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公开(公告)号：US20100190841A1
公开(公告)日：2010-07-29
申请号：US12595080
申请日：2008-04-14
申请人： Gwyneth Jane Farrar , Sophia Millington-Ward , Naomi Chadderton , Arpad Palfi , Mary O'Reilly , Paul Kenna , Peter Humphries
发明人： Gwyneth Jane Farrar , Sophia Millington-Ward , Naomi Chadderton , Arpad Palfi , Mary O'Reilly , Paul Kenna , Peter Humphries
IPC分类号： A61K31/7052 , C12N15/63 , C07H21/00 , C12N5/00 , A01K67/027 , A61P27/02
CPC分类号： A61K48/0066 , A61K31/7105 , C12N15/86 , C12N2310/14 , C12N2750/14143
摘要： The invention relates to gene suppression and replacement. In particular, the invention relates to enhanced expression of suppression agents for suppressing gene expression in a cell and in vivo and replacement nucleic acids that are not inhibited by the suppression agent. Regulatory elements are included in expression vectors to optimize expression of the suppression agent and/or replacement nucleic acid.
摘要翻译： 本发明涉及基因抑制和替代。 特别地，本发明涉及用于抑制细胞和体内基因表达的抑制剂的增强表达和不被抑制剂抑制的替代性核酸。 表达载体中包含调节元件以优化抑制剂和/或置换核酸的表达。
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2.发明授权公开(公告)号：US08617876B2
公开(公告)日：2013-12-31
申请号：US13539835
申请日：2012-07-02
申请人： Gwyneth Jane Farrar , Sophia Millington-Ward , Naomi Chadderton , Arpad Palfi , Mary O'Reilly , Paul Kenna , Peter Humphries
发明人： Gwyneth Jane Farrar , Sophia Millington-Ward , Naomi Chadderton , Arpad Palfi , Mary O'Reilly , Paul Kenna , Peter Humphries
CPC分类号： A61K48/0066 , A61K31/7105 , C12N15/86 , C12N2310/14 , C12N2750/14143
摘要： The invention relates to gene suppression and replacement. In particular, the invention relates to enhanced expression of suppression agents for suppressing gene expression in a cell and in vivo and replacement nucleic acids that are not inhibited by the suppression agent. Regulatory elements are included in expression vectors to optimize expression of the suppression agent and/or replacement nucleic acid.
摘要翻译： 本发明涉及基因抑制和替代。 特别地，本发明涉及用于抑制细胞和体内基因表达的抑制剂的增强表达和不被抑制剂抑制的替代性核酸。 表达载体中包含调节元件以优化抑制剂和/或置换核酸的表达。
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公开(公告)号：US20120278912A1
公开(公告)日：2012-11-01
申请号：US13539835
申请日：2012-07-02
申请人： Gwyneth Jane Farrar , Sophia Millington-Ward , Naomi Chadderton , Arpad Palfi , Mary O'Reilly , Paul Kenna , Peter Humphries
发明人： Gwyneth Jane Farrar , Sophia Millington-Ward , Naomi Chadderton , Arpad Palfi , Mary O'Reilly , Paul Kenna , Peter Humphries
IPC分类号： C12N15/85 , A61K31/7088 , A01K67/027 , C07H21/04 , C12N5/10
CPC分类号： A61K48/0066 , A61K31/7105 , C12N15/86 , C12N2310/14 , C12N2750/14143
摘要： The invention relates to gene suppression and replacement. In particular, the invention relates to enhanced expression of suppression agents for suppressing gene expression in a cell and in vivo and replacement nucleic acids that are not inhibited by the suppression agent. Regulatory elements are included in expression vectors to optimize expression of the suppression agent and/or replacement nucleic acid.
摘要翻译： 本发明涉及基因抑制和替代。 特别地，本发明涉及用于抑制细胞和体内基因表达的抑制剂的增强表达和不被抑制剂抑制的替代性核酸。 表达载体中包含调节元件以优化抑制剂和/或置换核酸的表达。
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公开(公告)号：US08257969B2
公开(公告)日：2012-09-04
申请号：US12595080
申请日：2008-04-14
申请人： Gwyneth Jane Farrar , Sophia Millington-Ward , Naomi Chadderton , Arpad Palfi , Mary O'Reilly , Paul Kenna , Peter Humphries
发明人： Gwyneth Jane Farrar , Sophia Millington-Ward , Naomi Chadderton , Arpad Palfi , Mary O'Reilly , Paul Kenna , Peter Humphries
CPC分类号： A61K48/0066 , A61K31/7105 , C12N15/86 , C12N2310/14 , C12N2750/14143
摘要： The invention relates to gene suppression and replacement. In particular, the invention relates to enhanced expression of suppression agents for suppressing gene expression in a cell and in vivo and replacement nucleic acids that are not inhibited by the suppression agent. Regulatory elements are included in expression vectors to optimize expression of the suppression agent and/or replacement nucleic acid.
摘要翻译： 本发明涉及基因抑制和替代。 特别地，本发明涉及用于抑制细胞和体内基因表达的抑制剂的增强表达和不被抑制剂抑制的替代性核酸。 表达载体中包含调节元件以优化抑制剂和/或置换核酸的表达。
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