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1.发明授权公开(公告)号：US07785434B2
公开(公告)日：2010-08-31
申请号：US12489357
申请日：2009-06-22
IPC分类号： B32B7/08
CPC分类号： A61M25/0009 , A61L29/085 , A61L29/14 , A61M25/0045 , A61M25/005 , A61M2025/0046 , A61M2025/0047 , A61M2025/0048 , A61M2025/006 , A61N1/056 , B29C47/0014 , B29C47/0028 , B29C47/0033 , B29C53/40 , B29C53/46 , B29C61/006 , B29C66/112 , B29C66/1122 , B29C66/1142 , B29C66/133 , B29C66/135 , B29C66/432 , B29C66/4322 , B29C66/438 , B29C66/49 , B29C66/52272 , B29C66/71 , B29C66/723 , B29C67/0018 , B29C69/001 , B29C2793/009 , B29D23/001 , B29L2031/602 , B29L2031/753 , B29L2031/7542 , B32B1/08 , B32B5/028 , B32B27/08 , B32B27/12 , B32B27/285 , B32B27/34 , B32B27/40 , B32B2250/24 , B32B2255/10 , B32B2255/26 , B32B2262/0269 , B32B2262/101 , B32B2262/103 , B32B2307/728 , B32B2307/736 , B32B2307/746 , B32B2535/00 , Y10T156/1008 , Y10T156/101 , Y10T156/1038 , Y10T156/1054 , Y10T156/1062 , Y10T156/1066 , Y10T156/1313 , Y10T156/1322 , C08L75/04 , B29K2075/00
摘要： Apparatus and methods are provided for substantially continuously forming thin-walled sleeves that may be incorporated into tubular devices sized for introduction into a patient. In one embodiment, a pair of sheets including coated surfaces oriented towards one another are directed through a cutting apparatus to cut the sheets into multiple pairs of strips. The pairs of strips are bonded together to create a plurality of sleeves having lumens defined by the coated surfaces. In another embodiment, a sheet having a coated surface is fed through a cutting tool to separate the sheet into a plurality of strips, and the strips are formed into sleeves, e.g., by feeding the strips through a die or mandrel using a substantially continuous process. Optionally, the sleeves may be subsequently cut into individual tubular devices and/or further processed, e.g., by providing one or more layers around the sleeves to create catheters, sheaths, or other apparatus.
摘要翻译： 提供了用于基本上连续地形成薄壁套筒的装置和方法，所述薄壁套筒可并入到尺寸适于引入患者体内的管状装置中。 在一个实施例中，包括朝向彼此定向的涂覆表面的一对片材被引导通过切割装置以将片材切割成多对条带。 这些条带被粘合在一起以产生多个具有被涂覆表面限定的腔的套筒。 在另一个实施例中，具有涂覆表面的片材通过切割工具进给以将片材分离成多个条带，并且条形成为套筒，例如通过使用基本连续的方法将条带穿过模具或心轴 。 任选地，可以随后将套管切割成单独的管状装置和/或进一步加工，例如通过围绕套管提供一个或多个层以产生导管，护套或其它装置。
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2.发明授权Apparatus and methods for delivering stem cells and other agents into cardiac tissue 有权将干细胞和其他药物递送到心脏组织中的装置和方法公开(公告)号：US07744564B2
公开(公告)日：2010-06-29
申请号：US12463111
申请日：2009-05-08
IPC分类号： A61M31/00
CPC分类号： A61M25/10 , A61M2025/105 , A61M2025/1052
摘要： A system for delivering an agent to tissue surrounding a target vessel includes an elongate delivery device and a source coupled to a proximal tubular portion of the device. A first lumen extends through the tubular portion and an expandable sheath of the device, wherein the expandable sheath has a proximal end that surrounds and overlies a distal end of the tubular portion. The device further includes a stiffening member, attached to the sheath, and a balloon attached to the stiffening member, at a location spaced apart from the sheath. A second lumen extends, within the tubular portion and the stiffening member, to the balloon. A volume of fluid may be delivered, from the source, through the first lumen and into a section of the target vessel that is downstream from the expandable sheath and upstream of the balloon, in order to expand the sheath, fill the section and apply a pressure sufficient to cause extravasation of the section.
