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1.发明授权公开(公告)号：US08617876B2
公开(公告)日：2013-12-31
申请号：US13539835
申请日：2012-07-02
申请人： Gwyneth Jane Farrar , Sophia Millington-Ward , Naomi Chadderton , Arpad Palfi , Mary O'Reilly , Paul Kenna , Peter Humphries
发明人： Gwyneth Jane Farrar , Sophia Millington-Ward , Naomi Chadderton , Arpad Palfi , Mary O'Reilly , Paul Kenna , Peter Humphries
CPC分类号： A61K48/0066 , A61K31/7105 , C12N15/86 , C12N2310/14 , C12N2750/14143
摘要： The invention relates to gene suppression and replacement. In particular, the invention relates to enhanced expression of suppression agents for suppressing gene expression in a cell and in vivo and replacement nucleic acids that are not inhibited by the suppression agent. Regulatory elements are included in expression vectors to optimize expression of the suppression agent and/or replacement nucleic acid.
摘要翻译： 本发明涉及基因抑制和替代。 特别地，本发明涉及用于抑制细胞和体内基因表达的抑制剂的增强表达和不被抑制剂抑制的替代性核酸。 表达载体中包含调节元件以优化抑制剂和/或置换核酸的表达。
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公开(公告)号：US20120278912A1
公开(公告)日：2012-11-01
申请号：US13539835
申请日：2012-07-02
申请人： Gwyneth Jane Farrar , Sophia Millington-Ward , Naomi Chadderton , Arpad Palfi , Mary O'Reilly , Paul Kenna , Peter Humphries
发明人： Gwyneth Jane Farrar , Sophia Millington-Ward , Naomi Chadderton , Arpad Palfi , Mary O'Reilly , Paul Kenna , Peter Humphries
IPC分类号： C12N15/85 , A61K31/7088 , A01K67/027 , C07H21/04 , C12N5/10
CPC分类号： A61K48/0066 , A61K31/7105 , C12N15/86 , C12N2310/14 , C12N2750/14143
摘要： The invention relates to gene suppression and replacement. In particular, the invention relates to enhanced expression of suppression agents for suppressing gene expression in a cell and in vivo and replacement nucleic acids that are not inhibited by the suppression agent. Regulatory elements are included in expression vectors to optimize expression of the suppression agent and/or replacement nucleic acid.
摘要翻译： 本发明涉及基因抑制和替代。 特别地，本发明涉及用于抑制细胞和体内基因表达的抑制剂的增强表达和不被抑制剂抑制的替代性核酸。 表达载体中包含调节元件以优化抑制剂和/或置换核酸的表达。
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公开(公告)号：US08257969B2
公开(公告)日：2012-09-04
申请号：US12595080
申请日：2008-04-14
申请人： Gwyneth Jane Farrar , Sophia Millington-Ward , Naomi Chadderton , Arpad Palfi , Mary O'Reilly , Paul Kenna , Peter Humphries
发明人： Gwyneth Jane Farrar , Sophia Millington-Ward , Naomi Chadderton , Arpad Palfi , Mary O'Reilly , Paul Kenna , Peter Humphries
CPC分类号： A61K48/0066 , A61K31/7105 , C12N15/86 , C12N2310/14 , C12N2750/14143
摘要： The invention relates to gene suppression and replacement. In particular, the invention relates to enhanced expression of suppression agents for suppressing gene expression in a cell and in vivo and replacement nucleic acids that are not inhibited by the suppression agent. Regulatory elements are included in expression vectors to optimize expression of the suppression agent and/or replacement nucleic acid.
摘要翻译： 本发明涉及基因抑制和替代。 特别地，本发明涉及用于抑制细胞和体内基因表达的抑制剂的增强表达和不被抑制剂抑制的替代性核酸。 表达载体中包含调节元件以优化抑制剂和/或置换核酸的表达。
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公开(公告)号：US20100190841A1
公开(公告)日：2010-07-29
申请号：US12595080
申请日：2008-04-14
申请人： Gwyneth Jane Farrar , Sophia Millington-Ward , Naomi Chadderton , Arpad Palfi , Mary O'Reilly , Paul Kenna , Peter Humphries
发明人： Gwyneth Jane Farrar , Sophia Millington-Ward , Naomi Chadderton , Arpad Palfi , Mary O'Reilly , Paul Kenna , Peter Humphries
IPC分类号： A61K31/7052 , C12N15/63 , C07H21/00 , C12N5/00 , A01K67/027 , A61P27/02
CPC分类号： A61K48/0066 , A61K31/7105 , C12N15/86 , C12N2310/14 , C12N2750/14143
摘要： The invention relates to gene suppression and replacement. In particular, the invention relates to enhanced expression of suppression agents for suppressing gene expression in a cell and in vivo and replacement nucleic acids that are not inhibited by the suppression agent. Regulatory elements are included in expression vectors to optimize expression of the suppression agent and/or replacement nucleic acid.
