-
公开(公告)号：US20120156724A1
公开(公告)日：2012-06-21
申请号：US13329658
申请日：2011-12-19
申请人： Yasufumi Kikuchi , Shinsuke Uno , Yasuko Kinoshita , Shigeyuki Iijima , Naoshi Fukushima , Masayuki Tsuchiya
发明人： Yasufumi Kikuchi , Shinsuke Uno , Yasuko Kinoshita , Shigeyuki Iijima , Naoshi Fukushima , Masayuki Tsuchiya
CPC分类号： C07K16/2803 , C07K2317/24 , C07K2317/50 , C07K2317/73
摘要： The present invention relates to humanized antibodies binding to CD47; diabodies binding to human CD47, characterized in that a disulfide bond exists between diabody-forming fragments; genes encoding any one of said antibodies; vectors containing said genes; host cells containing said vectors; processes for preparing antibodies comprising the step of culturing said host cells; and therapeutic agents for hematological disorders comprising said antibodies.
摘要翻译： 本发明涉及与CD47结合的人源化抗体; 结合人CD47的双抗体，其特征在于二糖键存在于形成双抗体的片段之间; 编码任何一种所述抗体的基因; 含有所述基因的载体; 含有所述载体的宿主细胞; 制备抗体的方法包括培养所述宿主细胞的步骤; 和包含所述抗体的血液病症治疗剂。
-
公开(公告)号：US20080107654A1
公开(公告)日：2008-05-08
申请号：US10578840
申请日：2004-11-11
申请人： Yasufumi Kikuchi , Shinsuke Uno , Yasuko Kinoshita , Shigeyuki Iijima , Naoshi Fukushima , Masayuki Tsuchiya
发明人： Yasufumi Kikuchi , Shinsuke Uno , Yasuko Kinoshita , Shigeyuki Iijima , Naoshi Fukushima , Masayuki Tsuchiya
CPC分类号： C07K16/2803 , C07K2317/24 , C07K2317/50 , C07K2317/73
摘要： The present invention relates to humanized antibodies binding to CD47; diabodies binding to human CD47, characterized in that a disulfide bond exists between diabody-forming fragments; genes encoding any one of said antibodies; vectors containing said genes; host cells containing said vectors; processes for preparing antibodies comprising the step of culturing said host cells; and therapeutic agents for hematological disorders comprising said antibodies.
摘要翻译： 本发明涉及与CD47结合的人源化抗体; 结合人CD47的双抗体，其特征在于二糖键存在于形成双抗体的片段之间; 编码任何一种所述抗体的基因; 含有所述基因的载体; 含有所述载体的宿主细胞; 制备抗体的方法包括培养所述宿主细胞的步骤; 和包含所述抗体的血液病症治疗剂。
-
公开(公告)号：US08759025B2
公开(公告)日：2014-06-24
申请号：US13329658
申请日：2011-12-19
申请人： Yasufumi Kikuchi , Shinsuke Uno , Yasuko Kinoshita , Shigeyuki Iijima , Naoshi Fukushima , Masayuki Tsuchiya
发明人： Yasufumi Kikuchi , Shinsuke Uno , Yasuko Kinoshita , Shigeyuki Iijima , Naoshi Fukushima , Masayuki Tsuchiya
CPC分类号： C07K16/2803 , C07K2317/24 , C07K2317/50 , C07K2317/73
摘要： The present invention relates to humanized antibodies binding to CD47; diabodies binding to human CD47, characterized in that a disulfide bond exists between diabody-forming fragments; genes encoding any one of said antibodies; vectors containing said genes; host cells containing said vectors; processes for preparing antibodies comprising the step of culturing said host cells; and therapeutic agents for hematological disorders comprising said antibodies.
