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16 条记录 (耗时 0.036 秒)

    ALLELE SUPPRESSION
    5.
    发明申请
    ALLELE SUPPRESSION 审中-公开
    可怕的抑制

    公开(公告)号：US20090233368A1

    公开(公告)日：2009-09-17

    申请号：US12188304

    申请日：2008-08-08

    申请人： Gwyneth Jane Farrar ,  Peter Humphries ,  Paul Francis Kenna

    发明人： Gwyneth Jane Farrar ,  Peter Humphries ,  Paul Francis Kenna

    IPC分类号： C12N15/87 ,  C07H21/04

    CPC分类号： C12N15/113 ,  A61K38/00 ,  A61K48/00 ,  C12N2310/111 ,  C12N2310/121 ,  C12N2310/15 ,  C12N2310/3181

    摘要： A strategy for suppressing expression of one allele of an endogenous gene is provided comprising providing suppression effectors such as antisense nucleic acids able to bind to polymorphisms within or adjacent to a gene such that one allele of a gene is exclusively or preferentially suppressed and if required of a replacement gene can be introduced.The invention has the advantage that the same suppression strategy when directed to polymorphisms could be used to suppress, in principle, many mutations in a gene. This is particularly relevant when large numbers of mutations within a single gene cause disease pathology.

    摘要翻译： 提供了抑制内源基因的一个等位基因表达的策略，其包括提供抑制效应子，例如能够结合基因内部或与基因相邻的多态性的反义核酸，使得基因的一个等位基因被单独或优先抑制， 可以引入替代基因。 本发明的优点在于，当针对多态性时，相同的抑制策略原则上可用于抑制基因中的许多突变。 当单个基因内的大量突变导致疾病病理学时，这尤其重要。

    SUPPRESSION OF POLYMORPHIC ALLELES
    6.
    发明申请
    SUPPRESSION OF POLYMORPHIC ALLELES 审中-公开
    抑制多态性对象

    公开(公告)号：US20090197336A1

    公开(公告)日：2009-08-06

    申请号：US12188405

    申请日：2008-08-08

    申请人： Gwenyth Jane Farrar ,  Peter Humphries ,  Sophia Millington-Ward ,  Paul Francis Kenna

    发明人： Gwenyth Jane Farrar ,  Peter Humphries ,  Sophia Millington-Ward ,  Paul Francis Kenna

    IPC分类号： C12N15/85 ,  C12N9/22

    CPC分类号： C12N15/113 ,  A61K38/00 ,  A61K48/00 ,  A61K48/005 ,  C12N2310/111 ,  C12N2310/121 ,  C12N2310/15 ,  C12N2310/3181

    摘要： Methods and agents for suppressing expression of a mutant allele of a gene having a polymorphism are provided. The methods of the invention provide suppression effectors such as antisense nucleic acids or ribozymes, that bind to nucleic acid regions having a polymorphism within a gene such that one allele of a gene is exclusively or preferentially suppressed. The method also provides the administration of a replacement nucleic acid, if required. The invention has the advantage that the same suppression strategy, when directed to polymorphisms, could be used to suppress, in principle, many mutations in a polymorphic gene. This is particularly relevant when large numbers of mutations within a single gene cause disease pathology.

    摘要翻译： 提供了用于抑制具有多态性的基因的突变等位基因表达的方法和试剂。 本发明的方法提供诸如反义核酸或核酶之类的抑制效应物，其与基因内具有多态性的核酸区域结合，使得基因的一个等位基因被专门或优先地抑制。 如果需要，该方法还提供了置换核酸的施用。 本发明的优点在于，当针对多态性时，相同的抑制策略原则上可用于抑制多态性基因中的许多突变。 当单个基因内的大量突变导致疾病病理学时，这尤其重要。

    Genetic suppression and replacement
    7.
    发明申请
    Genetic suppression and replacement 审中-公开

    公开(公告)号：US20060128648A1

    公开(公告)日：2006-06-15

    申请号：US11224524

    申请日：2005-09-12

    申请人： Gwenyth Farrar ,  Peter Humphries ,  Paul Kenna

    发明人： Gwenyth Farrar ,  Peter Humphries ,  Paul Kenna

    IPC分类号： A61K48/00

    CPC分类号： C12N15/113 ,  A61K38/00 ,  A61K48/00 ,  A61K48/005 ,  C12N2310/111 ,  C12N2310/121 ,  C12N2310/15 ,  C12N2310/3181

    摘要： A strategy for suppressing specifically or partially specifically an endogenous gene and introducing a replacement gene, said strategy comprising the steps of: 1. providing suppressing nucleic acids or other suppression effectors able to bind to an endogenous gene, gene transcript or gene product to be suppressed and 2. providing genomic DNA or cDNA (complete or partial) encoding a replacement gene wherein the suppressing nucleic acids are unable to bind to equivalent regions in the genomic DNA or cDNA to prevent expression of the replacement gene. The replacement nucleic acids have modifications in one or more third base (wobble) positions such that replacement nucleic acids still code for the wild type or equivalent amino acids.

