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公开(公告)号：US5986143A
公开(公告)日：1999-11-16
申请号：US700507
申请日：1996-09-23
申请人： Hiromi Uchiro , Norio Kawabe , Kouichi Tsuruta , Teiji Kawano
发明人： Hiromi Uchiro , Norio Kawabe , Kouichi Tsuruta , Teiji Kawano
IPC分类号： C07C319/02 , C07C319/24 , C07C321/26 , C07C321/28 , C07C321/00
CPC分类号： C07C319/24 , C07C319/02
摘要： The present invention relates to a method of producing bis(4-alkylthiophenyl) disulfides characterized by (a) reducing directly a 4-alkylthiobenzenesulfonyl chloride, or (b) oxidizing a 4-alkylthiobenzenethiol obtained by reducing a 4-alkylthiobenzenesulfonyl chloride. The present invention is capable of producing the compound below useful as an intermediate of pharmaceuticals. ##STR1##
摘要翻译： PCT No.PCT / JP95 / 02645 Sec。 371日期：1996年8月22日 102（e）日期1996年8月22日PCT提交1995年12月22日PCT公布。 WO96 / 19448 PCT公开号 日期：1996年6月27日本发明涉及一种生产双（4-烷硫基苯基）二硫化物的方法，其特征在于（a）直接还原4-烷硫基苯磺酰氯，或（b）氧化通过还原4-烷硫基苯磺酰基得到的4-烷硫基苯硫醇 氯化物。 本发明能够制备下面用作药物中间体的化合物。
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公开(公告)号：US5886206A
公开(公告)日：1999-03-23
申请号：US632421
申请日：1996-07-02
CPC分类号： C07F9/3865 , C07F9/4043
摘要： A process for production of l-alkylthiomethanediphosphonic acid compound or 1-arylthiomethanediphosphonic acid compound characterized by removing a thiolate byproduct as an insoluble salt, in the condensation represented by the following formula: ##STR1## wherein R'.sub.1 represents a linear or branched alkyl group having 1 to 6 carbon atoms, R.sub.2 represents an alkyl or aryl group, R.sub.1 represents a pharmaceutically allowable cation, hydrogen atom, or linear or branched alkyl group having 1 to 6 carbon atoms. The present invention significantly improves the yield compared with conventional methods, and simplifies the purification process at the same time, thus is extremely useful in an economical and industrial points of view.
摘要翻译： PCT No.PCT / JP95 / 01683 Sec。 371日期：1996年7月2日 102（e）日期1996年7月2日PCT提交1995年8月24日PCT公布。 出版物WO96 / 06100 日期：1996年2月29日制造1-烷基硫代甲烷二膦酸化合物或1-芳基硫代甲烷二膦酸化合物的方法，其特征在于以下述式表示的缩合物，除去作为不溶性盐的硫醇化物副产物：
（A） 其中R'1表示碳原子数1〜6的直链或支链烷基，R2表示烷基或芳基，R1表示药学上可允许的阳离子，氢原子或碳原子数1〜6的直链或支链烷基。 本发明与常规方法相比显着提高了产量，并且同时简化了净化过程，因此在经济和工业观点上是非常有用的。 -
公开(公告)号：US4496647A
公开(公告)日：1985-01-29
申请号：US514963
申请日：1983-07-18
申请人： Norio Kawabe , Mikio Tsuda , Sadao Kobashi
发明人： Norio Kawabe , Mikio Tsuda , Sadao Kobashi
CPC分类号： G03C5/00 , G03F7/0752 , G03F7/38
摘要： An image-forming laminated plate, particularly a dry planographic printing unprocessed plate, comprising a base substrate, a photosensitive layer containing a substance with quinonediazide structure and a silicone rubber layer in laminating order is treated with a base after imagewise exposure. In addition, the image-forming laminated plate may be subjected to a whole surface slight exposure to the extent that 5 to 60 molar % of the quinonediazide structure in the photosensitive layer to be exposed is photo-decomposed into carboxylic acid structure before or after the usual imagewise exposure for obtaining a negative working plate, or the image-forming laminated plate may be subjected to a imagewise slight exposure to the same extent without the usual imagewise exposure for obtaining a positive working plate. The base-treatment alone or in combination with the slight exposure enhances both the adhesion of the photosensitive layer to the silicone rubber layer and the solvent resistance of the photosensitive layer in non-image areas.
