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公开(公告)号：US10724009B2
公开(公告)日：2020-07-28
申请号：US16443217
申请日：2019-06-17
发明人： Jonathan E. Page , Jason M. Stout
摘要： Nucleic acid molecules from cannabis have been isolated and characterized and encode polypeptides having cannabichromenic acid synthase activity. Expression or over-expression of the nucleic acids alters levels of cannabinoid compounds. The polypeptides may be used in vivo or in vitro to produce cannabinoid compounds.
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公开(公告)号：US20170211049A1
公开(公告)日：2017-07-27
申请号：US15321585
申请日：2015-06-29
发明人： Jonathan E. Page , Jason M. Stout
CPC分类号： C12N9/001 , C07K16/40 , C12N15/52 , C12N15/8243 , C12P17/06 , C12Y103/03
摘要： Nucleic acid molecules from cannabis have been isolated and characterized and encode polypeptides having cannabi-chromenic acid synthase activity. Expression or over-expression of the nucleic acids alters levels of cannabinoid compounds. The polypeptides may be used in vivo or in vitro to produce cannabinoid compounds.
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公开(公告)号：US20140302435A1
公开(公告)日：2014-10-09
申请号：US13856267
申请日：2013-04-03
发明人： RICHARD P. VEREGIN , Qingbin Li , Andriy Kovalenko , Sergey Gusarov , Darren Makeiff , Valerie Farrugia , Michael S. Hawkins
IPC分类号： G03G9/113
CPC分类号： G03G9/1133 , Y10T428/2982
摘要： The disclosure generally describes carrier resins, and in particular, resins used for carrier coatings which include at least one ester functional group and at least one cyclic aliphatic group containing at least one nitrogen atom in the cyclic ring structure. Carriers having such resins in the coating exhibit high charge and excellent relative humidity (RH) sensitivity of charge to changing environmental conditions.
摘要翻译： 本发明通常描述载体树脂，特别是用于载体涂层的树脂，其包含至少一个酯官能团和至少一个在环状结构中含有至少一个氮原子的环状脂肪族基团。 在涂层中具有这种树脂的载体表现出高电荷和优异的相对湿度（RH）对电荷变化对环境条件的敏感性。
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公开(公告)号：US11092553B2
公开(公告)日：2021-08-17
申请号：US16465240
申请日：2017-11-29
IPC分类号： G01J3/30 , G01N21/71 , G01N21/31 , G01N23/223
摘要： A method for characterizing an aggregate sample involves using a first laser pulse to create a crater on the surface of a sample, using a second laser pulse to produce a plasma emission spectrum on the prepared crater surface, and detecting the emission spectrum to collect spectral data. Laser application, and detecting spectral emission are repeated on different points on the sample, then non-representative spectral data is discarded based on a ratio of ions to atoms in the data. Finally a calibration loading is used to determine a property characteristic of the aggregate sample. The sample may be an oil sands sample, and the properties detected may be percentages of bitumen, water, and solids. A laser-based system is provided for carrying out the characterization method.
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公开(公告)号：US20190382734A1
公开(公告)日：2019-12-19
申请号：US16443217
申请日：2019-06-17
发明人： Jonathan E. Page , Jason M. Stout
摘要： Nucleic acid molecules from cannabis have been isolated and characterized and encode polypeptides having cannabichromenic acid synthase activity. Expression or over-expression of the nucleic acids alters levels of cannabinoid compounds. The polypeptides may be used in vivo or in vitro to produce cannabinoid compounds.
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公开(公告)号：US10364416B2
公开(公告)日：2019-07-30
申请号：US15321585
申请日：2015-06-29
发明人： Jonathan E. Page , Jason M. Stout
摘要： Nucleic acid molecules from cannabis have been isolated and characterized and encode polypeptides having cannabichromenic acid synthase activity. Expression or over-expression of the nucleic acids alters levels of cannabinoid compounds. The polypeptides may be used in vivo or in vitro to produce cannabinoid compounds.
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公开(公告)号：US09896694B2
公开(公告)日：2018-02-20
申请号：US14438768
申请日：2013-10-22
发明人： Nicholas John Roberts , Amy Christina Curran , Somrutai Winichayakul , Marissa Roldan , Richard William Scott , David Charles Taylor , Elizabeth-France Marillia
IPC分类号： C12N15/82 , C12N9/10 , C10L1/02 , C12P7/64 , A23K20/147
CPC分类号： C12N15/8247 , A23K20/147 , C07K2319/00 , C10L1/026 , C10L2200/0476 , C10L2270/026 , C12N9/1029 , C12P7/6409 , C12Y203/0102
摘要： The invention provides chimeric DGAT1 proteins comprising: a) at their N-terminal ends, an N-terminal portion of a first DGAT1 protein, and b) at their C-terminal ends, a C-terminal portion of a second DGAT1 protein. The chimeric DGAT proteins show enhanced activity relative to at least one of the first DGAT1 protein and the second DGAT1 protein. The chimeric DGAT proteins of the invention can be expressed in cells to increase cellular lipid accumulation and/or modify the cellular lipid profile. The invention also provides polynucleotides encoding the chimeric DGAT1 proteins, cells and compositions comprising the polynucleotides or chimeric DGAT1 proteins, and methods using the chimeric DGAT1 proteins to produce oil.
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8.发明申请SOLUBILIZED FORMULATION OF COQ10 FOR USE IN TREATMENT OF PARKINSON'S DISEASE 审中-公开COQ10的溶解配方用于治疗帕金森病公开(公告)号：US20160228387A1
公开(公告)日：2016-08-11
申请号：US15028520
申请日：2014-10-10
IPC分类号： A61K31/122 , A61K9/00 , A23L2/52 , A61K31/353
CPC分类号： A61K31/122 , A23L2/52 , A23L33/10 , A23L33/40 , A23V2002/00 , A61K9/0019 , A61K9/0053 , A61K9/0095 , A61K9/107 , A61K31/353 , A61K31/355 , A61K47/22 , A61K2300/00
摘要： Provided herein are compositions and methods for reducing neurogeneration in a patient suffering from Parkinson's Disease, comprising administration of a composition comprising CoQ10 and polyoxyethanyl-a-tocopherylsebacate (PTS). The compositions of the invention have been shown to penetrate the blood-brain barrier in mammals, thus effecting delivery of CoQ10 directly to brain tissue. Beneficial effects of the treatment have been observed at lower doses of CoQ10 than previously described.
摘要翻译： 本文提供了用于在患有帕金森病的患者中减少神经发生的组合物和方法，包括施用包含CoQ10和聚氧乙烯基-α-生育酚酯（PTS）的组合物。 已经显示本发明的组合物渗透哺乳动物的血脑屏障，从而将CoQ10直接递送到脑组织。 在较低剂量的CoQ10下观察到治疗的有益效果，而不是先前描述的。
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