摘要翻译： 本发明涉及与CD47结合的人源化抗体; 结合人CD47的双抗体，其特征在于二糖键存在于形成双抗体的片段之间; 编码任何一种所述抗体的基因; 含有所述基因的载体; 含有所述载体的宿主细胞; 制备抗体的方法包括培养所述宿主细胞的步骤; 和包含所述抗体的血液病症治疗剂。
-
4.发明申请公开(公告)号：US20070212359A1
公开(公告)日：2007-09-13
申请号：US11547534
申请日：2005-03-31
申请人： Hiroyuki Aburatani , Yoshitaka Hippo , Akira Watanabe , Yukio Ito , Hirotaka Ito , Shin-ichi Funahashi , Masashi Fukayama , Masahiro Arai , Toshihiko Ohtomo , Yasuko Kinoshita
发明人： Hiroyuki Aburatani , Yoshitaka Hippo , Akira Watanabe , Yukio Ito , Hirotaka Ito , Shin-ichi Funahashi , Masashi Fukayama , Masahiro Arai , Toshihiko Ohtomo , Yasuko Kinoshita
IPC分类号： A61K39/395 , G01N33/574 , C07K16/30
CPC分类号： G01N33/57438 , C07K2317/732 , C07K2317/734 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/57446 , G01N33/576
摘要： A method for diagnosing cancer comprising detecting ROBO1 protein is disclosed. In addition, a method for treating a disease caused by abnormal cell growth comprising administrating an antibody that binds to ROBO1, as well as a pharmaceutical composition, a cell growth inhibitor and an anticancer agent comprising an antibody that binds to ROBO1 as an active ingredient are disclosed. Further, a method for inducing cell damages in a ROBO1 expressing cell and a method for inhibiting the growth of a ROBO1 expressing cell by bringing a ROBO1 expressing cell into contact with an antibody that binds to ROBO1, are disclosed. Furthermore, a method for monitoring progression of hepatitis by detecting ROBO1 protein is disclosed.
摘要翻译： 公开了一种诊断癌症的方法，包括检测ROBO1蛋白。 另外，用于治疗由异常细胞生长引起的疾病的方法包括施用与ROBO1结合的抗体，以及药物组合物，细胞生长抑制剂和抗癌剂，其包含结合ROBO1作为有效成分的抗体的方法， 披露 此外，公开了通过使ROBO1表达细胞与与ROBO1结合的抗体接触来抑制ROBO1表达细胞中的细胞损伤的方法和抑制ROBO1表达细胞的生长的方法。 此外，公开了通过检测ROBO1蛋白来监测肝炎进展的方法。
-
公开(公告)号：US08940488B2
公开(公告)日：2015-01-27
申请号：US11547534
申请日：2005-03-31
申请人： Hiroyuki Aburatani , Yoshitaka Hippo , Akira Watanabe , Masashi Fukayama , Yukio Ito , Masahiro Arai , Hirotaka Ito , Toshihiko Ohtomo , Shin-ichi Funahshi , Yasuko Kinoshita
发明人： Hiroyuki Aburatani , Yoshitaka Hippo , Akira Watanabe , Masashi Fukayama , Yukio Ito , Masahiro Arai , Hirotaka Ito , Toshihiko Ohtomo , Shin-ichi Funahshi , Yasuko Kinoshita
IPC分类号： G01N33/53 , G01N33/574 , G01N33/576
CPC分类号： G01N33/57438 , C07K2317/732 , C07K2317/734 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/57446 , G01N33/576
摘要： A method for diagnosing cancer comprising detecting ROBO1 protein is disclosed. In addition, a method for treating a disease caused by abnormal cell growth comprising administrating an antibody that binds to ROBO1, as well as a pharmaceutical composition, a cell growth inhibitor and an anticancer agent comprising an antibody that binds to ROBO1 as an active ingredient are disclosed. Further, a method for inducing cell damages in a ROBO1 expressing cell and a method for inhibiting the growth of a ROBO1 expressing cell by bringing a ROBO1 expressing cell into contact with an antibody that binds to ROBO1, are disclosed. Furthermore, a method for monitoring progression of hepatitis by detecting ROBO1 protein is disclosed.