摘要翻译： 在成像曝光后，用基底处理图像形成层压板，特别是干式平版印刷未加工板，其中包括基底基板，含有醌二叠氮化物结构的感光层和硅橡胶层。 此外，图像形成层压板可以经受整个表面的轻微曝光，使得要曝光的感光层中的5〜60摩尔％的醌二叠氮化物结构在其前后之前被光分解成羧酸结构 为了获得正的工作板，通常的成像曝光用于获得负极板或图像形成层压板可以经受相同程度的成像轻微曝光，而无需通常的成像曝光。 单独的基础处理或与轻微暴露的组合增强了感光层对硅橡胶层的粘附性和非图像区域中感光层的耐溶剂性。
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公开(公告)号：US5683992A
公开(公告)日：1997-11-04
申请号：US617937
申请日：1996-03-15
CPC分类号： C07F9/386 , C07F9/3865 , C07F9/4025 , C07F9/404 , C07F9/405
摘要： The present invention relates to a methanediphosphonate derivative, its manufacturing process, and pharmaceutical applications, that is represented with the following formula: ##STR1## wherein, D is either sulfur, oxygen, NH, alkyl-substituted N, CH.sub.2, or SCH.sub.2, X represents an alkyl group, alkyl group having a hetero atom as a substitution group, an aryl group or an acyl group, m represents an integer of 1 to 5, and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently represent hydrogen, alkyl groups having 1 to carbon atoms or pharmaceutically allowable cations. .function.The compounds of the present invention have excellent IL-1 inhibitory action, antioxidation action and bone resorption inhibitory action, and are useful as antiinflammatory agents, antirheumatic agents, bone metabolic disease drugs, autoimmune disease drugs, or osteoporosis drugs.
摘要翻译： 本发明涉及由下式表示的甲基二膦酸酯衍生物，其制备方法和药物应用：
或 取代的N，CH 2或SCH 2，X表示烷基，具有 杂原子作为取代基，芳基或酰基，m表示1〜5的整数，R 1，R 2，R 3和R 4分别表示氢，具有1〜碳原子的烷基或药学上可允许的阳离子。 f本发明的化合物具有优异的IL-1抑制作用，抗氧化作用和骨吸收抑制作用，可用作抗炎剂，抗风湿剂，骨代谢疾病药物，自身免疫性疾病药物或骨质疏松症药物。 -
公开(公告)号：US4342820A
公开(公告)日：1982-08-03
申请号：US215100
申请日：1980-12-10
申请人： Takao Kinashi , Takashi Fujita , Norio Kawabe
发明人： Takao Kinashi , Takashi Fujita , Norio Kawabe
CPC分类号： G03F7/022 , G03F7/0752
摘要： Provided is a presensitized planographic printing master plate requiring no dampening water for use in negative work which comprises a base substrate, a light releasing photosensitive layer overlying the base substrate and a silicone rubber layer overlying the photosensitive layer. When the printing master plate is exposed through a negative film and then treated with a developer, only the silicone rubber layer overlying the exposed photosensitive layer is removed, while the photosensitive layer remains as it is to form an image area. Dampening water is not required when printing is carried out.
