公开(公告)号：US20060139621A1

公开(公告)日：2006-06-29

申请号：US11236045

申请日：2005-09-26

申请人： Thomas Baer ,  Michael Youngquist ,  Brian Donovan ,  Alan Wessel ,  Norbert Leclerc ,  Michael Smith ,  George Dawson ,  Craig Barker

发明人： Thomas Baer ,  Michael Youngquist ,  Brian Donovan ,  Alan Wessel ,  Norbert Leclerc ,  Michael Smith ,  George Dawson ,  Craig Barker

IPC分类号： G01N1/00

CPC分类号： G01N1/2813 ,  G01B11/002 ,  G01N2001/282 ,  G01N2001/284 ,  Y10T156/10 ,  Y10T156/1054

摘要： Systems and methods for automated laser microdissection are disclosed including automatic slide detection, position detection of cutting and capture lasers, focus optimization for cutting and capture lasers, energy and duration optimization for cutting and capture lasers, inspection and second phase capture and/or ablation in a quality control station and tracking information for linking substrate carrier or output microdissected regions with input sample or slide.

摘要翻译： 公开了用于自动激光显微切割的系统和方法，包括自动滑动检测，切割和捕获激光器的位置检测，用于切割和捕获激光器的聚焦优化，用于切割和捕获激光器的能量和持续时间优化，检查和第二相捕获和/或消融 质量控制站和用于将衬底载体或输出显微切割区域与输入样品或载片连接的跟踪信息。

公开(公告)号：US08691524B2

公开(公告)日：2014-04-08

申请号：US13024121

申请日：2011-02-09

申请人： Norbert Leclerc

发明人： Norbert Leclerc

IPC分类号： A61B18/20

CPC分类号： G01N1/2813 ,  G01N2001/2833

摘要： A film (14) with a tissue section (10) is placed with the tissue section (10) downward on a microscope slide (18) and the microscope slide (18) positioned in the object plane of an inverse microscope; where an adhesive tape (20) is arranged, with a bonding agent (22) downward, above the film (14) and therefore above the tissue section (10); wherein the next step, tissue (36) to be isolated is excised by a focused laser beam, which also divides the film (14); whereupon removal of the adhesive tape (20) from the microscope, the excised tissue pieces (36) adhere to the adhesive tape (20), and the remnant of the film (14) and of the tissue section (10) remains adhering to the microscope slide (18).

摘要翻译： 将具有组织部分（10）的膜（14）放置在组织部分（10）的下方，在显微镜载玻片（18）和位于反显微镜的物平面中的显微镜载玻片（18） 其中粘合剂带（20）被布置成具有粘合剂（22）向下，在膜（14）上方，因此在组织部分（10）上方。 其中，下一步骤，被分离的组织（36）通过聚焦的激光束切除，聚焦的激光束也分割膜（14）; 然后从显微镜去除粘合带（20），切除的组织片（36）粘附到胶带（20）上，并且膜（14）和组织部分（10）的残留物保持粘附到 显微镜幻灯片（18）。

公开(公告)号：US20110192534A1

公开(公告)日：2011-08-11

申请号：US13024121

申请日：2011-02-09

申请人： Norbert Leclerc

发明人： Norbert Leclerc

IPC分类号： B32B38/10

CPC分类号： G01N1/2813 ,  G01N2001/2833

摘要： A film (14) with a tissue section (10) is placed with the tissue section (10) downward on a microscope slide (18) and the microscope slide (18) positioned in the object plane of an inverse microscope; where an adhesive tape (20) is arranged, with a bonding agent (22) downward, above the film (14) and therefore above the tissue section (10); wherein the next step, tissue (36) to be isolated is excised by a focused laser beam, which also divides the film (14); whereupon removal of the adhesive tape (20) from the microscope, the excised tissue pieces (36) adhere to the adhesive tape (20), and the remnant of the film (14) and of the tissue section (10) remains adhering to the microscope slide (18).

摘要翻译： 将具有组织部分（10）的膜（14）放置在组织部分（10）的下方，在显微镜载玻片（18）和位于反显微镜的物平面中的显微镜载玻片（18） 其中粘合剂带（20）被布置成具有粘合剂（22）向下，在膜（14）上方，因此在组织部分（10）上方。 其中，下一步骤，被分离的组织（36）通过聚焦的激光束切除，聚焦的激光束也分割膜（14）; 然后从显微镜去除粘合带（20），切除的组织片（36）粘附到胶带（20）上，并且膜（14）和组织部分（10）的残留物保持粘附到 显微镜幻灯片（18）。

公开(公告)号：US20080176275A1

公开(公告)日：2008-07-24

申请号：US11671702

申请日：2007-02-06

申请人： Norbert Leclerc

发明人： Norbert Leclerc

IPC分类号： G01N1/30

CPC分类号： G01N1/2813 ,  G01N2001/2833

摘要： A film with a tissue section is placed with the tissue section downward on a microscope slide and the microscope slide positioned in the object plane of an inverse microscope; where an adhesive tape is arranged, with a bonding agent downward, above the film and therefore above the tissue section; wherein the next step, tissue to be isolated is excised by a focused laser beam, which also divides the film; whereupon removal of the adhesive tape from the microscope, the excised tissue pieces adhere to the adhesive tape, and the remnant of the film and of the tissue section remains adhering to the microscope slide.