摘要翻译： 用于将试剂递送到围绕目标血管的组织的系统包括细长输送装置和耦合到装置的近端管状部分的源。 第一腔延伸穿过管状部分和装置的可膨胀护套，其中可扩张护套具有围绕并覆盖管状部分的远端的近端。 该装置还包括附接到护套的加强构件和附接到加强构件的气囊，在与护套间隔开的位置处。 第二内腔在管状部分和加强构件内延伸到气囊。 一定体积的流体可以从源通过第一内腔并进入目标血管的可扩张护套下游和气囊上游的部分，以便扩张护套，填充该部分并施加一个 压力足以导致部分外渗。
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公开(公告)号：US20100160952A1
公开(公告)日：2010-06-24
申请号：US12715517
申请日：2010-03-02
申请人： Stephen A. Leeflang , Christine P. Ventura , Christian S. Eversull , Nicholas J. Mourlas , Christopher Loew
发明人： Stephen A. Leeflang , Christine P. Ventura , Christian S. Eversull , Nicholas J. Mourlas , Christopher Loew
IPC分类号： A61M29/00
CPC分类号： A61M25/0662 , A61B17/3439 , A61M25/003 , A61M2025/0024 , A61M2025/0035 , A61N1/056
摘要： An apparatus for providing access to a body lumen includes a tubular proximal portion and an expandable distal portion, which extends distally from a distal end of the proximal portion. The expandable distal portion includes an expandable sheath and a stiffening member. The proximal portion has a first lumen extending from a proximal end to a distal end thereof, and the expandable sheath defines a second lumen that is in fluid communication with the first lumen and extends distally from the proximal portion to a distal terminal opening of the second lumen. The stiffening member is attached directly to the expandable sheath so as to extend alongside the second lumen, and the distal terminal opening of the second lumen is defined by a portion of a perimeter of a distal terminal end of the expandable sheath that becomes spaced apart from the stiffening member when the sheath is expanded.
摘要翻译： 用于提供对体腔的通路的装置包括管状近端部分和可伸展远侧部分，其从近端部分的远端向远侧延伸。 可扩展的远侧部分包括可扩张护套和加强构件。 近端部分具有从近端延伸到其远端的第一腔，并且可扩张护套限定与第一腔流体连通的第二腔，并且从第二内腔的近端部向远端延伸到第二腔的远侧端部开口 流明。 加强构件直接附接到可膨胀护套，以便沿着第二内腔延伸，并且第二内腔的远端终端开口由可扩张护套的远端终端的周边的一部分限定， 当护套膨胀时的加强构件。
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公开(公告)号：US07637902B2
公开(公告)日：2009-12-29
申请号：US11563142
申请日：2006-11-24
IPC分类号： A61M25/00
CPC分类号： A61M25/0668 , A61M25/0045 , A61M25/005
摘要： Splittable tubular devices and methods for making them are provided. In one embodiment, a tubular device includes a proximal end, a distal end sized for introduction into a body lumen, and a lumen extending between the proximal and distal ends. The tubular device includes an outer tubular layer defining a circumference; and a reinforcing layer bonded to the outer tubular layer, the reinforcing layer including a circumferential interruption. To make a tubular device, an elongate tubular reinforcing structure may be folded into itself to define first and second longitudinal edges, and rolled until the longitudinal edges are disposed adjacent one another. The reinforcing structure may be attached to a tubular structure such that the longitudinal edges define a circumferential interruption extending along a length of the tubular structure.
摘要翻译： 提供可分离的管状装置及其制造方法。 在一个实施例中，管状装置包括近端，尺寸适于引入体腔的远端和在近端和远端之间延伸的内腔。 管状装置包括限定圆周的外管层; 以及加强层，其与所述外管层接合，所述加强层包括周向中断。 为了制造管状装置，细长管状加强结构可以折叠成自身以限定第一和第二纵向边缘，并且滚动直到纵向边缘彼此相邻地设置。 加强结构可以附接到管状结构，使得纵向边缘限定沿着管状结构的长度延伸的圆周中断。
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5.发明授权公开(公告)号：US07556710B2
公开(公告)日：2009-07-07
申请号：US11340944
申请日：2006-01-26
IPC分类号： B29C63/10 , B29C53/78 , B29C53/00 , B29C47/00 , B29C65/00 , B32B27/00 , B32B37/00 , A61M5/32 , A61M25/00
CPC分类号： B29C61/006 , A61L29/085 , A61L29/14 , A61M25/0009 , A61M25/0045 , A61M2025/0046 , B29C47/0023 , B29C47/0026 , B29C47/0028 , B29C47/0033 , B29C47/0038 , B29C47/021 , B29C47/065 , B29C53/40 , B29C66/1122 , B29C66/1142 , B29C66/131 , B29C66/432 , B29C66/4322 , B29C66/49 , B29C66/52272 , B29C67/0018 , B29C69/001 , B29C2793/009 , B29D23/001 , B29L2031/602 , B29L2031/753 , B29L2031/7542 , B32B1/08 , B32B5/028 , B32B27/08 , B32B27/12 , B32B27/285 , B32B27/32 , B32B27/34 , B32B27/40 , B32B2255/10 , B32B2255/24 , B32B2255/26 , B32B2535/00 , Y10T156/1038 , C08L75/04
摘要： Coated devices for introduction into bodies and methods for making and using them are provided, such as delivery sheaths, guidewire lumen cores, and elongate leads. In one embodiment, a tubular device includes a proximal end, a distal end sized for introduction into a body lumen, and a lumen extending between the proximal and distal ends. The tubular device includes a relatively thin inner polyurethane liner including a coating on an inner surface thereof, e.g., providing a lubricious and/or hydrophilic lumen, and an outer layer surrounding the liner. In another embodiment, a lead is provided that includes a proximal end, a distal end, and at least one electrode on the distal end. A polyurethane cover surrounds at least a portion of an outer surface of the lead that include a coating, e.g., including a lubricious and/or hydrophilic material. Optionally, the cover may be removable from around the lead body.
