2日PCT公布。 公开号WO95 / 06748 1995年3月9日本发明的目的和目的是提供具有在骨髓细胞上引起凋亡的性质的单克隆抗体。 本发明涉及具有引起骨髓细胞凋亡的性质的单克隆抗体及其片段，此外涉及产生单克隆抗体的杂交瘤。 由于本发明的单克隆抗体可用作识别和鉴定特异性引起骨髓细胞凋亡的抗原的抗体，并且除了具有引起骨髓细胞凋亡的性质之外，它们可用作骨髓细胞白血病治疗领域中有用的药物，其利用 的财产。

    BMP antibodies and methods of treating kidney disease using the same
    7.
    发明授权
    BMP antibodies and methods of treating kidney disease using the same 有权
    BMP抗体和使用其治疗肾脏疾病的方法

    公开(公告)号：US08025881B2

    公开(公告)日：2011-09-27

    申请号：US12374473

    申请日：2007-07-19

    申请人： Toshio Doi ,  Hideharu Abe ,  Naoshi Fukushima ,  Hitoshi Tai ,  Takakazu Mizuno ,  Masahiko Kinosaki

    发明人： Toshio Doi ,  Hideharu Abe ,  Naoshi Fukushima ,  Hitoshi Tai ,  Takakazu Mizuno ,  Masahiko Kinosaki

    IPC分类号： A61K39/395 ,  C12N5/12 ,  C07K16/00 ,  C07K16/18 ,  C07K16/22

    CPC分类号： C07K16/22 ,  A61K2039/505 ,  C07K2317/76

    摘要： When an anti-human BMP antibody was added to cells of an immortalized human mesangial cell line cultured in the presence of human BMP, the anti-human BMP antibody significantly suppressed the production of type IV collagen in mesangial cells. A number of signaling pathways are involved in abnormal proliferation of type IV collagen. It was therefore completely unpredictable whether merely blocking the BMP signal would indeed suppress the abnormal proliferation of type IV collagen. However, for the first time, the present inventors demonstrated that anti-BMP antibodies are very effective in suppressing the abnormal proliferation of type IV collagen. Thus, anti-BMP antibodies can be used as novel therapeutic agents for kidney diseases associated with abnormal proliferation of the mesangial matrix.

    摘要翻译： 当将抗人BMP抗体加入到在人BMP存在下培养的永生化人肾小球系膜细胞的细胞中时，抗人BMP抗体显着抑制肾小球系膜细胞中IV型胶原的产生。 许多信号通路涉及IV型胶原异常增殖。 因此，完全不可预测的是，只是阻断BMP信号将确实抑制IV型胶原蛋白的异常增殖。 然而，本发明人第一次证明抗BMP抗体在抑制IV型胶原蛋白的异常增殖方面非常有效。 因此，抗BMP抗体可用作与肾小球系膜基质异常增殖相关的肾脏疾病的新型治疗剂。

    Monoclonal antibodies having property of causing apoptosis
    9.
    发明授权
    Monoclonal antibodies having property of causing apoptosis 失效
    具有引起细胞凋亡的单克隆抗体

    公开(公告)号：US06759043B2

    公开(公告)日：2004-07-06

    申请号：US09736146

    申请日：2000-12-15

    申请人： Naoshi Fukushima

    发明人： Naoshi Fukushima

    IPC分类号： A61K39395

    CPC分类号： C07K16/28 ,  A61K38/00

    摘要： It is the objective and purpose of the present invention to provide a monoclonal antibody having the property of causing apoptosis on myeloid cells. This invention relates to a monoclonal antibody having the property of causing apoptosis on myeloid cells, and fragments thereof, and furthermore relates to a hybridoma producing the monoclonal antibody. Since the monoclonal antibodies of the present invention are useful as antibodies recognizing and identifying antigens causing apoptosis on myeloid cells specifically and besides have the property of causing apoptosis on myeloid cells, they may be used as medicine useful in the field of remedies for myelocytic leukemia utilizing the property.

    摘要翻译： 本发明的目的和目的是提供具有引起骨髓细胞凋亡的性质的单克隆抗体。本发明涉及具有引起骨髓细胞凋亡的性质的单克隆抗体及其片段，此外涉及 产生单克隆抗体的杂交瘤。由于本发明的单克隆抗体可用作特异性鉴定和鉴定引起骨髓细胞凋亡的抗原的抗体，并且除了具有引起骨髓细胞凋亡的性质之外，还可用作在 使用这种性质的骨髓性白血病治疗领域。

    Monoclonal antibodies having property of causing apoptosis and used as anticancer agents
    10.
    发明授权
    Monoclonal antibodies having property of causing apoptosis and used as anticancer agents 有权
    具有引起细胞凋亡和用作抗癌剂的特性的单克隆抗体

    公开(公告)号：US06267959B1

    公开(公告)日：2001-07-31

    申请号：US09154498

    申请日：1998-09-17

    申请人： Naoshi Fukushima

    发明人： Naoshi Fukushima

    IPC分类号： A61K39395

    CPC分类号： C07K16/28 ,  A61K38/00

    摘要： It is the objective and purpose of the present invention to provide a monoclonal antibody having the property of causing apoptosis on myeloid cells. This invention relates to a monoclonal antibody having the property of causing apoptosis on myeloid cells, and fragments thereof, and furthermore relates to a hybridoma producing the monoclonal antibody. Since the monoclonal antibodies of the present invention are useful as antibodies recognizing and identifying antigens causing apoptosis on myeloid cells specifically and besides have the property of causing apoptosis on myeloid cells, they may be used as medicine useful in the field of remedies for myelocytic leukemia utilizing the property.

    摘要翻译： 本发明的目的和目的是提供具有引起骨髓细胞凋亡的性质的单克隆抗体。本发明涉及具有引起骨髓细胞凋亡的性质的单克隆抗体及其片段，此外涉及 产生单克隆抗体的杂交瘤。由于本发明的单克隆抗体可用作特异性鉴定和鉴定引起骨髓细胞凋亡的抗原的抗体，并且除了具有引起骨髓细胞凋亡的性质之外，它们可以用作在 使用这种性质的骨髓性白血病治疗领域。