摘要翻译： 提供了一种不需要用于负面工作的润版水的预觉平版印刷母版，其包括基底基板，覆盖基底基板的光释放感光层和覆盖在感光层上的硅橡胶层。 当印刷母板通过负片曝光，然后用显影剂处理时，仅去除覆盖曝光的感光层的硅橡胶层，同时感光层保持原状以形成图像区域。 打印时不需要防潮水。
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公开(公告)号：US4003936A
公开(公告)日：1977-01-18
申请号：US202597
申请日：1971-11-26
申请人： Masaji Ohno , Mutsuo Kataoka , Norio Kawabe
发明人： Masaji Ohno , Mutsuo Kataoka , Norio Kawabe
IPC分类号： A61K31/12 , C07C45/62 , C07C45/68 , C07C45/74 , C07C49/657 , C07C49/697 , C07C49/747 , C07C49/753 , C07C49/82 , C07D317/54 , C07C49/76 , C07C49/80 , C07C49/84
CPC分类号： C07D317/54 , C07C205/45 , C07C45/62 , C07C45/68 , C07C45/74 , C07C49/657 , C07C49/697 , C07C49/747 , C07C49/753
摘要： As new compound, a series of 2-hydrocinnamoyl-1,3-cyclopentanedione derivative of the general formula: ##STR1## WHEREIN Ar stands for a mono-valent aromatic radical, for example, phenyl and 3,4-methylenedioxy-phenyl, substituted or unsubstituted, have been found to have an activity to inhibit the action of tyrosine hydroxylase and to be useful as hypotensive agent. These new compounds may be produced by condensing 2-acetyl-1,3-cyclopentanedione with an aromatic aldehyde of the formula Ar-CHO wherein Ar is as defined, according to Claisen-Schmidt condensation, followed by the hydrogenation of the condensation product obtained, or the new compounds may also be produced by reacting 2-acetyl-1,3-cyclopentanedione with an aromatic halide of the formula Ar-CH.sub.2 X wherein Ar is as defined and X is a halogen, for example, in liquid ammonia and in the presence of an alkali metal amide.
摘要翻译： 作为新化合物，通式为：其中Ar表示一价芳族基团的一系列2-氢化肉桂酰基-1,3-环戊二酮衍生物，例如苯基和3,4-亚甲二氧基 - 苯基，取代 或未取代的，已经被发现具有抑制酪氨酸羟化酶作用的活性并且可用作降压剂。 这些新化合物可以通过将2-乙酰基-1,3-环戊二酮与式Ar-CHO的芳族醛缩合制备，其中Ar如所定义，根据Claisen-Schmidt缩合，然后氢化得到的缩合产物， 或者新化合物也可以通过使2-乙酰基-1,3-环戊二酮与式Ar-CH 2 X的芳族卤化物反应来制备，其中Ar如所定义，X是卤素，例如在液氨中，并且在存在下 的碱金属酰胺。
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7.发明授权Methanediphosphonate derivative, its manufacturing process and its pharmaceutical applications 失效甲烷二膦酸衍生物，其制造工艺及其制药应用
公开(公告)号：US5527940A
公开(公告)日：1996-06-18
申请号：US340819
申请日：1994-11-17
CPC分类号： C07F9/386 , C07F9/3865 , C07F9/4025 , C07F9/404 , C07F9/405
摘要： The present invention relates to a methanediphosphonate derivative, its manufacturing process and pharmaceutical applications, that is represented with the following formula: ##STR1## (wherein, B is either hydrogen, an alkyl group, hydroxyl group, alkoxy group or amino group, D is either sulfur, oxygen, NH, alkyl-substituted N, CH.sub.2 or SCH.sub.2, X represents an alkyl group, alkyl group having a hetero atom as a substitution group, an aryl group or an acyl group, m represents an integer of 1 to 5, and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently represent hydrogen, alkyl groups having 1 to 7 carbon atoms or pharmaceutically allowable cations). The compound of the present invention has excellent IL-1 inhibitory action, antioxidation action and bone resorption inhibitory action, and is useful as an antiinflammatory agent, antirheumatic, bone metabolic disease drug, autoimmune disease drug, osteoporosis drug and so forth.