摘要翻译： 将具有组织切片的膜放置在组织切片向下放置在显微镜载玻片上，并将显微镜载玻片放置在反相显微镜的物平面中; 其中粘合带布置有粘合剂向下，在膜上方，因此在组织部分上方; 其中下一个步骤中，待分离的组织被聚焦的激光束切除，聚焦的激光束也将膜分割; 于是从显微镜去除粘合带，切除的组织片粘附到胶带上，并且膜和组织部分的残余物保持粘附到显微镜载片上。

公开(公告)号：US08845623B2

公开(公告)日：2014-09-30

申请号：US11671702

申请日：2007-02-06

申请人： Norbert Leclerc

发明人： Norbert Leclerc

IPC分类号： A61B18/18 ,  G01N1/28

CPC分类号： G01N1/2813 ,  G01N2001/2833

摘要： A film with a tissue section is placed with the tissue section downward on a microscope slide and the microscope slide positioned in the object plane of an inverse microscope; where an adhesive tape is arranged, with a bonding agent downward, above the film and therefore above the tissue section; wherein the next step, tissue to be isolated is excised by a focused laser beam, which also divides the film; whereupon removal of the adhesive tape from the microscope, the excised tissue pieces adhere to the adhesive tape, and the remnant of the film and of the tissue section remains adhering to the microscope slide.

摘要翻译： 将具有组织切片的膜放置在组织切片向下放置在显微镜载玻片上，并将显微镜载玻片放置在反相显微镜的物平面中; 其中粘合带布置有粘合剂向下，在膜上方，因此在组织部分上方; 其中下一个步骤中，待分离的组织被聚焦的激光束切除，该聚焦的激光束也分裂膜; 于是从显微镜去除粘合带，切除的组织片粘附到胶带上，并且膜和组织部分的残余物保持粘附到显微镜载片上。

公开(公告)号：US08535905B2

公开(公告)日：2013-09-17

申请号：US10202118

申请日：2002-07-24

申请人： Norbert Leclerc

发明人： Norbert Leclerc

IPC分类号： G01N33/48

CPC分类号： G01N1/2813 ,  G01N2001/2833

摘要： A film (14) with a tissue section (10) is placed with the tissue section (10) downward on a microscope slide (18) and the microscope slide (18) positioned in the object plane of an inverse microscope; where an adhesive tape (20) is arranged, with a bonding agent (22) downward, above the film (14) and therefore above the tissue section (10); wherein the next step, tissue (36) to be isolated is excised by a focused laser beam, which also divides the film (14); whereupon removal of the adhesive tape (20) from the microscope, the excised tissue pieces (36) adhere to the adhesive tape (20), and the remnant of the film (14) and of the tissue section (10) remains adhering/to the microscope slide (18).

公开(公告)号：US20070208395A1

公开(公告)日：2007-09-06

申请号：US11686121

申请日：2007-03-14

申请人： Norbert Leclerc ,  Brendan Moran ,  James Flom ,  Michael Gertner ,  Jonathan Podmore ,  Michael Rode ,  John Crowe ,  Erica Rogers

发明人： Norbert Leclerc ,  Brendan Moran ,  James Flom ,  Michael Gertner ,  Jonathan Podmore ,  Michael Rode ,  John Crowe ,  Erica Rogers

IPC分类号： A61N5/06

CPC分类号： A61N5/0616 ,  A61B2017/00026 ,  A61B2017/00057 ,  A61B2018/00642 ,  A61B2018/00702 ,  A61B2018/00785 ,  A61N5/062 ,  A61N2005/007 ,  A61N2005/0628 ,  A61N2005/063 ,  A61N2005/0645 ,  A61N2005/0652

摘要： A method and apparatus is described for treating a target body surface using a radiation applicator. The therapeutic treatment apparatus adapted to conform to a patients body. The treatment apparatus comprises a plurality of light sources coupled with a flexible substrate, a light integrator in at least a portion of the optical path between the light source and the patient's body surface, a power supply, and a controller.

摘要翻译： 描述了使用辐射施加器来治疗目标体表的方法和装置。 该治疗设备适于符合患者身体。 处理装置包括与柔性基板耦合的多个光源，在光源和患者体表之间的光路的至少一部分中的光积分器，电源和控制器。