摘要翻译： 提供用于引入主体的涂覆装置和用于制造和使用它们的方法，例如输送护套，导丝管芯芯和细长引线。 在一个实施例中，管状装置包括近端，尺寸适于引入体腔的远端和在近端和远端之间延伸的内腔。 管状装置包括相对薄的内部聚氨酯衬里，其包括在其内表面上的涂层，例如提供润滑和/或亲水的内腔以及围绕衬垫的外层。 在另一个实施例中，提供了一种引线，其包括近端，远端和远端上的至少一个电极。 聚氨酯覆盖物包围引线的外表面的至少一部分，其包括涂层，例如包括润滑和/或亲水材料。 可选地，盖可以从引线主体周围移除。
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公开(公告)号：US09839771B2
公开(公告)日：2017-12-12
申请号：US12406897
申请日：2009-03-18
申请人： Christian Scott Eversull , Nicholas J. Mourlas , Stephen Arie Leeflang , Asha Shrinivas Nayak , David John Miller
发明人： Christian Scott Eversull , Nicholas J. Mourlas , Stephen Arie Leeflang , Asha Shrinivas Nayak , David John Miller
CPC分类号： A61M25/1027 , A61B17/3431 , A61B17/3439 , A61F2/95 , A61F2002/011 , A61F2002/9511 , A61M25/0662 , A61M25/0668 , A61M25/1002 , A61M25/104 , A61M2025/0177 , A61M2025/0681 , A61M2025/1004 , A61M2025/1088 , A61M2029/025
摘要： Apparatus and methods are provided for accessing body lumens and/or for delivering instruments into body lumens, e.g., vessels within a patient's vasculature. A flexible sheath is provided that is expandable from a contracted condition to an enlarged condition wherein the sheath at least partially defines a lumen therein. The sheath is lubricious and has a relatively thin wall, thereby providing a collapsible/expandable guide for delivering fluids and/or instruments through tortuous anatomy and/or into relatively narrow passages. The sheath is advanced from an entry site to a body lumen in the contracted condition. Once the sheath reaches a target body lumen, the sheath is expanded to the enlarged condition, thereby defining a lumen within the sheath, and fluids and/or instruments are introduced into the body lumen via the sheath lumen. Upon completing the procedure, the sheath is removed from the body lumen.
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公开(公告)号：US20110034790A1
公开(公告)日：2011-02-10
申请号：US12906965
申请日：2010-10-18
申请人： Nicholas J. Mourlas , Christian Scott Eversull , Stephen Arie Leeflang , Asha Shrinivas Nayak , David John Miller
发明人： Nicholas J. Mourlas , Christian Scott Eversull , Stephen Arie Leeflang , Asha Shrinivas Nayak , David John Miller
CPC分类号： A61B1/00082 , A61B1/00096 , A61B1/005 , A61B1/018 , A61B1/05 , A61B2017/00243 , A61B2017/00907 , A61M25/0147
摘要： Apparatus and methods for locating morphological features within a body cavity using a catheter including proximal and distal ends, a transparent balloon carried on the distal end, and an optical imaging assembly carried on the distal end for imaging through the balloon. The balloon includes a channel extending therethrough to a lumen extending through the catheter. A guidewire or other localization member is received in the lumen that is extendable through the channel. During use, the catheter is inserted into a right atrium of a heart, and the balloon is expanded and placed against the wall of the heart to locate the coronary sinus. Sufficient force is applied to clear blood between the surface and the wall and clear the field of view of the imaging assembly. The catheter is manipulated to locate the coronary sinus, whereupon the localization member is advanced into the coronary sinus.