摘要翻译： 公开了一种诊断癌症的方法，包括检测ROBO1蛋白。 另外，用于治疗由异常细胞生长引起的疾病的方法包括施用与ROBO1结合的抗体，以及药物组合物，细胞生长抑制剂和抗癌剂，其包含结合ROBO1作为有效成分的抗体的方法， 披露 此外，公开了通过使ROBO1表达细胞与与ROBO1结合的抗体接触来抑制ROBO1表达细胞中的细胞损伤的方法和抑制ROBO1表达细胞的生长的方法。 此外，公开了通过检测ROBO1蛋白来监测肝炎进展的方法。
-
公开(公告)号：US07919086B2
公开(公告)日：2011-04-05
申请号：US10583795
申请日：2005-07-08
申请人： Kiyotaka Nakano , Takeshi Yoshino , Jun-Ichi Nezu , Hiroyuki Tsunoda , Tomoyuki Igawa , Hiroko Konishi , Megumi Tanaka , Izumi Sugo , Shigeto Kawai , Takahiro Ishiguro , Yasuko Kinoshita
发明人： Kiyotaka Nakano , Takeshi Yoshino , Jun-Ichi Nezu , Hiroyuki Tsunoda , Tomoyuki Igawa , Hiroko Konishi , Megumi Tanaka , Izumi Sugo , Shigeto Kawai , Takahiro Ishiguro , Yasuko Kinoshita
CPC分类号： C07K16/28 , C07K7/06 , C07K14/47 , C07K16/303 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/92
摘要： An antibody capable of binding to a specific region of glypican 3, as well as a humanized antibody created based on that antibody are disclosed. The anti-GPC3 antibody of the invention has a higher ADCC activity and CDC activity compared with those of a conventional antibody. The antibody of the present invention is useful as a cell growth inhibitor, an anticancer agent and an agent for diagnosis of cancers.
摘要翻译： 公开了能够结合磷脂酰肌醇蛋白聚糖3的特定区域的抗体以及基于该抗体产生的人源化抗体。 本发明的抗GPC3抗体与常规抗体相比具有较高的ADCC活性和CDC活性。 本发明的抗体可用作细胞生长抑制剂，抗癌剂和癌症诊断剂。
-
公开(公告)号：US20070190599A1
公开(公告)日：2007-08-16
申请号：US10583795
申请日：2005-07-08
申请人： Kiyotaka Nakano , Takeshi Yoshino , Jun-Ichi Nezu , Hiroyuki Tsunoda , Tomoyuki Igawa , Hiroko Konishi , Megumi Tanaka , Izumi Sugo , Shigeto Kawai , Takahiro Ishiguro , Yasuko Kinoshita
发明人： Kiyotaka Nakano , Takeshi Yoshino , Jun-Ichi Nezu , Hiroyuki Tsunoda , Tomoyuki Igawa , Hiroko Konishi , Megumi Tanaka , Izumi Sugo , Shigeto Kawai , Takahiro Ishiguro , Yasuko Kinoshita
CPC分类号： C07K16/28 , C07K7/06 , C07K14/47 , C07K16/303 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/92
摘要： An antibody capable of binding to a specific region of glypican 3, as well as a humanized antibody created based on that antibody are disclosed. The anti-GPC3 antibody of the invention has a higher ADCC activity and CDC activity compared with those of a conventional antibody. The antibody of the present invention is useful as a cell growth inhibitor, an anticancer agent and an agent for diagnosis of cancers.
摘要翻译： 公开了能够结合磷脂酰肌醇蛋白聚糖3的特定区域的抗体以及基于该抗体产生的人源化抗体。 本发明的抗GPC3抗体与常规抗体相比具有较高的ADCC活性和CDC活性。 本发明的抗体可用作细胞生长抑制剂，抗癌剂和癌症诊断剂。
-
公开(公告)号：US07871613B2
公开(公告)日：2011-01-18
申请号：US11574091
申请日：2005-08-23
IPC分类号： A61K39/395 , A61K39/00 , C07K16/00 , C12P21/08
CPC分类号： C07K16/303 , A61K2039/505 , C07K2317/73
摘要： The present invention provides an anti-cancer agent comprising anti-glypican 3 antibody wherein the anti-cancer agent is administered after a cancer treatment, Preferably, after a cancer treatment is after a treatment for liver cancer, and the treatment for liver cancer is in particular a resection of liver cancer cells. The anti-cancer agent according to the present invention is preferably administered if glypican 3 is expressed in the resected liver cancer cells. The anti-glypican 3 antibody is preferably a monoclonal antibody. The anti-cancer agent according to the present invention is useful for preventing cancer and for preventing the recurrence of cancer.