    Alarm system
    9.
    发明授权
    Alarm system 失效
    警报系统

    公开(公告)号：US4356474A

    公开(公告)日：1982-10-26

    申请号：US241268

    申请日：1981-03-06

    申请人： Peter Humphries ,  Paul Aeberli

    发明人： Peter Humphries ,  Paul Aeberli

    IPC分类号： G08B17/00 ,  G08B29/06 ,  G08B19/00

    CPC分类号： G08B17/00 ,  G08B29/06

    摘要： A digital alarm system of the type having first and second electrically conductive loops connected by an alarm switch. The alarm switch is normally open, but can be closed when an alarm state exists to electrically short one loop to the other. Currents are generated in each of the loops for use in detecting either the closing of the alarm switch or the occurrence of a fault in one of the loops. Resistors are connected to each of the loops for use in detecting the presence or absence of the currents. A first pair of transistor switches alternatingly short-circuit one resistor then the other; and a second pair of transistor switches, synchronized with the first pair, alternatingly short the ends of one loop then those of the other so that when the alarm switch is closed the first pair of transistor switches simultaneously short-circuit both resistors even if a fault occurs anywhere in one of the loops. Recording devices, such as flip-flops, coupled to the resistors, record signals indicative of a magnitude of the resistor voltage drops during intervals in which the resistors are not short-circuited. Logic circuitry is then used to process this stored information to generate signals indicating whether the alarm switch has been tripped or whether a fault has occurred.

    摘要翻译： 一种具有通过报警开关连接的第一和第二导电回路的数字报警系统。 报警开关是常开的，但是当有一个报警状态存在电一个回路到另一个回路时可以关闭。 在每个回路中产生电流，用于检测报警开关的关闭或其中一个回路中发生故障。 电阻器连接到每个回路以用于检测电流的存在或不存在。 第一对晶体管开关交替地使一个电阻器短路另一个; 以及与第一对同步的第二对晶体管开关交替地将一个环路的端部交替地短路，使得当报警开关闭合时，第一对晶体管开关同时使两个电阻器短路，即使是故障 发生在其中一个循环中的任何位置。 耦合到电阻器的诸如触发器的记录装置在电阻器不短路的间隔期间记录指示电阻器电压下降幅度的信号。 然后使用逻辑电路来处理该存储的信息以产生指示报警开关是否已跳闸或是否发生故障的信号。

    Method for Opening Tight Junctions
    10.
    发明申请
    Method for Opening Tight Junctions 有权
    打开紧密连接的方法

    公开(公告)号：US20110064792A1

    公开(公告)日：2011-03-17

    申请号：US12682331

    申请日：2008-10-13

    申请人： Peter Humphries ,  Matthew Campbell ,  Anna-Sophia King

    发明人： Peter Humphries ,  Matthew Campbell ,  Anna-Sophia King

    IPC分类号： A61K31/7088 ,  A61K9/127 ,  A61K38/00 ,  A61K38/43 ,  A61P25/28 ,  A61P25/00 ,  A61P35/00 ,  A61P27/02 ,  C12N5/071

    CPC分类号： C12N15/1138 ,  A61K31/713 ,  A61K45/06 ,  C12N15/111 ,  C12N2310/14 ,  C12N2320/31 ,  C12N2320/32

    摘要： The present invention is directed to a method and use of RNA interference (RNAi) for the transient, reversible and controlled opening of the tight junctions of the blood brain barrier and/or the blood retinal barrier. This method may be used in the treatment of many diseases and disorders which require the opening of the blood brain barrier and/or blood retinal barrier. Such methods generally involve the use of an RNAi-inducing agent, such as siRNA, miRNA, shRNA or an RNAi-inducing vector whose presence within a cell results in production of an siRNA or shRNA, targeting tight junction proteins to open the blood brain barrier and/or blood retinal barrier.

    摘要翻译： 本发明涉及RNA干扰（RNAi）用于血脑屏障和/或血液视网膜屏障的紧密连接的瞬时，可逆和受控打开的方法和用途。 该方法可用于治疗需要开启血脑屏障和/或血液视网膜屏障的许多疾病和病症。 这样的方法通常涉及使用RNAi诱导剂，例如siRNA，miRNA，shRNA或RNAi诱导载体，其在细胞内的存在导致产生siRNA或shRNA，靶向紧密连接蛋白以打开血脑屏障 和/或血液视网膜屏障。