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公开(公告)号：US07837671B2
公开(公告)日：2010-11-23
申请号：US12617163
申请日：2009-11-12
IPC分类号： A61M25/00
CPC分类号： A61M25/0668 , A61M25/0045 , A61M25/005
摘要： A sheath for delivering a lead or other device into a body lumen is adapted to be removed from around the delivered lead or device via a longitudinally extending feature. This feature of the sheath may be a ripcord, a seam or interlocking features the releasably engage one another.
摘要翻译： 用于将引线或其他装置输送到体腔中的护套适于经由纵向延伸的特征从输送的引线或装置周围移除。 护套的这个特征可以是撕开，接缝或互锁特征可释放地彼此接合。
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9.发明授权Expandable guide sheath and apparatus with distal protection and methods for use 有权可扩展的导套和远端保护装置及使用方法公开(公告)号：US07591832B2
公开(公告)日：2009-09-22
申请号：US10934082
申请日：2004-09-02
IPC分类号： A61M29/00
CPC分类号： A61B17/3431 , A61B17/1204 , A61B17/12136 , A61F2/013 , A61F2/966 , A61M25/0023 , A61M25/005 , A61M25/0102 , A61M25/10 , A61M2025/0024 , A61M2025/0681
摘要： Apparatus and methods provide distal protection while accessing blood vessels within a patient's vasculature. A flexible sheath and distal protection element, e.g., a balloon or filter, are carried by a stiffening member. The sheath is lubricious and has a relatively thin wall, thereby providing a collapsible/expandable guide for delivering fluids and/or instruments. The sheath is advanced into a blood vessel in a contracted condition, expanded to an enlarged condition to define a lumen, and the distal protection element is deployed within the vessel beyond the sheath. Fluids and/or instruments are introduced into the vessel via the sheath lumen, the distal protection element retaining the fluids and/or capturing emboli released by the instruments. Upon completing the procedure, the sheath, distal protection element, and stiffening member are removed from the vessel.
摘要翻译： 装置和方法在进入患者脉管系统内的血管时提供远端保护。 柔性护套和远端保护元件，例如球囊或过滤器，由加强构件承载。 护套是光滑的并且具有相对薄的壁，从而提供用于输送流体和/或器械的可折叠/可扩展的引导件。 护套在收缩状态下进入血管，扩张到扩大的状态以限定内腔，并且远端保护元件展开在血管内超过护套。 流体和/或器械通过护套管腔引入血管，远端保护元件保持流体和/或捕获由器械释放的栓塞。 完成该程序后，护套，远端保护元件和加强构件从容器中取出。
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10.发明授权Apparatus and methods for delivering stem cells and other agents into cardiac tissue 有权将干细胞和其他药物递送到心脏组织中的装置和方法公开(公告)号：US07575569B2
公开(公告)日：2009-08-18
申请号：US11465109
申请日：2006-08-16
IPC分类号： A61M31/00
CPC分类号： A61M25/10 , A61M2025/105 , A61M2025/1052
摘要： Apparatus, systems, and methods are provided for delivering stem cells or other agents to cardiac tissue surrounding a cardiac vessel or to tissue adjacent other body lumens. The apparatus includes an expandable member and a source of one or more agents communicating with a lumen extending between proximal and distal ends of the apparatus. The distal end of the apparatus is advanced through one or more body lumens until the distal end is disposed within or adjacent the target body lumen. The target body lumen is sealed, e.g., by expanding the expandable member, thereby isolating the target body lumen. One or more agents are delivered into the target body lumen with sufficient pressure to extravasate the one or more agents into tissue surrounding the target body lumen.
摘要翻译： 提供了装置，系统和方法，用于将干细胞或其它药剂递送到围绕心脏血管的心脏组织或邻近其他体腔的组织。 该装置包括可扩张构件和一个或多个试剂的源，其与在装置的近端和远端之间延伸的内腔连通。 装置的远端通过一个或多个体腔前进直到远端设置在目标体腔内或邻近靶体腔。 目标体腔被密封，例如通过膨胀可扩张构件，从而隔离目标体腔。 一个或多个药剂以足够的压力被递送到目标体腔内，以将一种或多种药剂外渗到靶体周围的组织中。
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