Multiple laminar flow-based particle and cellular separation with laser steering
    6.
    发明授权
    Multiple laminar flow-based particle and cellular separation with laser steering 有权
    多层次流动粒子与细胞分离与激光转向

    公开(公告)号:US07402131B2

    公开(公告)日:2008-07-22

    申请号:US11543773

    申请日:2006-10-06

    IPC分类号: B04B7/08

    摘要: The invention provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.

    摘要翻译: 本发明提供了一种用于分离血液和其他类型的细胞组分的方法,装置和系统,并且可以与全息光学捕获操作或其他形式的光学镊子组合。 示例性方法之一包括提供具有多个血液成分的第一流; 提供第二流; 使第一流与第二流接触以提供第一分离区; 以及将所述多个血液成分的第一血细胞成分差异沉积到所述第二流中,同时在所述第一流中同时维持所述多个血液成分的第二血细胞成分。 然后,具有第一血细胞成分的第二流与具有第二血细胞成分的第一流有差别地移除。 全息光学捕集器也可以与各种流动结合使用,以将选定的组分从一个流移动到另一个流,作为分离阶段的一部分或除了分离阶段之外。