摘要翻译： 本发明涉及基因抑制和替代。 特别地，本发明涉及用于抑制细胞和体内基因表达的抑制剂的增强表达和不被抑制剂抑制的替代性核酸。 表达载体中包含调节元件以优化抑制剂和/或置换核酸的表达。
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公开(公告)号：US20060128648A1
公开(公告)日：2006-06-15
申请号：US11224524
申请日：2005-09-12
申请人： Gwenyth Farrar , Peter Humphries , Paul Kenna
发明人： Gwenyth Farrar , Peter Humphries , Paul Kenna
IPC分类号： A61K48/00
CPC分类号： C12N15/113 , A61K38/00 , A61K48/00 , A61K48/005 , C12N2310/111 , C12N2310/121 , C12N2310/15 , C12N2310/3181
摘要： A strategy for suppressing specifically or partially specifically an endogenous gene and introducing a replacement gene, said strategy comprising the steps of: 1. providing suppressing nucleic acids or other suppression effectors able to bind to an endogenous gene, gene transcript or gene product to be suppressed and 2. providing genomic DNA or cDNA (complete or partial) encoding a replacement gene wherein the suppressing nucleic acids are unable to bind to equivalent regions in the genomic DNA or cDNA to prevent expression of the replacement gene. The replacement nucleic acids have modifications in one or more third base (wobble) positions such that replacement nucleic acids still code for the wild type or equivalent amino acids.
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公开(公告)号：US20110229439A1
公开(公告)日：2011-09-22
申请号：US13063604
申请日：2009-09-11
申请人： Peter Humphries , Marian Humphries , Matthew Campbell , Paul Kenna , Lawrence Chi Shing Tam , Gwenyth Jane Farrar , Anna-Sophia Kiang
发明人： Peter Humphries , Marian Humphries , Matthew Campbell , Paul Kenna , Lawrence Chi Shing Tam , Gwenyth Jane Farrar , Anna-Sophia Kiang
IPC分类号： A61K35/76 , C07K14/435 , A61K38/16 , G01N33/53 , A61P27/02
CPC分类号： A61K38/1725
摘要： The present invention relates to classical pathway complement proteins and their use in the prognosis and prevention of diseases involving cone photoreceptor degeneration. Specifically, the present invention is directed to the use of one or more classical pathway complement proteins, preferably involved in the recognition phase, in the maintenance of cone photoreceptor cell viability in a degenerating retina. The invention is also directed to a method for determining the susceptibility, risk of development and/or progression of diseases involving cone photoreceptor degeneration in a subject.
摘要翻译： 本发明涉及经典途径补体蛋白及其在预后和预防涉及锥体感光器变性的疾病中的应用。 具体而言，本发明涉及一种或多种经典途径补体蛋白（优选参与识别阶段）在维持视网膜退行性视网膜中的锥体感光细胞活力的用途。 本发明还涉及用于确定受试者中涉及锥体感光器变性的疾病的易感性，发展风险和/或进展的方法。
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7.发明申请公开(公告)号：US20110098799A1
公开(公告)日：2011-04-28
申请号：US12606789
申请日：2009-10-27
申请人： Kevin Treacy , Lucy O'Keeffe , Patrick Duane , Paul Kenna , Tony O'Halloran
发明人： Kevin Treacy , Lucy O'Keeffe , Patrick Duane , Paul Kenna , Tony O'Halloran
IPC分类号： A61F2/06
CPC分类号： A61L31/16 , A61L31/005
摘要： Disclosed herein are implantable medical device, and in particular, vascular stent having a biocompatible scaffold seeded with endothelial cells. The stent can provide structural support to maintain the openness of a vessel lumen following angioplasty while the biological scaffold seeded with endothelial cells can provide a new, healthy blood vessel wall.
摘要翻译： 本文公开了可植入医疗装置，特别是具有用内皮细胞接种的生物相容性支架的血管支架。 支架可以提供结构支撑以维持血管成形术后血管腔的开放性，而用内皮细胞接种的生物支架可提供新的健康的血管壁。
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