摘要翻译： 本发明涉及由下式表示的甲基二膦酸酯衍生物，其制备方法和药物应用：其中，B为氢，烷基，羟基，烷氧基或氨基 ，D是硫，氧，NH，烷基取代的N，CH 2或SCH 2，X表示烷基，具有杂原子作为取代基的烷基，芳基或酰基，m表示1的整数 至5，R 1，R 2，R 3和R 4独立地表示氢，具有1至7个碳原子的烷基或药学上允许的阳离子）。 本发明化合物具有优异的IL-1抑制作用，抗氧化作用和骨吸收抑制作用，可用作抗炎剂，抗风湿剂，骨代谢疾病药物，自身免疫疾病药物，骨质疏松症药物等。
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8.发明授权Methylenediphosphonic acid compounds and methods of use for the treatment of rheumatism and osteophorosis 失效甲基磷酸化合物及其用于治疗恶病质和卵巢功能的方法
公开(公告)号：US5153183A
公开(公告)日：1992-10-06
申请号：US663958
申请日：1991-05-06
申请人： Norio Kawabe , Keijiro Takanishi , Shu Matsumoto
发明人： Norio Kawabe , Keijiro Takanishi , Shu Matsumoto
CPC分类号： C07F9/386 , C07F9/3865 , C07F9/4043
摘要： This invention relates to a methylenediphosphonic acid compound expressed by the formula (1). The compound has a marked effect as an anti-inflammatory agent or, more particularly, against inflammations accompanying disturbances in bone metabolism. ##STR1##
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公开(公告)号：US4939003A
公开(公告)日：1990-07-03
申请号：US147202
申请日：1988-01-22
申请人： Takao Aoki , Takamasa Harada , Kokichi Ito , Koji Iwasa , Norio Kawabe , Hiroyuki Ikeuchi
发明人： Takao Aoki , Takamasa Harada , Kokichi Ito , Koji Iwasa , Norio Kawabe , Hiroyuki Ikeuchi
IPC分类号： G02F1/1337
CPC分类号： G02F1/133711 , Y10T428/1077
摘要： Disclosed is a liquid crystal element with an improved orientation layer and a coating composition for forming such an orientation layer. The orientation layer consists essentially of a polymer with a Mark-Houwink coefficient of not less than 0.85, the Mark-Houwink coefficient being represented by the formula [I]:[.eta.]=K.multidot.M.sup..alpha. [I]wherein [.eta.] represents intrinsic viscosity of the polymer determined by solution viscosity measuring method, K represents a constant, M represents molecular weight of the polymer, and .alpha. represents the Mark-Houwink coefficient. The coating composition comprises a polyfumaric acid ester represented by the formula [I]: ##STR1## wherein R.sup.1 and R.sup.2, are the same or different and each represents a straight or branched alkyl group, cycloalkyl group, haloalkyl group, silalkyl group or siloxanylalkyl group; and a halogen-containing organic solvent.
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公开(公告)号：US4814132A
公开(公告)日：1989-03-21
申请号：US214911
申请日：1988-06-28
申请人： Takao Aoki , Norio Kawabe
发明人： Takao Aoki , Norio Kawabe
CPC分类号： B29C41/24 , B29C41/36 , B29K2027/12 , B29K2027/18 , B29K2105/0073 , B29L2007/008
摘要： A process for preparing a thin film having a large area. A casting solution of a film-forming material and a solvent is fed to the surface of a liquid substrate immiscible with the solution by utilizing interfacial tension. Spontaneous spreading of the casting solution occurs across the surface of the liquid substrate and evaporation of the solvent produces a thin film on the liquid surface which is continuously collected. The feed of the casting solution to the surface of the substrate is at least either a material which shows selective wettability for the casting solution in preference to the liquid substrate or a structure capable of developing capillarity.
摘要翻译： 一种制备面积大的薄膜的方法。 通过利用界面张力将成膜材料和溶剂的浇铸溶液供给到与溶液不混溶的液体基材的表面。 铸造溶液的自发扩散发生在液体基材的表面上，并且溶剂的蒸发在液体表面上产生连续收集的薄膜。 铸造溶液进料到基材的表面至少是对于液体基材或能够产生毛细作用的结构而言，对铸造溶液显示出选择性润湿性的材料中的至少一种。
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