摘要翻译： 本发明提供了包含抗磷脂酰肌醇蛋白聚糖3抗体的抗癌剂，其中抗癌剂在癌症治疗后施用，优选在癌症治疗后经肝癌治疗后，肝癌治疗为 特别是切除肝癌细胞。 如果在切除的肝癌细胞中表达磷脂酰肌醇蛋白聚糖3，则优选施用本发明的抗癌剂。 抗磷脂酰肌醇蛋白聚糖3抗体优选为单克隆抗体。 根据本发明的抗癌剂可用于预防癌症和预防癌症复发。
-
公开(公告)号：US07776329B2
公开(公告)日：2010-08-17
申请号：US10583795
申请日：2005-07-08
申请人： Kiyotaka Nakano , Takeshi Yoshino , Jun-Ichi Nezu , Hiroyuki Tsunoda , Tomoyuki Igawa , Hiroko Konishi , Megumi Tanaka , Izumi Sugo , Shigeto Kawai , Takahiro Ishiguro , Yasuko Kinoshita
发明人： Kiyotaka Nakano , Takeshi Yoshino , Jun-Ichi Nezu , Hiroyuki Tsunoda , Tomoyuki Igawa , Hiroko Konishi , Megumi Tanaka , Izumi Sugo , Shigeto Kawai , Takahiro Ishiguro , Yasuko Kinoshita
摘要： An antibody capable of binding to a specific region of glypican 3, as well as a humanized antibody created based on that antibody are disclosed. The anti-GPC3 antibody of the invention has a higher ADCC activity and CDC activity compared with those of a conventional antibody. The antibody of the present invention is useful as a cell growth inhibitor, an anticancer agent and an agent for diagnosis of cancers.
-
公开(公告)号：US20110104157A1
公开(公告)日：2011-05-05
申请号：US12936367
申请日：2009-03-19
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： C07K16/303 , A61K31/404 , A61K31/44 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K2317/24 , C07K2317/565 , A61K2300/00
摘要： A novel pharmaceutical composition for treating or preventing hepatocellular carcinoma and a method of treatment are provided. A pharmaceutical composition for treating or preventing liver cancer is obtained by combining a chemotherapeutic agent with an anti-glypican 3 antibody. Also disclosed is a pharmaceutical composition for treating or preventing liver cancer which comprises as an active ingredient an anti-glypican 3 antibody for use in combination with a chemotherapeutic agent, or which comprises as an active ingredient a chemotherapeutic agent for use in combination with an anti-glypican 3 antibody. Using the chemotherapeutic agent and the anti-glypican 3 antibody in combination yields better therapeutic effects than using the chemotherapeutic agent alone, and mitigates side effects that arise from liver cancer treatment with the chemotherapeutic agent.
摘要翻译： 提供了一种用于治疗或预防肝细胞癌的新型药物组合物和治疗方法。 通过将化学治疗剂与抗磷脂酰肌醇蛋白聚糖3抗体组合来获得用于治疗或预防肝癌的药物组合物。 还公开了用于治疗或预防肝癌的药物组合物，其包含与化疗剂组合使用的抗磷脂酰肌醇蛋白聚糖3抗体作为活性成分，或者包含作为活性成分的化学治疗剂，其与抗 - - 糖蛋白3抗体。 使用化学治疗剂和抗磷脂酰肌醇蛋白聚糖3抗体组合产生比单独使用化学治疗剂更好的治疗效果，并减轻由化学治疗剂肝癌治疗产生的副作用。
-
-
-
-
-
-
-
-
-
搜索结果
12 条记录 (耗时 0.029 秒)
